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Τετάρτη 24 Απριλίου 2019

Candidiasis

1
CelAgace™ OraRinse Solution for Treatment ofCandidiasis
  • Candidiasis, Oral
  • Drug: silver citrate complex and acemannan
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Texas A&M University College of Dentistry
    Dallas, Texas, United States
2
Epidemiological Study in Subjects With VulvovaginalCandidiases
  • Vulvovaginal Candidiases
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • Instituto Palacios
    Madrid, Spain
3
A Comparative Clinical Trial to Evaluate the Safety and Clinical Equivalence of Clotrimazole Troche/Lozenges USP, 10mg (Unique Pharmaceutical Laboratories, India) With Clotrimazole Troche 10mg (Roxane Laboratories Inc., USA) in Subjects With Oropharyngeal Candidiasis.
  • Oropharyngeal Candidiasis
  • Drug: Unique Pharmaceutical Laboratories, India
  • Drug: Roxane Laboratories Inc., USA
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment
  • Grant Government Medical College & Sir JJ group of Hospital
    Mumbai, Maharashtra, India
  • Curie Manavata Cancer Centre
    Nashik, Maharashtra, India
  • Manas Hospital
    Nashik, Maharashtra, India
  • (and 23 more...)
4
Patients With Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Drug: EPP-AF Gel 1%
  • Drug: EPP-AF Gel 2%
  • Drug: Clotrimazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Clinical Hospital of Sao Paulo University
    Ribeirao Preto, Sao Paulo, Brazil
5
Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis
  • Candidiasis, Vulvovaginal
  • Other: Clotrimazole
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Health Services Research
  • Instituto Palacios
    Madrid, Spain
6
Invasive Candidiasis in Saudi ICUs
  • Invasive Candidiasis
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • King Abdulaziz Medical City
    Riyadh, Saudi Arabia
  • King Fahad Medical City
    Riyadh, Saudi Arabia
7
Clinical Performance of a Vaginal Pessary (pHyph) in Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Device: pHyph, Gedea pessary
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Hoftekliniken
    Helsingborg, Sweden
  • Annerokliniken
    Hofterup, Sweden
8
Staging Candidiasis in ICU Patients
  • Candidiasis
  • Biological: Tests for candidiasis
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • CHU de Nîmes
    Nimes, Gard, France
  • CHU de Montpellier
    Montpellier Cedex 05, France
9
Single Dose Versus Two Weeks Course of Fluconazole in the Treatment of Oropharyngeal Candidiasis in HIV Infected Individuals in Tanzania
  • Oropharyngeal Candidiasis
  • Drug: fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment
  • ART clinic Muhimbili National Hospital/Muhimbili University College of Health Sciences
    Dar es Salaam, Tanzania
10
Fluconazole Versus Micafungin in Neonates WithCandidiasis
  • Candidiasis
  • Drug: Fluconazole
  • Drug: Micafungin
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Antwerp, Rocourt, Liège, Louvain, Namur, Belgium
  • Paris, Lyon, Saint-Pierre de la Réunion, France
  • Roma, Torino, Catania, Foggia, Reggio Emilia, Italy
  • (and 2 more...)
11
Ketoconazole Gel Versus Terconazole Cream for VaginalCandidiasis
  • Vaginal Candidiasis
  • Drug: Ketoconazole
  • Drug: Terconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
12
Acidophilus for the Treatment and Prevention of OralCandidiasis in Patients Undergoing Radiation Therapy
  • Oral Candidiasis
  • Dietary Supplement: Acidophilus
  • Dietary Supplement: Acidolphilus
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Summa Health System
    Akron, Ohio, United States
13
Comparison of Two Diagnostic Tests in Patients With Suspected Invasive Candidiasis in Internal Medicine Wards and Who Are Currently Timely Treated With Micafungin
  • Invasive Candidiasis
  • Diagnostic Test: 1,3-β-D-glucan quantification
  • Drug: Micafungin
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Diagnostic
  • Osp. Generale Regionale F. Miulli
    Acquaviva Delle Fonti, Italy
  • Nuovo Ospedale Civile S. Agostino-Estense
    Baggiovara, Italy
  • Ospedale di Bussolengo
    Bussolengo, Italy
  • (and 17 more...)
