Age-dependent alterations of hormonal states have been considered to be involved in age related decline of cognitive abilities. Most of the studies in animal models are based on hormonal substitution in adrena...
Sun Jun 30, 2019 03:00
Brain Sciences, Vol. 9, Pages 159: Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies Brain Sciences doi: 10.3390/brainsci9070159 Authors: George P. Paraskevas Vasilios C. Constantinides Efstratios-Stylianos Pyrgelis Elisabeth Kapaki Background: Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid in small/medium size brain vessels, and may coexist with Alzheimer’s disease or dementia with Lewy bodies (DLB). We describe a...
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Brain Sciences, Vol. 9, Pages 158: The Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis Brain Sciences doi: 10.3390/brainsci9070158 Authors: Claudia Jorgensen James Taylor Tyler Barton Adult neurogenesis—the formation and functional integration of adult-generated neurons—remains a hot neuroscience topic. Decades of research have identified numerous endogenous (such as neurotransmitters and hormones) and exogenous (such as environmental...
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Brain Sciences, Vol. 9, Pages 157: Poor Synchronization to Musical Beat Generalizes to Speech Brain Sciences doi: 10.3390/brainsci9070157 Authors: Marie-Élaine Lagrois Caroline Palmer Isabelle Peretz The rhythmic nature of speech may recruit entrainment mechanisms in a manner similar to music. In the current study, we tested the hypothesis that individuals who display a severe deficit in synchronizing their taps to a musical beat (called beat-deaf here) would also experience difficulties...
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Brain Sciences, Vol. 9, Pages 156: Neural State Monitoring in the Treatment of Epilepsy: Seizure Prediction—Conceptualization to First-In-Man Study Brain Sciences doi: 10.3390/brainsci9070156 Authors: Daniel John DiLorenzo Kent W. Leyde Dmitry Kaplan This research study is part of a therapy development effort in which a novel approach was taken to develop an implantable electroencephalographic (EEG) based brain monitoring and seizure prediction system. Previous attempts to predict...
Mon Jul 01, 2019 03:00
Abstract Neuroanatomical correlates of apathy and disinhibition, behavioral abnormalities in behavioral variant Frontotemporal dementia (bvFTD) remain unclear. In this study 45 participants (25 bvFTD patients and 20 controls) provided data on clinical, neuropsychological, behavioral (on Frontal Systems Behavior (FrSBe) Scale), cortical volume (on voxel-based morphometry (VBM)) and tract based spatial fractional anisotropy ((FA) on magnetic resonance imaging (MRI), allowing examination...
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Abstract The pathogenesis of HIV-associated neurocognitive impairment (NCI) may involve iron dysregulation. In 243 HIV-seropositive adults without severe comorbidities, we therefore genotyped 250 variants in 20 iron-related genes and evaluated their associations with magnetic resonance imaging measures of brain structure and metabolites, including measures previously linked to NCI. Multivariable regression analyses examined associations between genetic variants and neuroimaging...
Wed Jul 03, 2019 03:00
Abstract Presbycusis, associated with a diminished quality of life characterized by bilateral sensorineural hearing loss at high frequencies, has become an increasingly critical public health problem. This study aimed to identify directed functional connectivity (FC) of the hippocampus in patients with presbycusis and to explore the causes if the directed functional connections of the hippocampus were disrupted. Presbycusis patients (n = 32) and age-, sex-, and education-matched...
Wed Jul 03, 2019 03:00
Abstract During infancy, the human brain rapidly expands in size and complexity as neural networks mature and new information is incorporated at an accelerating pace. Recently, it was shown that single electrode EEG in preterms at birth exhibits scale-invariant intermittent bursts. Yet, it is currently not known whether the normal infant brain, in particular, the cortex maintains a distinct dynamical state during development that is characterized by scale-invariant spatial as well...
Tue Jul 02, 2019 03:00
Abstract Resting state electroencephalography (EEG) during eyes-closed and eyes-open conditions is widely used to evaluate brain states of healthy populations and brain dysfunctions in clinical conditions. Although several results have been obtained by measuring these brain activities in humans, it remains unclear whether the same results can be replicated in animals, i.e., whether the physiological properties revealed by these findings are phylogenetically conserved across species....
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Abstract Astroblastomas are unique tumours with unresolved issues in terms of their origin, molecular biology, clinical behaviour, and response to treatment. To decipher the characteristics of this tumour, we reviewed cases histologically diagnosed as astroblastoma in our institute over the past 8 years, with immunohistochemistry, and performed fluorescence in situ hybridisation (FISH), for the newly emerged MN1 rearrangement which was reported in central nervous system high-grade...
