IJERPH, Vol. 16, Pages 5065: Vulnerability and Adaptation to Extreme Heat in Odisha, India: A Community Based Comparative Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16245065 Authors: Subhashisa Swain Shreeporna Bhattacharya Ambarish Dutta Sanghamitra Pati Lipika Nanda Background: Extreme heat and heat illness are becoming very frequent in India. We aimed to identify the factors associated with heat illness and the coping practices...
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IJERPH, Vol. 16, Pages 5064: Influence of a Municipal Solid Waste Landfill on the Surrounding Environment: Landfill Vegetation as a Potential Risk of Allergenic Pollen International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16245064 Authors: Magdalena Daria Vaverková Dana Adamcová Jan Winkler Eugeniusz Koda Jana Červenková Anna Podlasek When the landfill use comes to end, important subsequent steps include aftercare, safety assurance, and ecological...
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IJERPH, Vol. 16, Pages 5066: Classic Bioelectrical Impedance Vector Reference Values for Assessing Body Composition in Male and Female Athletes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16245066 Authors: Francesco Campa Catarina Matias Hannes Gatterer Stefania Toselli Josely C. Koury Angela Andreoli Giovanni Melchiorri Luis B. Sardinha Analiza M. Silva Bioimpedance standards are well established for the normal healthy...
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IJMS, Vol. 20, Pages 6263: The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases” International Journal of Molecular Sciences doi: 10.3390/ijms20246263 Authors: Jan B. Parys Cláudia F. Pereira Carlos Villalobos The European Calcium Society (ECS) is very glad to present the realization of a special issue of the International Journal of Molecular Sciences (IJMS) related to the eighth ECS workshop organized this year around the theme of “Calcium...
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Microorganisms, Vol. 7, Pages 686: Pathogenesis and Immune Response Caused by Vector-Borne and Other Viral Infections in a Tupaia Model Microorganisms doi: 10.3390/microorganisms7120686 Authors: Mohammad Enamul Hoque Kayesh Md Abul Hashem Bouchra Kitab Kyoko Tsukiyama-Kohara The Tupaia or tree shrew (Tupaia belangeri), a small mammal of the Tupaiidae family, is an increasingly used and promising infection model for virological and immunological research. Recently, sequencing...
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Microorganisms, Vol. 7, Pages 685: Preservation, Characterization and Exploitation of Microbial Biodiversity: The Perspective of the Italian Network of Culture Collections Microorganisms doi: 10.3390/microorganisms7120685 Authors: Luciana De Vero Maria Beatrice Boniotti Marilena Budroni Pietro Buzzini Stefano Cassanelli Roberta Comunian Maria Gullo Antonio F. Logrieco Ilaria Mannazzu Rosario Musumeci Iolanda Perugini Giancarlo Perrone Andrea Pulvirenti Paolo...
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Microorganisms, Vol. 7, Pages 687: Transmission Network of Deer-Borne Mycobacterium bovis Infection Revealed by a WGS Approach Microorganisms doi: 10.3390/microorganisms7120687 Authors: Lorraine Michelet Cyril Conde Maxime Branger Thierry Cochard Franck Biet Maria Laura Boschiroli Bovine tuberculosis (TB) is a zoonotic disease, mainly caused by Mycobacterium bovis. France was declared officially TB free in 2001, however, the disease persists in livestock and wildlife....
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Molecules, Vol. 24, Pages 4543: A New Strategy for Effective Succinic Acid Production by Enterobacter sp. LU1 Using a Medium Based on Crude Glycerol and Whey Permeate Molecules doi: 10.3390/molecules24244543 Authors: Marcin Podleśny Jakub Wyrostek Jagoda Kucharska Piotr Jarocki Elwira Komoń-Janczara Zdzisław Targoński The newly-isolated strain Enterobacter sp. LU1, which has previously been shown to be an effective producer of succinic acid on glycerol with the addition...
