Recurrence factors in pediatric ameloblastoma: Clinical features and a new classification system
Rong Yang DDS  Yu Tang BDS  Xu Zhang DDS  Zheqi Liu BDS  Sandhya Gokavarapu MDS  Chengzhong Lin DDS  Zhenhu Ren MD, PhD  Yongmei Zhou MD, PhD  Wei Cao MD, PhD  Tong Ji MD, PhD
First published: 19 July 2019 https://doi.org/10.1002/hed.25867
Rong Yang, Yu Tang, Xu Zhang contributed equally to this work.
Funding information: National Natural Science Foundation of China, Grant/Award Numbers: 81671009, 81672745; Shanghai Jiao Tong University, Grant/Award Number: YG2017QN01; Shanghai Science and Technology Innovation Action plan, Grant/Award Number: 17511110300
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Abstract
Background
Ameloblastomas of jaw in the pediatric population are a rare clinical entity and have not been well addressed in the literatures. The present retrospective study analyzed the risk factors associated with recurrence of pediatric ameloblastomas.

Methods
Cases of primary pediatric ameloblastomas seen in a tertiary hospital between 2005 and 2015 were analyzed to identify the clinical factors associated with recurrence.

Results
There were a total of 104 cases of primary pediatric ameloblastomas. The overall mean maximum tumor diameter was 4.11 ± 1.339 cm. The receiver operating characteristic curve and the Youden Index showed an optimal cutoff point of 4.95 cm to accurately predict recurrence. Bone cortex/soft tissue invasion were associated with tumor recurrence (P < .001).

Conclusions
The maximum tumor diameter, root resorption, and bone cortex/soft tissue invasion were risk factors for recurrence of pediatric ameloblastomas. The new classification system may serve as a predictor of recurrence in pediatric ameloblastomas.