Antibiotics, Vol. 8, Pages 249: Synthesis and Identification of Pentathiepin-Based Inhibitors of Sporothrix brasiliensis Antibiotics doi: 10.3390/antibiotics8040249 Authors: Asquith Machado de Miranda Konstantinova Almeida-Paes Rakitin Pereira Sporothrix brasiliensis is the causative agent of zoonotic sporotrichosis in Brazil and is currently referred to as the most virulent species among those of clinical importance within the genus. Sporotrichosis is an emergent...
Tue Dec 03, 2019 02:00
Antibiotics, Vol. 8, Pages 248: Proteomic and Metabolomic Analyses of a Tea-Tree Oil-Selected Staphylococcus aureus Small Colony Variant Antibiotics doi: 10.3390/antibiotics8040248 Authors: Torres Hartson Rogers Gustafson Tea tree oil (TTO) is hypothesized to kill bacteria by indiscriminately denaturing membrane and protein structures. A Staphylococcus aureus small colony variant (SCV) selected with TTO (SH1000-TTORS-1) demonstrated slowed growth, reduced susceptibility...
Tue Dec 03, 2019 02:00
Antibiotics, Vol. 8, Pages 247: Anti-Tubercular Activity of Substituted 7-Methyl and 7-Formylindolizines and In Silico Study for Prospective Molecular Target Identification Antibiotics doi: 10.3390/antibiotics8040247 Authors: Katharigatta N. Venugopala Christophe Tratrat Melendhran Pillay Fawzi M. Mahomoodally Subhrajyoti Bhandary Deepak Chopra Mohamed A. Morsy Michelyne Haroun Bandar E. Aldhubiab Mahesh Attimarad Anroop B. Nair Nagaraja Sreeharsha Rashmi...
Tue Dec 03, 2019 02:00
Antibodies, Vol. 8, Pages 55: Antibody Structure and Function: The Basis for Engineering Therapeutics Antibodies doi: 10.3390/antib8040055 Authors: Chiu Goulet Teplyakov Gilliland Antibodies and antibody-derived macromolecules have established themselves as the mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure–function relationships of antibodies provides a platform for protein engineering that has been exploited to generate...
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 615: Antioxidant Metabolism and Chlorophyll Fluorescence during the Acclimatisation to Ex Vitro Conditions of Micropropagated Stevia rebaudiana Bertoni Plants Antioxidants doi: 10.3390/antiox8120615 Authors: Acosta-Motos Noguera-Vera Barba-Espín Piqueras Hernández In this study, the functioning of antioxidant metabolism and photosynthesis efficiency during the acclimatisation of Stevia rebaudiana plants to ex vitro conditions was determined....
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 614: The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion Antioxidants doi: 10.3390/antiox8120614 Authors: Parra-Flores Riquelme Valenzuela-Bustamante Leiva-Navarrete Vivar Cayupi-Vivanco Castro Espinoza-Pérez Ruz-Cortés Pedrozo Lavandero Rodrigo Diaz-Araya Acute...
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 616: From Past to Present: The Link Between Reactive Oxygen Species in Sperm and Male Infertility Antioxidants doi: 10.3390/antiox8120616 Authors: Villaverde Netherton Baker Reactive oxygen species (ROS) can be generated in mammalian cells via both enzymatic and non-enzymatic mechanisms. In sperm cells, while ROS may function as signalling molecules for some physiological pathways, the oxidative stress arising from the ubiquitous production of these...
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 613: Green Extraction Approaches for Carotenoids and Esters: Characterization of Native Composition from Orange Peel Antioxidants doi: 10.3390/antiox8120613 Authors: Daniella C. Murador Fabio Salafia Mariosimone Zoccali Paula L. G. Martins Antônio G. Ferreira Paola Dugo Luigi Mondello Veridiana V. de Rosso Daniele Giuffrida Orange peel is a by-product produced in large amounts that acts as a source of natural pigments such as carotenoids....
