Summary 月桂酸钠 (SLS) 是一种化学物质,被用于诱导皮肤刺激,模拟刺激性接触性皮炎 (ICD)。ICD 是一种由于直接接触某些物质而导致皮疹、发红、起泡、瘙痒、干燥和皮肤开裂的疾病。这是一种常见的职业病,在英国所有的皮肤科会诊中占 4‐7%。这种由 SLS 诱导的刺激通常用于测试可用于缓解 ICD 症状的不同治疗方法的有效性。刺激通常是在前臂上诱导,但也已经发现被用于其他位置,例如上背部。不同解剖部位的刺激程度可能不同。这些差异可能会影响治疗检测的结果。这意味着治疗在一个位置取得的有益效果可能不会在另一个位置取得。这项来自克罗地亚的研究旨在研究皮肤对刺激反应的变化及其对 SLS 诱导的 ICD 治疗的影响。刺激物被涂在健康志愿者的前臂和上背部。选择润肤(保湿)霜作为治疗手段。其中一只前臂和背部一侧接受了为期九天的润肤霜治疗,而另一些则没有接受治疗。用皮肤探针测量皮肤刺激程度和恢复情况。研究人员发现,与前臂相比,上背部对刺激物的反应更强烈,皮肤恢复得更快。此外,所测试的润肤乳霜并没有改善皮肤的恢复。综上所述,解剖位置是影响用于测试治疗效果的研究结果的重要因素。未来的研究应该始终准确地报告测试位置。在不同的解剖位置使用这种刺激模型的研究产生的结果不一定能够直接可比。
Mon Jul 01, 2019 15:17
Mon Jul 01, 2019 15:17
Summary Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, severe, skin blistering conditions in which areas of skin die and detach. They actually represent a single disease with a spectrum of severity: less than 10% body surface area detachment in SJS and more than 30% in TEN. It affects around 500 people in the UK each year and is most commonly caused by a reaction to a wide‐range of commonly prescribed drugs. This study brought together researchers and patients from...
Mon Jul 01, 2019 15:17
Summary Actinic keratoses (AK) are rough skin lesions (patches) caused by long‐term sun exposure in light skinned individuals, affecting 24‐60% of people above the age of 50. The current management of AK patients (meaning how they are diagnosed and treated and how long they are ‘followed up’ for) seems to vary within and between primary care (e.g. GPs) and secondary care (e.g. hospital dermatology departments). This Dutch study aimed to provide insight into underlying motives of current AK management....
Mon Jul 01, 2019 15:17
Summary Systemic sclerosis (SSc) is an autoimmune condition which means that the body's immune system, which usually fights off disease, wrongly targets healthy parts of the body, and SSc patients produce antibodies to their own tissues (‘autoantibodies’). Extensive thickening and scarring of tissues (fibrosis) is the main feature of the condition and is due to over‐production of collagen. Changes in small blood vessels also occur. When fibrosis occurs in the lungs (pulmonary fibrosis) it can lead...
Mon Jul 01, 2019 15:17
Summary 史蒂文斯‐约翰逊综合征 (SJS) 和中毒性表皮坏死松解症 (TEN) 是一种罕见的、严重的、皮肤起泡的疾病,其中皮肤的某些部位会死亡和脱落。它们实际上代表着严重程度不同的同一种疾病:SJS 患者的体表脱皮面积低于 10%,而 TEN 患者超过 30%。 在英国,每年约有 500 人感染此病,最常见的原因是对多种常用处方药产生反应。这项研究汇集了来自英国、西班牙、台湾地区和美国的研究人员和患者,目的是检测 SJS/TEN 患者血清(部分血液)、水泡液和皮肤活检组织中一种名为高迁移率族蛋白B1 (HMGB1) 的水平。HMGB1 是一种蛋白,它被认为是发生在 SJS/TEN 中的 a) 组织/细胞损伤和 b) 免疫反应激活的标志物(生物学标志)。 作者在三个独立的患者群体中检测到 SJS/TEN 患者在反应时血清 HMGB1 水平升高,患者水泡液中 HMGB1 水平也非常高。SJS/TEN 患者的皮肤表皮(上)层 HMGB1 水平明显降低,但未出现健康对照或药物引起的皮疹。 皮肤表皮中 HMGB1 水平的下降似乎发生在起水泡之前,这可能是一个早期指标。此外,HMGB1...
