Global rosacea treatment guidelines and expert consensus points: The differences
Juliandri Juliandri MD Xiaoyan Wang MD Zijing Liu MD Jiawen Zhang MD Yang Xu MD, PhD Chao Yuan MD, PhD
First published: 26 February 2019 https://doi.org/10.1111/jocd.12903
Funding information:
Natural National Science Foundation of China (81301394, 81602778); Construction Program of Jiangsu Provincial Clinical Research Center Support System (BL2014084)

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Summary
Background
Rosacea is a highly prevalent, chronic inflammatory disease. The treatment of rosacea remains a challenge to dermatologists. Therapies include skin care, medications, lasers, and various combinations of these modalities. The appropriate treatment depends on clinical types and patient's various clinical symptoms.

Purpose
The purpose of this study was to review and compare current therapies for rosacea of all severities from four different guidelines.

Methodology
We searched PubMed using the keywords “rosacea,” “treatment” AND [“erythema rosacea” OR “papulopustular rosacea” OR “ocular rosacea” OR “phymatous rosacea”]. We selected randomized controlled trials, observational studies, controlled clinical trials, and clinical trials. We indentified further studies (including the guidelines) by hand‐searching relevant publications and included those that met the inclusion criteria.

Results
The total number of records identified was 421. We limited our search to the specific abovementioned study types. Twenty‐five of these studies met with our inclusion criteria. An additional five manuscripts were selected using the abovementioned method, and four guidelines were included in this review.

Conclusion
Diagnosing and choosing the appropriate treatment options of rosacea according to guidelines is the basis of scientific criteria. More large‐scale randomized controlled clinical trials on new treatment methods, new drugs, or new dosage forms provide a new guideline for future rosacea treatment. Although there are some differences in the treatment of rosacea, it is generally based on anti‐demodex, anti‐inflammatory, and anti‐angiogenesis.