A series of N-aryl-5,6,7,8-tetra-hydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines were synthesized in moderate to good yield by using a microwave-enhanced conditions. The selected compounds were evaluated for their cytotoxic effects (IC50 values) on human pulmonary carcinoma (A549), murine BALB/c spontaneous colon adenocarcinoma (CT26) and human hepatocellular liver carcinoma (HepG2) cell lines in vitro. Amongst these compounds, one compound was found to have the better cytotoxic activity with reference...
Thu Jul 04, 2019 21:02
Prostate cancer is one of the most common form of cancer among men, and its incidence has been increasing progressively. Since the prostate depends on androgenic hormones to regulate its growth and development, interference with androgenic biosynthesis are important to control the disease. Thus, in this work, a 4D-quantitative structure-activity relationship (QSAR) receptor independent study was carried out using the Laborat ório de Quimiometria Teórica e Aplicada (LQTA)-QSAR approach and the new...
Thu Jul 04, 2019 21:02
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Laura Alice Hager, Stephan Mokesch, Claudia Kieler, Silvia Alonso-de Castro, Dina Baier, Alexander Roller, Wolfgang Kandioller, Bernhard K Keppler, Walter Berger, Luca Salassa, Alessio Terenzi Quadruplex nucleic acids – DNA/RNA secondary structures formed in guanine rich sequences – proved to have key roles in the biology of cancers and, as such, in the last years... The content of this RSS Feed (c) The...
Thu Jul 04, 2019 21:02
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC04084F, CommunicationZhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, Juan L. Iovanna, Ling Peng, Yi Xia Quercetin –alkylphospholipid conjugates are promising chemical entities with anticancer activity and the ability to inhibit lipid synthesis and metabolism. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun....
Thu Jul 04, 2019 21:02
The study of tumorigenic rewiring of metabolic flux is at the heart of cancer metabolic research. Here, we review two widely used computational flux inference approaches: isotope tracing coupled with Metabolic... (Source: BMC Biology)
Thu Jul 04, 2019 02:00
The Editor-in-Chief has retracted this article [1] due to significant overlap with previously published articles [2 –5]. Both authors agree with this retraction. (Source: Journal of Biomedical Science)
Thu Jul 04, 2019 02:00
ConclusionsAt low indoor radon exposure levels, reverse (negative) LRCs between radon exposure level and lung cancer mortality predominate. The strengths of these associations vary with local demographics.Graphical abstract (Source: Regulatory Toxicology and Pharmacology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Jul 04, 2019 20:38
Conclusions: The expression of MMP-9 is most common in severe forms compared to the mild forms of GRD. PMID: 31264989 [PubMed - in process] (Source: Cirugia y Cirujanos)
Thu Jul 04, 2019 20:20
Authors: Imtara H, Kmail A, Touzani S, Khader M, Hamarshi H, Saad B, Lyoussi B Abstract The aim of this in vitro study is to characterize the phenolic compounds of twelve honey samples collected from different locations in Palestine (H1-6) and Morocco (H7-12) and to evaluate their cytotoxic and cytostatic effects in cells from the human colorectal carcinoma cell line HCT-116 and breast cancer cell line MCF-7. Quantitative HPLC analysis revealed nine phenolic compounds in three Moroccan...
Thu Jul 04, 2019 20:11
Publication date: Available online 3 July 2019Source: Genes & DiseasesAuthor(s): Hongxing Shen, Eddy Shih-Hsin Yang, Marty Conry, John Fiveash, Carlo Contreras, James A. Bonner, Lewis Zhichang ShiAbstractImmune checkpoint blockade therapies (ICBs) are a prominent breakthrough in cancer immunotherapy in recent years (named the 2013 “Breakthrough of the Year” by the Science magazine). Thus far, FDA-approved ICBs primarily target immune checkpoints CTLA-4, PD-1, and PD-L1. Notwithstanding their...
Thu Jul 04, 2019 19:42
ConclusionIn the NCDB, significant inter-facility variability exists regardless of case volume, case mix, and risk adjustment. There were fewer reoperations after the SSO-ASTRO guideline. An endorsed target rate of 10% was achieved by only 1 in 4 facilities. The most impactful determinant of reoperation was the facility itself. Thus, all stakeholders should consider participation in improvement activities. Such activities will benefit from risk-adjusted profiling; the relevant adjustors were identified....
