Dermatologic Therapy

The Benefit of a Ceramide‐Linoleic Acid‐Containing Moisturizer as an Adjunctive Therapy for a Set of Xerotic Dermatoses
Qi Yang M.D.  Min Liu M.D.  Xia Li M.D.  Jie Zheng M.D/Ph.D.
First published: 05 July 2019 https://doi.org/10.1111/dth.13017
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ABSTRACT
Atopic dermatitis (AD), chronic eczema and pruritus hiemalis are a set of prevalent chronic xerotic skin disorders which share clinical features such as dryness, scales and pruritus. A ceramide deficiency and defective epidermal functions are common in these diseases. This study was designed to assess the effect of ceramide‐linoleic acid (LA‐Cer) containing moisturizer as an adjunctive therapy in the treatment of AD, chronic eczema and pruritus hiemalis. In a 2‐month study, patients with one of these three diseases were divided into two groups. The control group was treated with mometasone furoate (0.1%) cream (MF), while the treatment group received 0.1% MF in combination with an LA‐Cer containing moisturizer. Capacitance (CAP), and transepidermal water loss (TEWL) were measured in normal and lesional skin, along with Eczema Assessment Severity Index (EASI) and pruritus scores at weeks 0, 2, 4, 8. The results showed that tropical applications of an LA‐Cer‐containing moisturizer in combination with a topical glucocorticoid accelerated the reestablishment of epidermal permeability barrier and the amelioration of pruritus in patients with AD and pruritus hiemalis. However, it did not provide the same effect for chronic eczema. Thus, the efficacy of this combination therapy for this set of xerotic disorders requires further evaluation.

Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature
Ayman Abdelmaksoud MSc  Dharmendra Dineshchandra Dave MBBS, DVD  Torello Lotti MD Michelangelo Vestita MD
First published: 02 July 2019 https://doi.org/10.1111/dth.13013
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Abstract
Vitiligo is quite a common hypopigmentary disorder, which may affect both children and adults with important psychological effects due to the well‐known leopard skin‐like appearance. Even if asymptomatic and not life threatening, vitiligo has to be increasingly studied and treated. Hitherto, the efficacy of topical methotrexate in treatment of vitiligo has not been reported. We herein reporting our preliminary observation on the promising efficacy of topical methotrexate in 1 patient with stable vitiligo. The patient applied topical methotrexate 1% gel twice daily for 12 weeks. Significant improvement of the lesion with no local or systemic side effects were noted during the course of therapy. We propose that this well‐tolerated drug can be used for vitiligo therapy; however, further investigations should be performed to ascertain the exact topically effective dose.

Dermatologic Therapy Accepted Articles Accepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.

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The Benefit of a Ceramide‐Linoleic Acid‐Containing Moisturizer as an Adjunctive Therapy for a Set of Xerotic Dermatoses

Qi Yang M.D., Min Liu M.D., Xia Li M.D., Jie Zheng M.D/Ph.D.

e13017 | First Published: 05 July 2019

Corticosteroid Injection in Treatment of Persistent Oral Lichen Planus: Three Cases

Mehmet Hakan Kurt DDS, PhD, Mehmet Eray Kolsuz DDS, PhD, Hakan Eren DDS, PhD

e13015 | First Published: 03 July 2019

Iranian guideline for rituximab therapy in pemphigus patients

Maryam Daneshpazhooh MD, Kamran Balighi MD, Hamidreza Mahmoudi MD, Soheil Tavakolpour MS, Robabeh Abedini MD, Tahereh Soori MD, MS, Amir‐Houshang Ehsani MD, Maryam Ghiasi MD, Pedram Noormohammadpour MD, Narges Ghandi MD, Vahideh Lajevardi MD, Ali Sadeghinia MD, Maryam Nasimi MD, Arghavan Azizpour MD, MPH, Cheyda Chams‐Davatchi MD

e13016 | First Published: 03 July 2019

A First Report of Porphyria Cutanea Tarda Successfully Treated with Glycyrrhizin

Ying Li, Ning Yu, Dandan Han, Yangfeng Ding, Yueming Xu

e13014 | First Published: 03 July 2019

Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature

Ayman Abdelmaksoud MSc, Dharmendra Dineshchandra Dave MBBS, DVD, Torello Lotti MD, Michelangelo Vestita MD

e13013 | First Published: 02 July 2019