Antibiotics, Vol. 8, Pages 261: Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline Antibiotics doi: 10.3390/antibiotics8040261 Authors: Jickky Palmae Sarathy Gerhard Gruber Thomas Dick Bedaquiline (BDQ) inhibits ATP generation in Mycobacterium tuberculosis by interfering with the F-ATP synthase activity. Two mechanisms of action of BDQ are broadly accepted. A direct mechanism involves BDQ binding to the enzyme’s c-ring to block its rotation,...
Wed Dec 11, 2019 02:00
Antioxidants, Vol. 8, Pages 638: Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy Antioxidants doi: 10.3390/antiox8120638 Authors: Kar Shahshahan Hackfort Yadav Yadav Kambis Lefer Mishra Obesity increases the risk of developing diabetes and subsequently, diabetic cardiomyopathy (DMCM). Reduced cardioprotective antioxidant hydrogen sulfide (H2S) and increased...
Wed Dec 11, 2019 02:00
Antioxidants, Vol. 8, Pages 637: Inhibitory Effect of β-Carotene on Helicobacter pylori-Induced TRAF Expression and Hyper-Proliferation in Gastric Epithelial Cells Antioxidants doi: 10.3390/antiox8120637 Authors: Park Lee Lim Kim Helicobacter pylori infection causes the hyper-proliferation of gastric epithelial cells that leads to the development of gastric cancer. Overexpression of tumor necrosis factor receptor associated factor (TRAF) is shown in gastric cancer cells....
Wed Dec 11, 2019 02:00
Antioxidants, Vol. 8, Pages 636: Impact of Alpha-Lipoic Acid Chronic Discontinuous Treatment in Cardiometabolic Disorders and Oxidative Stress Induced by Fructose Intake in Rats Antioxidants doi: 10.3390/antiox8120636 Authors: Ghibu Craciun Rusu Morgovan Mogosan Rochette Gal Dronca Insulin resistance (IR) and cardiometabolic disorders are the main consequences of today’s alimentary behavior. This study evaluates the effects of a chronic-discontinuous...
Wed Dec 11, 2019 02:00
Antioxidants, Vol. 8, Pages 633: Chronic Oxidative Stress Promotes Molecular Changes Associated with Epithelial Mesenchymal Transition, NRF2, and Breast Cancer Stem Cell Phenotype Antioxidants doi: 10.3390/antiox8120633 Authors: Ana Čipak Gašparović Lidija Milković Nadia Dandachi Stefanie Stanzer Iskra Pezdirc Josip Vrančić Sanda Šitić Christoph Suppan Marija Balic Oxidative stress plays a role in carcinogenesis, but it also contributes to the modulation of tumor...
Wed Dec 11, 2019 02:00
Antioxidants, Vol. 8, Pages 635: Flavanol Polymerization Is a Superior Predictor of α-Glucosidase Inhibitory Activity Compared to Flavanol or Total Polyphenol Concentrations in Cocoas Prepared by Variations in Controlled Fermentation and Roasting of the Same Raw Cocoa Beans Antioxidants doi: 10.3390/antiox8120635 Authors: Kathryn C. Racine Brian D. Wiersema Laura E. Griffin Lauren A. Essenmacher Andrew H. Lee Helene Hopfer Joshua D. Lambert Amanda C. Stewart Andrew...
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Antioxidants, Vol. 8, Pages 634: Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice Antioxidants doi: 10.3390/antiox8120634 Authors: Haoxuan Yang Izhar Hyder Qazi Bo Pan Christiana Angel Shichao Guo Jingyu Yang Yan Zhang Zhang Ming Changjun Zeng Qingyong Meng Hongbing Han Guangbin Zhou Female reproductive (ovarian) aging is distinctively characterized by a markedly reduced reproductive function due to a remarkable...
