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Σάββατο 20 Ιουλίου 2019


Laboratory Evaluation of Spasmodic Dysphonia,

Publication date: Available online 6 July 2019
Source: Journal of Voice
Author(s): Sammy Othman, Srihari Daggumati, Rohan Patel, Justin Ross, Robert T. Sataloff
Summary
Objectives
To evaluate the utility of comprehensive laboratory evaluation in patients with spasmodic dysphonia (SD).
Study Design
Retrospective chart review.
Methods
A review of the medical records of 40 patients diagnosed with spasmodic dysphonia from 2009-2018 was preformed to evaluate abnormal test results that were significant when compared with abnormal results of the general population and for any other clinically relevant pathology.
Results
Erythrocyte sedimentation rate, ceruloplasmin levels, and anti-AChR were found to be elevated at levels considered statistically significant (p <0.05). Furthermore, we found levels of cholesterol, thyroid-stimulating hormone (TSH), T3, fasting blood glucose, creatine kinase, immunoglobulin, antinuclear antibody (ANA), and alpha-fetoprotein (AFP) levels to be abnormal at a greater rate in our population, but these were not statistically significant. Workup revealed several underlying conditions including thyroid neoplasms, hypothyroidism, and laryngopharyngeal reflux. Additionally, brain MRI revealed age-related ischemic pathology in an elevated number of patients, but with no obvious clinical sequalae.
Conclusion
There is an association between serological values and spasmodic dysphonia that can aid in diagnosing pathology, as well as establishing a directed workup. Additionally, our study shows the utility of comprehensive evaluation in identifying undetected disease.

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