Adamantinoma Craniopharyngioma Adamantinoma (from the Greek word adamantinos, meaning "very hard") is a rare bone cancer, making up less than 1% of all bone cancers.It almost always occurs in the bones of the lower leg[3] and involves both epithelial and osteofibrous tissue.

1		Management of Pediatric Craniopharyngiomaby a Combination of Partial Surgical Resection, and Protontherapy (Craniopharyngioma)	Craniopharyngioma	Radiation: Protontherapy	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	Institut Curie Paris, France Groupe Hospitalier Necker Enfants Malades Paris, France Gustave Roussy Villejuif, France
2		Social Participation After ChildhoodCraniopharyngioma	Children With a Craniopharyngioma	Other: observational study so no intervention	Observational Model: Cohort Time Perspective: Cross-Sectional
3		Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients	Craniopharyngioma		Observational Model: Cohort Time Perspective: Prospective	St . Jude Children's Research Hospital Memphis, Tennessee, United States
4		1.5T Intraoperative MR Imaging inCraniopharyngiomas	Craniopharyngioma	Other: Intraoperative imaging using 1.5T MRI	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Department of Neurosurgery University of Erlangen Erlangen, Germany
5		A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely ResectedCraniopharyngioma and Observation forCraniopharyngioma After Radical Resection	Craniopharyngioma	Radiation: Proton Therapy Procedure: Surgery	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	St. Jude Children's Research Hospital Memphis, Tennessee, United States
6		Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma	Craniopharyngioma	Procedure: Different surgical approach and techniques being used to treat three subtype of CP	Observational Model: Cohort Time Perspective: Cross-Sectional	Neurosurgery department, Nanfang hospital Guangzhou, Guangdong, China
7		A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection	Craniopharyngioma	Procedure: Radical Surgery or Limited Surgery Device: Proton Therapy Drug: ^1^8F-fluorodeoxyglucose Drug: ^1^1C-methionine	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	University of Florida Health Proton Therapy Institute Jacksonville, Florida, United States St. Jude Children's Research Hospital Memphis, Tennessee, United States
8		Dabrafenib and Trametinib in Treating Patients With BRAF Mutated Ameloblastoma	Ameloblastoma BRAF Gene Mutation	Drug: Dabrafenib Other: Laboratory Biomarker Analysis Drug: Trametinib	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Stanford University, School of Medicine Stanford, California, United States
9		Peginterferon Alfa-2b in Treating Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery	Childhood Craniopharyngioma	Biological: peginterferon alfa-2b Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Hospital Los Angeles Los Angeles, California, United States Stanford University and Lucile Packard Children Hospital Palo Alto, California, United States Children's National Medical Center Washington, District of Columbia, United States (and 6 more...)
10		Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation PositiveCraniopharyngioma	BRAF V600E Mutation Present Papillary Craniopharyngioma	Drug: Vemurafenib Drug: Cobimetinib Other: Laboratory Biomarker Analysis Other: Quality-of-Life Assessment	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn, California, United States Alta Bates Summit Medical Center-Herrick Campus Berkeley, California, United States (and 81 more...)
11		Prospective Study of Children and Adolescents With Craniopharyngioma	Craniopharyngioma Obesity	Radiation: Radiation Other: wait and watch	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	Klinikum Oldenburg Oldenburg, Niedersachsen, Germany
12		Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity AfterCraniopharyngioma Therapy	Craniopharyngiomas Hypothalamic Obesity	Drug: Exenatide Drug: Placebo	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment	CHU d'Angers Angers, France CHU de Brest Brest, France CHU de Grenoble Grenoble, France (and 8 more...)