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Nutrients, Vol. 11, Pages 3034: Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study Nutrients doi: 10.3390/nu11123034 Authors: Giovanna Muscogiuri Luigi Barrea Carolina Di Somma Daniela Laudisio Ciro Salzano Gabriella Pugliese Giulia de Alteriis Annamaria Colao Silvia Savastano Growing evidence reported that vitamin D deficiency is a common finding in obesity. Vitamin D status also seems to be sex-related, although...
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Particles, Vol. 2, Pages 499-510: Exploring Cosmic Matter in the Laboratory—The Compressed Baryonic Matter Experiment at FAIR Particles doi: 10.3390/particles2040031 Authors: Senger The Compressed Baryonic Matter (CBM) experiment is one of four scientific pillars of the future Facility for Antiproton and Ion Research (FAIR) in Darmstadt. In collisions between heavy nuclei at FAIR energies, it is expected that the matter in the reaction zone is compressed to more than five times saturation...
Wed Dec 11, 2019 02:00
Particles, Vol. 2, Pages 491-498: Improving Center Vortex Detection by Usage of Center Regions as Guidance for the Direct Maximal Center Gauge Particles doi: 10.3390/particles2040030 Authors: Rudolf Golubich Manfried Faber The center vortex model of quantum chromodynamic states that vortices, a closed color-magnetic flux, percolate the vacuum. Vortices are seen as the relevant excitations of the vacuum, causing confinement and dynamical chiral symmetry breaking. In an appropriate...
Wed Dec 11, 2019 02:00
Pharmaceutics, Vol. 11, Pages 672: 3D-Printed Solid Dispersion Drug Products Pharmaceutics doi: 10.3390/pharmaceutics11120672 Authors: Suet Li Chew Laura Modica de Mohac Bahijja Tolulope Raimi-Abraham With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further research and development is required...
Wed Dec 11, 2019 02:00
Pharmaceutics, Vol. 11, Pages 673: In Vitro and In Vivo Assessment of Metabolic Drug Interaction Potential of Dutasteride with Ketoconazole Pharmaceutics doi: 10.3390/pharmaceutics11120673 Authors: Seong-Wook Seo Jin Woo Park Dong-Gyun Han Ji-Min Kim Sanghyun Kim Taeuk Park Kyung-Hwa Kang Min Hye Yang In-Soo Yoon Dutasteride (DUT) is a selective, potent, competitive, and irreversible inhibitor of both type-1 and type-2 5α-reductase (5AR) commonly used...
Wed Dec 11, 2019 02:00
Pharmacy, Vol. 7, Pages 169: Implementation of an Extended-Infusion Piperacillin-Tazobactam Dosing Protocol: Unexpected Findings when Monitoring Safety and Compliance with Smart Pump Technology Pharmacy doi: 10.3390/pharmacy7040169 Authors: Nathaniel J. Rhodes Jenna Lopez Cecilia K. Pham Helga Brake Michael Fotis Spencer E. Harpe Sean Avedissian Marc H. Scheetz Compliance with recommended infusion rates was evaluated before, during, and after the implementation of...
Wed Dec 11, 2019 02:00
Plants, Vol. 8, Pages 593: Understanding the Environmental Background of an Invasive Plant Species (Asclepias syriaca) for the Future: An Application of LUCAS Field Photographs and Machine Learning Algorithm Methods Plants doi: 10.3390/plants8120593 Authors: Péter Szilassi Gábor Szatmári László Pásztor Mátyás Árvai József Szatmári Katalin Szitár Levente Papp For developing global strategies against the dramatic spread of invasive species, we need to identify the geographical,...
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Plants, Vol. 8, Pages 592: Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development Plants doi: 10.3390/plants8120592 Authors: Manu Kumar Mahipal Singh Kesawat Asjad Ali Sang-Choon Lee Sarvajeet Singh Gill and Hyun Uk Kim Plants are immobile and, to overcome harsh environmental conditions such as drought, salt, and cold, they have evolved complex signaling pathways. Abscisic acid (ABA), an isoprenoid phytohormone, is...
Wed Dec 11, 2019 02:00
Plants, Vol. 8, Pages 590: New Insights into Multistep-Phosphorelay (MSP)/ Two-Component System (TCS) Regulation: Are Plants and Bacteria that Different? Plants doi: 10.3390/plants8120590 Authors: Mira-Rodado The Arabidopsis multistep-phosphorelay (MSP) is a signaling mechanism based on a phosphorelay that involves three different types of proteins: Histidine kinases, phosphotransfer proteins, and response regulators. Its bacterial equivalent, the two-component system (TCS), is the...
Wed Dec 11, 2019 02:00
Plants, Vol. 8, Pages 589: Secoiridoids Metabolism Response to Wounding in Common Centaury (Centaurium erythraea Rafn) Leaves Plants doi: 10.3390/plants8120589 Authors: Jelena Božunović Marijana Skorić Dragana Matekalo Suzana Živković Milan Dragićević Neda Aničić Biljana Filipović Tijana Banjanac Branislav Šiler Danijela Mišić Centaurium erythraea Rafn produces and accumulates various biologically active specialized metabolites, including secoiridoid glucosides...
Wed Dec 11, 2019 02:00
Plants, Vol. 8, Pages 591: New Insight into HPts as Hubs in Poplar Cytokinin and Osmosensing Multistep Phosphorelays: Cytokinin Pathway Uses Specific HPts Plants doi: 10.3390/plants8120591 Authors: François Héricourt Mélanie Larcher Françoise Chefdor Konstantinos Koudounas Inês Carqueijeiro Pamela Lemos Cruz Vincent Courdavault Mirai Tanigawa Tatsuya Maeda Christiane Depierreux Frédéric Lamblin Gaëlle Glévarec Sabine Carpin We have previously identified...
Wed Dec 11, 2019 02:00
Risks, Vol. 7, Pages 121: On the Padé and Laguerre–Tricomi–Weeks Moments Based Approximations of the Scale Function W and of the Optimal Dividends Barrier for Spectrally Negative Lévy Risk Processes Risks doi: 10.3390/risks7040121 Authors: Florin Avram Andras Horváth Serge Provost Ulyses Solon This paper considers the Brownian perturbed Cramér–Lundberg risk model with a dividends barrier. We study various types of Padé approximations and Laguerre...
Wed Dec 11, 2019 02:00
Robotics, Vol. 8, Pages 102: Design of Multiple Wearable Robotic Extra Fingers for Human Hand Augmentation Robotics doi: 10.3390/robotics8040102 Authors: Malvezzi Iqbal Valigi Pozzi Prattichizzo Salvietti Augmenting the human hand with robotic extra fingers is a cutting-edge research topic and has many potential applications, in particular as a compensatory and rehabilitation tool for patients with upper limb impairments. Devices composed of two extra fingers are...
Wed Dec 11, 2019 02:00
Social Sciences, Vol. 8, Pages 330: The Impact of Productivity, Investment and Real Wages on Employment Absorption Rate in South Africa Social Sciences doi: 10.3390/socsci8120330 Authors: Habanabakize Meyer Oláh Many developing countries are facing high levels of unemployment and most people who are employed are poorly remunerated due to low skills and productivity levels. Although jobs are important, a productive job is even more important, not only for employees, but also...
Wed Dec 11, 2019 02:00
Sports, Vol. 7, Pages 250: Erratum: Bujnovsky, D., et al. Physical Fitness Characteristics of High-level Youth Football Players: Influence of Playing Position. Sports 2019, 7, 46 Sports doi: 10.3390/sports7120250 Authors: David Bujnovsky Tomas Maly Kevin R. Ford Dai Sugimoto Egon Kunzmann Mikulas Hank Frantisek Zahalka The authors wish to make the following correction to this paper [...]
Wed Dec 11, 2019 02:00
Sports, Vol. 7, Pages 248: Reliability and Structural Validity of the Movement Assessment Battery for Children-2 in Croatian Preschool Children Sports doi: 10.3390/sports7120248 Authors: Ivan Serbetar Jan Morten Loftesnes Asgeir Mamen Monitoring and assessment of the development of motor skills is an important goal for practitioners in many disciplines as well as researchers interested in motor development. A well-established tool for such purpose is the Movement Assessment Battery...
Wed Dec 11, 2019 02:00
Sports, Vol. 7, Pages 249: Exploring Cognitive Dissonance on a Ski Mountaineering Traverse: A Personal Narrative of an Expedition to ISHINCA (5530 m) in PERU Sports doi: 10.3390/sports7120249 Authors: Melissa Hart Through a personal narrative account, this paper explores the nature of the author’s cognitive dissonance experienced during a traverse of a high-altitude ski mountaineering objective (Nevado Ishinca 5530 m) in Peru’s Cordillera Blanca. The author experienced...
Wed Dec 11, 2019 02:00
Toxins, Vol. 11, Pages 727: Co-occurrence of DON and Emerging Mycotoxins in Worldwide Finished Pig Feed and Their Combined Toxicity in Intestinal Cells Toxins doi: 10.3390/toxins11120727 Authors: Khoshal Novak Martin Jenkins Neves Schatzmayr Oswald Pinton Food and feed can be naturally contaminated by several mycotoxins, and concern about the hazard of exposure to mycotoxin mixtures is increasing. In this study, more than 800 metabolites were analyzed in...
Wed Dec 11, 2019 02:00
Toxins, Vol. 11, Pages 723: Metabolome Variation between Strains of Microcystis aeruginosa by Untargeted Mass Spectrometry Toxins doi: 10.3390/toxins11120723 Authors: Marianne Racine Ammar Saleem Frances R. Pick Cyanobacteria are notorious for their potential to produce hepatotoxic microcystins (MCs), but other bioactive compounds synthesized in the cells could be as toxic, and thus present interest for characterization. Ultra performance liquid chromatography and high-resolution...
Wed Dec 11, 2019 02:00
Toxins, Vol. 11, Pages 726: Analysis of Pyrrolizidine Alkaloids in Queensland Honey: Using Low Temperature Chromatography to Resolve Stereoisomers and Identify Botanical Sources by UHPLC-MS/MS. Toxins doi: 10.3390/toxins11120726 Authors: Hungerford Carter Anuj Tan Hnatko Martin Sharma Yin Nguyen Melksham Fletcher Pyrrolizidine alkaloids (PAs) are a diverse group of plant secondary metabolites with known varied toxicity. Consumption of 1,2-unsaturated...
Wed Dec 11, 2019 02:00
Toxins, Vol. 11, Pages 725: The Effect of a Combined Hydrogen Peroxide-MlrA Treatment on the Phytoplankton Community and Microcystin Concentrations in a Mesocosm Experiment in Lake Ludoš Toxins doi: 10.3390/toxins11120725 Authors: Dziga Tokodi Backović Kokociński Antosiak Puchalski Strzałka Madej Meriluoto Svirčev Harmful cyanobacteria and their toxic metabolites constitute a big challenge for the production of safe drinking water. Microcystins (MC),...
Wed Dec 11, 2019 02:00
Toxins, Vol. 11, Pages 724: A Rapid Extraction Method Combined with a Monoclonal Antibody-Based Immunoassay for the Detection of Amatoxins Toxins doi: 10.3390/toxins11120724 Authors: Candace S. Bever Robert M. Hnasko Luisa W. Cheng Larry H. Stanker Amatoxins (AMAs) are lethal toxins found in a variety of mushroom species. Detection methods are needed to determine the occurrence of AMAs in mushroom species suspected in mushroom poisonings. In this manuscript, we report the generation...
Wed Dec 11, 2019 02:00
Toxins, Vol. 11, Pages 722: Ciguatoxin Occurrence in Food-Web Components of a Cuban Coral Reef Ecosystem: Risk-Assessment Implications Toxins doi: 10.3390/toxins11120722 Authors: Lisbet Díaz-Asencio Rachel J. Clausing Mark Vandersea Donaida Chamero-Lago Miguel Gómez-Batista Joan I. Hernández-Albernas Nicolas Chomérat Gabriel Rojas-Abrahantes Wayne Litaker Patricia Tester Jorge Diogène Carlos M. Alonso-Hernández Marie-Yasmine Dechraoui Bottein In Cuba,...