14
NOBICS - NOvel BIomarker In InvasiveCandidiasiS/Candida Sepsis
  • Invasive Candidiasis
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • Medical University of Graz
    Graz, Stmk, Austria
15
An Efficacy and Safety Study of Miconazole and Hydrocortisone Cream in the Treatment of VulvarCandidiasis
  • Vulva; Candidiasis
  • Drug: Miconazole plus Hydrocortisone
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
16
A Study Of The Safety, Tolerability And Effective Of Voriconazole For The Treatment Of Serious Candida Infection And Candida Infection Of The Throat In Pediatric Patients
  • Candidiasis
  • Drug: voriconazole
  • Allocation: Non-Randomized
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
    Wuhan, Hubei, China
  • Beijing Children's Hospital, Capital University of Medical Sciences
    Beijing, China
  • Fakultni nemocnice Brno - Klinika detske onkologie
    Brno, Czech Republic
  • (and 11 more...)
17
The Safety and Efficacy of Intravenous Anidulafungin as a Treatment for Azole-Refractory Mucosal Candidiasis(FRMC)
  • Candidiasis
  • Drug: Anidulafungin, VER002
  • Allocation: Non-Randomized
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Versicor, Inc.
    King of Prussia, Pennsylvania, United States
18
Safety, Tolerability, Immunogenicity and Efficacy of NDV-3A Vaccine in Preventing Recurrent Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Biological: NDV-3A
  • Biological: NDV-3
  • Biological: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Prevention
  • Precision Trials LLC
    Phoenix, Arizona, United States
  • Arkansas Women's Center
    Little Rock, Arkansas, United States
  • Women's Health Care Research Corp
    San Diego, California, United States
  • (and 17 more...)
19
Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Drug: Fluomizin vaginal tablets
  • Drug: Canesten vaginal tablets
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • Siriraj Gynaecologic ID and Female STD Unit, Department of Obstetrics & Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University
    Bangkok, Bangkok Noi district, Thailand
20
Safety and Equivalence of a Terconazole Vaginal Suppository (Test Product) Compared to the Reference Terconazole Vaginal Suppository in the Treatment of Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Drug: Terconazole Vaginal Suppository
  • Drug: Terazol Vaginal Suppository
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Single (Investigator)
  • Primary Purpose: Treatment
21
Study of the Efficacy and Tolerance of Intra-vaginal Treatment With a Total Freeze-dried Culture of Lcr Regenerans® in the Prevention of Relapses of Recurrent Vulvovaginal Candidiasis
  • Candidiasis, Vulvovaginal
  • Drug: Lcr Regenerans
  • Drug: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Prevention
  • Probionov
    Aurillac, France
22
Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067)
  • Invasive Candidiasis
  • Drug: Caspofungin acetate
  • Drug: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment
23
Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis
  • Candidiasis
  • Drug: micafungin
  • Drug: amphotericin B deoxycholate
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment
  • Children's Hospital of Orange County
    Orange, California, United States
  • UMDNJ/Robert Wood Johnson Medical School
    New Brunswick, New Jersey, United States
  • Duke University
    Durham, North Carolina, United States
  • (and 14 more...)
24
Use of 405nm Blue Light Emitting Diode in the Treatment of Women With Vulvovaginal Candidiasis: a Clinical Trial
  • Candidiasis, Vulvovaginal
  • Device: Blue LED 405 nm
  • Other: Questionnaire of anamnesis
  • Allocation: Non-Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
25
CAMB/MAT2203 in Patients With MucocutaneousCandidiasis
  • Candidiasis, Chronic Mucocutaneous
  • Drug: Amphotericin B
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • National Institute of Allergy and Infectious Disease (NIAID)
    Bethesda, Maryland, United States
26
Efficacy, Safety LactiSal 1% Gel, LactSal 50 mg, Clotrimazole 100 mg Tablet in Treatment VulvovaginalCandidiasis
  • Vulvovaginal Candidiasis
  • Device: LactiSal vaginal gel 1%
  • Device: LactiSal vaginal tablet 50mg
  • Drug: Clotrimazole vaginal tablet 100mg
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
27
Monthly Itraconazole Versus Classic Homeopathy for Treatment of Recurrent Vulvovaginal Candidiasis (RVVC)
  • Vulvovaginal Candidiasis
  • Drug: itraconazole
  • Drug: lactobacillus gasseri
  • Drug: classic homeopathy (carcinosin M, nux vomica, pulsatilla M, ferrum metallicum, sepia M, etc. as prescribed)
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Vienna Medical School
    Vienna, Austria
28
Safety and Efficacy of Oral SCY-078 vs. Oral Fluconazole in Subjects With Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Drug: SCY-078
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Single (Investigator)
  • Primary Purpose: Treatment
  • Hospital Dr. Francisco E. Moscoso Puello
    Santo Domingo, Dominican Republic
  • Instituto Dermatologico y Cirugia de Piel
    Santo Domingo, Dominican Republic
29
Phase 2B Dose-Ranging Study of PAC113 Mouthrinse in HIV Seropositive Individuals With Oral Candidiasis
  • Oral Candidiasis
  • Drug: PAC113
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Outcomes Assessor)
  • Primary Purpose: Treatment
  • Rosedale Infectious Disease
    Huntersville, North Carolina, United States
30
Comparative Trial of Micafungin Versus Fluconazole for Treating Esophageal Candidiasis
  • Candidiasis, Oral
  • Drug: Micafungin
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • Abadia Uberaba, Brazil
  • Barretos, Brazil
  • 5 Sites
    Belo Horizonte, Brazil
  • (and 34 more...)