13		Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy	Craniopharyngioma, Child	Procedure: Tumor and Blood Specimens	Observational Model: Cohort Time Perspective: Prospective	Children's Hospital Colorado Aurora, Colorado, United States
14		Weight Gain in Surgically Treated Adult-onsetCraniopharyngioma	Adult-onset Craniopharyngioma Postoperative Weight Gain		Observational Model: Case-Only Time Perspective: Retrospective	Department of Endocrinology and Metabolism Shanghai, Shanghai, China
15		Sleep Wake and Melatonin Pattern inCraniopharyngioma	Sleep Disorders, Circadian Rhythm Craniopharyngioma		Observational Model: Cohort Time Perspective: Cross-Sectional
16		Hypothalamic Obesity FollowingCraniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy	Hypothalamic Obesity	Drug: Diazoxide Drug: Metformin	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	The Hospital for Sick Children Toronto, Ontario, Canada
17		Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor	Obesity Overweight Craniopharyngioma	Drug: Exenatide	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Vanderbilt University Nashville, Tennessee, United States
18		Intranasal Oxytocin in Hypothalamic Obesity	Craniopharyngioma Hypothalamic Obesity	Drug: Syntocinon Drug: Placebo (for Syntocinon)	Allocation: Randomized Intervention Model: Crossover Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment	Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States
19		Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma	Brain and Central Nervous System Tumors Long-term Effects Secondary to Cancer Therapy in Children Perioperative/Postoperative Complications (and 2 more...)	Other: metabolic assessment Other: physiologic testing Procedure: biopsy (and 7 more...)	Masking: None (Open Label) Primary Purpose: Diagnostic	Krankenhaus Dornbirn Dornbirn, Austria Landeskrankenhaus Feldkirch Feldkirch-Tisis, Austria Universitaet Kinderklinik Graz, Austria (and 106 more...)
20		Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions	Hypothalamic-pituitary Lesions Craniopharyngiomas	Drug: DIAZOXIDE	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment	Hopital Kremlin-Bicetre Paris, France
21		Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions	Pituitary Neoplasms Craniopharyngiomas	Drug: Hydrocortisone Drug: Prednisone	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment	West China Hospital, Sichuan University Chengdu, Sichuan, China
22		Neuromodulation for Hypothalamic Obesity	Craniopharyngioma Hypothalamic Obesity Metabolic Syndrome	Device: Hypothalamic Deep Brain Stimulation	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment
23		An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury	Obesity Over-weight Hypothalamic Injury Craniopharyngioma	Drug: ZGN-440 sterile diluent Drug: ZGN-440 for injectable suspension	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Treatment	Children's Hospitals and Clinics of Minnesota St. Paul, Minnesota, United States Vanderbilt University Medical Center Nashville, Tennessee, United States The Boden Institute Sydney, New South Wales, Australia Austin Health, Metabolic Disorders Centre Heidelberg Heights, Victoria, Australia
24		SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors	Low Grade Gliomas Craniopharyngioma Ependymomas Meningiomas	Radiation: Stereotactic Conformal radiotherapy Radiation: Conventional radiotherapy	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	Tata Memorial Centre Mumbai, Maharashtra, India
25		Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors	Glioma of Brain Craniopharyngioma Ependymoma Germ Cell Tumor	Drug: Memantine Other: Placebo Other: Cognitive Assessment	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Supportive Care	St. Jude Children's Research Hospital Memphis, Tennessee, United States
26		Energy Balance & Weight Loss inCraniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity	Hypothalamic Obesity	Drug: Exenatide Drug: placebo	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment	Children's Hospitals adn Clinics of Minnesota Minneapolis, Minnesota, United States Vanderbilt University School of Medicine Nashville, Tennessee, United States Seattle Childrens Seattle, Washington, United States
27		Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Acoustic Schwannoma Adult Anaplastic Astrocytoma Adult Anaplastic Ependymoma (and 92 more...)	Radiation: gallium Ga 68-edotreotide Procedure: positron emission tomography Procedure: computed tomography Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	University of Iowa Hospitals and Clinics Iowa City, Iowa, United States
28		Stereotactic Radiosurgery in Treating Patients With Brain Tumors	Adult Central Nervous System Germ Cell Tumor Adult Malignant Meningioma Adult Medulloblastoma (and 11 more...)	Procedure: Sterotactic radiosurgery	Primary Purpose: Treatment	Radiation Oncology Branch Bethesda, Maryland, United States
29		Molecular-Guided Therapy for Childhood Cancer	Neuroblastoma Medulloblastoma Glioma (and 16 more...)	Device: Guided Therapy	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Arkansas Children's Hospital Little Rock, Arkansas, United States Rady Children's Hospital San Diego, California, United States Connecticut Children's Hospital Hartford, Connecticut, United States (and 16 more...)