Wed Dec 11, 2019 02:00
TropicalMed, Vol. 4, Pages 142: The Flipside of Eradicating a Disease; Human African Trypanosomiasis in a Woman in Rural Democratic Republic of Congo: A Case Report Tropical Medicine and Infectious Disease doi: 10.3390/tropicalmed4040142 Authors: Junior Mudji Jonathan Benhamou Erick Mwamba-Miaka Christian Burri Johannes Blum Human African Trypanosomiasis (HAT) is a neglected disease caused by the protozoan parasites Trypanosoma brucei and transmitted by tsetse flies that...
Wed Dec 11, 2019 02:00
Viruses, Vol. 11, Pages 1149: A Novel Bacterium-Like Particle-Based Vaccine Displaying the SUDV Glycoprotein Induces Potent Humoral and Cellular Immune Responses in Mice Viruses doi: 10.3390/v11121149 Authors: Shengnan Xu Cuicui Jiao Hongli Jin Wujian Li Entao Li Zengguo Cao Zhikang Shi Feihu Yan Shengnan Zhang Hongbin He Hang Chi Na Feng Yongkun Zhao Yuwei Gao Songtao Yang Jianzhong Wang Hualei Wang Xianzhu Xia Sudan virus (SUDV) causes...
Wed Dec 11, 2019 02:00
Viruses, Vol. 11, Pages 1150: Reply to Comments by Yih et al. (Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross-Sectional Study) Viruses doi: 10.3390/v11121150 Authors: Yomani D. Sarathkumara Chandika D. Gamage Sithumini Lokupathirage Devinda S. Muthusinghe Nishantha Nanayakkara Lishanthe Gunarathne Kenta Shimizu Yoshimi Tsuda Jiro Arikawa Kumiko Yoshimatsu Dear Drs. W. Katherine Yih, Martin Kulldorff, Jessica H....
Wed Dec 11, 2019 02:00
Viruses, Vol. 11, Pages 1148: A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana Viruses doi: 10.3390/v11121148 Authors: Daniel A. Truchado José Manuel Diaz-Piqueras Esperanza Gomez-Lucia Ana Doménech Borja Milá Javier Pérez-Tris Jonas Schmidt-Chanasit Daniel Cadar Laura Benítez Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics,...
Wed Dec 11, 2019 02:00
Viruses, Vol. 11, Pages 1146: From a Movement-Deficient Grapevine Fanleaf Virus to the Identification of a New Viral Determinant of Nematode Transmission Viruses doi: 10.3390/v11121146 Authors: Lorène Belval Aurélie Marmonier Corinne Schmitt-Keichinger Sophie Gersch Peggy Andret-Link Véronique Komar Emmanuelle Vigne Olivier Lemaire Christophe Ritzenthaler Gérard Demangeat Grapevine fanleaf virus (GFLV) and arabis mosaic virus (ArMV) are nepoviruses responsible...
Wed Dec 11, 2019 02:00
Viruses, Vol. 11, Pages 1147: Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study Viruses doi: 10.3390/v11121147 Authors: W. Katherine Yih Martin Kulldorff Jessica H. Leibler David J. Friedman Daniel R. Brooks In a recent paper, Sarathkumara et al [...]
Wed Dec 11, 2019 02:00
Vision, Vol. 3, Pages 68: A Novel Method for Detection and Progress Assessment of Visual Distortion Caused by Macular Disorder: A Central Serous Chorioretinopathy (CSR) Case Study Vision doi: 10.3390/vision3040068 Authors: Mohaghegh Magierowski Ghafar-Zadeh This paper presents a new mathematical model along with a measurement platform for accurate detection and monitoring of various visual distortions (VD) caused by macular disorders such as central serous chorioretinopathy...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2617: Projecting Future Impacts of Global Change Including Fires on Soil Erosion to Anticipate Better Land Management in the Forests of NW Portugal Water doi: 10.3390/w11122617 Authors: Pastor Nunes Ciampalini Koopmans Baartman Huard Calheiros Le-Bissonnais Keizer Raclot Wildfire is known to create the pre-conditions leading to accelerated soil erosion. Unfortunately, its occurrence is expected to increase with climate change....