31
Trial of Two Dosing Regimens of Micafungin Versus Caspofungin for the Treatment of Esophageal Candidiasis
  • Candidiasis, Oral
  • Drug: micafungin
  • Drug: caspofungin
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • 5 Sites
    Buenos Aires, Argentina
  • Cordoba, Argentina
  • Neuquen, Argentina
  • (and 28 more...)
32
Fluconazole Prophylaxis for the Prevention of Candidiasisin Infants Less Than 750 Grams Birthweight
  • Candidiasis
  • Drug: fluconazole
  • Drug: placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Prevention
  • University of Alabama at Birmingham
    Birmingham, Alabama, United States
  • University of Arkansas for Medical Sciences
    Little Rock, Arkansas, United States
  • Arkansas Childrens Hospital
    Little Rock, Arkansas, United States
  • (and 30 more...)
33
MGCD290 and Fluconazole Versus Fluconazole Alone for the Treatment of Moderate to Severe VulvovaginalCandidiasis
  • Vulvovaginal Candidiasis
  • Drug: MGCD290
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment
  • University of Alabama at Birmingham
    Birmingham, Alabama, United States
  • Women's Health Care Research Corp.
    San Diego, California, United States
  • Altus Research
    Lake Worth, Florida, United States
  • (and 16 more...)
34
A Study of Oral VT-1161 for the Treatment of Acute VaginalCandidiasis (Yeast Infection) in Patients With Recurrent Vaginal Candidiasis
  • Recurrent Vulvovaginal Candidiasis
  • Drug: VT-1161 150 mg capsule
  • Drug: Fluconazole 150 mg
  • Other: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • 43
    Phoenix, Arizona, United States
  • 34
    Tucson, Arizona, United States
  • 39
    Encino, California, United States
  • (and 41 more...)
35
A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)
  • Recurrent Vulvovaginal Candidiasis
  • Drug: VT-1161
  • Drug: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • 31123
    Birmingham, Alabama, United States
  • 31108
    San Diego, California, United States
  • 31139
    Lauderdale Lakes, Florida, United States
  • (and 22 more...)
36
A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)
  • Recurrent Vulvovaginal Candidiasis
  • Drug: VT-1161
  • Drug: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • 31215
    Phoenix, Arizona, United States
  • 31227
    Little Rock, Arkansas, United States
  • 31217
    Los Angeles, California, United States
  • (and 11 more...)
37
The Study Of Fluconazole For Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Drug: Fluconazole
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Ai WOMEN'S CLINIC
    Asahikawa, Hokkaido, Japan
  • Shirokane Ladies' Clinic
    Minato-ku, Tokyo, Japan
  • Takane Medical Clinic
    Shinagawa-ku, Tokyo, Japan
  • (and 7 more...)
