Acoustic Neuroma Vestibular schwannoma

1		Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery	Acoustic Neuroma	Other: Testing of Pre-Positioning Frame	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Basic Science	Vanderbilt University Medical Center Nashville, Tennessee, United States
2		RGD PET/MRI in Sporadic Vestibular Schwannoma	Acoustic Neuroma	Drug: One injection of 68Ga-NODAGA-E[c(RGDyK)]2	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	Department of Otolaryngology, Head and Neck Surgery & Audiology, Rigshospitalet Copenhagen, Denmark
3		Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma	Vestibular Schwannoma Acoustic Neuroma	Radiation: Fractionated proton radiation	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Massachusetts General Hospital Boston, Massachusetts, United States
4		Vestibular Schwannoma - Radiosurgery or Expectation: V-REX.	Vestibular Schwannoma	Radiation: gamma knife radiosurgery	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Investigator, Outcomes Assessor) Primary Purpose: Treatment	Haukeland Unviersity Hospital Bergen, Norway
5		Vestibular Schwannoma and Psychological Factors	Vestibular Schwannoma		Observational Model: Cohort Time Perspective: Prospective	Centre Hospitalier Universitaire de Nancy Nancy, France
6		Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study	Vestibular Schwannoma	Radiation: Initial Gamma knife radiosurgery	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	Department of Neurosurgery, Karolinska univeristy hospital Stockholm, Sweden
7		WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neuroma	Diagnostic Test: Whole exome sequencing	Observational Model: Case-Control Time Perspective: Other	University Department of Neurosurgery Tübingen Tübingen, Germany
8		Stereotactic Radiation in Vestibular Schwannoma	Vestibular Schwannoma	Radiation: stereotactic radiotherapy Radiation: stereotactic radiosurgery	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment
9		Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment ofVestibular Schwannoma	Vestibular Schwannoma	Drug: Bevacizumab (Avastin)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Lenox Hill Brain Tumor Center New York, New York, United States
10		Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma	Hearing Loss, Cochlear Neurinoma of the Acoustic Nerve	Device: Neuristim Device: Cochlear implant	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	University Hospital Bordeaux - Pellegrin Bordeaux, France University Hospital Grenoble - A. Michallon Grenoble, France University Hospital Lyon - Edouard Herriot Lyon, France University Hospital Pitié Salpétrière Paris, France
11		Vestibular Outcomes in Vestibular Schwannoma	Vestibular Schwannoma		Observational Model: Cohort Time Perspective: Prospective	Haukeland University Hospital Bergen, Hordaland, Norway
12		Response Prediction After GKS in Patients WithVestibular Schwannoma Using DCE MR Imaging	Vestibular Schwannoma		Observational Model: Cohort Time Perspective: Prospective
13		Secondary Endolymphatic Hydrops andVestibular Schwannomas on 3 Tesla MRI	Vestibular Schwannoma		Observational Model: Cohort Time Perspective: Retrospective	Service Imagerie 1 Strasbourg, France
14		Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma	Vestibular Schwannoma	Drug: gentamicin	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Supportive Care
15		Preoperative Vestibular Rehabilitation Effectiveness After Vestibular SchwannomaSurgery	Vestibular Schwannoma	Other: Preoperative vestibular rehabilitation	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	University Hospital of Nancy Nancy, France
16		Study of Aspirin in Patients With Vestibular Schwannoma	Vestibular Schwannoma Acoustic Neuroma Neurofibromatosis 2	Drug: Aspirin Drug: Placebo	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment	Stanford Otolaryngology/HNS Stanford, California, United States University of Iowa Iowa City, Iowa, United States Massachusetts Eye and Ear Infirmary Boston, Massachusetts, United States (and 3 more...)
17		A Study of Nilotinib in Growing Vestibular Schwannomas	Growing Vestibular Schwannomas	Drug: Nilotinib	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Toronto Western Hospital Toronto, Ontario, Canada University Health Network Toronto, Ontario, Canada
18		Study of Axitinib in Patients With Neurofibromatosis Type 2 and ProgressiveVestibular Schwannomas	Neurofibromatosis Type 2 Vestibular Schwannomas	Drug: Axitinib	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	NYU Langone Medical Center New York, New York, United States
19		Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and ProgressiveVestibular Schwannomas	Neurofibromatosis Type 2 Progressive Vestibular Schwannomas	Drug: Bevacizumab	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Children's Hospital Los Angeles Los Angeles, California, United States Children's National Medical Center Washington, District of Columbia, United States Children's HealthCare of Atlanta Atlanta, Georgia, United States (and 9 more...)
