Purpose of review Although checkpoint inhibitor blockade is now widely used clinically for cancer immunotherapy, the reverse process, (i.e. induction of checkpoints to slow autoimmunity) has not been extensively explored. CD8 T-cell exhaustion is a state of immune hyporesponsiveness that may be harnessed to treat autoimmunity. Recent findings We focus on the potential role of CD8 T-cell exhaustion as a mechanism of peripheral tolerance in T1D and its therapeutic implications. Summary CD8...
05:14
(Source: Clinical Interventions in Aging)
05:13
Publication date: Available online 4 July 2019Source: Trends in Pharmacological SciencesAuthor(s): Shelton R. Boyd, Damian W. YoungIt has been a widely held notion within the biomedical research community that the reliable modulation of transcription factors with small molecules would represent a holy grail, given their role in directly potentiating oncogenic programs. Among the transcription factors that have been held in highest regard is Myc, since its dysregulation is among the most recurrent...
05:09
In conclusion, pretreatment with XAP enhanced the exposure of PTX and C3’-OHP. There would be herb-drug interaction happening between XAP and PTX in rats.Graphical abstract (Source: Journal of Pharmaceutical and Biomedical Analysis)
05:09
Authors: Haskins JS, Kato TA Abstract The G2 chromosomal radiosensitivity assay or, simply G2 assay, measures the number of chromatid type aberrations induced by radiation in G2 phase. Typically, asynchronous growing cells are irradiated with less than 1 Gy and allowed 0.5-1 h for cells in mitosis, at the time of irradiation, to transit into G1. Later, the G2 phase cells, at the time irradiation, are blocked by colcemid for 1-4 h at metaphase. Cells are collected by standard hypotonic solution...
05:05
Authors: Gotoh E Abstract Chromosome analysis is a fundamental technique for a wide range of cytogenetic studies. Chromosome aberrations are easily introduced by many kinds of clastogenic agents such as ionizing irradiation, UV, or alkylating agents, and damaged chromosomes may be prone to cancer. Chromosomes are conventionally prepared from mitotic cells arrested by the colcemid block method. However, obtaining of mitotic chromosomes is sometimes hampered under several circumstances, for...
05:05
Publication date: Available online 3 July 2019Source: Practical Radiation OncologyAuthor(s): Daniel E. Spratt (Source: Practical Radiation Oncology)
04:07
Publication date: Available online 4 July 2019Source: Practical Radiation OncologyAuthor(s): Daniel E. Roos (Source: Practical Radiation Oncology)
04:07
ConclusionInjection of a liquid fiducial marker for esophageal cancer radiotherapy is technically feasible with no adverse events observed. Volumes of>0.05 ml have an appropriate visibility on CT, CBCT, and MRI, with an excellent positional stability. Liquid fiducial markers are therefore promising for use in image-guided radiotherapy. (Source: Practical Radiation Oncology)
04:07
ConclusionVertebral body coverage in proton CSI varies amongst radiation oncologists in respect to target delineation, CTV expansions and modifications for organs at risk. These data suggest the radiation oncology community may benefit from a standardized approach to pediatric proton based CSI. (Source: Practical Radiation Oncology)
04:07
(Source: Cancer Management and Research)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
03:50
(Source: Cancer Management and Research)
03:44
(Source: Cancer Management and Research)
03:37
(Source: Vascular Health and Risk Management)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
01:58
(Source: OncoTargets and Therapy)
01:39
(Source: OncoTargets and Therapy)
01:37
High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that UGT2B17 impacts intracellular levels of hormone-like signaling molecules involved in the regulation of gene expression in leukemic cells. We initially confirmed in a third cohort of 291 CLL patients that those with high UGT2B17 displayed poor prognosis...
00:00
ConclusionsAlterations in several oncogenes are associated with CRC, among those RAS, BRAF, and HER2 are of current clinical importance. Chemotherapy drugs, along with vascular endothelial growth factor or epidermal growth factor receptor monoclonal antibodies, are proven to be efficient with manageable toxicity profiles in metastatic CRC. Additional researches on Her-2-directed therapy, BRAF-targeted agents, immunotherapeutic, and newer molecularly targeted agents are needed for further improvement...
00:00
(Source: OncoTargets and Therapy)
Thu Jul 04, 2019 23:49
DiscussionResults of this pre-clinical study pave the way to a somatic cell therapy approach aimed at preventing or treating relapse in children given haplo-HSCT for WT1-positive leukemia. (Source: Cytotherapy)
02:11
Publication date: Available online 3 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Leanne Qiaojing Tan, Daniel De-Liang Loh, Liming Qiu, Yew Poh Ng, Peter Ying Khai HwangAbstractChronic subdural haematomas are common neurosurgical conditions, especially in the elderly patients, with straightforward surgical treatments. However, infrequently, tumours are misdiagnosed as subdural haematoma on initial brain CT scans and are only discovered intraoperatively. In this case series, we presented...
02:02
We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of three paragangliomas in a SDHD mutation carrier. (Source: The Annals of Thoracic Surgery)
01:05
Epithelioid sarcoma involving sciatic nerve with lung metastasis and local recurrence: A case report
We report a rare case of epithelioid sarcoma involved the sciatic nerve which presented with chronic sciatic pain and treated with radically wide resection, but lung metastasis and local recurrence have occurred shortly after surgical resection and resulting in the patient's death in six months after initial presentation. (Source: Interdisciplinary Neurosurgery)
00:41
Publication date: Available online 3 July 2019Source: The Veterinary JournalAuthor(s): B.D.X. Lascelles, D.C. Brown, M.G. Conzemius, M. Gill, M.L. Oshinsky, M. SharkeyAbstractIn the face of increasing recognition and interest in treating chronic pain in companion animals, we struggle with a lack of therapeutic options. A significant barrier to the development of new therapeutics, or the critical evaluation of current therapies, is our inability to accurately measure chronic pain and its impact on...