30		Methionine PET/CT Studies In Patients With Cancer	Brain Tumors and/or Solid Tumors Including Brain Stem Glioma High Grade CNS Tumors (and 11 more...)	Drug: Methionine	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	St. Jude Children's Research Hospital Memphis, Tennessee, United States
31		ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors	Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor (and 25 more...)	Drug: veliparib Drug: temozolomide Other: pharmacological study Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Pediatric Brain Tumor Consortium Memphis, Tennessee, United States
32		RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma	Acoustic Schwannoma Adult Anaplastic (Malignant) Meningioma Adult Anaplastic Astrocytoma (and 26 more...)	Radiation: 3-Dimensional Conformal Radiation Therapy Drug: Gamma-Secretase Inhibitor RO4929097 Radiation: Intensity-Modulated Radiation Therapy (and 4 more...)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Memorial Sloan-Kettering Cancer Center New York, New York, United States University of Virginia Cancer Center Charlottesville, Virginia, United States
33		Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia	Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Choriocarcinoma Childhood Central Nervous System Germinoma (and 43 more...)	Drug: gamma-secretase/Notch signalling pathway inhibitor RO4929097 Other: diagnostic laboratory biomarker analysis Other: pharmacological study Drug: dexamethasone	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Lucile Packard Children's Hospital Stanford University Palo Alto, California, United States Stanford University Hospitals and Clinics Stanford, California, United States Lurie Children's Hospital-Chicago Chicago, Illinois, United States (and 9 more...)
34		Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors	Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Choriocarcinoma Childhood Central Nervous System Embryonal Tumor (and 31 more...)	Drug: vorinostat Drug: temozolomide Other: diagnostic laboratory biomarker analysis Other: pharmacological study	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Childrens Memorial Hospital Chicago, Illinois, United States C S Mott Children's Hospital Ann Arbor, Michigan, United States University of Minnesota Medical Center-Fairview Minneapolis, Minnesota, United States (and 6 more...)
35		Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors	Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Cerebral Anaplastic Astrocytoma (and 17 more...)	Other: Cytology Specimen Collection Procedure		Children's Hospital of Alabama Birmingham, Alabama, United States University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States Phoenix Childrens Hospital Phoenix, Arizona, United States (and 184 more...)
36		Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma	Childhood Burkitt Lymphoma Childhood Central Nervous System Choriocarcinoma Childhood Central Nervous System Germ Cell Tumor (and 32 more...)	Drug: vorinostat Drug: bortezomib Other: pharmacological study Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Childrens Memorial Hospital Chicago, Illinois, United States Dana-Farber Cancer Institute Boston, Massachusetts, United States Columbia University Medical Center New York, New York, United States (and 3 more...)
37		Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma	Childhood Burkitt Lymphoma Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor (and 22 more...)	Drug: ispinesib Other: laboratory biomarker analysis Other: pharmacological study	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Oncology Group Arcadia, California, United States
38		Collecting and Storing Tissue From Young Patients With Cancer	Acute Lymphoblastic Leukemia Ann Arbor Stage I Childhood Burkitt Lymphoma Ann Arbor Stage I Childhood Hodgkin Lymphoma (and 120 more...)	Other: Cytology Specimen Collection Procedure Other: Laboratory Biomarker Analysis		Children's Hospital of Alabama Birmingham, Alabama, United States University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States Arkansas Children's Hospital Little Rock, Arkansas, United States (and 63 more...)
