Publication date: Available online 2 July 2019Source: Allergology InternationalAuthor(s): Takehito Kobayashi, Tomoyuki Soma, Kazuyuki Nakagome, Hidetomo Nakamoto, Makoto Nagata
Wed Jul 03, 2019 14:10
Publication date: Available online 2 July 2019Source: Allergology InternationalAuthor(s): Junya Ono, Masayuki Takai, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Shoichiro Ohta, Koubun Yasuda, Simon J. Conway, Yasuyuki Yokosaki, Kenji IzuharaAbstractBackgroundPeriostin is a matricellular protein belonging to the fasciclin family, playing a role for the pathogenesis of allergic diseases by binding to integrins on cell surfaces. Serum periostin is elevated in various allergic...
Tue Jul 02, 2019 14:31
Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study
Publication date: Available online 2 July 2019Source: Allergology InternationalAuthor(s): Hironobu Sunadome, Hisako Matsumoto, Yumi Izuhara, Tadao Nagasaki, Yoshihiro Kanemitsu, Yumi Ishiyama, Chie Morimoto, Tsuyoshi Oguma, Isao Ito, Kimihiko Murase, Shigeo Muro, Takahisa Kawaguchi, Yasuharu Tabara, Kazuo Chin, Fumihiko Matsuda, Toyohiro HiraiAbstractBackgroundObesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic...
Tue Jul 02, 2019 14:31
Publication date: July 2019Source: Allergology International, Volume 68, Issue 3Author(s): Masao Yamaguchi, Kenji Izuhara
Mon Jul 01, 2019 14:42
Publication date: Available online 2 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Emily C. Milam, David E. Cohen
Wed Jul 03, 2019 14:10
Publication date: Available online 2 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Irene Mikhail, Mitchell H. Grayson
Wed Jul 03, 2019 14:10
Publication date: Available online 2 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): S Shahzad Mustafa, Theresa Bingemann, Holly Blue, Kelly Conn, Todd Hanley, Allison Ramsey
Wed Jul 03, 2019 14:10
Abstract Allergen‐specific immunotherapy (AIT) is a potent and precise immune tolerance‐inducing treatment towards specific proteins. AIT is a successful, but long‐term treatment and therefore it is very demanding for the patients. Moreover, there are patients who do not respond to this therapy and others who develop allergic symptoms after initial success of the treatment. Therefore, novel approaches are urgently needed to potentiate its efficacy (i.e. new adjuvants), uncover unknown biological...
Wed Jul 03, 2019 22:52
Abstract Background The aim was to study the association between allergic multimorbidity and adult‐onset asthma considering the number of allergic diseases and the age effect. Methods We used population‐based data from Finnish national registers including 1205 adults over 30 years of age with recently diagnosed asthma (age range: 30‐93), matched for gender, age, and living region with one or two controls (n=2050). Allergic rhinitis (AR), allergic conjunctivitis (AC) and allergic dermatitis...
Wed Jul 03, 2019 22:50
Wed Jul 03, 2019 22:48
Abstract Background STAT3 hyper‐IgE syndrome (STAT3‐HIES) is caused by heterozygous mutations in the STAT3 gene, and is associated with eczema, elevated serum‐IgE, and recurrent infections resembling severe atopic dermatitis while clinically relevant specific IgE is almost absent. Methods To investigate the impact of STAT3 signaling on B cell responses, we assessed lymph node and bone marrow, blood B and plasma cell subsets, somatic hypermutations in Ig genes, in vitro proliferation and...
Wed Jul 03, 2019 22:46
Abstract Background In recent years, the BRAF‐inhibitor vemurafenib has been successfully established in the therapy of advanced melanoma. Despite its superior efficacy, the use of vemurafenib is limited by frequent inflammatory cutaneous adverse events that affect patients’ quality of life and may lead to dose reduction or even cessation of anti‐tumor therapy. To date, the molecular and cellular mechanisms of vemurafenib‐induced rashes have remained largely elusive. Methods In this study...
Wed Jul 03, 2019 22:08
Abstract Background Asthma patients present with distinct immunological profiles, with a predominance of type 2 endotype. The aim of this study was to investigate the impact of high altitude treatment on the clinical and immunological response in asthma. Methods Twenty‐six hospitalized asthma patients (9 eosinophilic allergic; EA, 9 non‐eosinophilic allergic; NEA and 8 non‐eosinophilic non‐allergic; NN) and 9 healthy controls in high‐altitude for 21 days were enrolled in the study. We assessed...
Wed Jul 03, 2019 11:54
Abstract Background Group 2 innate lymphoid cells (ILC2s) play important roles in allergic inflammation. However, their roles in the pathophysiology of allergic rhinitis (AR) are poorly understood. Objective Prevalence of ILC2s in the inferior nasal turbinate (INT) tissues and the activating mechanisms of ILC2s were examined in patients with house dust mites (HDM)‐induced AR. Methods 18 patients with HDM‐induced AR and 13 control subjects were recruited. Fresh INT tissues and peripheral...
