Autologous pure platelet‐rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient‐reported outcomes to support antiaging effects
Peter A Everts PhD  Pedro Contreiras Pinto PhD  Leonor Girão MD
First published: 23 October 2018 https://doi.org/10.1111/jocd.12802 Cited by: 1
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Summary
Background
During skin aging, a degeneration of connective tissue and decrease in hyaluronic acid polymers occur. Since platelet‐rich plasma (PRP) contains growth factors and various cytokines, it was hypothesized that it could play a role in fibroblast activation and type I collagen expression in human fibroblasts.

Objectives
This study was performed to assess the efficacy of autologous PRP injections for facial skin rejuvenation, measured by biometric instrumental evaluations and patient‐reported outcomes.

Patients and Methods
Patients signed an informed consent form. The EmCyte PurePRP® system technology was used to produce neutrophil‐poor PurePRP. The efficacy of the procedures was assessed by biometric parameters, and a patient outcome a self‐assessment questionnaire on each visit and at 6‐month follow‐up.

Results
Eleven volunteers were included in the study, receiving 3 PurePRP® treatments. A significant decrease in brown spot counts and area (P < 0.05) was seen after 3 months. Wrinkle count and volume were significantly reduced (P < 0.05 for total wrinkle appearance). Skin firmness parameters were significantly improved. Skin redness was significantly improved after 169 days post‐therapy for both the nasolabial and malar areas. A decrease in SLEB thickness was already noted at 2 months after the first injection, with an increase in SLEB density (P < 0.05 for both parameters), without affecting subcutaneous fat thickness. Self‐assessment at 6‐month follow‐up revealed an average satisfaction score of >90%.

Conclusions
A series of 3 PurePRP injections at 6‐month follow‐up resulted in significant skin rejuvenation as demonstrated by biometric parameters and confirmed by patient self‐assessment score.