Medical Hypotheses,

Is Ulcerative Colitis a disease of a Dysfunctional Microbiota?

Publication date: Available online 4 July 2019Source: Medical HypothesesAuthor(s): Gilles R.G. MonifAbstractUsing the gross pathology literature and the prior decoupling of Crohn’s disease from inflammatory bowel disease, IDI’s White Paper puts into question the current understanding of what ulcerative colitis is and how it can be therapeutically addressed. The pathology literature, when coupled with the ability of fecal enema therapy to achieve a remission rate significantly superior to those documented...

ScienceDirect Publication: Medical Hypotheses

Thu Jul 04, 2019 16:20

High lithium levels in tobacco may account for reduced incidences of both Parkinson’s disease and melanoma in smokers through enhanced β-catenin-mediated activity

Publication date: Available online 4 July 2019Source: Medical HypothesesAuthor(s): Thomas GuttusoAbstractParkinson’s disease (PD) patients have higher rates of melanoma and vice versa, observations suggesting that the two conditions may share common pathogenic pathways. β-catenin is a transcriptional cofactor that, when concentrated in the nucleus, upregulates the expression of canonical Wnt target genes, such as Nurr1, many of which are important for neuronal survival. β -catenin-mediated activity...

ScienceDirect Publication: Medical Hypotheses

Thu Jul 04, 2019 16:20

Are caffeine’s performance-enhancing effects partially driven by its bitter taste?

Publication date: Available online 4 July 2019Source: Medical HypothesesAuthor(s): Craig PickeringAbstractCaffeine is a well-established ergogenic aid, with its performance-enhancing effects replicated across a variety of exercise types. Caffeine exerts its performance-benefits through many mechanisms, including acting as an adenosine receptor antagonist, and serving to reduce sensations of fatigue and pain. One potential mechanism that is currently underexplored is whether caffeine’s bitter taste...

ScienceDirect Publication: Medical Hypotheses

Thu Jul 04, 2019 16:20

Apnea Events in neonatal age: a case report and literature review

Publication date: Available online 3 July 2019Source: Medical HypothesesAuthor(s): Raffaele Falsaperla, Giovanna Vitaliti, Carla Cimino, Stefano Catanzaro, Giovanni CorselloAbstractBackgroundAmong the most common autonomic signs visible in preterm neonates, apnea can represent the first sign of several neurologic and non-neurologic disorders, and seizure is a relatively infrequent cause. Herein authors present a case of neonatal autonomic apnea, discussing the polygraphic video-EEG features of this...

ScienceDirect Publication: Medical Hypotheses

Thu Jul 04, 2019 16:20