38
Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis
  • Candidiasis, Vulvovaginal
  • Drug: Clotrimazole vaginal tablet
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Peking University Shenzhen Hospital
    Shenzhen, Guangdong, China
39
Clotrimazole vs. Mycelex® in Patients With Human Insufficiency Virus (HIV) Infection for the Treatment of Oropharyngeal Candidiasis
  • Candidiasis, Oral
  • Drug: Roxanes's clotrimazole troches
  • Drug: Mycelex® troches
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Single
  • Primary Purpose: Treatment
40
Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or InvasiveCandidiasis
  • Candidiasis
  • Drug: Eraxis (anidulafungin)
  • Drug: Diflucan (fluconazole)
  • Drug: Vfend (voriconazole)
  • Allocation: Non-Randomized
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Pfizer Investigational Site
    Birmingham, Alabama, United States
  • Pfizer Investigational Site
    Birmingham, Alabama, United States
  • Pfizer Investigational Site
    Little Rock, Arkansas, United States
  • (and 40 more...)
41
The Safety and Effectiveness of Intravenous Anidulafungin as a Treatment for Patients With Invasive Candidiasis.
  • Candidiasis
  • Drug: Anidulafungin, VER002
  • Allocation: Non-Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Versicor, Inc.
    King of Prussia, Pennsylvania, United States
42
Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of InvasiveCandidiasis in Neonates and Infants (MK-0991-064)
  • Candidiasis, Invasive
  • Drug: Caspofungin
  • Drug: Amphotericin B Deoxycholate
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment
43
Effect of Saccharomyces Cerevisiae on Improving the Effectiveness of Conventional Treatment of Vulvo-vaginalCandidiasis
  • Vulvo-vaginal Candidiasis
  • Dietary Supplement: Saccharomyces cerevisiae
  • Dietary Supplement: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Supportive Care
  • Eurofins Optimed
    Gières, France
44
A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Acute Vaginal Candidiasis (Yeast Infection)
  • Candidiasis, Vulvovaginal
  • Drug: VT-1161
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • Altus Research
    Lake Worth, Florida, United States
  • Healthcare Clinical Data, Inc
    North Miami, Florida, United States
  • SUNY Downstate Medical Center
    Brooklyn, New York, United States
  • (and 5 more...)
45
β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients
  • Invasive Candidiasis
  • Drug: Preemptive Therapy with Anidulafungin
  • Drug: Empiric antifungal therapy based on physician discretion.
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Duke University Medical Center
    Durham, North Carolina, United States
46
Caspofungin to Prevent Candidiasis in Adults in Hospital Intensive Care Units
  • Candidiasis
  • Drug: Caspofungin
  • Primary Purpose: Treatment
  • National Cancer Institute (NCI)
    Bethesda, Maryland, United States
47
A Study to Evaluate Oral VT-1161 in the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)
  • Recurrent Vulvovaginal Candidiasis
  • Drug: VT-1161
  • Drug: Placebo
  • Allocation: Randomized
  • Intervention Model: Single Group Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment
  • University of Alabama Birmingham
    Birmingham, Alabama, United States
  • Precision Trials
    Phoenix, Arizona, United States
  • NEA Baptist Clinic
    Jonesboro, Arkansas, United States
  • (and 29 more...)
48
A Comparison of Gentian Violet (GV) Mouth Washes, Nystatin, and Ketoconazole Tabs in Treating OropharyngealCandidiasis
  • Candidiasis, Oral
  • Drug: Gentian violet 1% solution
  • Drug: Gentian violet 0.00165% solution
  • Drug: Nystatin solution
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double
  • Primary Purpose: Treatment
  • Queen Elizabeth Central Hospital, Paediatric Dept, Box 360
    Blantyre, Malawi
49
A Multicenter Observational Study of Invasive Candida Infections Among ICU Patients in China
  • Candidiasis
  • Observational Model: Case-Only
  • Time Perspective: Prospective
  • Gulou District
    Nanjing, Jiangsu, China
50
The Safety and Efficacy of Anidulafungin Versus Comparator in Patients With Candidemia and InvasiveCandidiasis
  • Candidiasis
  • Drug: Anidulafungin
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Single Group Assignment
  • Masking: Double
  • Primary Purpose: Treatment
  • Versicor, Inc.
    King of Prussia, Pennsylvania, United States
51
Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU)
  • Invasive Candidiasis
  • Drug: Caspofungin
  • Drug: Normal Saline
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Prevention
  • University of Alabama at Birmingham
    Birmingham, Alabama, United States
  • University of Southern California
    Los Angeles, California, United States
  • University of Colorado
    Denver, Colorado, United States
  • (and 9 more...)
52
Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in InvasiveCandidiasis.