Thu Jul 04, 2019 23:35
Authors: Hussain M, Fishman J, Fisher E PMID: 31267882 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Jul 04, 2019 22:34
ConclusionLycopene could inhibit the proliferation of SKOV3 cells and enhance their apoptosis in vitro. The induction of cell apoptosis might be mediated by up-regulating Bax expression and down-regulating Bcl-2 expression. (Source: Molecular and Cellular Probes)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Jul 04, 2019 22:02
Publication date: 15 November 2019Source: Journal of Molecular Structure, Volume 1196Author(s): Mohamed H. Abdel-Rhman, Mostafa A. Hussien, Heba M. Mahmoud, Nasser M. HosnyAbstractN-benzyl-2-isonicotinoylhydrazine-1-carbothioamide (H3L) and its complexes with Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized. The metal complexes have been characterized by elemental and thermal analyses, spectral studies of FT-IR, 1H and 13C NMR, ESR, MS, and UV-Visible, conductance and magnetic moments measurements....
Thu Jul 04, 2019 22:02
Publication date: Available online 3 July 2019Source: Journal of Molecular LiquidsAuthor(s): Prathap Somu, Subhankar PaulAbstractHere, we prepared gold‑silver alloy nanoparticle (AgAuNPCS) of ~8.5 nm mean size via one-pot biogenic synthesis using casein as reducing as well as capping agent and explored its potential in various biomedical applications using curcumin (CUR) as a drug delivery agent. When we prepared the nanoconjugate with curcumin (AgAuNPCS-CUR) of 10.5 nm mean size via chemical activation...
Thu Jul 04, 2019 22:02
Publication date: Available online 3 July 2019Source: Journal of Molecular LiquidsAuthor(s): M.L. Alvarado–Noguez, C. Hernández-Aguilar, A. Cruz–Orea, F.A. Domínguez-PachecoAbstractPhotoacoustic spectroscopy (PAS) is singled out by its capability to resolve the optical absorption spectra of each element, of a multicomponent system, by the named phase resolved method. The possibility of the use of this method is due to the fact that the Photoacoustic signal is not only sensitive to the optical absorption...
Thu Jul 04, 2019 22:02
Publication date: Available online 28 June 2019Source: Journal of Molecular LiquidsAuthor(s): Maryam Roza Yazdani, Nicola Duimovich, Alberto Tiraferri, Panu Laurell, Maryam Borghei, Julie B. Zimmerman, Riku VahalaAbstractNatural organic matter (NOM) raises major issues for drinking water treatment including undesirable taste and color, formation of carcinogenic disinfection by-products, and promotion of microbial regrowth in the water distribution system. As such, mesoporous biochars have been tailored...
Thu Jul 04, 2019 22:02
Publication date: Available online 3 July 2019Source: Life SciencesAuthor(s): Sanaz Koosha, Zahurin Mohamed, Ajantha Sinniah, Zaridatulaini. Ibrahim, Atefehalsadat Seyedan, Mohammed A. AlshawshAbstractAimsThe compound 8-prenylnaringenin (8-PN) is a prenylflavonoid that can be isolated from hops and beer and has anti-cancer properties against breast cancer. The aim of this study is to investigate the anti-proliferative and apoptotic activities of 8-PN against human colon cancer HCT-116 cells.Main...
Thu Jul 04, 2019 21:11
Publication date: Available online 3 July 2019Source: Chemico-Biological InteractionsAuthor(s): Edward J. Calabrese, Robert J. GoldenAbstractThe linear non-threshold (LNT) dose response model for cancer risk assessment has been a controversial concept since its initial proposal during the 1930s. It was long advocated by the radiation genetics community in the 1950s, some two decades prior to being generally adopted within the chemical toxicology community. This paper explores possible reasons for...
Thu Jul 04, 2019 21:06
A series of N-aryl-5,6,7,8-tetra-hydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines were synthesized in moderate to good yield by using a microwave-enhanced conditions. The selected compounds were evaluated for their cytotoxic effects (IC50 values) on human pulmonary carcinoma (A549), murine BALB/c spontaneous colon adenocarcinoma (CT26) and human hepatocellular liver carcinoma (HepG2) cell lines in vitro. Amongst these compounds, one compound was found to have the better cytotoxic activity with reference...
Thu Jul 04, 2019 21:02
Prostate cancer is one of the most common form of cancer among men, and its incidence has been increasing progressively. Since the prostate depends on androgenic hormones to regulate its growth and development, interference with androgenic biosynthesis are important to control the disease. Thus, in this work, a 4D-quantitative structure-activity relationship (QSAR) receptor independent study was carried out using the Laborat ório de Quimiometria Teórica e Aplicada (LQTA)-QSAR approach and the new...
Thu Jul 04, 2019 21:02
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Laura Alice Hager, Stephan Mokesch, Claudia Kieler, Silvia Alonso-de Castro, Dina Baier, Alexander Roller, Wolfgang Kandioller, Bernhard K Keppler, Walter Berger, Luca Salassa, Alessio Terenzi Quadruplex nucleic acids – DNA/RNA secondary structures formed in guanine rich sequences – proved to have key roles in the biology of cancers and, as such, in the last years... The content of this RSS Feed (c) The...
Thu Jul 04, 2019 21:02
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου