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Colorectal cancer-associated ~6 kDa hyaluronan serves as a novel biomarker for cancer progression and metastasis.
FEBS J. 2019 Apr 19;:
Authors: Zhang G, Lu R, Wu M, Liu Y, He Y, Xu J, Yang C, Du Y, Gao F
Abstract
Low molecular weight hyaluronan (LMW-HA) is believed to accumulate in tumors and to exert pro-tumor effects. This study aimed to identify colorectal cancer (CRC)-associated LMW-HA, precisely determine its molecular weight and elucidate its role in predicting tumor progression. The molecular weight distribution of hyaluronan extracted from CRC and paired non-cancerous tissues was evaluated. We found that the level of hyaluronan with a molecular weight below 30 kDa was markedly elevated in CRC tissues, and we defined hyaluronan with a molecular weight of ~6 kDa as CRC-associated LMW-HA. In line with this finding, ~6 kDa hyaluronan was significantly accumulated in cancer tissues relative to total hyaluronan, and this LMW-HA played a critical role in tumor metastasis. Moreover, serum ~6 kDa HA levels in CRC patients were significantly increased and positively correlated with the levels in matched cancer tissues. Elevated serum ~6 kDa hyaluronan levels could be used to discriminate patients with or without CRC and was associated with early relapse, advanced TNM stage, lymphovascular invasion, and lymph node metastasis. Notably, serum ~6 kDa hyaluronan levels were significantly reduced after tumor resection. Our study suggests that ~6 kDa hyaluronan may serve as a new biomarker for estimating tumor progression, predicting lymph node metastasis, and monitoring tumor recurrence. This article is protected by copyright. All rights reserved.
Low molecular weight hyaluronan (LMW-HA) is believed to accumulate in tumors and to exert pro-tumor effects. This study aimed to identify colorectal cancer (CRC)-associated LMW-HA, precisely determine its molecular weight and elucidate its role in predicting tumor progression. The molecular weight distribution of hyaluronan extracted from CRC and paired non-cancerous tissues was evaluated. We found that the level of hyaluronan with a molecular weight below 30 kDa was markedly elevated in CRC tissues, and we defined hyaluronan with a molecular weight of ~6 kDa as CRC-associated LMW-HA. In line with this finding, ~6 kDa hyaluronan was significantly accumulated in cancer tissues relative to total hyaluronan, and this LMW-HA played a critical role in tumor metastasis. Moreover, serum ~6 kDa HA levels in CRC patients were significantly increased and positively correlated with the levels in matched cancer tissues. Elevated serum ~6 kDa hyaluronan levels could be used to discriminate patients with or without CRC and was associated with early relapse, advanced TNM stage, lymphovascular invasion, and lymph node metastasis. Notably, serum ~6 kDa hyaluronan levels were significantly reduced after tumor resection. Our study suggests that ~6 kDa hyaluronan may serve as a new biomarker for estimating tumor progression, predicting lymph node metastasis, and monitoring tumor recurrence. This article is protected by copyright. All rights reserved.
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