Histone demethylases are promising therapeutic targets as they play fundamental roles for survival of Mixed lineage leukemia rearranged acute leukemia (MLLr AL). Here we focused on the catalytic Jumonji domain of histone H3 lysine 9 (H3K9) demethylase JMJD1C to screen for potential small molecular modulators from 149,519 natural products and 33,765 Chinese medicine components via virtual screening. JMJD1C Jumomji domain inhibitor 4 (JDI‐4) and JDI‐12 that share a common structural backbone were detected...
Thu Jul 04, 2019 19:14
The Mediator complex is a transcriptional regulator interacting with transcription factors and RNA‐polymerase‐II. Recently, we identified its subunit CDK19 to be specifically expressed in prostate cancer (PCa) and to be functionally implicated in PCa aggressiveness. Aim of this study was to comprehensively characterize the protein expression of CDK19 and its paralog CDK8 in PCa. We performed immunohistochemistry (IHC) for CDK19/CDK8 on a large cohort including needle biopsies from 202 patients, 799...
Thu Jul 04, 2019 18:44
Genome‐wide association studies have thus far identified 130 genetic variants linked to colorectal cancer (CRC) risk (r2<0.2). Given their implication in disease causation, and thus plausible biologically effects on cancer‐relevant biological pathways, we investigated whether these variants are associated with CRC prognosis and also whether they might provide predictive value for survival outcome. We conducted the analysis in a well‐characterised population‐based study of 5,675 patients after...
Thu Jul 04, 2019 18:42
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