  • Invasive Candidiasis; Treatment With Echinocandin
  • Biological: Blood sample taken on the day the treatment is initiated
  • Biological: Blood sample taken on day 3 after initiation of treatment
  • Biological: Blood sample taken on day 5 after initiation of
  • (and 2 more...)
  • Observational Model: Case-Only
  • Time Perspective: Prospective
  • CHU de DIJON
    Dijon, France
53
Efficacy and Safety of LAS41003 in the Treatment of Intertriginous Candida Infections
  • Candidiasis
  • Drug: LAS41003
  • Drug: LAS189962
  • Drug: LAS189961
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment
  • Investigational Site #5
    Augsburg, Germany
  • Investigational Site #4
    Bad Saarow, Germany
  • Investigational Site #2
    Berlin, Germany
  • (and 3 more...)
54
A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
  • Invasive Candidiases
  • Abdominal Infection
  • Diagnostic Test: De-escalation
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Single (Care Provider)
  • Primary Purpose: Other
  • Azienda Ospealiero Universitaria di Bologna Policlinico S.Orsola-Malpighi
    Bologna, Italy
55
Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study
  • Invasive Candidiasis
  • Drug: Anidulafungin
  • Drug: Fluconazole
  • Drug: Voriconazole
  • Allocation: Non-Randomized
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Pfizer Investigational Site
    Wien, Austria
  • Pfizer Investigational Site
    Brussels, Belgium
  • Pfizer Investigational Site
    Brussel, Belgium
  • (and 58 more...)
56
Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia
  • Candidiasis
  • Drug: Micafungin
  • Drug: Liposomal Amphotericin B
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment
  • Birmingham, Alabama, United States
  • Orange, California, United States
  • Denver, Colorado, United States
  • (and 34 more...)
57
Novel Rinse to Treat in Oral Candidiasis in Cancer Patients
  • Candidiasis, Oral
  • Thrush
  • Candidiasis
  • Drug: Frio Oral Rinse
  • Observational Model: Case-Only
  • Time Perspective: Prospective
  • University of Missouri at Kansas City, School of Dentistry
    Kansas City, Missouri, United States
  • Cancer Therapy and Researh Center
    San Antonio, Texas, United States
58
Study of FK463 in the Treatment of Candidemia or InvasiveCandidiasis
  • Candidiasis
  • Drug: FK463
  • Allocation: Non-Randomized
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Medizinische Univ.-Klinik
    Graz, Austria
  • Krankenhaus Elisabethinen Linz
    Linz, Austria
  • Hopital Henri Mondor, Dervice d'Hematologie Clinique
    Creteil, France
  • (and 20 more...)
59
Determination of Levels of Micafungin in Neonates Suffering From Systemic Candidiasis and/or Candida Meningitis
  • Candidiasis, Systemic
  • Candida Meningitis
  • Drug: Micafungin
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Site IT39001
    Rome, Italy
  • Site IT39002
    Rome, Italy
60
A Study to Evaluate the Efficacy and Safety of Micafungin Against Invasive Candidiasis or Candidemia
  • Candidemia
  • Candidiasis
  • Drug: Micafungin
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Beijing, China
  • Changsha, China
  • Chengdu, China
  • (and 12 more...)
61
Arasertaconazole Nitrate Pessaries - Dose Finding Study for the Vulvovaginal Candidiasis (VVC) Treatment
  • Vulvovaginal Candidiasis
  • Drug: arasertaconazole nitrate
  • Drug: placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment
  • Ferrer Internacional S.A.
    Barcelona, Spain
62
Caspofungin for the Treatment of Non-blood Candida Infections (0991-045)
  • Candidiasis
  • Drug: MK0991, caspofungin acetate/Duration of Treatment: variable
  • Allocation: Non-Randomized
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
63
Caspofungin Study for Fungal Infections in Adults in Critical Care Settings
  • Candidiasis
  • Drug: Caspofungin
  • Other: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double
  • Primary Purpose: Prevention
  • University of Alabama Hospital - Infectious Diseases
    Birmingham, Alabama, United States
  • University of Southern California - Infectious Diseases
    Los Angeles, California, United States
  • Harbor UCLA Medical Center - Medicine - Infectious Diseases
    Torrance, California, United States
  • (and 23 more...)
64
Open-Label Study to Evaluate the Efficacy and Safety of SCY-078 in Patients With Candidiasis Caused by Candida Auris (CARES)
  • Candidiasis, Invasive
  • Candidemia
  • Drug: SCY-078
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Scynexis, Inc.