20		Role of Psychiatric Profile in Prehabituated Patients After Vestibular SchwannomaSurgery	Vestibular Schwannoma Vestibular Function Disorder	Procedure: intratympanic application of gentamicin Procedure: microsurgical removal of vestibular schwannoma	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	Charles University Prague, Czechia
21		Simultaneous Translabyrinthine Surgery ofVestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results	Vestibular Schwannoma Hearing Loss		Observational Model: Case-Only Time Perspective: Prospective	AKH, MUW Vienna, Austria
22		Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment ofVestibular Schwannoma and Meningioma	Vestibular Schwannoma Meningioma Acoustic Neuroma Neurofibromatosis Type 2	Drug: AR-42	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Stanford University Stanford, California, United States Johns Hopkins University Baltimore, Maryland, United States Massachusetts Eye and Ear Boston, Massachusetts, United States Mayo Clinic Rochester, Minnesota, United States
23		Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)	Vestibular Schwannoma Neurofibromatosis Type 2	Biological: bevacizumab Other: laboratory biomarker analysis Procedure: quality-of-life assessment	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States National Cancer Institute Rockville, Maryland, United States Massachusetts General Hospital Charlestown, Massachusetts, United States
24		Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function	Vestibular Schwannoma	Drug: Gentamicins	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention	Dept. OtoRhinoLaryngology Head and Neck Surgery, Skane University Hospital Lund, Sweden
25		Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function	Vestibular Schwannoma	Drug: Gentamicin	Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention	Dept. OtoRhinoLaryngology Head and Neck Surgery, Skane University Hospital Lund, Sweden
26		Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas	Neurofibromatosis Type 2 Vestibular Schwannomas Meningiomas	Drug: RAD001	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Other	New York University School of Medicine New York, New York, United States
27		Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach	Unilateral Acoustic Neuroma Meniere's Disease	Device: Cochlear Implant	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States
28		Concentration and Activity of Lapatinib inVestibular Schwannomas	Vestibular Schwannoma NF2 Neurofibromatosis 2 (and 2 more...)	Drug: lapatinib	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Basic Science	House Reserach Institute Los Angeles, California, United States Johns Hopkins Hospital Baltimore, Maryland, United States Massachusetts General Hospital Boston, Massachusetts, United States (and 4 more...)
29		Cyberknife Radiosurgery for Patients With Neurinomas	Sporadic Acoustic Neuromas Useful Hearing	Radiation: Radiosurgery	Allocation: Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Istittuto Nazionale Neurologico Carlo Besta Milano, Mi, Italy
30		Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy	Neuroma, Acoustic	Procedure: Microsurgery Procedure: Stereotactic radiation therapy	Observational Model: Cohort Time Perspective: Prospective	Stanford University School of Medicine Stanford, California, United States George Washington University Washington, District of Columbia, United States Indiana University Indianapolis, Indiana, United States (and 6 more...)
