IJMS, Vol. 20, Pages 6098: RankerGUI: A Computational Framework to Compare Differential Gene Expression Profiles Using Rank Based Statistics International Journal of Molecular Sciences doi: 10.3390/ijms20236098 Authors: Amarinder Singh Thind Kumar Parijat Tripathi Mario Rosario Guarracino The comparison of high throughput gene expression datasets obtained from different experimental conditions is a challenging task. It provides an opportunity to explore the cellular response to...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6097: The Role of Immune Cells and Cytokines in Intestinal Wound Healing International Journal of Molecular Sciences doi: 10.3390/ijms20236097 Authors: Xiang Xue Daniel M. Falcon Intestinal wound healing is a complicated process that not only involves epithelial cells but also immune cells. In this brief review, we will focus on discussing the contribution and regulation of four major immune cell types (neutrophils, macrophages, regulatory T cells, and innate...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6096: OsMSR3, a Small Heat Shock Protein, Confers Enhanced Tolerance to Copper Stress in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms20236096 Authors: Yanchun Cui Manling Wang Xuming Yin Guoyun Xu Shufeng Song Mingjuan Li Kai Liu Xinjie Xia Copper is a mineral element essential for the normal growth and development of plants; however, excessive levels can severely affect plant growth and development. Oryza...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6095: Bioinformatics Analysis of the Lipoxygenase Gene Family in Radish (Raphanus sativus) and Functional Characterization in Response to Abiotic and Biotic Stresses International Journal of Molecular Sciences doi: 10.3390/ijms20236095 Authors: Jinglei Wang Tianhua Hu Wuhong Wang Haijiao Hu Qingzhen Wei Xiaochun Wei Chonglai Bao Lipoxygenases (LOXs) are non-heme iron-containing dioxygenases involved in many developmental and stress-responsive processes...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6093: Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells International Journal of Molecular Sciences doi: 10.3390/ijms20236093 Authors: Hui Cao Qingling Jia Li Yan Chuan Chen Sanli Xing Dingzhu Shen Objective: To investigate the process by which quercetin suppresses atherosclerosis by upregulating MST1-mediated autophagy in RAW264.7 macrophages. Methods: An...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6092: DNA Oxidation and Excision Repair Pathways International Journal of Molecular Sciences doi: 10.3390/ijms20236092 Authors: Tae-Hee Lee Tae-Hong Kang The physiological impact of the aberrant oxidation products on genomic DNA were demonstrated by embryonic lethality or the cancer susceptibility and/or neurological symptoms of animal impaired in the base excision repair (BER); the major pathway to maintain genomic integrity against non-bulky DNA oxidation. However,...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6090: Disclosure of the Molecular Mechanism of Wheat Leaf Spot Disease Caused by Bipolaris sorokiniana through Comparative Transcriptome and Metabolomics Analysis International Journal of Molecular Sciences doi: 10.3390/ijms20236090 Authors: Wei Ye Taomei Liu Weimin Zhang Saini Li Muzi Zhu Haohua Li Yali Kong Liqiong Xu Wheat yield is greatly reduced because of the occurrence of leaf spot diseases. Bipolaris sorokiniana is the main pathogenic...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6089: Molecular Characterization of XX Maleness International Journal of Molecular Sciences doi: 10.3390/ijms20236089 Authors: Romina P. Grinspon Rodolfo A. Rey Androgens and anti-Müllerian hormone (AMH), secreted by the foetal testis, are responsible for the development of male reproductive organs and the regression of female anlagen. Virilization of the reproductive tract in association with the absence of Müllerian derivatives in the XX foetus...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6091: Multifocal Signal Modulation Therapy by Celecoxib: A Strategy for Managing Castration-Resistant Prostate Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20236091 Authors: Roberto Benelli Paola Barboro Delfina Costa Simonetta Astigiano Ottavia Barbieri Matteo Capaia Alessandro Poggi Nicoletta Ferrari Background: Prostate cancer (PCa) is a significant health concern throughout the world. Standard therapy for advanced disease...
Tue Dec 03, 2019 02:00
IJMS, Vol. 20, Pages 6081: Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib International Journal of Molecular Sciences doi: 10.3390/ijms20236081 Authors: Berthold Reis David Vehlow Tarik Rust Dirk Kuckling Martin Müller To overcome the high relapse rate of multiple myeloma (MM), a drug delivery coating for functionalization of bone substitution materials (BSM) is reported based on adhesive, catechol-containing and stimuli-responsive...