Mon Jul 01, 2019 15:17
Mon Jul 01, 2019 15:17
Summary 光化性角化病 (AK) 是浅色皮肤的人因为长期暴露在阳光下而引起的粗糙的皮肤损伤(斑块),它影响 24‐60% 的 50 岁以上人群。目前对 AK 患者的管理(即他们如何被诊断和治疗,以及他们被“随访”多久)似乎在初级护理(如全科医生)和二级护理(如医院皮肤科)之间存在差异。这项荷兰的研究旨在深入了解当前 AK 管理的潜在动机。研究人员对 22 名全科医生和 18 名皮肤科医生进行了访谈。由于缺乏知识和经验以及对 AK 护理的认知价值较低,全科医生在诊断 AK 和确定治疗和随访计划方面的方法各不相同。皮肤科医生表示,他们努力根据官方指南提供 AK 治疗,但患者偏好和其他患者相关因素会影响治疗选择,并且经常会导致粗放式的随访方案。为了使 AK 护理在荷兰初级护理中变得更加标准化和统一,需要实施指南和持续教育,以解决普遍报道的全科医生缺乏价值、经验和知识的障碍。为了帮助预防二级护理中的粗放式随访(因此确保有效使用护理),共享决策工具和足够的患者信息可能有助于皮肤科医生管理患者的偏好。
Mon Jul 01, 2019 15:17
Summary 系统性硬化症 (SSc) 是一种自身免疫性疾病,它意味着通常负责对抗疾病的身体免疫系统会错误地瞄准身体的健康部位,而SSc患者会产生针对自身组织的抗体(“自身抗体”)。广泛的增厚和瘢痕组织(纤维化)是这种疾病的主要特征,并且原因是胶原蛋白的过度生成。小血管也会发生变化。当纤维化发生在肺(肺纤维化)时,它可以导致高血压动脉进入肺,而这可能会危及生命。这种疾病在女性中比较常见。根据皮肤受累的程度,SSc 可能是局部的,也可能是广泛的。尽管引起 SSc 的原因还没有完全弄清楚,但人们相信其中以这样或那样的方式涉及到许多与这种疾病相关的自身抗体。在另一种名为系统性红斑狼疮的自身免疫性疾病中,确定发现了一种名为“抗‐C1q”的自身抗体,因此,来自希腊和美国的这项研究的目的是研究它们是否也存在于 SSc 中。在这项研究中的 124 名 SSc 患者中,有 16.1% 的患者体内发现了抗‐C1q 自身抗体,其发生频率与第三高的自身抗体(即抗‐RNA 聚合酶 III)一样高。尤其是在男性和散播性 SSc 患者中发现了这种抗体。抗‐C1q 抗体的存在与肺纤维化有关,但与 SSc 的任何其他特征无关。因此,作者认为抗‐C1q...
Mon Jul 01, 2019 15:17
Abstract Background Atopic dermatitis is highly prevalent in black/African American, Asian, and Hispanic patients, making assessment of these populations in clinical trials important. Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. In two pivotal phase III clinical trials in patients aged ≥ 2 years, crisaborole was superior to vehicle in reducing global...
Mon Jul 01, 2019 03:00
No abstract available
Fri Jun 28, 2019 03:00
Abstract: Atypical Spitz tumor (AST) is a melanocytic proliferation that shares histopathologic features of Spitz nevus and spitzoid melanoma. Distinction of AST from spitzoid melanoma is critical because the majority of ASTs will follow an indolent course. Array-based comparative genomic hybridization (aCGH) has been suggested as a potential tool for evaluating malignant potential in spitzoid tumors. We present a case of a 52-year-old woman with an AST in which aCGH was crucial in guiding correct...
Fri Jun 28, 2019 03:00
Abstract: In the past decades, there was a considerable advance in regard to recognition of morphologic findings and classification of several benign and malignant vascular proliferations. In 2002, attention was called by Requena et al to a new variant of cutaneous hemangioma named acquired elastotic hemangioma. In this article, a case of acquired elastotic hemangioma is reported with documentation of clinical, dermatoscopic, histopathological, and immunohistochemical findings. A systematic review...
Fri Jun 28, 2019 03:00
Abstract: Histoid leprosy (HL) was originally described by Wade in 1963 and is regarded as a rare variant of lepromatous leprosy (LL). These characteristic clinical lesions are firm, deeply adhered nodules with features reminiscent of dermatofibromas or keloids in a background of apparently healthy skin. The main histopathological findings described are the presence of spindle cell histiocytes immersed in a richly collagenized background, usually forming a nodular pattern of infiltration with...