31		CI Following VS Removal or Labyrinthectomy	Vestibular Schwannoma Meniere Disease	Device: Cochlear Implant	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	The Ohio State University Columbus, Ohio, United States
32		Vestibular Evaluation After Vestibular Schwannoma Treatment	Dizziness	Radiation: Radiosurgery gammaknife Procedure: Microsurgery resection	Observational Model: Case-Control Time Perspective: Retrospective	CHU Grenoble-Alpes La Tronche, France
33		Endoscopic-assisted Microsurgical Removal of Cerebellopontine Angle Lesions	Cerebellopontine Angle Tumor	Device: endoscope	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment
34		Study of RAD001 for Treatment of NF2-relatedVestibular Schwannoma	Neurofibromatosis Type 2 Neuroma, Acoustic	Drug: RAD001, everolimus	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	University of California Los Angeles Los Angeles, California, United States
35		Maintaining Cochlear Patency After VIIIth Nerve Surgery	Acoustic Neuroma Labyrinthitis Ossificans Profound Hearing Impairment	Device: MedEl Test Electrode Placer	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	The Michigan Ear Institute Farmington Hills, Michigan, United States
36		Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients	Neurofibromatosis 2	Drug: RAD001	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Hôpital Beaujon, 100 boulevard du Général Leclerc Clichy, France
37		Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors	Vestibular Schwannoma Neurofibromatosis Type 2	Drug: Icotinib	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing, Beijing, China Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing, China
38		Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors	Vestibular Schwannoma Neurofibromatosis Type 2	Drug: Endostatin	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing, Beijing, China
39		AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular SchwannomaResection	Vestibular Vertigo	Drug: Intranasal Drug Drug: Oral Tablet Other: Intranasal Placebo	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment
40		Robot Based Tympanic Tube Placement	Patient Operated on From a Vestibular Schwannoma With a Middle Ear Exclusion	Device: Robot Based Transtympanic drain placement	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Device Feasibility	Pitié Salpêtrière Hospital Paris, France
41		Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study	Vestibular Schwannoma Hearing Loss	Other: eABR	Observational Model: Other Time Perspective: Prospective	AKH; MUW Vienna, Austria
42		Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors	Neurofibromatosis 2 Vestibular Schwannoma	Drug: Lapatinib	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	New York University School of Medicine New York, New York, United States
43		Consequence of Unilateral Vestibular Loss on Visual Abilities	Vestibular Schwannoma Visual Impairment Vestibular Meniere Syndrome	Diagnostic Test: orthoptic balance	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Other	Assistance Publique Des Hopitaux de Marseille Marseille, Paca, France
44		Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery	Vestibular Schwannoma Brain Metastases Para-optic Meningioma	Device: Intuitive Plan	Observational Model: Other Time Perspective: Prospective	Assistance Publique Hôpitaux de Marseille Marseille, France
45		Recovery of Visual Acuity in People With Vestibular Deficits	Vestibular Neuronitis Vestibular Neuronitis, Bilateral Vestibular Schwannoma	Other: Control exercises Other: gaze stabilization exercises	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment	Center for Rehabilitation Medicine, Emory University Atlanta, Georgia, United States
46		Vegetative Monitoring During Brainstem-associated Surgery	Brain Tumor, Recurrent Vestibular Schwannoma Brainstem Neoplasm Brainstem Glioma	Procedure: Intraoperative Monitoring during resection of brain tumor	Observational Model: Case-Control Time Perspective: Prospective	Department of Neurosurgery Tübingen, Germany
47		Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors	Neurofibromatosis 2 Vestibular Schwannoma Meningioma (and 2 more...)	Drug: Selumetinib	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment	Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States
48		Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Acoustic Schwannoma Adult Anaplastic Astrocytoma Adult Anaplastic Ependymoma (and 92 more...)	Radiation: gallium Ga 68-edotreotide Procedure: positron emission tomography Procedure: computed tomography Other: laboratory biomarker analysis	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic	University of Iowa Hospitals and Clinics Iowa City, Iowa, United States
49		Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas	Acoustic Schwannoma Adult Anaplastic Meningioma Adult Ependymoma (and 7 more...)	Biological: bevacizumab	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Northwestern University Chicago, Illinois, United States Dana-Farber Cancer Institute Boston, Massachusetts, United States Columbia University Medical Center New York, New York, United States (and 2 more...)
50		RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma	Acoustic Schwannoma Adult Anaplastic (Malignant) Meningioma Adult Anaplastic Astrocytoma (and 26 more...)	Radiation: 3-Dimensional Conformal Radiation Therapy Drug: Gamma-Secretase Inhibitor RO4929097 Radiation: Intensity-Modulated Radiation Therapy (and 4 more...)	Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment	Memorial Sloan-Kettering Cancer Center New York, New York, United States University of Virginia Cancer Center Charlottesville, Virginia, United States
51		Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery	Facial Palsy	Drug: methylprednisolone	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Prevention	Assistance Publique Hopitaux de Paris Clichy, France
52		Natural History Study of Patients With Neurofibromatosis Type 2	Spinal Cord Disease Intracranial Central Nervous System Disorder Neurologic Disorders Brain Neoplasms		Observational Model: Cohort Time Perspective: Prospective	National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States
53		Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients	Neoplasms Nervous System Disease Vestibular Disease		Time Perspective: Prospective	National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States
54		Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2	Neurofibromatosis 2	Device: Multichannel Auditory Brain Stem Implant	Primary Purpose: Treatment