Mon Dec 02, 2019 02:00
IJMS, Vol. 20, Pages 6088: siRNA Conjugated Nanoparticles—A Next Generation Strategy to Treat Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20236088 Authors: Rasha Itani Achraf Al Faraj Despite major progress in both therapeutic and diagnostic techniques, lung cancer is still considered the leading cause of cancer mortality in the world due to the ineffectiveness of the classical treatments used nowadays. Luckily, the discovery of small interfering RNA (siRNA)...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2133: Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke Journal of Clinical Medicine doi: 10.3390/jcm8122133 Authors: Wigner Saluk-Bijak Synowiec Miller Sliwinski Cichon Bijak The abnormal activation of the tryptophan catabolites pathway (TRYCATs) is observed in patients suffering from cerebrovascular disease, including stroke. A previous study confirmed that lower bioavailability of tryptophan for serotonin synthesis...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2137: Impaired HDL Metabolism Links GlycA, A Novel Inflammatory Marker, with Incident Cardiovascular Events Journal of Clinical Medicine doi: 10.3390/jcm8122137 Authors: Riggs Joshi Khera Singh Akinmolayemi Ayers Rohatgi High-density lipoproteins (HDL) exert anti-atherosclerotic effects via reverse cholesterol transport, yet this salutary property is impaired in the setting of inflammation. GlycA, a novel integrated glycosylation marker of...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2135: Triple Network Resting State Connectivity Predicts Distress Tolerance and Is Associated with Cocaine Use Journal of Clinical Medicine doi: 10.3390/jcm8122135 Authors: Reese Yi McKay Stein Ross Daughters Distress tolerance (DT), a predictor of substance use treatment retention and post-treatment relapse, is associated with task based neural activation in regions located within the salience (SN), default mode (DMN), and executive control networks...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2132: Cardiac Imaging in Liver Transplantation Candidates: Current Knowledge and Future Perspectives Journal of Clinical Medicine doi: 10.3390/jcm8122132 Authors: Dimitroglou Aggeli Alexopoulou Mavrogeni Tousoulis Cardiovascular dysfunction in cirrhotic patients is a recognized clinical entity commonly referred to as cirrhotic cardiomyopathy. Systematic inflammation, autonomic dysfunction, and activation of vasodilatory factors lead to hyperdynamic...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2136: International Differences in Outpatient Pain Management: A Survey of Sickle Cell Disease Journal of Clinical Medicine doi: 10.3390/jcm8122136 Authors: El-Amin Nietert Kanter Vaso-occlusive pain crises are the hallmark of sickle cell disease (SCD) and the primary reason for health care utilization. Both national and international guidelines recommend aggressive intravenous opioids, intravenous fluids and anti-inflammatory therapy as the mainstay of treatment...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2134: TMPRSS4: A Novel Tumor Prognostic Indicator for the Stratification of Stage IA Tumors and a Liquid Biopsy Biomarker for NSCLC Patients Journal of Clinical Medicine doi: 10.3390/jcm8122134 Authors: Villalba Exposito Pajares Sainz Redrado Remirez Wistuba Behrens Jantus-Lewintre Camps Montuenga Pio Lozano de Andrea Calvo Relapse rates in surgically resected non-small-cell lung cancer (NSCLC) patients are between...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2138: How to Interpret a Positive Campylobacter PCR Result Using the BD MAXTM System in the Absence of Positive Culture? Journal of Clinical Medicine doi: 10.3390/jcm8122138 Authors: Thomas Gueudet Marie Carole Paolini Alice Buissonnière Anne Trens Jean Marc Rousée Matthieu Lefranc Lucie Bénéjat Astrid Ducournau Francis Mégraud Emilie Bessède Philippe Lehours The aim of this study was to evaluate, using two independent polymerase chain...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2130: Beware of a Fragile Footplate: Lessons from Ossiculoplasty in Patients with Ossicular Anomalies Related to Second Pharyngeal Arch Defects Journal of Clinical Medicine doi: 10.3390/jcm8122130 Authors: Han Choe Kim Koo Choi Song Background and objectives: We review the intraoperative findings and postoperative outcomes of ossiculoplasty in subjects with second pharyngeal arch (SPA)-derived ossicular anomalies. We summarize potential intraoperative...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2131: Hippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck Journal of Clinical Medicine doi: 10.3390/jcm8122131 Authors: Santos-de-Frutos Segrelles Lorz Head and neck cancer affects the upper aerodigestive tract and is the sixth leading cancer worldwide by incidence and the seventh by cause of death. Despite significant advances in surgery and chemotherapy, molecularly targeted therapeutic options for this type of cancer are...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2129: Molecular Pattern and Density of Axons in the Long Head of the Biceps Tendon and the Superior Labrum Journal of Clinical Medicine doi: 10.3390/jcm8122129 Authors: Sandra Boesmueller Roland Blumer Bernhard Gesslbauer Lena Hirtler Christian Fialka Rainer Mittermayr The type II superior labrum anterior to posterior (SLAP) repair is a viable option in young and demanding patients, although a prolonged period of pain after surgery is described in the...
