Genes,

Single-nucleotide polymorphisms (rs342275, rs342293, rs7694379, rs11789898, and rs17824620) showed significant association with lobaplatin-induced thrombocytopenia

Publication date: Available online 4 July 2019Source: GeneAuthor(s): Panpan Lv, Shaoxing Yang, Fangfang Wu, Wenjing Liu, Haifeng Qin, Xiuhua Tang, Zeyuan Liu, Hongjun GaoAbstractThis study aimed to investigate single-nucleotide polymorphisms (SNPs) associated with lobaplatin-induced thrombocytopenia in patients with advanced lung cancer in China. Thirty-nine patients who received lobaplatin-based chemotherapy in the 307 Hospitals of Chinese People's Liberation Army from April 2017 to March 2018 were...

Gene

Thu Jul 04, 2019 17:28

Comment on: ‘A 40-bp insertion/deletion polymorphism in the constitutive promoter of MDM2 confers risk for hepatocellular carcinoma in a Chinese population’

Publication date: Available online 4 July 2019Source: GeneAuthor(s): Kheirollah Yari, Amin JalilvandAbstractRecently, we read the published article in GENE. Dong et al. presented the evaluation of the MDM2 40-bp insertion/deletion status in Hepatocellular carcinoma patients (Dong et al., 2012).The authors stated that the insertion allele showed a 521-bp band and the deletion allele showed a 481-bp band on agarose gel electrophoresis. While it seems that these reported sizes for insertion and deletion...

Gene

Thu Jul 04, 2019 17:28

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity in adult male albino rats

Publication date: Available online 4 July 2019Source: GeneAuthor(s): Marwa M. Ahmad, Noha A. Rezk, Amal Fawzy, Mohamed SabryAbstractBackgroundAcute paracetamol (PCM) toxicity is a clinical problem; can result in a serious liver injury that finally may progress to acute liver failure. Curcumin (CUR) is a prevalent natural compound that can maintain prooxidant/antioxidant balance and thus can help in liver protection; also, Silymarin (SL) is a traditional antioxidant herb, used to treat liver disorders...

Gene

Thu Jul 04, 2019 17:28

<em>Hsa-miR-942</em> fingerprint in colorectal cancer through Wnt signaling pathway

Publication date: Available online 3 July 2019Source: GeneAuthor(s): Ali Fasihi, Bahram M. Soltani, Zahra Sadat Ranjbaran, Sajedeh Bahonar, Romina Norouzi, Shirzad NasiriAbstractThe Wnt signaling pathway has been identified for its function in carcinogenesis and embryonic development. It is known to play a vital role in the initiation and development of colorectal cancer (CRC). Therefore, it is of great importance for CRC research to illuminate the mechanisms which regulate Wnt pathway activity....

Gene

Thu Jul 04, 2019 17:28

Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis

Publication date: Available online 3 July 2019Source: GeneAuthor(s): Qingbai Liu, Zaifeng Wu, Tianlei Hu, Lin Zhang, Laijie Wang, Gang LiuAbstractBlockade of Hedgehog signaling can prevent osteoarthritis (OA) syndromes. However, the amelioration of related inflammation condition is limited. The purpose of this study was to observe the effect of combined use of Hedgehog signaling inhibitor GANT-61 and common clinical anti-inflammatory drug indomethacin on cartilage injury and inflammation in experimental...

Gene

Thu Jul 04, 2019 17:28

LncRNA MIR503HG is downregulated in Han Chinese with colorectal cancer and inhibits cell migration and invasion mediated by TGF-β2

Publication date: Available online 3 July 2019Source: GeneAuthor(s): Dongyu Chuo, Fang Liu, Yuze Chen, Mingdi YinAbstractIn this study we investigated the role of lncRNA MIR503HG in colorectal cancer (CRC). We found that MIR503HG was downregulated and TGF-β2 was upregulated in CRC included in this study. Low levels of MIR503HG were associated with poor survival of CRC patients within 5 years after admission. MIR503HG and TGF-β2 were inversely correlated in CRC tissues, and in CRC cells, MIR503HG...

Gene

Thu Jul 04, 2019 17:28

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 Genes

Genes, Vol. 10, Pages 508: Identification of TPX2 Gene Family in Upland Cotton and Its Functional Analysis in Cotton Fiber Development

Genes, Vol. 10, Pages 508: Identification of TPX2 Gene Family in Upland Cotton and Its Functional Analysis in Cotton Fiber Development Genes doi: 10.3390/genes10070508 Authors: Lei Liu Fan Peng Zou Zhen Huang Fan Zhang Deng Ge Gong Li Gong Shi Jiang Zhang Jia Zhang Yuan Shang Microtubules (MTs) are of importance to fiber development. The Xklp2 (TPX2) proteins as a class of microtubule-associated proteins...

Genes

Thu Jul 04, 2019 03:00

Genes, Vol. 10, Pages 507: Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis

Genes, Vol. 10, Pages 507: Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis Genes doi: 10.3390/genes10070507 Authors: Zhang Taenia pisiformis is a tapeworm causing economic losses in the rabbit breeding industry worldwide. Due to the absence of genomic data, our knowledge on the developmental process of T. pisiformis is still inadequate. In this study, to better characterize differential and specific genes and pathways associated with the parasite...

Genes

Thu Jul 04, 2019 03:00