The risk of tumor recurrence in patients with laryngeal carcinoma was quantified by our newly constructed nomogram. Patients categorized as high‐risk were found to benefit from POAT in RFS.................Recurrence‐free survival (RFS)...................Postoperative adjuvant treatments (POAT)

A prognostic nomogram for predicting risk of recurrence in laryngeal squamous cell carcinoma patients after tumor resection to assist decision making for postoperative adjuvant treatment
Xiaoke Zhu MS  Yu Heng MS  Liang Zhou MD  Lei Tao MD  Ming Zhang MD
First published: 04 July 2019 https://doi.org/10.1002/jso.25614
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Abstract
Background
This study aimed to create a nomogram for postoperative prediction of the risk of recurrence in laryngeal squamous cell carcinoma patients who received laryngectomy alone and to assess indications for postoperative adjuvant treatments (POAT).

Methods
A retrospective analysis of 1571 newly diagnosed laryngeal carcinoma patients was conducted. Those patients were divided into two groups—the development cohort (n = 1102) and the validation cohort (n = 469). Patients were classified into three subgroups according to their individual points calculated from the nomogram. The efficiency of POAT was examined among various subgroups.

Results
Five variables, including pT classification, pN classification, surgical margin, tumor differentiation, and primary location, were included in the nomogram. The C‐index was 0.753 in development cohort and 0.744 in validation cohort. Patients were classified into three subgroups with incremental risks of recurrence. In the high‐risk group, patients receiving POAT showed significantly better recurrence‐free survival (RFS) than did those receiving surgery alone, while POAT was not significantly associated with RFS in either the low‐ or moderate‐risk groups.

Conclusions
The risk of tumor recurrence in patients with laryngeal carcinoma was quantified by our newly constructed nomogram. Patients categorized as high‐risk were found to benefit from POAT in RFS.

jso25614-sup-0001-Supplementary_Fig_1.tif2.6 MB	Supporting information
jso25614-sup-0002-Supplementary_Table_1.docx32.9 KB	Supporting information
jso25614-sup-0003-Supplementary_Table_2.docx36.5 KB	Supporting information
jso25614-sup-0004-SupMat.docx13.3 KB	Supporting information