    Jersey City, New Jersey, United States
  • St John's Medical College and Hospital
    Bangalore, Karnataka, India
  • Amrita Institute of Medical Sciences (AIMS)
    Kanayannur, Kochi, India
  • (and 2 more...)
65
Risk Of Severe Hepatic Injury In Patients With InvasiveCandidiasis Treated With Echinocandins
  • Invasive Candidiasis
  • Candidemia
  • Other: Does not apply
  • Observational Model: Case Control
  • Time Perspective: Retrospective
66
Effect of Saccharomyces Cerevisiae on Vulvo-vaginalCandidiasis
  • Candidiasis, Vulvovaginal
  • Device: Saccharomyces cerevisiae
  • Device: Placebo
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Supportive Care
  • Dermscan
    Villeurbanne, France
67
CRITIC - Treatment of Candidemia and InvasiveCandidiasis
  • Candidemia
  • Invasive Candidiasis
  • Drug: AmBisome
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Gilead Sciences Srl
    Milan, Italy
68
Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis
  • Vulvovaginal Candidiasis
  • Drug: Terconazole Vaginal Suppository
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Peking University Shenzhen Hosptal
    Shenzhen, Guangdong, China
69
Micafungin Versus Fluconazole in the Treatment of InvasiveCandidiasis and Candidemia
  • Invasive Candidiasis
  • Candidemia
  • Drug: Micafungin
  • Drug: fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Taipei, Republic of China, Taiwan
70
This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasis
  • Candidemia
  • Invasive Candidiasis
  • Drug: Anidulafungin
  • Drug: Voriconazole
  • Allocation: Non-Randomized
  • Intervention Model: Single Group Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Pfizer Investigational Site
    Brasilia, DF, Brazil
  • Pfizer Investigational Site
    Curitiba, PR, Brazil
  • Pfizer Investigational Site
    Rio de Janeiro, RJ, Brazil
  • (and 10 more...)
71
A Randomized Study Evaluating the Therapeutic Equivalence of Two Butoconazole Nitrate Vaginal Cream, 2% Formulations
  • Vulvovaginal Candidiasis
  • Drug: Butoconazole Nitrate Vaginal Cream
  • Drug: Placebo
  • Drug: Gynazole 1 vaginal cream
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Care Provider)
  • Primary Purpose: Treatment
  • PharmaNet, Inc. (PharmaNet)
    Charlotte, North Carolina, United States
72
Prevention of Recurrent Vulvovaginal Candidiasis With Lactibiane Candisis 5M®
  • Vaginal Candidiasis
  • Dietary Supplement: Lactibiane candisis 5M
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Prevention
  • Pileje
    37 Quai de Grenelle, Paris, France
73
Incidence of Oral Candidiasis, Prevalence of C. Dubliniensis in HIV Patients and In-vitro Azole Susceptibility
  • Candidiasis
  • HIV Infections
  • Time Perspective: Prospective
  • Duval County Department of Health. Boulevard Comprehensive Care Center
    Jacksonville, Florida, United States
74
Study of Micafungin in Patients With Invasive Candidiasisor Candidemia
  • Candidiasis
  • Candidemia
  • Drug: Micafungin
  • Drug: Caspofungin
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment
  • Birmingham, Alabama, United States
  • Little Rock, Arkansas, United States
  • Los Angeles, California, United States
  • (and 164 more...)
75
Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week
  • Pulmonary Candidiasis
  • Drug: fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Diagnostic
  • Beijing Chaoyang Hospital,Affiliate of Capital Medical University
    Beijing, Beijing, China
76
Diabetes Mellitus and Vulvovaginal Candidiasis
  • Diabetes Mellitus
  • Vulvovaginal Candidiasis
  • Drug: Boric
  • Drug: Fluconazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Dr Ravinder Goswami
    Delhi, India
77
A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women
  • Candidiasis
  • Candidiasis, Esophageal
  • HIV Infections
  • Drug: Fluconazole
  • Masking: Double
  • Primary Purpose: Treatment
  • Community Consortium of San Francisco
    San Francisco, California, United States
  • Denver CPCRA / Denver Public Hlth
    Denver, Colorado, United States
  • Wilmington Hosp / Med Ctr of Delaware
    Wilmington, Delaware, United States
  • (and 13 more...)