39		Cilengitide in Treating Children With Refractory Primary Brain Tumors	Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor Childhood Craniopharyngioma (and 23 more...)	Drug: cilengitide Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Pediatric Brain Tumor Consortium Memphis, Tennessee, United States
40		Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors	Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor (and 23 more...)	Drug: lenalidomide Procedure: perfusion-weighted magnetic resonance imaging Procedure: diffusion-weighted magnetic resonance imaging Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Pediatric Brain Tumor Consortium Memphis, Tennessee, United States
41		Irinotecan in Treating Children With Refractory Solid Tumors	Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor Childhood Craniopharyngioma (and 18 more...)	Drug: irinotecan hydrochloride	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Oncology Group Arcadia, California, United States
42		Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors	Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor Childhood Craniopharyngioma (and 22 more...)	Drug: O6-benzylguanine Drug: temozolomide Biological: filgrastim (and 2 more...)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Pediatric Brain Tumor Consortium Memphis, Tennessee, United States
43		Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors	Adult Anaplastic Astrocytoma Adult Anaplastic Ependymoma Adult Anaplastic Oligodendroglioma (and 24 more...)	Drug: EF5 Procedure: conventional surgery Procedure: positron emission tomography (and 2 more...)	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	Abramson Cancer Center of The University of Pennsylvania Philadelphia, Pennsylvania, United States
44		FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia	Blastic Phase Chronic Myelogenous Leukemia Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor (and 22 more...)	Drug: romidepsin	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Oncology Group Arcadia, California, United States
45		90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors	Cystic Tumors of the Sellar/Parasellar Region	Radiation: 90yttrium colloid	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Halifax Infirmary Halifax, Nova Scotia, Canada
46		Effects of Exenatide on Hypothalamic Obesity	Hypothalamic Obesity	Drug: Exenatide	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Hospital of Orange County Orange, California, United States Children's Hospitals & Clincis of Minnesota Saint Paul, Minnesota, United States
47		Methylphenidate HCl or Modafinil in Treating Young Patients With Excessive Daytime Sleepiness After Cancer Therapy	Central Nervous System Tumor, Pediatric Fatigue Specific Disorders of Sleep	Drug: methylphenidate hydrochloride Drug: modafinil Drug: placebo	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Supportive Care
48		Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial	Brain and Central Nervous System Tumors Leukemia Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific	Other: questionnaire administration Procedure: psychosocial assessment and care	Observational Model: Cohort Time Perspective: Prospective
49		Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors	Brain and Central Nervous System Tumors Metastatic Cancer	Drug: verteporfin Procedure: conventional surgery	Primary Purpose: Treatment	Medical College of Wisconsin Cancer Center Milwaukee, Wisconsin, United States Midwest Children's Cancer Center at Children's Hospital of Wisconsin Milwaukee, Wisconsin, United States
50		Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas	Brain Tumor, Recurrent	Drug: Photofrin photodynamic therapy.	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Medical College of Wisconsin/ Froedtert Hospital Milwaukee, Wisconsin, United States
51		Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors	Brain Tumor, Recurrent	Drug: Photofrin (porfimer sodium) & photodynamic therapy.	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Hospital of Wisconsin Wauwatosa, Wisconsin, United States
52		O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors	Brain and Central Nervous System Tumors	Drug: O6-benzylguanine Drug: carmustine	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	University of Arkansas for Medical Sciences Little Rock, Arkansas, United States University of California San Diego Cancer Center La Jolla, California, United States Children's Hospital Los Angeles Los Angeles, California, United States (and 53 more...)
53		SU5416 in Treating Children With Recurrent or Progressive Brain Tumors	Brain and Central Nervous System Tumors	Drug: semaxanib	Primary Purpose: Treatment	UCSF Cancer Center and Cancer Research Institute San Francisco, California, United States Children's National Medical Center Washington, District of Columbia, United States Dana-Farber Cancer Institute Boston, Massachusetts, United States (and 6 more...)
54		SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors	Brain and Central Nervous System Tumors	Drug: lonafarnib	Primary Purpose: Treatment	UCSF Comprehensive Cancer Center San Francisco, California, United States Children's National Medical Center Washington, District of Columbia, United States Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States (and 6 more...)
55		A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors	Brain and Central Nervous System Tumors Metastatic Cancer	Drug: temsirolimus Other: pharmacological study Other: cytokine levels	Allocation: Non-Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary Purpose: Treatment	City of Hope Comprehensive Cancer Center Duarte, California, United States
56		Antineoplaston Therapy in Treating Children With Brain Tumors	Childhood Brain Tumors	Drug: Antineoplaston therapy (Atengenal + Astugenal)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Burzynski Clinic Houston, Texas, United States
57		Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor (and 5 more...)	Biological: filgrastim Drug: carboplatin Drug: cyclophosphamide (and 3 more...)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Johns Hopkins Oncology Center Baltimore, Maryland, United States
58		Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor (and 7 more...)	Drug: ixabepilone	Primary Purpose: Treatment	Children's National Medical Center Washington, District of Columbia, United States Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States
59		Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor (and 6 more...)	Drug: O6-benzylguanine Drug: temozolomide	Primary Purpose: Treatment	Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States
60		Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors	Brain and Central Nervous System Tumors	Other: laboratory biomarker analysis Procedure: biopsy Procedure: magnetic resonance imaging Radiation: gadopentetate dimeglumine	Primary Purpose: Diagnostic
61		Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors	Brain and Central Nervous System Tumors Unspecified Adult Solid Tumor, Protocol Specific	Dietary Supplement: calcitriol Drug: carboplatin	Primary Purpose: Treatment	University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States
62		Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors	Brain and Central Nervous System Tumors Neuroblastoma	Drug: carmustine Drug: irinotecan hydrochloride Procedure: surgical procedure Radiation: iodine I 131 monoclonal antibody 81C6	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Duke Comprehensive Cancer Center Durham, North Carolina, United States
63		Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer	Brain and Central Nervous System Tumors Lymphoma Neuroblastoma Retinoblastoma	Biological: filgrastim Drug: carboplatin Drug: etoposide (and 2 more...)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	St. Louis Children's Hospital Saint Louis, Missouri, United States Roswell Park Cancer Institute Buffalo, New York, United States University of Texas - MD Anderson Cancer Center Houston, Texas, United States
64		Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Head and Neck Cancer (and 5 more...)	Biological: filgrastim Drug: temozolomide Procedure: peripheral blood stem cell transplantation	Primary Purpose: Treatment	Duke Comprehensive Cancer Center Durham, North Carolina, United States
65		DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas	Brain and Central Nervous System Tumors Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific	Biological: filgrastim Drug: exatecan mesylate	Primary Purpose: Treatment	Memorial Sloan-Kettering Cancer Center New York, New York, United States St. Jude Children's Research Hospital Memphis, Tennessee, United States Children's Medical Center of Dallas Dallas, Texas, United States Institute for Drug Development San Antonio, Texas, United States
66		Study of Tissue Samples From Patients With Glioma or Other Brain Tumors	Central Nervous System Lymphoma	Other: laboratory biomarker analysis Other: pharmacogenomic studies	Observational Model: Cohort Time Perspective: Retrospective	CHU Montpellier Montpellier, France Clinique Gui de Chauliac Montpellier, France
67		Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy	Central Nervous System Tumor, Pediatric Chemotherapy-induced Nausea and Vomiting Unspecified Childhood Solid Tumor, Protocol Specific	Procedure: Real Acupressure Band Procedure: Placebo Acupressure Band	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Supportive Care	Miller Children's Hospital Long Beach, California, United States Childrens Hospital Los Angeles Los Angeles, California, United States Connecticut Children's Medical Center Hartford, Connecticut, United States (and 22 more...)
68		Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom	Bladder Cancer Brain and Central Nervous System Tumors Esophageal Cancer (and 6 more...)	Genetic: DNA analysis Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: questionnaire administration		University of Cambridge Cancer Research UK Cambridge, England, United Kingdom
69		Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors	Brain and Central Nervous System Tumors Metastatic Cancer Neuroblastoma	Procedure: surgical procedure Radiation: astatine At 211 monoclonal antibody 81C6	Primary Purpose: Treatment	Duke Comprehensive Cancer Center Durham, North Carolina, United States
70		Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment	Brain and Central Nervous System Tumors Lymphoma Metastatic Cancer Unspecified Adult Solid Tumor, Protocol Specific	Drug: bortezomib Drug: temozolomide Other: pharmacological study	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	City of Hope Comprehensive Cancer Center Duarte, California, United States City of Hope Medical Group Pasadena, California, United States
71		Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain	Cancer	Drug: Fentanyl sublingual spray Drug: Placebo	Intervention Model: Crossover Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Treatment	InSys Therapeutics, Incorporated Chandler, Arizona, United States
72		Metabolic Syndrome in Childhood Cancer Survivors	Brain and Central Nervous System Tumors Leukemia Lymphoma (and 2 more...)	Other: metabolic assessment Other: questionnaire administration	Observational Model: Cohort Time Perspective: Prospective	University of Minnesota Children's Hospital - Fairview Minneapolis, Minnesota, United States
73		Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors	Brain and Central Nervous System Tumors Chemotherapeutic Agent Toxicity Infertility		Observational Model: Cohort Time Perspective: Prospective	Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States
74		Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors	Brain and Central Nervous System Tumors		Observational Model: Cohort Time Perspective: Prospective	Children's National Medical Center Washington, District of Columbia, United States Children's Memorial Hospital - Chicago Chicago, Illinois, United States Dana-Farber Cancer Institute Boston, Massachusetts, United States (and 5 more...)
75		Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor (and 8 more...)	Drug: carboplatin Drug: dasatinib Drug: etoposide phosphate (and 7 more...)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	City of Hope Comprehensive Cancer Center Duarte, California, United States
76		Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma	Brain and Central Nervous System Tumors Lymphoma Neuroblastoma (and 3 more...)	Drug: becatecarin	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, Alabama, United States University of South Alabama Medical Center Mobile, Alabama, United States Phoenix Children's Hospital Phoenix, Arizona, United States (and 223 more...)
77		Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors	Brain and Central Nervous System Tumors Neuroblastoma	Drug: temozolomide	Primary Purpose: Treatment	Duke Comprehensive Cancer Center Durham, North Carolina, United States
78		Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors	Brain Tumors Metastatic Disease	Drug: donepezil hydrochloride Drug: Placebo	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Supportive Care	Associates in Womens Health, PA - North Review Wichita, Kansas, United States Cancer Center of Kansas, PA - Medical Arts Tower Wichita, Kansas, United States Cancer Center of Kansas, PA - Wichita Wichita, Kansas, United States (and 13 more...)
79		Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors	Brain and Central Nervous System Tumors Neuroblastoma	Drug: enzastaurin hydrochloride	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	UCSF Medical Center at Parnassus San Francisco, California, United States Children's National Medical Center Washington, District of Columbia, United States Children's Memorial Hospital - Chicago Chicago, Illinois, United States (and 5 more...)
80		Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor	Brain and Central Nervous System Tumors Radiation Toxicity	Dietary Supplement: EGb761 Drug: donepezil hydrochloride Procedure: cognitive assessment	Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double Primary Purpose: Supportive Care	CCOP - Western Regional, Arizona Phoenix, Arizona, United States Regional Radiation Oncology Center at Rome Rome, Georgia, United States Comprehensive Cancer Center at Wake Forest University Winston-Salem, North Carolina, United States CCOP - Upstate Carolina Spartanburg, South Carolina, United States
81		MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer	Brain and Central Nervous System Tumors	Drug: MK-0752	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States Children's National Medical Center Washington, District of Columbia, United States Children's Memorial Hospital - Chicago Chicago, Illinois, United States (and 9 more...)
82		Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders	Brain and Central Nervous System Tumors Metastatic Cancer Radiation Toxicity	Other: Questionnaire	Observational Model: Case-Only Time Perspective: Prospective	Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States
83		Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment	Brain and Central Nervous System Tumors Leukemia Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific	Drug: talotrexin Procedure: chemotherapy	Primary Purpose: Treatment
84		Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain	Brain and Central Nervous System Tumors Cognitive/Functional Effects Long-term Effects Secondary to Cancer Therapy in Children (and 3 more...)	Drug: Donepezil	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Supportive Care	Tufts-NEMC Cancer Center Boston, Massachusetts, United States Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States
85		Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors	Childhood Soft Tissue Sarcoma Childhood Liver Cancer Bone Cancer (and 2 more...)	Drug: doxorubicin HCl liposome	Primary Purpose: Treatment	Pediatric Oncology Branch Bethesda, Maryland, United States Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States
86		Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma	Brain and Central Nervous System Tumors	Drug: erlotinib hydrochloride Genetic: mutation analysis Genetic: polymorphism analysis (and 3 more...)	Allocation: Non-Randomized Masking: None (Open Label) Primary Purpose: Treatment	Our Lady's Hospital for Sick Children Crumlin Dublin, Ireland Birmingham Children's Hospital Birmingham, England, United Kingdom Institute of Child Health at University of Bristol Bristol, England, United Kingdom (and 18 more...)