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 612: Quantification of Polyphenols in Seaweeds: A Case Study of Ulva intestinalis Antioxidants doi: 10.3390/antiox8120612 Authors: Marie Emilie Wekre Karoline Kåsin Jarl Underhaug Bjarte Holmelid Monica Jordheim In this case study, we explored quantitative 1H NMR (qNMR), HPLC-DAD, and the Folin-Ciocalteu assay (TPC) as methods of quantifying the total phenolic content of a green macroalga, Ulva intestinalis, after optimized accelerated solvent...
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 611: Potential of Smoke-Water and One of Its Active Compounds (karrikinolide, KAR1) on the Phytochemical and Antioxidant Activity of Eucomis autumnalis Antioxidants doi: 10.3390/antiox8120611 Authors: Adeyemi Oladapo Aremu Nqobile Andile Masondo Jiri Gruz Karel Doležal Johannes Van Staden Eucomis autumnalis (Mill.) Chitt. subspecies autumnalis is a popular African plant that is susceptible to population decline because the bulbs are widely utilized...
Tue Dec 03, 2019 02:00
Antioxidants, Vol. 8, Pages 610: The Effect of Hydrogen Sulfide on Different Parameters of Human Plasma in the Presence or Absence of Exogenous Reactive Oxygen Species Antioxidants doi: 10.3390/antiox8120610 Authors: Beata Olas Paulina Brodek Bogdan Kontek The main aim of the study is to examine the effect of sodium hydrosulfide (NaHS), an H2S donor, on the oxidative stress in human plasma in vitro. It also examined the effects of very high concentrations of exogenous hydrogen...
Tue Dec 03, 2019 02:00
Atmosphere, Vol. 10, Pages 773: Rainfall Estimates with Respect to Rainfall Types using S-band Polarimetric Radar in Korea Atmosphere doi: 10.3390/atmos10120773 Authors: You Kang Lee To investigate the impact of rainfall type on rainfall estimation using polarimetric variables, rainfall relations such as those between rain rate (R) and specific differential phase (KDP), between R and KDP/differential reflectivity (ZDR), and between R and reflectivity (Z)/ZDR, were examined with...
Tue Dec 03, 2019 02:00
Atmosphere, Vol. 10, Pages 772: Nanoparticle Behaviour in an Urban Street Canyon at Different Heights and Implications on Indoor Respiratory Doses Atmosphere doi: 10.3390/atmos10120772 Authors: Manigrasso Protano Vitali Avino The amount of outdoor particles that indoor environments receive depends on the particle infiltration factors (Fin), peculiar of each environment, and on the outdoor aerosol concentrations and size distributions. The respiratory doses received, while...
Tue Dec 03, 2019 02:00
Atmosphere, Vol. 10, Pages 771: Emission Factors for Biofuels and Coal Combustion in a Domestic Boiler of 18 kW Atmosphere doi: 10.3390/atmos10120771 Authors: Marianna Czaplicka Ewelina Cieślik Bogusław Komosiński Tomasz Rachwał The differences in the pollutant emissions from the combustion of bituminous coal and biofuels (wood, straw, and miscanthus pellets) under real-world boiler operating conditions were investigated. The experiments were performed on an experimental installation...
Tue Dec 03, 2019 02:00
Atmosphere, Vol. 10, Pages 769: Determination of Thermal Comfort in Indoor Sport Facilities Located in Moderate Environments: An Overview Atmosphere doi: 10.3390/atmos10120769 Authors: Fantozzi Lamberti In previous years, providing comfort in indoor environments has become a major question for researchers. Thus, indoor environmental quality (IEQ)—concerning the aspects of air quality, thermal comfort, visual and acoustical quality—assumed a crucial role. Considering...