Wed Dec 11, 2019 02:00
Arts, Vol. 8, Pages 165: On the Interpretation of Watercraft in Ancient Art Arts doi: 10.3390/arts8040165 Authors: Shelley Wachsmann In the past six decades since its inception, nautical archaeologists have excavated and studied the hulls, cargoes, and other remains of ancient watercraft. However, shipwrecks themselves only tell part of the story. The archaeological record is replete with examples of known shipwrecks from some cultures and periods, but, for others, no hulls exist in...
Wed Dec 11, 2019 02:00
Atmosphere, Vol. 10, Pages 801: An Assessment of the Suitability of Active Green Walls for NO2 Reduction in Green Buildings Using a Closed-Loop Flow Reactor Atmosphere doi: 10.3390/atmos10120801 Authors: Pettit Irga Surawski Torpy Nitrogen dioxide (NO2) is a common urban air pollutant that is associated with several adverse human health effects from both short and long term exposure. Additionally, NO2 is highly reactive and can influence the mixing ratios of nitrogen oxide...
Wed Dec 11, 2019 02:00
Atmosphere, Vol. 10, Pages 800: June Temperature Trends in the Southwest Deserts of the USA (1950–2018) and Implications for Our Urban Areas Atmosphere doi: 10.3390/atmos10120800 Authors: Anthony Brazel Within the United States, the Southwest USA deserts show the largest temperature changes (1901–2010) besides Alaska, according to the most recent USA National Climate Assessment report. The report does not discuss urban effects vs. regional effects that might be evident in trends. Twenty-five...
Wed Dec 11, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 152: Profession Loss Crisis at an Old Age: Specific Features, Factors, and Mechanisms of Coping Behavioral Sciences doi: 10.3390/bs9120152 Authors: Symanyuk Borisov Berdnikova Tomberg Ryabukhina This article discusses the specific characteristics of profession loss crisis at an old age. Profession loss crisis is the last normative crisis of personal professional development that is caused by the completion of one’s professional...
Wed Dec 11, 2019 02:00
Bioengineering, Vol. 6, Pages 112: Probing the Antitumor Mechanism of Solanum nigrum L. Aqueous Extract against Human Breast Cancer MCF7 Cells Bioengineering doi: 10.3390/bioengineering6040112 Authors: Ling Xiao Yang Wei Sakharkar Yang Solanum nigrum L. is one of the major medicinal plants used to treat cancer. However, the functional mechanism of S. nigrum L. extract is still unknown in spite of numerous studies on its active components. In this study, we probed...
Wed Dec 11, 2019 02:00
Biology, Vol. 8, Pages 93: Transcriptome Analysis of Wheat Roots Reveals a Differential Regulation of Stress Responses Related to Arbuscular Mycorrhizal Fungi and Soil Disturbance Biology doi: 10.3390/biology8040093 Authors: Catarina Campos Tânia Nobre Michael J. Goss Jorge Faria Pedro Barrulas Mário Carvalho Symbioses with soil microorganisms are central in shaping the diversity and productivity of land plants and provide protection against a diversity of stresses, including...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 862: Identification of Homeobox Genes Associated with Lignification and Their Expression Patterns in Bamboo Shoots Biomolecules doi: 10.3390/biom9120862 Authors: Xu Lou Yang Shan Zhu Gao : Homeobox (HB) genes play critical roles in regulating various aspects of plant growth and development. However, little is known about HB genes in bamboo. In this study, a total of 115 HB genes (PeHB001‒PeHB115) were identified from moso bamboo (Phyllostachys...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 857: Fatty Acids of Marine Mollusks: Impact of Diet, Bacterial Symbiosis and Biosynthetic Potential Biomolecules doi: 10.3390/biom9120857 Authors: Zhukova The n-3 and n-6 polyunsaturated fatty acid (PUFA) families are essential for important physiological processes. Their major source are marine ecosystems. The fatty acids (FAs) from phytoplankton, which are the primary producer of organic matter and PUFAs, are transferred into consumers via food webs. Mollusk...