87		Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer	Brain and Central Nervous System Tumors Chordoma Kidney Cancer (and 7 more...)	Drug: polyvinylpyrrolidone-sodium hyaluronate gel	Masking: None (Open Label) Primary Purpose: Supportive Care	Our Lady's Hospital for Sick Children Crumlin Dublin, Ireland Birmingham Children's Hospital Birmingham, England, United Kingdom Institute of Child Health at University of Bristol Bristol, England, United Kingdom (and 18 more...)
88		Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Kidney Cancer (and 5 more...)	Drug: carboplatin Drug: talabostat mesylate Drug: temozolomide Other: pharmacological study	Primary Purpose: Treatment	Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States
89		Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer	Brain and Central Nervous System Tumors Breast Cancer Gastrointestinal Carcinoid Tumor (and 5 more...)	Radiation: yttrium Y 90-edotreotide	Primary Purpose: Treatment	H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States
90		ABT-751 in Treating Young Patients With Refractory Solid Tumors	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor (and 6 more...)	Drug: ABT-751	Masking: None (Open Label) Primary Purpose: Treatment	Children's Memorial Hospital - Chicago Chicago, Illinois, United States Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States
91		Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors	Brain and Central Nervous System Tumors Unspecified Childhood Solid Tumor, Protocol Specific	Drug: irinotecan hydrochloride Drug: temozolomide Drug: vincristine sulfate	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham Birmingham, Alabama, United States Children's Hospital of Orange County Orange, California, United States Stanford Cancer Center Stanford, California, United States (and 15 more...)
92		Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors	Brain and Central Nervous System Tumors Carcinoma of Unknown Primary Leukemia (and 2 more...)	Drug: topotecan hydrochloride	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States Children's National Medical Center Washington, District of Columbia, United States Children's Memorial Hospital - Chicago Chicago, Illinois, United States (and 8 more...)
93		Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors	Brain and Central Nervous System Tumors Unspecified Childhood Solid Tumor, Protocol Specific	Drug: valproic acid	Allocation: Randomized Intervention Model: Single Group Assignment Masking: Single (Participant) Primary Purpose: Treatment	Children's Hospital of Orange County Orange, California, United States Stanford Comprehensive Cancer Center - Stanford Stanford, California, United States Children's National Medical Center Washington, District of Columbia, United States (and 14 more...)
94		Thalidomide and Docetaxel in Treating Patients With Advanced Cancer	Cancer	Drug: docetaxel Drug: thalidomide	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States
95		MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma	Cancer	Drug: entinostat	Masking: None (Open Label) Primary Purpose: Treatment	National Naval Medical Center Bethesda, Maryland, United States Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States NCI - Center for Cancer Research Bethesda, Maryland, United States
96		Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas	Brain and Central Nervous System Tumors Breast Cancer Kidney Cancer (and 6 more...)	Drug: carboxyamidotriazole Drug: paclitaxel	Primary Purpose: Treatment	Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States NCI - Medical Oncology Clinical Research Unit Bethesda, Maryland, United States
97		VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors	Brain and Central Nervous System Tumors	Drug: laromustine	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	UCSF Comprehensive Cancer Center San Francisco, California, United States Children's National Medical Center Washington, District of Columbia, United States Children's Memorial Hospital - Chicago Chicago, Illinois, United States (and 7 more...)
98		Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer	Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor (and 8 more...)	Procedure: psychosocial assessment and care		University of California Davis Medical Center Sacramento, California, United States Shands Hospital and Clinics, University of Florida Gainesville, Florida, United States Sylvester Cancer Center, University of Miami Miami, Florida, United States (and 28 more...)
99		Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment	Brain Tumor Central Nervous System Tumors Cachexia (and 5 more...)	Drug: cyproheptadine hydrochloride Drug: megestrol acetate	Allocation: Non-Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary Purpose: Supportive Care	CCOP - Bay Area Tumor Institute Oakland, California, United States Children's Hospital & Research Center Oakland Oakland, California, United States Children's National Medical Center Washington, District of Columbia, United States (and 40 more...)