Medicinal Chemistry. Year 2019 Issue 03 is now available on CAOD.

In this issue: Concise elucidation of coordinating PD and PK based upon biological principles (生物学导向协调药效和药代的药物设计) GUO Zong-ru, ,Institute of Material Medica,Chinese Academy of Medical Sciences and Peking Medical College, , ...... page:167-174 Synthesis and antitumor activity in vitro of novel PARP-1 inhibitors (新型PARP-1抑制剂的合成及体外抗肿瘤活性研究) KUANG Yuan-jie, ,BAO Gang, ,WANG Xiao-long, ,XUE Xin, ,School of Pharmacy,Nanjing University of Chinese Medicine, , ...... page:175-185 xi xun : shen yang yao ke da xue xue bao he zhong guo yao wu hua xue za zhi shuang shuang ru bian zhong wen he xin qi kan yao mu zong lan (喜讯:《沈阳药科大学学报》和《中国药物化学杂志》双双入编《中文核心期刊要目总览》) ...... page:185 Design,synthesis and activity evaluation of 6-chloroquinazoline PAK4 inhibitors (6-氯喹唑啉类PAK4抑制剂的设计合成及生物活性研究) CHEN Yi-xuan, ,YU Si-jia, ,ZHAO Xiang-xin, ,WANG Rui-feng, ,ZHAO Dong-mei, ,CHENG Mao-sheng, ,Key Laboratory of Structure-Based Drug Design & Discovery(Shenyang Pharmaceutical University),Ministry of Education, , ...... page:186-193 Synthesis and activity evaluation of new selective inhibitors for histone deacetylase SIRT2 (选择性组蛋白去乙酰化酶 SIRT2抑制剂的合成及活性研究) ZHANG Xing, ,LI Chao, ,XU Jia, ,ZENG Jing, ,YAN Jie, ,WANG Zhou-yu, ,YANG Ling-ling, ,College of Food and Bioengineering,Xihua University, ,College of Science,Xihua University, , ...... page:194-200 zhong guo yao wu hua xue za zhi rong huo 2018 nian du zhong guo gao xiao you xiu ke ji qi kan (《中国药物化学杂志》荣获2018年度中国高校优秀科技期刊) ...... page:200 Improved synthesis of macrolides antibiotics solithromycin (大环内酯类抗生素索利霉素的合成工艺改进) HONG Yue, ,ZHU Liang-yu, ,KONG Bo, ,ZHANG Xian, ,GONG Ping, ,ZHAO Yan-fang, ,Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University),Ministry of Education, , ...... page:201-205+244 Improved synthesis of novel CDK4/6 inhibitor abemaciclib (新型CDK4/6抑制剂abemaciclib的合成工艺改进) GU En-ke, ,ZHANG Yue, ,HU Xiao-xia, ,FENG Bai-nian, ,School of Pharmacy,Jiangnan University, , ...... page:206-210 Study on purification of preparative HPLC for solid-phase synthetic thymopentin (固相合成胸腺五肽的制备高效液相纯化工艺研究) REN Xue-lian, ,ZHAO Lin-xiang, ,LIANG Zhi-min, ,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University, ,Northeast Pharmaceutical Group Co.,Ltd., , ...... page:211-213 Synthesis of a novel antischizophrenic drug SIPI6398 and determination of key impurity methanesulfonic acid (抗精神分裂症候选新药SIPI6398的合成及其关键杂质甲磺酸的测定) ZENG Jing, ,XUE Liang-feng, ,QIAN Hao, ,CHEN Xiao-wen, ,LI Jian-qi, ,ZHOU Ai-nan, ,Novel Technology Center of Pharmaceutical Chemistry,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry, ,School of Pharmacy,Fudan University, , ...... page:214-218 Synthesis of related substances of lacosamide (拉科酰胺原料药中有关物质的合成) CHEN Meng-di, ,YANG An-jiang, ,ZHANG Xiao-qing, ,ZHANG Fu-li, ,ZHAO Chun-jie, ,School of Pharmacy,Shenyang Pharmaceutical University, ,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmacetical Industry, , ...... page:219-223 Progress on the synthesis of ursodeoxycholic acid from hyodeoxycholic acid (猪去氧胆酸合成熊去氧胆酸的研究进展) HU Xiang-zheng, ,SHI Xiao-ya, ,College of Chemical Engineering and Materials Science,Tianjin University of Science and Technology, ,College of Food Engineering and Biotechnology,Tianjin University of Science and Technology, , ...... page:224-233 Research progress on PROTAC inducing protein degradation (蛋白降解靶向嵌合体(PROTAC)的研究进展) WANG Rui-feng, ,YANG Bo-wen, ,ZHAO Dong-mei, ,CHENG Mao-sheng, ,Key Laboratory of Structure-Based Drug Design & Discovery(Shenyang Pharmaceutical University),Ministry of Education, , ...... page:234-240 Graphical synthetic routes to vonoprazan fumarate (富马酸沃诺拉赞合成路线图解) WANG Chun-yan, ,CHENG-Lei, ,WANG Xin-ping, ,TI Wen-li, , ...... page:241-244 patisiran(onpattro) (Patisiran(Onpattro)) HUANG Liancheng, ,BAO Kai, , ...... page:245 Migalastat,Galafold (米加司他) TAN Xiaoyu, ,HU Chun, , ...... page:246 Stiripentol,Diacomi (司替戊醇) WU Mengtong, ,SUN Tiemin, , ...... page:247 eravacycline(xerava) (Eravacycline(Xerava)) XING Yajie, ,JIA Zuo, , ...... page:248 Doravirine,Pifeltro (多拉韦林) WANG Yanjun, ,WANG Dun, , ...... page:249 delstrigo(doravirine/tdf/lamivudine) (Delstrigo(Doravirine/TDF/Lamivudine)) ZHANG Zhenzuo, ,ZHAO Linxiang, , ...... page:250