Tue Dec 03, 2019 02:00
Atmosphere, Vol. 10, Pages 768: Unprecedented Rainfall and Moisture Patterns during El Niño 2016 in the Eastern Pacific and Tropical Andes: Northern Perú and Ecuador Atmosphere doi: 10.3390/atmos10120768 Authors: Janeet Sanabria Carlos M. Carrillo David Labat Using vertically integrated water vapor and its convergence, associated with large-scale and regional atmospheric circulation, we found two patterns of rainfall over the Eastern Pacific (EP) and the tropical Andes-with a focus...
Tue Dec 03, 2019 02:00
Atmosphere, Vol. 10, Pages 770: Late-Spring Severe Blizzard Events over Eastern Romania: A Conceptual Model of Development Atmosphere doi: 10.3390/atmos10120770 Authors: Caian Andrei In this paper, the mechanism and model-representation of a late-spring severe blizzard event on eastern Romania are studied. The mechanism relies on the coupled contribution of the tropospheric ageostrophic circulations associated to jet streaks. These circulations: (1) interact under local and regional...
Tue Dec 03, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 136: Crafting Task and Cognitive Job Boundaries to Enhance Self-Determination, Impact, Meaning and Competence at Work Behavioral Sciences doi: 10.3390/bs9120136 Authors: Hornung Job crafting refers to physical and cognitive changes in task or relational work boundaries, enacted by individuals to recreate their work experience in a more motivating and rewarding way, and to realize self-actualization, growth, and meaning at work. This study tests a model...
Tue Dec 03, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 135: Intolerance of Uncertainty and Mindfulness as Determinants of Anxiety and Depression in Female Students Behavioral Sciences doi: 10.3390/bs9120135 Authors: Marina Nekić Severina Mamić Bearing in mind the characteristics of an academic setting, as well as the developmental tasks young people inevitably face, there is a need to identify and study the factors that play an important role in the development and maintenance of psychological distress...
Tue Dec 03, 2019 02:00
Behavioral Sciences, Vol. 9, Pages 134: Attachment and Adulthood in a Sample of Southeastern Mexico Behavioral Sciences doi: 10.3390/bs9120134 Authors: Gabriela Isabel Pérez-Aranda Vianey Peralta-López Sinuhé Estrada-Carmona Liliana García Reyes Miguel Angel Tuz-Sierra The main purpose of this research is to analyze the attachment styles of men and women from 20 to 40 years old (early adulthood) and from 40 to 65 years old (middle adulthood) who are in a romantic relationship...
Tue Dec 03, 2019 02:00
Beverages, Vol. 5, Pages 69: Red Rooibos Tea Stimulates Osteoblast Mineralization in a Dose-Dependent Manner Beverages doi: 10.3390/beverages5040069 Authors: McAlpine Gittings MacNeil Ward Most studies show a positive association between higher tea intake and bone mineral density (BMD), while associations with fracture are inconclusive. Although a few studies have investigated the potential effects of rooibos tea on the bone cell metabolism, only 1 or 2 doses were tested...
Tue Dec 03, 2019 02:00
Bioengineering, Vol. 6, Pages 109: Frontiers in Microfluidics, a Teaching Resource Review Bioengineering doi: 10.3390/bioengineering6040109 Authors: Jack Merrin This is a literature teaching resource review for biologically inspired microfluidics courses or exploring the diverse applications of microfluidics. The structure is around key papers and model organisms. While courses gradually change over time, a focus remains on understanding how microfluidics has developed as well as what...
Tue Dec 03, 2019 02:00
Biomolecules, Vol. 9, Pages 823: Genome-Wide Analysis of Abscisic Acid Biosynthesis, Catabolism, and Signaling in Sorghum Bicolor under Saline-Alkali Stress Biomolecules doi: 10.3390/biom9120823 Authors: Ma Lv Meng Zhou Fu Shen Zhang Li Sorghum (Sorghum bicolor) is the fifth most important cereal crop in the world. It is an annual C4 crop due to its high biomass and wide usage, and has a strong resistance to stress. Obviously, there are many benefits of planting...