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 860: New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures Biomolecules doi: 10.3390/biom9120860 Authors: Draut Liebenstein Begemann Retinoic acid (RA) signaling is an important regulator of chordate development. RA binds to nuclear RA receptors that control the transcriptional activity of target genes. Controlled local degradation of RA by enzymes of the Cyp26a gene family...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 859: Glucose Uptake Stimulatory and PTP1B Inhibitory Activities of Pimarane Diterpenes from Orthosiphon stamineus Benth Biomolecules doi: 10.3390/biom9120859 Authors: Nguyen Tuan Hoang Vu Pham Tran To Seven pimarane diterpenes (1–7) were isolated from Orthosiphon stamineus Benth. by assay-guided isolation. All of the isolates possessed a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)-d-glucose uptake effect in 3T3-L1...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 861: Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors Biomolecules doi: 10.3390/biom9120861 Authors: Opoku Govender Pooe Simelane To date, Plasmodium falciparum is one of the most lethal strains of the malaria parasite. P. falciparum lacks the required enzymes to create its own purines via the de novo pathway, thereby making Plasmodium falciparum...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 863: Lemon-Fruit-Based Green Synthesis of Zinc Oxide Nanoparticles and Titanium Dioxide Nanoparticles against Soft Rot Bacterial Pathogen Dickeya dadantii Biomolecules doi: 10.3390/biom9120863 Authors: Hossain Abdallah Ali Masum Li Sun Meng Wang An Edible plant fruits are safe raw materials free of toxicants and rich in biomolecules for reducing metal ions and stabilizing nanoparticles. Zinc oxide nanoparticles (ZnONPs) and...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 858: Herbal Extracts Incorporated into Shortbread Cookies: Impact on Color and Fat Quality of the Cookies Biomolecules doi: 10.3390/biom9120858 Authors: Kozlowska Zbikowska Marciniak-Lukasiak Kowalska This study aimed at determining the effect of aqueous ethanolic extracts from lemon balm, hyssop and nettle, and butylated hydroxyanisole (BHA) on properties of shortbread cookies. This was achieved by instrumental measurements of color and sensory...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 856: Medical Therapy of Patients Contaminated with Radioactive Cesium or Iodine Biomolecules doi: 10.3390/biom9120856 Authors: Jan Aaseth Valeria Marina Nurchi Ole Andersen Follow-up studies after the Chernobyl and Fukushima accidents have shown that 137Cs and 131I made up the major amount of harmful contaminants in the atmospheric dispersion and fallout. Other potential sources for such radionuclide exposure may be terrorist attacks, e.g., via contamination...
Wed Dec 11, 2019 02:00
Biomolecules, Vol. 9, Pages 855: The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG Biomolecules doi: 10.3390/biom9120855 Authors: Tomas Sneideris Andrius Sakalauskas Rebecca Sternke-Hoffmann Alessia Peduzzo Mantas Ziaunys Alexander K. Buell Vytautas Smirnovas Millions of people around the world suffer from amyloid-related disorders, including Alzheimer’s and Parkinson’s diseases. Despite significant and sustained efforts,...
Wed Dec 11, 2019 02:00
Brain Sciences, Vol. 9, Pages 368: Noli Me Tangere: Social Touch, Tactile Defensiveness, and Communication in Neurodevelopmental Disorders Brain Sciences doi: 10.3390/brainsci9120368 Authors: Daniela Smirni Pietro Smirni Marco Carotenuto Lucia Parisi Giuseppe Quatrosi Michele Roccella Tactile defensiveness is a common feature in neurodevelopmental disorders (NDDs). Since the first studies, tactile defensiveness has been described as the result of an abnormal response to...
