Biosciences

On Linguistic history and language diversity in India: Views and counterviews By Sonal Kulkarni-Joshi

Development of typological classification and its relationship to microdifferentiation in ethnic India Abstract The history of the racial classification of the people of India can be looked at in three temporal phases: (1) at the national level, the initial studies of racial classification attempted along with the Census of India; (2) at the regional level, studies by anthropologists and statisticians following systematic sampling and statistical procedures were conducted after the initial national-level studies and (3) population-specific studies in different regions across the country including micro-evolutionary studies of individual populations followed the regional studies. Initially the racial classification was part of the Census survey conducted by British anthropologists in some parts of the country among castes and tribes and was based on a few physical traits. This was followed by a systematic anthropometric survey in particulars regions (e.g., UP, Bengal, etc.) by anthropologists and statisticians. This was followed by population specific micro-evolutionary studies across different regions by numerous anthropologists investigating the role of selection, drift, migration and admixture and other population structure variables among endogamous castes and tribes.

On Ancient Indian history: What do we know and how? By Rajesh Kochhar

On Early ‘Aryans’ and their neighbors outside and inside India By M Witzel

On Trails, footprints, hoofprints By Shereen Ratnagar

Ancient Indian history: What do we know and how? Abstract When and where was the Rigveda (Rv) composed? How are the Vedic people related to the vast Harappan archaeological tradition? These quintessential questions have no direct answers. At our current level of understanding, archaeology and sacred texts constitute two distinct streams which do not intersect. We must therefore collate evidence from different sources and try to produce a synthesis. It is particularly important to take note of archaeological evidence from Central Asia, because it has not received the attention it deserves. What is well known in science must be kept in mind in the case of history also. A theory to be valid must explain each and every fact (known at present or to be known in future) in a self-consistent manner. Conversely, even if there is one piece of evidence that a theory is unable to explain, it should be put on hold, modified or even rejected.

Trails, footprints, hoofprints Abstract This paper takes issue with the notion behind some genetic sampling of populations that there are autochthonous groups (designated tribal) in India, and that to give a group, its ‘anthropological name’ [sic] is valid. The archaeological and textual evidence of the earliest known Indo-Europeans and Indo-Iranians is given in bare outline. Possible trails of the Indo-Aryans of Iron-age South Asia are detected in archaeological records, immigration through mountains in the northwest with horses and two-humped camels, and also incursions of small groups of horse-riders, from Vidarbha all the way south to the Tamil country.

Linguistic history and language diversity in India: Views and counterviews Abstract This paper addresses the theme of the seminar from the perspective of historical linguistics. It introduces the construct of ‘language family’ and then proceeds to a discussion of contact and the dynamics of linguistic exchange among the main language families of India over several millennia. Some prevalent hypotheses to explain the creation of India as a linguistic area are presented. The ‘substratum view’ is critically assessed. Evidence from historical linguistics in support of two dominant hypotheses – ‘the Aryan migration view’ and ‘the out-of-India hypothesis’ – is presented and briefly assessed. In conclusion, it is observed that the current understanding in historical linguistics favours the Aryan migration view though the ‘substratum view’ is questionable.

Early ‘Aryans’ and their neighbors outside and inside India Abstract Data from archaeology, linguistics, population genetics, and from early Vedic texts, which deal with religion, mythology and rituals, have to be assembled and closely compared in order to gain a comprehensive picture of the early ‘Aryans’. Such interdisciplinary dialogue is necessary in order to establish areas of overlap of data. This paper attempts to indicate a western Central Asian origin of the Indo-Aryan speakers, in the steppe belt near the Urals, from where they moved, via the Inner Asian Mountain belt and Bactria, into India. Their gradual migration entailed acculturation with previous populations, their languages and cultures.

Phosphorylation mapping of Laminin β1-chain: Kinases in association with active sites Abstract Laminins are a major constituent of the extracellular matrix (ECM). Laminin-111, the most extensively studied laminin isoform, consists of the α1, the β1 and the γ1 chain, and is involved in many cellular processes, like adhesion, migration and differentiation. Given the regulatory role of phosphorylation in protein function, it is important to identify the phosphorylation sites of human laminin β1-chain sequence (LAMB1). Therefore, we computationally predicted all possible phosphorylation sites in LAMB1. For the first time, we identified the possibly responsible kinases for already in vitro experimentally observed phosphorylated residues in LAMB1. All known functional (active) sites of LAMB1, were recorded after an extensive literature search and combined with the experimentally observed and our predicted phosphorylated residues. This generated a detailed phosphorylation map of LAMB1. Five kinases (PKA, PKC, CKII, CKI and GPCR1) were indicated important, while the role of PKA, PKC and CKII, kinases known for ecto-phosphorylation activity, was highlighted. The activity of PKA and PKC was associated with the active site RIQNLLKITNLRIKFVKLHTLGDNLLDS. Also, predicted phosphorylations inside two amyloidogenic (DSITKYFQMSLE, VILQHSAADIAR) and two anti-cancerous (YIGSR and PDSGR) sites suggested a possible role in the development of the corresponding diseases.