Thu Jul 04, 2019 19:04
ConclusionThis study did not reveal a significant impact of tumor-free margin distance on recurrence and survival in vulvar cancer. Moreover, the benefit of re-excision seems stronger when tumor-free margins are positive or very close (<3 mm), cases in which invasive or in situ lesions are often present closest to the edge of the specimen. (Source: European Journal of Surgical Oncology (EJSO))
Thu Jul 04, 2019 19:04
Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia
SummaryHair loss is a common dermatosis symptom and side-effect in cancer chemotherapeutics. Imiquimod application at mid and late telogen activated the hair follicle stem cells leading to premature hair cycle entry. Based on quinoline structure, a newly synthesized compound 6b displayed proliferation activity in vitro and in vivo through branch chain replacement and triazole ring cyclization. Toll-like receptors (TLRs) are also critical mediators of the immune system, and their activation is linked...
Thu Jul 04, 2019 00:00
ConclusionsThis clinical case suggests that RFA may be effective and safe for treatment of MTC when surgery cannot be performed. (Source: Endocrine)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Jul 04, 2019 00:00
ConclusionThe overall operative mortality for minimally invasive surgery in gynecologic oncology is 1 in 381 (95% CI 1:306-1:474). For patients with early cervical cancer is 1:2049 (95% CI 1:356-1: 11832), for endometrial cancer with node dissection is 1:195 (95% CI 1:109- 1:349), and for ovarian cancer is 1 in 685 (95% 1:44–1:10971). There is no difference between the type of MIS approach for patients undergoing any type of gynecologic oncology surgery. (Source: Journal of Minimally Invasive Gynecology)MedWorm...
Thu Jul 04, 2019 17:06
Publication date: Available online 3 July 2019Source: Gynecologic Oncology ReportsAuthor(s): Amanda L. Shepherd-Littlejohn, Wyatt J. Hanft, Vanessa A. Kennedy, Edwin A. Alvarez (Source: Gynecologic Oncology Reports)
Thu Jul 04, 2019 17:06
AbstractPrimary adrenal failure (Addison ’s disease) is a rare complication of immune checkpoint inhibitor (ICI) therapy. Untreated – and also sometimes under adequate hydrocortisone replacement therapy – the levels of ACTH (Adrenocorticotropic hormone) and MSH (Melanocyte stimulating hormone) are elevated. This may be a reason for c oncern in patients with malignant melanoma (MM): Melanocortin receptors bind to ACTH and the different isoforms of MSH. For example, the melanocortin 1 receptor (MC1R)...
Thu Jul 04, 2019 00:00
Basal cell carcinoma has a potential for early and late metastasis. Depending on the location of the primary site, the relevant lymphatic drainage routes have to be monitored. Regional lymph edema may be a first indicator for metastasizing disease. AbstractBasal cell carcinoma has a potential for early and late metastasis. Depending on the location of the primary site, the relevant lymphatic drainage routes have to be monitored. Regional lymph edema may be a first indicator for metastasizing disease....
Thu Jul 04, 2019 00:00
AbstractNowadays, Cancer diagnosis is one of the major challenging characteristics for treating cancer. The reality of cancer patients rely on the diagnosis of cancer at the early stages (either in stage 1 or stage 2). If the cancer is diagnosed in stage 3 or later stages means the changes of survival of the patient will become more critical. Normally, single patient records will generate a huge amount of data if the data could be manage and analyze means to solve many problems for identifying the...
Thu Jul 04, 2019 00:00
ConclusionOur data illustrated a MHRT/miR-4529-5p/ROCK2 regulatory axis that contributes to the tumorigenesis of gastric cancer and provided potential therapeutic targets for precise gastric cancer treatment. (Source: Digestive Diseases and Sciences)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Jul 04, 2019 00:00
(Source: Infection and Drug Resistance)
Thu Jul 04, 2019 03:43
In conclusion, overexpression of H19 improved HMEC-1 cells viability, migration and tube-formation capacity. H19 exerted pro-angiogenic effects possibly by down-regulating miR-181a, and thus activating JNK and AMPK signalling pathways. PMID: 31267802 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income...
Thu Jul 04, 2019 15:49
CONCLUSION: Both pembrolizumab and nivolumab exhibited tolerable cutaneous safety profiles in a variety of cancer patients undergoing anti-PD-1 therapy. Cutaneous AEs of anti-PD-1 therapy were not associated with antibody type, underlying malignancy, patient characteristics, or improved response. PMID: 31269545 [PubMed - in process] (Source: J Korean Med Sci)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best...