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Brain Sciences, Vol. 9, Pages 367: Individual Differences in Ethanol Drinking and Seeking Behaviors in Rats Exposed to Chronic Intermittent Ethanol Vapor Exposure is Associated with Altered CaMKII Autophosphorylation in the Nucleus Accumbens Shell Brain Sciences doi: 10.3390/brainsci9120367 Authors: Sucharita S. Somkuwar Chitra D. Mandyam Chronic intermittent ethanol vapor exposure (CIE) in rodents produces reliable and high blood ethanol concentration and behavioral symptoms associated...
Wed Dec 11, 2019 02:00
Brain Sciences, Vol. 9, Pages 365: Get Set or Get Distracted? Disentangling Content-Priming and Attention-Catching Effects of Background Lure Stimuli on Identifying Targets in Two Simultaneously Presented Series Brain Sciences doi: 10.3390/brainsci9120365 Authors: Rolf Verleger Kamila Śmigasiewicz Lars Michael Laura Heikaus Michael Niedeggen In order to study the changing relevance of stimulus features in time and space, we used a task with rapid serial presentation of two...
Wed Dec 11, 2019 02:00
Brain Sciences, Vol. 9, Pages 366: Inflammatory Biomarkers are Correlated with Some Forms of Regressive Autism Spectrum Disorder Brain Sciences doi: 10.3390/brainsci9120366 Authors: Margherita Prosperi Letizia Guiducci Diego G. Peroni Chiara Narducci Melania Gaggini Sara Calderoni Raffaella Tancredi Maria Aurora Morales Amalia Gastaldelli Filippo Muratori Elisa Santocchi Background: Several studies have tried to investigate the role of inflammatory biomarkers...
Wed Dec 11, 2019 02:00
Cancers, Vol. 11, Pages 1996: Patterns of Care and Outcomes of Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis Cancers doi: 10.3390/cancers11121996 Authors: Mark C. Korpics W. Tyler Turchan Michael K. Rooney Matthew Koshy Michael T. Spiotto Early stage glottic cancer has traditionally been treated with 3D conformal radiotherapy (3DCRT). However, intensity-modulated radiotherapy (IMRT) has been...
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Cancers, Vol. 11, Pages 1995: Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer Cancers doi: 10.3390/cancers11121995 Authors: Shashwat Sharad Zsófia M. Sztupinszki Yongmei Chen Claire Kuo Lakshmi Ravindranath Zoltan Szallasi Gyorgy Petrovics Taduru L. Sreenath Albert Dobi Inger L. Rosner Alagarsamy Srinivasan Shiv Srivastava Jennifer Cullen...
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Cancers, Vol. 11, Pages 1993: Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species Cancers doi: 10.3390/cancers11121993 Authors: Yoshikawa Saito Manabe Nakaoka Uchida Furukawa Muramatsu Sugiyama Kimura Saito Cancer cells are strongly dependent on the glycolytic pathway for generation of energy even under aerobic condition through a phenomenon...
Wed Dec 11, 2019 02:00
Cancers, Vol. 11, Pages 1992: Malignant Rhabdoid Tumor, an Aggressive Tumor Often Misclassified as Small Cell Variant of Hepatoblastoma Cancers doi: 10.3390/cancers11121992 Authors: Ladan Fazlollahi Susan J. Hsiao Manpreet Kochhar Mahesh M. Mansukhani Darrell J. Yamashiro Helen E. Remotti The clinical management of pediatric liver tumors involves stratification into risk groups. One previously defined, high-risk group of hepatoblastomas is the small cell undifferentiated...
Wed Dec 11, 2019 02:00
Cancers, Vol. 11, Pages 1994: Transcriptomic Analyses Revealed Systemic Alterations in Gene Expression in Circulation and Tumor Microenvironment of Colorectal Cancer Patients Cancers doi: 10.3390/cancers11121994 Authors: Shaath Toor Nair Elkord Alajez Colorectal cancer (CRC) is among the leading causes of cancer-related deaths worldwide, underscoring a need for better understanding of the disease and development of novel diagnostic biomarkers and therapeutic interventions....