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2616: Sub-Daily Rainfall Intensity Extremes: Evaluating Suitable Indices at Australian Arid and Wet Tropical Observing Sites Water doi: 10.3390/w11122616 Authors: Dunkerley Rainfall intensity extremes are relevant to many aspects of climatology, climate change, and landsurface processes. Intensity is described and analysed using a diversity of approaches, reflecting its importance in these diverse areas. The characteristics of short-interval intensity extremes,...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2615: Potential Health Risks Linked to Emerging Contaminants in Major Rivers and Treated Waters Water doi: 10.3390/w11122615 Authors: Kessler Dawley Crow Garmany Georgel The presence of endocrine-disrupting chemicals (EDCs) in our local waterways is becoming an increasing threat to the surrounding population. These compounds and their degradation products (found in pesticides, herbicides, and plastic waste) are known to interfere with a range of...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2614: The Impact of Vegetation Successional Status on Slope Runoff Erosion in the Loess Plateau of China Water doi: 10.3390/w11122614 Authors: Chang Li Li Su Zhang Zhang Liu Li : Slope vegetation restoration is known to influence erosion in the Loess Plateau region in China. The ability of vegetation to mitigate soil erosion under extreme runoff, however, has not been studied in great detail in this region. Here, we examine five typical...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2613: Assessment of Remotely Sensed Near-Surface Soil Moisture for Distributed Eco-Hydrological Model Implementation Water doi: 10.3390/w11122613 Authors: Echeverría Ruiz-Pérez Puertes Samaniego Barrett Francés The aim of this study was to implement an eco-hydrological distributed model using only remotely sensed information (soil moisture and leaf area index) during the calibration phase. Four soil moisture-based metrics were assessed, and...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2611: Irrigation Water Allocation at Farm Level Based on Temporal Cultivation-Related Data Using Meta-Heuristic Optimisation Algorithms Water doi: 10.3390/w11122611 Authors: Bahram Saeidian Mohammad Saadi Mesgari Biswajeet Pradhan Abdullah M. Alamri The present water crisis necessitates a frugal water management strategy. Deficit irrigation can be regarded as an efficient strategy for agricultural water management. Optimal allocation of water to agricultural...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2610: Mapping Micro-Pollutants and Their Impacts on the Size Structure of Streambed Communities Water doi: 10.3390/w11122610 Authors: Ignacio Peralta-Maraver Malte Posselt Daniel M. Perkins Anne L. Robertson Recently there has been increasing concern over the vast array of emerging organic contaminants (EOCs) detected in streams and rivers worldwide. Understanding of the ecological implications of these compounds is limited to local scale case studies,...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2612: Conserving Rivers and Their Biodiversity in Tanzania Water doi: 10.3390/w11122612 Authors: Nadia A. Seeteram Pendo T. Hyera Lulu T. Kaaya Makarius C. S. Lalika Elizabeth P. Anderson The United Republic of Tanzania (Tanzania) is rich in freshwater resources and biodiversity. In this article, we highlight the importance of Tanzanian rivers and make a case for the conservation of the freshwater and terrestrial species that rely on these rivers. We...
Wed Dec 11, 2019 02:00
Water, Vol. 11, Pages 2609: Landslide Susceptibility Based on Extreme Rainfall-Induced Landslide Inventories and the Following Landslide Evolution Water doi: 10.3390/w11122609 Authors: Chunhung Wu Landslide susceptibility assessment is crucial for mitigating and preventing landslide disasters. Most landslide susceptibility studies have focused on creating landslide susceptibility models for specific rainfall or earthquake events, but landslide susceptibility in the years after specific...
Wed Dec 11, 2019 02:00
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