78
ProF-001_Phase IIa
  • Vulvovaginal Candidiasis(VVC)
  • Drug: Candiplus
  • Drug: Clotrimazole
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Care Provider, Investigator)
  • Primary Purpose: Treatment
  • Medical University Innsbruck
    Innsbruck, Austria
  • Bezirkskrankenhaus Schwaz
    Schwaz, Austria
  • Medical University Vienna
    Vienna, Austria
79
An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory OropharyngealCandidiasis in HIV-Positive Subjects.
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Itraconazole
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Univ of Alabama at Birmingham
    Birmingham, Alabama, United States
  • Univ of Arkansas for Med Sciences
    Little Rock, Arkansas, United States
  • East Bay AIDS Ctr
    Berkeley, California, United States
  • (and 15 more...)
80
Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.
  • Candidiasis, Esophageal
  • HIV Infections
  • Drug: Itraconazole
  • Drug: Fluconazole
  • Masking: Double
  • Primary Purpose: Treatment
  • Dr Eskild A Petersen
    Tucson, Arizona, United States
  • Los Angeles County - USC Med Ctr
    Los Angeles, California, United States
  • UCSD Med Ctr
    San Diego, California, United States
  • (and 15 more...)
81
Nystatin Pastilles for the Prevention of Oral Candidiasis in Patients With AIDS or ARC
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Nystatin
  • Primary Purpose: Treatment
  • Birmingham Veterans Administration Med Ctr / Univ of Alabama
    Birmingham, Alabama, United States
  • Bristol - Myers Squibb Co
    Princeton, New Jersey, United States
82
Impact of a Loading Dose of Caspofungin in InvasiveCandidiasis in ICU Patients
  • Candida Infections
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • Reanimation Medicale et Infectieuse-Hopital Bichat
    Paris, France
83
A Comparison of SCH 56592 and Fluconazole in the Treatment of Oropharyngeal Candidiasis (OPC) in HIV-Positive Patients
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Posaconazole
  • Drug: Fluconazole
  • Masking: Double
  • Primary Purpose: Treatment
  • Tucson Veterans Administration Med Ctr
    Tucson, Arizona, United States
  • Northeast Arkansas Clinic
    Jonesboro, Arkansas, United States
  • Miami Veterans Administration Med Ctr
    Miami, Florida, United States
  • (and 50 more...)
84
Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis
  • Candidiasis
  • Bacterial Vaginosis
  • Drug: Clindamycin 100mg and Ketoconazole 400mg
  • Drug: Tetracycline 100mg and Amphotericin B 50mg
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Vox Femina
    Jundiaí, SP, Brazil
85
PEACE: Pediatric Antifungal Comparative Effectiveness
  • Pediatric Invasive Candidiasis
  • Drug: Observational antifungal therapy
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • Arkansas Children's Hospital
    Little Rock, Arkansas, United States
  • Children's Hospital of Orange County
    Orange, California, United States
  • Lucile Packard Children's Hospital at Stanford
    Palo Alto, California, United States
  • (and 32 more...)
86
A Multicenter, Randomized, Double-Blind, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of 2 Dosing Regimens of an Antifungal Drug in the Treatment of Fungal Infections in Adults (0991-801)(COMPLETED)
  • Invasive Candidiasis
  • Drug: caspofungin acetate
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment
87
A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis(P08077)
  • Vaginosis, Bacterial
  • Candidiasis, Vulvovaginal
  • Drug: 100 mg clindamycin /800 mg ketoconazole vaginal ovule
  • Drug: 100 mg tetracycline hydrochloride /50 mg amphotericin B cream
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
88
Safety and Immunogenicity Study of a Virosomal Vaccine Against Recurrent Vulvovaginal Candida Infection
  • Recurrent Vulvovaginal Candidiasis
  • Biological: PEV7C1
  • Biological: PEV7C9
  • Biological: PEV7B2
  • Biological: PEV7B1
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Prevention
  • Covance Clinical Research Unit AG
    Allschwil, Basel, Switzerland
  • CHUV, Vaccine and Immunotherapy Center
    Lausanne, Switzerland
89
Funguria in Hospitalized Patients
  • Candidiasis
  • Time Perspective: Prospective
  • Cedars Sinai Medical Center
    Los Angeles, California, United States
  • UCLA Center For Vaccine Research
    Torrance, California, United States
90
A Study to Compare the Use of Fluconazole as Continuous Therapy Versus Periodic Therapy in HIV-Positive Patients With Recurrent Thrush
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Fluconazole
  • Intervention Model: Parallel Assignment
  • Primary Purpose: Treatment
  • Univ of Southern California / LA County USC Med Ctr
    Los Angeles, California, United States
  • UCLA CARE Ctr
    Los Angeles, California, United States
  • Univ of California / San Diego Treatment Ctr
    San Diego, California, United States
  • (and 51 more...)