Wed Dec 11, 2019 02:00
Cancers, Vol. 11, Pages 1991: The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration Cancers doi: 10.3390/cancers11121991 Authors: Nguyen Liao Ho Chen Chang Cheng Liu Lee Shen Wu Tu Cigarette smoking is associated with an increased risk of melanoma metastasis. Smokers show higher PD-L1 expression and better responses to PD-1/PD-L1 inhibitors than nonsmokers. Here,...
Wed Dec 11, 2019 02:00
Cancers, Vol. 11, Pages 1990: How Valuable Is the RT-qPCR of Pituitary-Specific Transcription Factors for Identifying Pituitary Neuroendocrine Tumor Subtypes According to the New WHO 2017 Criteria? Cancers doi: 10.3390/cancers11121990 Authors: María Eugenia Torregrosa-Quesada Araceli García-Martínez Sandra Silva-Ortega Sebastián Martínez-López Rosa Cámara Carmen Fajardo Cristina Lamas Ignacio Aranda Antonio Picó The classification of pituitary neuroendocrine tumors...
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Cancers, Vol. 11, Pages 1989: Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development Cancers doi: 10.3390/cancers11121989 Authors: Jie Feng Niall M. Byrne Wafa Al Jamal Jonathan A. Coulter Hypoxia is one of the most common phenotypes of malignant tumours. Hypoxia leads to the increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of genes controlling a raft of pro-tumour phenotypes. These include...
Wed Dec 11, 2019 02:00
Cells, Vol. 8, Pages 1617: Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease? Cells doi: 10.3390/cells8121617 Authors: Jin Li Deli Zhang Bianca J. J. M. Brundel Marit Wiersma Cardiac disease is still the leading cause of morbidity and mortality worldwide, despite some exciting and innovative improvements in clinical management. In particular, atrial fibrillation (AF) and heart failure show a steep increase in incidence and healthcare costs...
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Cells, Vol. 8, Pages 1615: The Relationship Between the miRNA Sequence and Disease May be Revealed by Focusing on Hydrogen Bonding Sites in RNA–RNA Interactions Cells doi: 10.3390/cells8121615 Authors: Osone Yoshida MicroRNAs are important genes in biological processes. Although the function of microRNAs has been elucidated, the relationship between the sequence and the disease is not sufficiently clear. It is important to clarify the relationship between the sequence and the disease...
Wed Dec 11, 2019 02:00
Cells, Vol. 8, Pages 1614: Rare Human Diseases: Model Organisms in Deciphering the Molecular Basis of Primary Ciliary Dyskinesia Cells doi: 10.3390/cells8121614 Authors: Poprzeczko Bicka Farahat Bazan Osinka Fabczak Joachimiak Wloga Primary ciliary dyskinesia (PCD) is a recessive heterogeneous disorder of motile cilia, affecting one per 15,000–30,000 individuals; however, the frequency of this disorder is likely underestimated. Even though more...
Wed Dec 11, 2019 02:00
Cells, Vol. 8, Pages 1616: Effect of High Glucose-Induced Oxidative Stress on Paraoxonase 2 Expression and Activity in Caco-2 Cells Cells doi: 10.3390/cells8121616 Authors: Morresi Cianfruglia Sartini Cecati Fumarola Emanuelli Armeni Ferretti Bacchetti (1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved...
Wed Dec 11, 2019 02:00
Cells, Vol. 8, Pages 1612: Effect of Ethylene on Cell Wall and Lipid Metabolism during Alleviation of Postharvest Chilling Injury in Peach Cells doi: 10.3390/cells8121612 Authors: Zhu Wang Wu Zhao Yin Zhang Grierson Chen Xu Peach is prone to postharvest chilling injury (CI). Here it was found that exogenous ethylene alleviated CI, accompanied by an increased endogenous ethylene production. Ethylene treatment resulted in a moderately more rapid flesh softening...
Wed Dec 11, 2019 02:00
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