ABSTRACT Objective Compared to older Caucasians, older African Americans have higher risks of developing Alzheimer's disease (AD), and lower cerebrospinal fluid (CSF) tau biomarker levels. It is not known whether tau‐related differences begin earlier in life, and whether race modifies other AD‐related biomarkers such as inflammatory proteins. Methods We performed multiplex cytokine analysis in a healthy middle‐aged cohort with family history of AD (n=68) and an older cohort (n=125) with...
Thu Jul 04, 2019 18:38
Abstract Higher plasma total‐tau level is associated with incident dementia but its relationship with stroke risk is unknown. In this prospective community‐based study, we evaluated plasma total‐tau level as a biomarker of stroke risk in 2794 Framingham Heart Study participants. Persons with plasma total‐tau levels in the top quintile, versus the bottom four, had an increased risk of incident stroke over a mean follow‐up of 8.3 years (Hazard Ratio, 2.01; 95% Confidence Interval, 1.32‐3.08) following...
Thu Jul 04, 2019 18:34
Abstract Incomplete recovery of sensory function is common after peripheral nerve injury (PNI). Despite reinnervation following injury, disorganized cortical representations persist and may contribute to functional deficits. There is a dearth of literature characterizing cortical responses after PNI in rodent models. Here we develop a quantitative electrophysiological method for mapping forepaw digit responses in primary somatosensory cortex (S1) of rats. We tested the hypothesis...
Thu Jul 04, 2019 03:00
Publication date: Available online 3 July 2019Source: Journal of Neuroscience MethodsAuthor(s): Dhanya Parameshwaran, Narayan P. Subramaniyam, Tara C. ThiagarajanAbstractBackgroundEEG represents a cost-efficient mechanism to evaluate brain function. To realize this potential, it is essential to identify aspects of the signal that provide insight into differences in cognitive, emotional and behavioral outcomes and can therefore aid in diagnostic measurement. Here we define a new metric of the EEG...
Thu Jul 04, 2019 17:59
Abstract Purpose Cerebellar mutism syndrome (CMS) is a serious source of morbidity following posterior fossa surgery in the pediatric population. However, methods for effectively decreasing its incidence and impact remain unclear. It is our aim to examine the impact of adjusting surgical factors, namely the use of a telovelar approach and avoidance of cavitronic ultrasonic aspirator, on the incidence of CMS in our population as well as...
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Working with animal models and analyzing human genetic information, researchers discover how one gene may be key to the development of autism.
Thu Jul 04, 2019 18:00
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