Tue Dec 03, 2019 02:00
Biomolecules, Vol. 9, Pages 822: N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes Biomolecules doi: 10.3390/biom9120822 Authors: Battista Bari Bisogno The lipid signal is becoming increasingly crowded as increasingly fatty acid amide derivatives are being identified and considered relevant therapeutic targets. The identification of N-arachidonoyl-ethanolamine as endogenous ligand of cannabinoid type-1 and type-2 receptors as well as the development...
Tue Dec 03, 2019 02:00
Biomolecules, Vol. 9, Pages 821: Effect of Ozone Treatment on Flavonoid Accumulation of Satsuma Mandarin (Citrus unshiu Marc.) during Ambient Storage Biomolecules doi: 10.3390/biom9120821 Authors: Zhu Jiang Yin Li Jiang Shan This study aimed to compare the flavonoid accumulation between ozone-treated and untreated Satsuma mandarin (Citrus unshiu Marc.) fruits. The fruits exposed to gaseous ozone were found to have higher antioxidant activities and content of flavonoid...
Tue Dec 03, 2019 02:00
Biomolecules, Vol. 9, Pages 820: Functionalized Upconversion Nanoparticles for Targeted Labelling of Bladder Cancer Cells Biomolecules doi: 10.3390/biom9120820 Authors: Polikarpov Liang Care Sunna Campbell Walsh Balalaeva Zvyagin Gillatt Guryev Bladder cancer is the ninth most common cancer worldwide. Due to a high risk of recurrence and progression of bladder cancer, every patient needs long-term surveillance, which includes regular cystoscopy, sometimes...
Tue Dec 03, 2019 02:00
Biomolecules, Vol. 9, Pages 819: Comparison of Physicochemical Properties of Bee Pollen with Other Bee Products Biomolecules doi: 10.3390/biom9120819 Authors: Adaškevičiūtė Kaškonienė Kaškonas Barčauskaitė Maruška The aim of this study was to compare the physichochemical composition of various bee products, namely, bee pollen, beebread, propolis, honey, and royal jelly. The samples (37 out of 53) were collected in Lithuania, several samples from other Europe countries...
Tue Dec 03, 2019 02:00
Biomolecules, Vol. 9, Pages 818: The Actual and Potential Aroma of Winemaking Grapes Biomolecules doi: 10.3390/biom9120818 Authors: Ferreira Lopez This review intends to rationalize the knowledge related to the aroma of grapes and to the aroma of wine with specific origin in molecules formed in grapes. The actual flavor of grapes is formed by the few free aroma molecules already found in the pulp and in the skin, plus by those aroma molecules quickly formed by enzymatic/catalytic...
Tue Dec 03, 2019 02:00
Biosensors, Vol. 9, Pages 139: Biochar from Brewers’ Spent Grain: A Green and Low-Cost Smart Material to Modify Screen-Printed Electrodes Biosensors doi: 10.3390/bios9040139 Authors: Cancelliere Carbone Pagano Cacciotti Micheli In the present study, biochar from brewers’ spent grain was used, for the first time, to develop screen-printed electrodes. After having investigated the dispersion behaviour of biochar in different organic solvents, a biochar-based...
