We estimate the fractions of cancer attributed to infections in Africa in 2018. The number of new cancer cases occurring were taken from Globocan2018 with some additional estimations based on data from African population‐based registries. Population attributable fractions were calculated using prevalence of infection and relative risk in exposed versus non‐exposed. The greatest share of infection‐associated cancers is due to the human papilloma viruses (12.1% of all cancers in Africa and 15.4% in...
Sat Jun 29, 2019 19:13
Mammography screening may save women from dying of breast cancer, although it has not been shown to reduce all‐cause mortality. Screening also leads to overdiagnosis and many false positive mammograms aggravating women's quality of life. QALY analyses of mammography screening has so far, calculated life years gained assuming that all prevented breast cancer deaths translate into a reduction in all‐cause mortality. We calculated net QALYs in two hypothesized cohorts of 100,000 Norwegian women; one...
Sat Jun 29, 2019 18:49
The role of Fyn‐related kinase (FRK) in malignant tumors remains controversial. This study investigated the function of FRK in lung cancer. Immunohistochemistry staining and generating a knockout of FRK by CRISPR/Cas9 in H1299 (FRK‐KO‐H1299) cells were strategies used to explore the role of FRK. Immunohistochemistry staining indicated that FRK expression was elevated in 223 lung cancer tissues compared with 26 distant normal lung tissues. FRK contributed to poor survival status in lung cancer patients...
Fri Jun 28, 2019 19:34
Panels of single nucleotide polymorphisms (SNPs) stratify risk for breast cancer in women from the general population, but studies are needed assess their use in a fully‐comprehensive model including classical risk factors, mammographic density and more than 100 SNPs associated with breast cancer. A case‐control study was designed (1668 controls, 405 cases) in women aged 47‐73 years attending routine screening in Manchester UK, and enrolled in a wider study to assess methods for risk assessment....
Fri Jun 28, 2019 19:34
We used a cross‐sectional survey to examine short‐term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24‐65 (n=1127) who had attended screening at one of five sites piloting HPV primary screening in England, including a control group with normal cytology who were not tested for HPV. Women completed a postal questionnaire ~2 weeks after receiving their screening result. Unadjusted...
Fri Jun 28, 2019 19:34
Abstract It is essential for at-risk women to be screened for breast and cervical cancer in a timely manner. Despite a growing interest in the role of health information technology including personal health records (PHRs) to improve quality and outcomes in health care, less is known about the effectiveness of PHRs to promote breast and cervical cancer screening among women with a family history of cancer (FHC). We examined the association between access to PHRs and the use of a...
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Discoidin domain receptor-1 (DDR1) tyrosine kinase is highly expressed in a variety of human cancers and involved in various steps of tumorigenesis. However, the precise mechanisms underlying the abnormal expr...
Fri Jun 28, 2019 03:00
Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level i...
Fri Jun 28, 2019 03:00
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