Tue Dec 03, 2019 02:00
JCM, Vol. 8, Pages 2128: Quantitative Analysis of the Seminal Plasma Proteome in Secondary Hypogonadism Journal of Clinical Medicine doi: 10.3390/jcm8122128 Authors: Giuseppe Grande Federica Vincenzoni Francesca Mancini Ferran Barrachina Antonella Giampietro Massimo Castagnola Andrea Urbani Rafael Oliva Domenico Milardi Alfredo Pontecorvi In the grey zone of testosterone levels between 8 and 12 nmol/L, the usefulness of therapy is controversial; as such, markers...
Tue Dec 03, 2019 02:00
JDB, Vol. 7, Pages 22: Paralogues of Mmp11 and Timp4 Interact during the Development of the Myotendinous Junction in the Zebrafish Embryo Journal of Developmental Biology doi: 10.3390/jdb7040022 Authors: Matchett Wang Crawford The extracellular matrix (ECM) of the myotendinous junction (MTJ) undergoes dramatic physical and biochemical remodeling during the first 48 h of development in zebrafish, transforming from a rectangular fibronectin-dominated somite boundary to a chevron-shaped...
Tue Dec 03, 2019 02:00
JoF, Vol. 5, Pages 113: Serial Detection of Circulating Mucorales DNA in Invasive Mucormycosis: A Retrospective Multicenter Evaluation Journal of Fungi doi: 10.3390/jof5040113 Authors: Mercier Reynders Beuselinck Guldentops Maertens Lagrou Invasive mucormycosis is a fungal infection with high mortality. Early diagnosis and initiation of appropriate treatment is essential to improve survival. However, current diagnostic tools suffer from low sensitivity, leading to...
Tue Dec 03, 2019 02:00
Medicina, Vol. 55, Pages 771: Laparoscopic Management of Initially Unrecognized Splenic Hydatid Cysts: A Case Report and Review of the Literature Medicina doi: 10.3390/medicina55120771 Authors: Milosavljevic Veselinovic Tadic Galun Ceranic Eric Bjelovic We present a case report that demonstrates diagnostic and intraoperative challenges in the laparoscopic management of initially unrecognized splenic hydatid disease. A male patient, aged 44, was admitted to our...
Tue Dec 03, 2019 02:00
Membranes, Vol. 9, Pages 164: Synthesis of Imidazolium based PILs and Investigation of Their Blend Membranes for Gas Separation Membranes doi: 10.3390/membranes9120164 Authors: Thanasis Chouliaras Aristofanis Vollas Theophilos Ioannides Valadoula Deimede Joannis Kallitsis Polymeric (ionic liquid) (PIL) copolymers bearing cationic imidazolium pendants and polar acrylic acid groups (P(VBCImY-co-AAx)), which both favor the interaction with CO2 molecules, have been synthesized...
Tue Dec 03, 2019 02:00
Membranes, Vol. 9, Pages 163: Ionizing Radiation for Preparation and Functionalization of Membranes and Their Biomedical and Environmental Applications Membranes doi: 10.3390/membranes9120163 Authors: Casimiro Ferreira Leal Pereira Monteiro The use of ionizing radiation processing technologies has proven to be one of the most versatile ways to prepare a wide range of membranes with specific tailored functionalities, thus enabling them to be used in a variety of industrial,...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 645: Profiling the Oral Microbiome and Plasma Biochemistry of Obese Hyperglycemic Subjects in Qatar Microorganisms doi: 10.3390/microorganisms7120645 Authors: Sohail Elrayess Al Thani Al-Asmakh Yassine The present study is designed to compare demographic characteristics, plasma biochemistry, and the oral microbiome in obese (N = 37) and lean control (N = 36) subjects enrolled at Qatar Biobank, Qatar. Plasma hormones, enzymes, and lipid profiles...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 643: Characterization and Phylodynamics of Reassortant H12Nx Viruses in Northern Eurasia Microorganisms doi: 10.3390/microorganisms7120643 Authors: Sharshov Mine Sobolev Kurskaya Dubovitskiy Kabilov Alikina Nakayama Tsunekuni Derko Prokopyeva Alekseev Shchelkanov Druzyaka Gadzhiev Uchida Shestopalov Saito Wild waterfowl birds are known to be the main reservoir for a variety of avian influenza...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 644: Isolation and Molecular Typing of Leishmania infantum from Phlebotomus perfiliewi in a Re-Emerging Focus of Leishmaniasis, Northeastern Italy Microorganisms doi: 10.3390/microorganisms7120644 Authors: Calzolari Carra Rugna Bonilauri Bergamini Bellini Varani Dottori Visceral leishmaniasis (VL) caused by Leishmania (L.) infantum is a public health threat in the Emilia-Romagna region, northeastern Italy, but its epidemiology...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 642: Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building Microorganisms doi: 10.3390/microorganisms7120642 Authors: Saija Hyvönen Hannu Syrjala Background: An association between fungal exposure at work and asthma onset has been shown, but a causal relationship between them has not beTanle en established. Methods: The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 639: The Bacterial Amyloid-Like Hfq Promotes In Vitro DNA Alignment Microorganisms doi: 10.3390/microorganisms7120639 Authors: Frank Wien Denis Martinez Etienne Le Brun Nykola C. Jones Søren Vrønning Hoffmann Jehan Waeytens Melanie Berbon Birgit Habenstein Véronique Arluison The Hfq protein is reported to be involved in environmental adaptation and virulence of several bacteria. In Gram-negative bacteria, Hfq mediates the interaction...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 641: The Simplified Human Intestinal Microbiota (SIHUMIx) Shows High Structural and Functional Resistance against Changing Transit Times in In Vitro Bioreactors Microorganisms doi: 10.3390/microorganisms7120641 Authors: Stephanie Serena Schäpe Jannike Lea Krause Beatrice Engelmann Katarina Fritz-Wallace Florian Schattenberg Zishu Liu Susann Müller Nico Jehmlich Ulrike Rolle-Kampczyk Gunda Herberth Martin von Bergen Many functions...
Tue Dec 03, 2019 02:00
Microorganisms, Vol. 7, Pages 640: Modifications of the Aerobic Respiratory Chain of Paracoccus Denitrificans in Response to Superoxide Oxidative Stress Microorganisms doi: 10.3390/microorganisms7120640 Authors: Vojtěch Sedláček Igor Kučera Paracoccus denitrificans is a strictly respiring bacterium with a core respiratory chain similar to that of mammalian mitochondria. As such, it continuously produces and has to cope with superoxide and other reactive oxygen species. In this work,...
Tue Dec 03, 2019 02:00
Molecules, Vol. 24, Pages 4424: Nickel-Doped Cerium Oxide Nanoparticles: Green Synthesis Using Stevia and Protective Effect against Harmful Ultraviolet Rays Molecules doi: 10.3390/molecules24244424 Authors: Mehrdad Khatami Mina Sarani Faride Mosazadeh Mohammadreza Rajabalipour Alireza Izadi Meghdad Abdollahpour-Alitappeh Marcos Augusto Lima Nobre Fariba Borhani Nanoparticles of cerium oxide CeO2 are important nanomaterials with remarkable properties for use in both...
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Molecules, Vol. 24, Pages 4423: Surface Enhanced Raman Spectroscopy for DNA Biosensors—How Far Are We? Molecules doi: 10.3390/molecules24244423 Authors: Edyta Pyrak Jan Krajczewski Artur Kowalik Andrzej Kudelski Aleksandra Jaworska A sensitive and accurate identification of specific DNA fragments (usually containing a mutation) can influence clinical decisions. Standard methods routinely used for this type of detection are PCR (Polymerase Chain Reaction, and its modifications),...
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Molecules, Vol. 24, Pages 4422: Exploring the Self-Assembled Tacticity in Aurophilic Polymeric Arrangements of Diphosphanegold(I) Fluorothiolates Molecules doi: 10.3390/molecules24234422 Authors: Moreno-Alcántar Salazar Romo-Islas Flores-Álamo Torrens Despite the recurrence of aurophilic interactions in the solid-state structures of gold(I) compounds, its rational control, modulation, and application in the generation of functional supramolecular structures is an area...
Tue Dec 03, 2019 02:00
Molecules, Vol. 24, Pages 4421: Antiprotozoal Activity of Turkish Origanum onites Essential Oil and Its Components Molecules doi: 10.3390/molecules24234421 Authors: Tasdemir Kaiser Demirci Demirci Baser Essential oil of Origanum species is well known for antimicrobial activity, but only a few have been evaluated in narrow spectrum antiprotozoal assays. Herein, we assessed the antiprotozoal potential of Turkish Origanum onites L. oil and its major constituents against...
Tue Dec 03, 2019 02:00
Molecules, Vol. 24, Pages 4419: Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities Molecules doi: 10.3390/molecules24234419 Authors: Ari Satia Nugraha Yuvita Dian Damayanti Phurpa Wangchuk Paul A. Keller Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and...
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