Tue Dec 03, 2019 02:00
Brain Sciences, Vol. 9, Pages 354: Diffusion Tensor Magnetic Resonance Imaging for Differentiating Multiple System Atrophy Cerebellar Type and Spinocerebellar Ataxia Type 3 Brain Sciences doi: 10.3390/brainsci9120354 Authors: Jao Soong Huang Duan Wu Wu Wang Multiple system atrophy cerebellar type (MSA-C) and spinocerebellar ataxia type 3 (SCA3) demonstrate similar manifestations, including ataxia, pyramidal and extrapyramidal signs, as well as atrophy and signal...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1929: ER Stress and Unfolded Protein Response in Cancer Cachexia Cancers doi: 10.3390/cancers11121929 Authors: Roy Kumar Cancer cachexia is a devastating syndrome characterized by unintentional weight loss attributed to extensive skeletal muscle wasting. The pathogenesis of cachexia is multifactorial because of complex interactions of tumor and host factors. The irreversible wasting syndrome has been ascribed to systemic inflammation, insulin resistance,...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1928: How Prostate Cancer Cells Use Strategy Instead of Brute Force to Achieve Metastasis Cancers doi: 10.3390/cancers11121928 Authors: Tharp Nandana Akin to many other cancers, metastasis is the predominant cause of lethality in prostate cancer (PCa). Research in the past decade or so has revealed that although metastatic manifestation is a multi-step and complex process that is orchestrated by distinct cellular and molecular mechanisms, the process in itself...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1930: Direct Targeting Options for STAT3 and STAT5 in Cancer Cancers doi: 10.3390/cancers11121930 Authors: Anna Orlova Christina Wagner Elvin D. de Araujo Dávid Bajusz Heidi A. Neubauer Marco Herling Patrick T. Gunning György M. Keserű Richard Moriggl Signal transducer and activator of transcription (STAT)3 and STAT5 are important transcription factors that are able to mediate or even drive cancer progression through hyperactivation or...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1927: The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation Cancers doi: 10.3390/cancers11121927 Authors: Hong Chung Shin Lee Gil Lee Choi Choi Hassan Lee Lee We previously reported the potential anti-proliferative activity of 3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)-N-(3,4,5-trimethoxyphenyl) benzamide (TMS-TMF-4f) against human...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1925: Deterioration in Muscle Mass and Physical Function Differs According to Weight Loss History in Cancer Cachexia Cancers doi: 10.3390/cancers11121925 Authors: Guro Birgitte Stene Trude Rakel Balstad Anne Silja M. Leer Asta Bye Stein Kaasa Marie Fallon Barry Laird Matthew Maddocks Tora S. Solheim Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1926: Rationale of Immunotherapy in Hepatocellular Carcinoma and Its Potential Biomarkers Cancers doi: 10.3390/cancers11121926 Authors: Tai Choo Chew Hepatocellular carcinoma (HCC), the most common type of liver cancer, is derived mostly from a background of chronic inflammation. Multiple immunotherapeutic strategies have been evaluated in HCC, with some degree of success, particularly with immune checkpoint blockade (ICB). Despite the initial enthusiasm,...
Tue Dec 03, 2019 02:00
Cancers, Vol. 11, Pages 1924: Gathering Novel Circulating Exosomal microRNA in Osteosarcoma Cell Lines and Possible Implications for the Disease Cancers doi: 10.3390/cancers11121924 Authors: Nicola Cuscino Lavinia Raimondi Angela De Luca Claudia Carcione Giovanna Russelli Laura Conti Jacopo Baldi Pier Giulio Conaldi Gianluca Giavaresi Alessia Gallo One of the goals of personalized medicine is to understand and treat diseases with greater precision through the...
Tue Dec 03, 2019 02:00
Cells, Vol. 8, Pages 1562: An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight Cells doi: 10.3390/cells8121562 Authors: Tomal Kwasniak-Owczarek Janska Contrary to the widely held belief that mitochondrial ribosomes (mitoribosomes) are highly similar to bacterial ones, recent experimental evidence reveals that mitoribosomes do differ significantly from their bacterial counterparts. This review is focused on plant mitoribosomes, but we also highlight...
Tue Dec 03, 2019 02:00
Cells, Vol. 8, Pages 1561: Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism Cells doi: 10.3390/cells8121561 Authors: Melica La Regina Parri Peired Romagnani Lasagni Stem cell (SC)-based tissue engineering and regenerative medicine (RM) approaches may provide alternative therapeutic strategies for the rising number of patients suffering from chronic kidney disease. Embryonic SCs and inducible pluripotent...
Tue Dec 03, 2019 02:00
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