Fri Jun 28, 2019 03:00
Abstract: Melanotic schwannoma is a pigmented tumor of peripheral nerve differentiation. Primary cutaneous presentations are extremely rare, as the bulk of melanotic schwannomas tend to develop in paraspinal and axial sites. Tumors arise sporadically and in the setting of the Carney complex. Alterations in the gene encoding protein kinase A regulatory subunit-α (PRKAR1A) underlie most patients with the Carney complex and mediate melanotic schwannoma tumorigenesis. Melanotic schwannomas from noncutaneous...
Fri Jun 28, 2019 03:00
Abstract: Sarcomatoid variant of primary cutaneous anaplastic large cell lymphoma is rare and is a diagnostic challenge. Clinical manifestation often mimics that of an infectious disease. Predominance of spindle cells in the biopsy specimen prevents from suspecting lymphoma. Here, we report the fourth case of this entity with good prognosis. A 30-year-old woman presented with several nodules on the whole body. The biopsy revealed infiltration of spindle cells in the dermis with myxomatous background....
Fri Jun 28, 2019 03:00
Abstract: B-cell chronic lymphocytic leukemia (CLL), a low-grade malignancy consisting of CD5(+), CD23(+), and CD43(+) small B lymphocytes, is the most frequent leukemia in the western world. Patients with CLL may exhibit skin changes characterized by histopathologic evidence of infiltration by atypical B lymphocytes, also known as “specific cutaneous infiltrates of CLL”; in addition, CLL is known to be associated with an increased risk of second cancers, including Kaposi sarcoma (KS). The combination...
Fri Jun 28, 2019 03:00
Abstract: Primary localized cutaneous nodular amyloidosis is a rare plasma cell dyscrasia in which an amorphous material consisting of light chain amyloid is produced and deposited in the dermis, with varied clinical presentation. We describe the case with unusual and tumor lush clinical presentation in the face with no progression to systemic disease and no evidence of extracutaneous commitment. Correspondence: Letícia Dupont, Valparaíso, 1075/1403, Porto Alegre, RS, Brazil (e-mail: dupont.leticia@gmail.com). ...
Fri Jun 28, 2019 03:00
Abstract The efficacy of lauromacrogol injection therapy and intralesional triamcinolone for infantile hemangiomas (IH) has been well documented recently, but with an increase in serious or rare adverse reactions. The aim of this study is to investigate the safety concerns regarding intralesional injection of lauromacrogol combined with triamcinolone for IH and to study its effect on infant growth and development. A total of 1039 IH patients who were subjected to intralesional injection of lauromacrogol...
11:58
Abstract The "chik sign" is considered to be one of the most common cutaneous features of chikungunya fever and has been considered unique to this disorder. It consists of brownish hyperpigmentation involving the nose. We report a case of a 3‐year‐old boy with dengue infection who presented with macular hyperpigmentation of nose simulating the chik sign. Hyperpigmentation is an unusual cutaneous manifestation in cases of dengue.
Mon Jul 01, 2019 16:44
Abstract Verrucous perforating collagenoma is an extremely rare variant of acquired perforating dermatosis that has been seldom described in literature. We present the case of an 18‐month‐old boy who presented with an erythematous plaque with a central keratotic plug on the leg. Histopathology revealed transepidermal elimination of collagen, consistent with a diagnosis of verrucous perforating collagenoma.
Mon Jul 01, 2019 15:09
Abstract Sexual and gender minority (SGM) individuals, including lesbian, gay, bisexual, transgender/gender diverse, questioning/queer, intersex, and asexual (LGBTQIA) persons, represent a historically underserved population within the field of medicine, though their unique health needs are increasingly recognized. Part 2 of this two‐part review will address unique concerns regarding acne, tanning behavior, sexually transmitted infections, and other health disparities among SGM adolescents. A more...
Mon Jul 01, 2019 15:08
Abstract Red ear syndrome has been reported in the literature to have similarities to erythromelalgia with auricular involvement; however, the distinction between the two is controversial. Red ear syndrome has previously been classified as idiopathic (primary) or secondary, with headaches being the most common association in the idiopathic or primary form. We present a case of pediatric red ear syndrome with hand and foot involvement that we believe represents auricular erythromelalgia. In this...
Mon Jul 01, 2019 15:07
Abstract Sexual and gender minority (SGM) persons, including lesbian, gay, bisexual, transgender/gender diverse, questioning/queer, intersex, and asexual (LGBTQIA) individuals, represent a historically underserved population within the field of medicine, though their unique health needs are increasingly recognized. Unfortunately, our understanding of these needs as they relate to dermatology is still nascent, particularly with respect to children and adolescents. This two‐part review will discuss...
Mon Jul 01, 2019 15:07
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