Abstract There is currently no definitive treatment for vitiligo; various modalities include immune modulators phototherapy and skin camouflage. We investigated the efficacy and safety of topical tacrolimus either as monotherapy or combined therapy in the treatment of vitiligo. Electronic systematic search of the literature was carried out using four major databases. Randomised clinical trials (RCTs) that reported the use of topical tacrolimus in the treatment of human vitiligo have been included...
Tue Jul 02, 2019 20:33
Tue Jul 02, 2019 14:54
Abstract Perioral ulcerative plaques have a broad list of differential diagnoses. We describe an unusual presentation of chronic progressive perioral ulceration due to herpes simplex type (HSV)‐1 on a background of undiagnosed human immunodeficiency virus infection with acquired immunodeficiency syndrome. Whilst chronic mucocutaneous HSV is an AIDS‐defining condition with both HSV‐1 and HSV‐2 implicated, typical reported cases describe vesicular eruptions rather than perioral ulcerative plaques....
Tue Jul 02, 2019 14:48
A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update
Abstract Hidradenitis suppurativa is a chronic skin disease characterised by repeated skin abscesses with sinus tracts and scar formation. Currently, the aetiology and pathogenesis of hidradenitis suppurativa remain unclear. Genetic factors, immune disorders, hormonal abnormalities, skin‐microbial dysbiosis, smoking, obesity and mechanical friction all influence hidradenitis suppurativa pathogenesis. Moreover, hidradenitis suppurativa has a familial subset with autosomal dominant transmission proposed...
Tue Jul 02, 2019 14:45
Abstract Background/Objectives Atypical fibroxanthoma (AFX) is a mesenchymal neoplasm of unknown incidence. It has been determined that AFX is a tumour with low aggressiveness as long as it is properly diagnosed. Our objectives were to exclude pleomorphic dermal sarcomas or other skin tumours incorrectly diagnosed as AFX in our centre after applying strict diagnostic criteria and to assess the behaviour of appropriately diagnosed AFX. Methods We conducted an observational retrospective...
Mon Jul 01, 2019 15:19
Abstract Background/Objectives Hidradenitis suppurativa has been associated with a number of pathologies, including various endocrine and autoimmune disorders. Although signs of hyperandrogenism are common in hidradenitis suppurativa, few formal studies have assessed the relationship between hidradenitis suppurativa and polycystic ovarian syndrome. Therefore, we performed a systematic review and meta‐analysis to assess the association between hidradenitis suppurativa and polycystic ovarian syndrome....
Mon Jul 01, 2019 13:19
Abstract Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory skin condition for which the pathogenesis is not completely elucidated1. With the increase in HS‐related research comes the need to enhance reproducibility, quality and accuracy of scientific methods. Unlike other inflammatory dermatoses such as psoriasis or atopic dermatitis, HS lesions are morphologically diverse and include nodules, abscesses, tunnels and fibrosis in various permutations and combinations admixed in the...
Wed Jul 03, 2019 11:44
Abstract X‐linked adrenoleukodystrophy (X‐ALD) is a progressive, genetic disorder caused by mutations in the ABCD1 gene that causes the accumulation of very long‐chain fatty acids (VLCFA) in all tissues of the body.1 These VLCFA are harmful to organs and primarily affect the brain, spinal cord, and adrenal glands.2 The spectrum and severity of the disease vary, ranging from isolated adrenal insufficiency and myelopathy to cerebral demyelination.2 The possibility of cerebral X‐ALD, which can be rapidly...
Wed Jul 03, 2019 11:43
Tue Jul 02, 2019 11:02
Abstract Pityriasis rubra pilaris (PRP) is an uncommon inflammatory disorder of the skin characterized by pruritic, follicular, hyperkeratotic papules that merge to form generalized salmon‐colored plaques with islands of sparing1. Palmoplantar keratoderma and erythroderma are present in a number of cases as well. This article is protected by copyright. All rights reserved.
Mon Jul 01, 2019 18:39
Abstract Primary cutaneous amyloidosis (PCA) is defined as cutaneous amyloidosis in the absence of other systemic and dermatological manifestations. Amyloidosis cutis dyschromica (ACD) is a distinct form of autosomal recessive PCA.1 The main cutaneous feature is generalized hyper‐ and hypopigmentation. This article is protected by copyright. All rights reserved.
Mon Jul 01, 2019 18:39
Abstract Biological drugs have revolutionized the control of immune‐mediated diseases,1 but most of the safety studies have not evaluated the risk of endemic infections, such as leishmaniasis, in underdeveloped regions.2 The control of this parasite is strongly dependent on the production of specific cytokines (IL‐1, TNF‐α, IL‐6),3 which are important targets of biological therapies. This article is protected by copyright. All rights reserved.
Mon Jul 01, 2019 18:37
Abstract Background Epidermal necrolysis (EN) is a rare and life‐threatening condition. Objectives We aimed to assess whether admitting hospital characteristics and inter‐hospital transfer are associated with EN mortality. Methods We studied the French nationwide hospital discharge database (retrospective national cohort). All patients admitted during 2012‐2016 with a code for EN in the International Classification of Diseases, 10th Revision, were eligible. We extracted data on the...
Mon Jul 01, 2019 18:13
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