91
Safety and Effectiveness of Fluconazole Versus SCH 56592 to Treat Thrush in HIV-Positive Patients
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Posaconazole
  • Drug: Fluconazole
  • Masking: Double
  • Primary Purpose: Treatment
  • East Bay AIDS Ctr
    Berkeley, California, United States
  • ViRx Inc
    San Francisco, California, United States
  • Kaiser Foundation Hospital
    San Francisco, California, United States
  • (and 15 more...)
92
Safety and Effectiveness of Giving L-743,872 to Patients With Thrush That Has Not Been Cured With Fluconazole
  • Candidiasis, Oral
  • HIV Infections
  • Drug: L-743,872
  • Intervention Model: Parallel Assignment
  • Primary Purpose: Treatment
  • Carol Sable
    Rahway, New Jersey, United States
93
Safety and Effectiveness of Giving Lamisil to HIV-Positive Subjects With Thrush Who Have Not Responded to Fluconazole Treatment
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Terbinafine hydrochloride
  • Intervention Model: Parallel Assignment
  • Primary Purpose: Treatment
  • Therafirst Med Ctr
    Fort Lauderdale, Florida, United States
  • Associates in Research
    Fort Myers, Florida, United States
  • Clireco Inc
    Tamarac, Florida, United States
  • (and 6 more...)
94
Comparative Randomized Study of the Efficacy, Safety, and Toleration of Fluconazole Oral Suspension or Nystatin Oral Suspension in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome
  • Candidiasis, Oral
  • HIV Infections
  • Drug: Nystatin
  • Drug: Fluconazole
  • Intervention Model: Parallel Assignment
  • Primary Purpose: Treatment
  • California Med Research Group
    Fresno, California, United States
  • UCSF Hosp
    San Francisco, California, United States
  • Johns Hopkins School of Medicine
    Baltimore, Maryland, United States
  • (and 2 more...)
95
Oral SCY-078 vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis
  • Mycoses
  • Candidiasis, Invasive
  • Candidemia
  • Drug: SCY-078
  • Drug: Fluconazole
  • Drug: Micafungin
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • University of Alabama at Birmingham
    Birmingham, Alabama, United States
  • UC Davis Medical Center
    Sacramento, California, United States
  • University of Colorado Denver
    Aurora, Colorado, United States
  • (and 27 more...)
96
Immunological Interaction Between the Host and Candida Albicans Biofilm
  • Candidiasis
  • Observational Model: Case Control
  • Time Perspective: Retrospective
  • Universitair Ziekenhuis Leuven
    Leuven, Flemish Brabant, Belgium
97
Early Discontinuation of Empirical Antifungal Therapy and Biomarkers
  • Invasive Candidiasis
  • Other: Biomarker strategy
  • Other: Routine strategy
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Hôpital Roger Salengro, CHU
    Lille, France
98
Pharmacokinetics (PK) Study of a Fluconazole Loading Dose in Infants and Toddlers
  • Candidiasis
  • Drug: Fluconazole Loading Dose
  • Drug: Fluconazole Loading Dose & High Dose
  • Allocation: Non-Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment
  • Duke Univeristy Medical Center
    Durham, North Carolina, United States
99
Anidulafungin Versus Fluconazole in the Treatment of Candidemia
  • Candida
  • Candidiasis
  • Drug: Anidulafungin
  • Primary Purpose: Treatment
  • National Cancer Institute (NCI)
    Bethesda, Maryland, United States
100
Study Evaluating the Optimal Dosage for Equivalence Between Lcr Regenerans® Capsules and Tablets (Lactobacillus Rhamnosus Lcr35®) on the Vaginal Flora Colonisation
  • Candidiasis, Vulvovaginal
  • Device: Lcr Regenerans® vaginal capsules
  • Device: Lcr Regenerans® vaginal tablet
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Other
  • BIOSE
    Aurillac, France

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