Tue Jul 02, 2019 21:59
Tue Jul 02, 2019 21:58
Abstract The identification of sputum eosinophilia indicating corticosteroid responsiveness in subjects with severe asthma heralded the beginning of phenotyping asthmatic subjects based on airways inflammation. Since then, the heterogeneity of severe asthma has been explored and the importance of immunobiology has come sharply into focus with the identification of the key Type 2 cytokine pathways driving eosinophilic inflammation. The development of molecules targeting these Type 2 pathways has...
Tue Jul 02, 2019 21:55
Abstract Background Germline‐encoded innate immune pattern recognition receptors (PRR) are expressed at epithelial surfaces and modulate epithelial defenses. Evidence suggests that stimulation of the Toll‐like receptor (TLR) family of PRR may regulate epithelial barrier integrity by upregulating tight junction (TJ) complex protein expression, but it is not known if this mechanism is utilized in esophageal epithelial cells. TJ complex proteins maintain intact barrier function, and are dysregulated...
Tue Jul 02, 2019 21:54
It is known that small airway disease is present across all asthma severities; however, its prevalence and clinical characteristics in cough variant asthma (CVA) have not been fully illuminated.
Tue Jul 02, 2019 03:00
Chronic diarrhea affects 4-5% of adults 1. Post-prandial diarrhea (PPD) represents a subset of these patients. Here, we present five cases of idiopathic PPD associated with concurrent dermatographia and chronic urticaria. The diarrhea occurred consistently and exclusively after meals, absent identifiable specific food allergens or food intolerances, and was mitigated by daily pre-treatment with H1 and H2 antagonists. We report herein the clinical presentations of these patients along with laboratory...
Wed Jul 03, 2019 03:00
Allergic rhinitis (AR) and asthma both lead to significant morbidity and healthcare usage in the United States.1,2 Pollens contribute to increased AR symptoms and asthma exacerbations. Ragweed (Ambrosia spp) and other weed pollens have been shown to affect AR and asthma issues in the Midwestern US, especially in the late summer and early fall season. Knowledge about pollen season lengths and patterns can help with management of allergic rhinitis and asthma.3,4,5
Wed Jul 03, 2019 03:00
We conducted a trial to compare the rates of positive oral provocation tests (OPTs) and of clinical symptoms present from different systems (gut, skin, respiratory tract) in cases with a positive OPT in a group of IgE and in one of non-IgE cow’s milk protein allergy (CMPA) at 1 year of age. Moreover, we tried to identify possible prognostic factors contributing to tolerance at one year of age OPT, such as the existence of multiple food allergies, a family history of atopy, the type of milk feeding...
Wed Jul 03, 2019 03:00
Abstract Background A close asssociation between obesity and asthma has been described. The nature of this association remains elusive, especially with respect to allergic asthma. Controversial findings exist regarding the impact short‐term high fat diet (HFD) feeding on the development of allergic asthma. Objective To delineate the impact of short‐term HFD feeding on the development of experimental allergic asthma. Methods Female C57BL/6JRJ mice were fed with a short‐term HFD or...
Tue Jul 02, 2019 18:03
Abstract Background Dysfunction of the bronchial epithelium plays an important role in asthma, however its measurement is challenging. Columnar epithelial cells are often quantified, yet rarely analysed, in induced sputum studies. Objective We aimed to test if sputum columnar epithelial cell proportion and count are altered in asthma, and if they are associated with clinical and inflammatory variables. We aimed to test whether sputum‐based measures could provide a relatively non‐invasive...
Mon Jul 01, 2019 21:53
Abstract Background Extra‐fine particle formulations of inhaled corticosteroid (ICS) are associated with improved lung delivery. Objectives A pragmatic study to assess patient reported outcomes after switching from fine to extra‐fine particle ICS in persistent asthma. Methods 24 patients (Mean age 48 year, FEV1 84%, ACQ 1.67) received 4 weeks run‐in with a constant dose of fine particle ICS (mean dose 710 μg), followed by switching to an equivalent dose of extra fine particle hydrofluoroalkane...
Mon Jul 01, 2019 21:53
Purpose of review The purpose of this article is to provide an update on the advances made through recent clinical trials regarding the treatment of the signs and symptoms of allergic conjunctivitis and its associated conditions. Recent findings Recent studies have demonstrated significant advancement in the various forms of immunotherapy treatments. Nutritional interventions such as probiotics have surfaced as a viable complementary treatment option. Novel delivery methods such as contact...
Mon Jul 01, 2019 03:00
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