Thu Jul 04, 2019 15:45
Publication date: Available online 3 July 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Stephen J. Wagner, David A. Leiby, John D. Roback (Source: Hematology Oncology Clinics of North America)
Thu Jul 04, 2019 15:41
CONCLUSIONS:: Clinical and molecular data showed that there was spatiotemporal heterogeneity in intra-tumor of EC, which may add to the complexity of diagnosis and therapeutics for EC. Considering the intra-tumor heterogeneity, sequential chemotherapy and precision medicine may be a more suitable treatment plan for EC. PMID: 31268882 [PubMed - in process] (Source: Chinese Medical Journal)
Thu Jul 04, 2019 15:40
ConclusionIntraoperative cytological analysis of bone medullary could represent an easy, fast, reliable and inexpensive method to reduce the rate of r1 surgeries attributable to the infiltration of the bone margin. This may have a positive impact on overall survival without increasing the duration and the iatrogenicity of surgery. (Source: American Journal of Otolaryngology)
Thu Jul 04, 2019 15:11
ConclusionIn this review we identified and summarized relevant information related to seaweed-isolated compounds and extracts having biological activity; their role in different signal pathways to better understand their potential to further development of cures for cancer, diabetes, and inflammation-related diseases.Graphical Abstract (Source: Phytomedicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Jul 04, 2019 15:06
Conclusionα-Hederin could inhibit the proliferation and induce apoptosis of ESCC via dissipation of the MMP with simultaneous ROS generation and activation of the mitochondrial pathway. (Source: Digestive Diseases and Sciences)
Thu Jul 04, 2019 00:00
Authors: Maike Kober-Hasslacher Marc Schmidt-Supprian Aberrant constitutive activation of Rel/NF-κB transcription factors is a hallmark of numerous cancers. Of the five Rel family members, c-Rel has the strongest direct links to tumorigenesis. c-Rel is the only member that can malignantly transform lymphoid cells in vitro. Furthermore, c-Rel is implicated in human B cell lymphoma through the frequent occurrence of REL gene locus gains and amplifications. In normal physiology, high c-Rel...
Thu Jul 04, 2019 00:00
AbstractGastrectomy is the mainstay treatment for gastric cancer. To reduce the associated patient burden, minimally invasive gastrectomy was introduced in almost 30 years ago. The increase in the availability of surgical robotic systems led to the first robotic-assisted gastrectomy to be performed in 2002 in Japan. Robotic gastrectomy however, particularly in Europe, has not yet gained significant traction. Most reports to date are from Asia, predominantly co ntaining observational studies. These...
Thu Jul 04, 2019 00:00
ConclusionThere is a small risk of ypN+ in patients with pCR after neoadjuvant CRT and surgery for rectal cancer. However, further research is warranted to establish these findings and to identify predictive factors for this specific group of patients. (Source: International Journal of Colorectal Disease)
Thu Jul 04, 2019 00:00
This article reviews current knowledge regarding intrathecal opioid therapy, focusing particularly on the use of IDD in elderly patients. Current literature is presented, and the arguments in favor of and against this therapy in elderly patients are discussed. (Source: Drugs and Aging)
Thu Jul 04, 2019 00:00
(Source: Hereditary Cancer in Clinical Practice)
Thu Jul 04, 2019 00:00
CONCLUSION: Recent advances in diagnostic methods increase the cognitive demands on clinicians and thus their uncertainty. By uncritically using advanced technologies in their practice, physicians exploit their archetypical powers of healers. In a paradoxical way, modern technologies reduce uncertainties felt by doctors and their patients in an archaic fashion. PMID: 31266739 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)MedWorm...
Thu Jul 04, 2019 14:13
ConclusionTreatment decision based on G8 screening followed by CGA had no impact on completion rate of planned oncologic treatment, OS or PFS, but resulted in a borderline significant lower incidence of grade 3–4 toxicity. (Source: Journal of Geriatric Oncology)
Thu Jul 04, 2019 14:05
Publication date: Available online 29 May 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Bita Fakhri, Amanda F. Cashen, Eric J. Duncavage, Marcus P. Watkins, Lukas D. Wartman, Nancy L. Bartlett (Source: Clinical Lymphoma Myeloma and Leukemia)
Thu Jul 04, 2019 14:04
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