Mon Jul 01, 2019 03:00
Abstract There is currently no accepted classification of autosomal recessive cerebellar ataxias, a group of disorders characterized by important genetic heterogeneity and complex phenotypes. The objective of this task force was to build a consensus on the classification of autosomal recessive ataxias in order to develop a general approach to a patient presenting with ataxia, organize disorders according to clinical presentation, and define this field of research by identifying...
Tue Jul 02, 2019 03:00
New experiments with ice at very high pressures could force us to rethink our understanding of water on Earth and other planets
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Take a BBC micro:bit, add a motor, a chassis and some infrared sensors and then put your feet up with a nice cup of tea: your biscuits will be on their way shortly
Wed Jul 03, 2019 20:00
We haven’t found any moons around exoplanets, which may be because they are flung away and turn into “ploonets” - a fate that could one day befall our own moon
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The National Trust, a UK conservation charity, will sell off its investments in fossil fuel companies including BP, Shell and Total over the next three years
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The small molecules we use during metabolism form the basis of a new way to store digital information – and it could be more stable than electronic memory
Wed Jul 03, 2019 21:00
A forensic analysis of a 33,000-year-old skull finds a clear explanation for the mysterious pattern of fractures preserved in the bone: it was murder
Wed Jul 03, 2019 21:00
The small molecules we use during metabolism form the basis of a new way to store digital information – and it could be more stable than electronic memory
Wed Jul 03, 2019 21:00
Genetic sequencing of bones and teeth from ten Philistines who lived in what is now Israel 3200 years ago suggests a surge of migration from the Aegean at the time
Wed Jul 03, 2019 21:00
Livestock are responsible for 14.5 per cent of global greenhouse gas emissions but it turns out that we could breed cows with gut bacteria that produce less methane
Wed Jul 03, 2019 21:00
From the speed of global warming to the likelihood of developing cancer, we must grasp uncertainty to understand the world. Here’s how to know your unknowns
Wed Jul 03, 2019 20:00
A complete map of all the neurons and their connections in both sexes of an animal – a tiny worm – has been described for the first time
Wed Jul 03, 2019 20:00
Dozens of wildfires are burning across the Arctic circle and have released as much CO2 in just one month as Sweden’s total annual emissions
Wed Jul 03, 2019 18:48
Google has created a virtual soccer training pitch for AIs to use to learn how to play football. The AIs will need to learn short-term control and high-level strategies
Wed Jul 03, 2019 18:03
AIs don't think like children, but if they made a common assumption that children use whilst learning a language they would become better faster
Wed Jul 03, 2019 17:45
Shops that let you bring your own containers aim to tackle the plastic packaging scourge, but they may not be the perfect solution
Wed Jul 03, 2019 17:00
Seals and sea lions can repeat their last action on command, as long as they are asked to do so within 18 seconds , hinting at a degree of self-awareness
Wed Jul 03, 2019 16:55
Special polymers that expand when heated allow a solar panel to unfurl when it’s exposed to sunlight, which could be useful for solar-powered spacecraft
Wed Jul 03, 2019 15:00
We all feel the passing of time, but nothing in physics suggests it is a fundamental property of the universe. So where does our sense of time’s flow come from?
Wed Jul 03, 2019 14:00
On 2 July, the moon blocked out the sun over areas of Chile and Argentina in the first solar eclipse since the one that passed over the US in 2017
Wed Jul 03, 2019 12:18
The decision by Japan to resume commercial whaling should be condemned – if not for its uncertain effect on whales, then for its contempt for international agreements
Tue Jul 02, 2019 19:14
A tiny jellyfish-like robot could be used to deliver drugs in the body. It is only 3 millimeters across and is controlled by magnetic fields
Tue Jul 02, 2019 18:00
Some mice receiving a therapy that includes CRISPR gene editing appear to have been cured of HIV, but safety concerns must be overcome before human trials
Tue Jul 02, 2019 18:00
The story of triplets who were unwitting subjects in a research study incites outrage, but the researchers were constrained by regulations we now see as wrong
Tue Jul 02, 2019 18:00
Climate change attribution researchers have shown that record-breaking heat in France was made at least five times more likely by global warming
Tue Jul 02, 2019 15:05
The light from a pair of stars about 360 light years away dimmed and brightened again 28 times in three months and astronomers have no explanation
Tue Jul 02, 2019 13:20
AIs don't think like children, but if they made a common assumption that children use whilst learning a language they would become better faster
Tue Jul 02, 2019 12:54
Astro-ecologist Claire Burke uses her astrophysics knowledge to protect endangered species and stop poaching, and she loves to watch orangutans in Borneo
Wed Jun 26, 2019 20:00
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