IN THIS ISSUE OF JAMA, Highlights Audio Summary: ICU Delirium and PTSD, Protocolized Sepsis Care and Mortality, Time-To-Reperfusion and Stroke Outcomes, and more ORIGINAL INVESTIGATION Caring for the Critically Ill Patient Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial Regis Goulart Rosa, MD, PhD; Maicon Falavigna, MD, PhD; Daiana Barbosa da Silva, RN, MSc; et al. Earn CME credit Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families; Louise Rose, RN, MN, PhD; Fiona Muttalib, MDCM; Neill K. J. Adhikari, MDCM, MSc Caring for the Critically Ill Patient Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial Maité Garrouste-Orgeas, MD; Cécile Flahault, PhD; Isabelle Vinatier, MD; et al. Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families; Louise Rose, RN, MN, PhD; Fiona Muttalib, MDCM; Neill K. J. Adhikari, MDCM, MSc Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis Jeremy M. Kahn, MD, MS; Billie S. Davis, PhD; Jonathan G. Yabes, PhD; et al. Editor's Note: Government Regulation of Sepsis Care; Demetrios N. Kyriacou, MD, PhD Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice Reza Jahan, MD; Jeffrey L. Saver, MD; Lee H. Schwamm, MD; et al. Earn CME credit Editor's Note: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice; Christopher C. Muth, MD RESEARCH LETTER Price Increases of Protected-Class Drugs in Medicare Part D, Relative to Inflation, 2012-2017 Thomas J. Hwang, AB; Stacie B. Dusetzina, PhD; Josh Feng, PhD; et al. Association Between Declared Hurricane Disasters and Survival of Patients With Lung Cancer Undergoing Radiation Treatment Leticia M. Nogueira, PhD; Liora Sahar, PhD; Jason A. Efstathiou, MD; et al. VIEWPOINT Health Policy State Efforts to Lower Health Care Prices Paid by Private Insurers Aditi P. Sen, PhD; Amber Willink, PhD; Gerard F. Anderson, PhD Academic Medical Centers: Too Large for Their Own Health? S. Claiborne Johnston, MD, PhD Audio Interview: Academic Medical Centers—Too Large for Their Own Good? Advancing the Academic Medical Center Value Debate: Are Teaching Hospitals Worth It? Dhruv Khullar, MD, MPP; Austin B. Frakt, PhD; Laura G. Burke, MD Employ Cybersecurity Techniques Against the Threat of Medical Misinformation Eric Perakslis, PhD; Robert M. Califf, MD Preserving Civility in Vaccine Policy Discourse: A Way Forward Gregory A. Poland, MD; Jon C. Tilburt, MD; Edgar K. Marcuse, MD A PIECE OF MY MIND What’s in a Name? Jennifer Reilly Lukela, MD EDITORIAL Psychological Consequences of Admission to the ICU: Helping Patients and Families Louise Rose, RN, MN, PhD; Fiona Muttalib, MDCM; Neill K. J. Adhikari, MDCM, MSc JAMA CLINICAL CHALLENGE Dilated Pupil in a Patient With Hyperhidrosis Robert Micieli, MD; Jonathan A. Micieli, MD, CM Earn CME credit EDITOR'S NOTE Government Regulation of Sepsis Care Demetrios N. Kyriacou, MD, PhD Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice Christopher C. Muth, MD MEDICAL NEWS & PERSPECTIVES New Guidelines Aim to Expand Palliative Care Beyond Specialists Jennifer Abbasi Audio: New Guidelines Aim to Expand Palliative Care Beyond Specialists Building a Better Death, One Conversation at a Time Rebecca Voelker, MSJ NEWS FROM THE FOOD AND DRUG ADMINISTRATION Episodic Cluster Headache Antibody Therapy Feyza Sancar, PhD Cranial Nerve Stimulator for Adolescents With IBS Feyza Sancar, PhD Chemoimmunotherapy for Lymphoma Feyza Sancar, PhD GLOBAL HEALTH Containing Nipah Virus Infection Bridget Kuehn, MSJ Growing Global Alcohol Use Bridget Kuehn, MSJ; Bridget Kuehn, MSJ Reducing Cervical Cancer Deaths Bridget Kuehn, MSJ THE ARTS AND MEDICINE The Bleeding Edge: Documenting Innovation and Injury in the Medical Device Industry Akshay Pendyal, MD, MHS; Joseph S. Ross, MD, MHS POETRY AND MEDICINE Jacqui’s Comet Lisa Wiley JAMA REVISITED About Foot Wear JAMA PATIENT PAGE Steroid Side Effects Dara Grennan, MD; Sheila Wang, PharmD AUDIO Audio Summary ICU Delirium and PTSD, Protocolized Sepsis Care and Mortality, Time-To-Reperfusion and Stroke Outcomes, and more Audio Interview Academic Medical Centers—Too Large for Their Own Good? Audio New Guidelines Aim to Expand Palliative Care Beyond Specialists COMMENT & RESPONSE Intravenous Acetaminophen for Postoperative Delirium Matthew R. Wanek, PharmD, BCPS, BCCCP Intravenous Acetaminophen for Postoperative Delirium—Reply Balachundhar Subramaniam, MD, MPH; Puja Shankar, MD; Ariel Mueller, MA Cannabis as a Substitute for Opioids Charles John Gonzalez, MD; Nicole Quackenbush, PharmD; Sharon Stancliff, MD Cannabis as a Substitute for Opioids—Reply Keith Humphreys, PhD; Richard Saitz, MD Outcomes Associated With Overlapping Surgery John W. Urwin, MD; Ezekiel J. Emanuel, MD, PhD Outcomes Associated With Overlapping Surgery Azeem Tariq Malik, MBBS; Carmen E. Quatman, MD, PhD; Scott Strassels, PharmD, PhD Outcomes Associated With Overlapping Surgery—Reply Eric Sun, MD, PhD; Sachin Kheterpal, MD, MBA; Anupam B. Jena, MD, PhD CORRECTION Incorrect Data Due to Incorrect Conversion Factor Addition of Funding Source JAMA MASTHEAD JAMA