Cell Research - AOP,

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Cell Research, Published online: 04 July 2019; doi:10.1038/s41422-019-0195-ySingle-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Cell Research - AOP

Thu Jul 04, 2019 03:00

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 Cells

Cells, Vol. 8, Pages 679: Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming

Cells, Vol. 8, Pages 679: Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming Cells doi: 10.3390/cells8070679 Authors: Bektik Fu Coronary artery disease is the most common form of cardiovascular diseases, resulting in the loss of cardiomyocytes (CM) at the site of ischemic injury. To compensate for the loss of CMs, cardiac fibroblasts quickly respond to injury and initiate cardiac remodeling in an injured heart. In the remodeling process, cardiac...

Cells

Thu Jul 04, 2019 03:00

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 Journal of Cellular Physiology

Hippuric acid and 3‐(3‐hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL‐RANK independent pathway

We provide evidence for the first time that phenolic hippuric acid (HA) and 3‐(3‐hydroxyphenyl) propionic acid (3‐3‐PPA) had dose‐dependent suppressive effects on osteoclastogenesis and osteoclast resorptive activity in Corning osteo‐assay plates. Inhibitory effects of HA and 3‐3‐PPA on osteoclastogenesis utilized the RANKL/RANK independent mediators. Abstract Nutritional factors influence bone development. Previous studies demonstrated that bone mass significantly increased with suppressed...

Journal of Cellular Physiology

Thu Jul 04, 2019 19:14