Publication date: Available online 2 July 2019Source: GeneAuthor(s): Hui Chen, Jie Zheng, Zhenping Chen, Honghao Ma, Rui Zhang, Runhui WuAbstractMPIG6B has orthologous physiological effects in human and mice, which regulates platelet production and function. For this reason, germline loss-of-function mutations in this gene cause congenital thrombocytopenia that is associated with bone marrow fibrosis, organomegaly and subsequent anemia. This was described in a consanguineous Arabian family with a...
Wed Jul 03, 2019 13:46
Publication date: Available online 1 July 2019Source: GeneAuthor(s): Yuyi Li, Qianfei Xu, Wei Yang, Tongli Wu, Xirong LuAbstractGastric cancer represents a common malignancy of digestive tract with high incidence and mortality. Increasing evidence suggests that the growth of gastric tumor cells relies largely on aerobic glycolysis. Currently, many potential anti-cancer candidates are derived from natural products. Here, we evaluated the effects of oleanolic acid (OA), a triterpenoid component widely...
Mon Jul 01, 2019 14:09
Publication date: Available online 30 June 2019Source: GeneAuthor(s): Maruthan Karthik, Shanmugaraja Meenakshi, M.Hussain MunavarAbstractRifampicin (RIF) is still a first line of antibiotic in the treatment of bacterial diseases, in particular the Mycobacterial infections. The antimicrobial activity of RIF is attributed to its ability to inhibit transcription by binding to the β subunit of bacterial RNA polymerase (encoded by rpoB). Continued use of this drug resulted in the emergence of RIF resistant...
Mon Jul 01, 2019 14:09
Genes, Vol. 10, Pages 506: Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma Genes doi: 10.3390/genes10070506 Authors: Edie-Rosmin Wu Ying-Erh Chou Yu-Fan Liu Kuan-Chun Hsueh Hsiang-Lin Lee Shun-Fa Yang Shih-Chi Su Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to...
03:00
Genes, Vol. 10, Pages 505: Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas Genes doi: 10.3390/genes10070505 Authors: Marilia Takada Lauren A. Smyth Tuddow Thaiwong Marlee Richter Sarah M. Corner Peter Z. Schall Matti Kiupel Vilma Yuzbasiyan-Gurkan While the genetic contributions to the predisposition of Bernese mountain dogs (BMDs) to histiocytic sarcoma (HS) remains unclear, some insights into key genetic drivers have been gained. Our group...
03:00
Genes, Vol. 10, Pages 504: Human Sperm Chromosomes: To Form Hairpin-Loops, Or Not to Form Hairpin-Loops, That Is the Question Genes doi: 10.3390/genes10070504 Authors: Dimitrios Ioannou Helen G. Tempest Background: Genomes are non-randomly organized within the interphase nucleus; and spermatozoa are proposed to have a unique hairpin-loop configuration, which has been hypothesized to be critical for the ordered exodus of the paternal genome following fertilization. Recent studies suggest...
Wed Jul 03, 2019 03:00
Genes, Vol. 10, Pages 503: Landscape of Overlapping Gene Expression in The Equine Placenta Genes doi: 10.3390/genes10070503 Authors: Pouya Dini Jamie Norris Hossam El-Sheikh Ali Shavahn C. Loux Mariano Carossino Alejandro Esteller-Vico Ernest Bailey Theodore Kalbfleisch Peter Daels Barry A. Ball Increasing evidence suggests that overlapping genes are much more common in eukaryotic genomes than previously thought. These different-strand overlapping genes are...
Tue Jul 02, 2019 03:00
Marc Haber<br />Jun 13, 2019; 0:genetics.119.302368v1-genetics.302368.2019<br />INVESTIGATIONS
Thu Jun 13, 2019 03:00
Abstract Posterior elongation of the developing embryo is a common feature of animal development. One group of genes that is involved in posterior elongation is represented by the Wnt genes, secreted glycoprotein ligands that signal to specific receptors on neighbouring cells and thereby establish cell-to-cell communication. In segmented animals such as annelids and arthropods, Wnt signalling is also likely involved in segment border formation and regionalisation of the segments....
03:00
Abstract Rabies is endemic in Zambia and Zimbabwe. The previously investigated strains of rabies virus in central Zambia belong to the Africa 1b lineage, with similar circulating virus strains found in the various tested hosts and regions. However, prior work assessed only limited regions and host species. Thus, this study aimed to more comprehensively determine the genetic diversity of rabies virus across regions of Zambia and Zimbabwe. RNA (n = 76) was extracted from positive...
Wed Jul 03, 2019 03:00
Abstract Fowl adenovirus serotype 4 (FAdV-4) is a causative agent of inclusion body hepatitis and hydropericardium–hepatitis syndrome. These diseases cause considerable economic losses in the global poultry industry and are significant stressors for infected chickens. However, the molecular mechanisms of FAdV-4 pathogenesis are poorly understood. In the present study, we identified differentially expressed genes from the livers of FAdV-4-infected chickens using RNA-seq at 7, 14...
Mon Jul 01, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου