The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Abstract

Objective

Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.

Method

We performed polysomnography (PSG) and Aβ imaging with [¹¹C]-Pittsburgh compound B PET computed tomography (¹¹C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).

Results

The abnormal accumulation of enhanced ¹¹C-PiB PET was observed only one patient with severe, but not the most severe.

Conclusions

The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.