EXPLODING DROPLETS AND SINGING BUBBLES IN THERAPEUTIC ULTRASOUND K. J. Haworth1,2 1 Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA 2 Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA e-mail: hawortkn@ucmail.uc.edu Though widely used clinically for diagnostic imaging, microbubbles also provide a rich opportunity for inducing bioeffects, both intended and unintended. Phase-change agents that take advantage of acoustic droplet vaporization are particularly interesting for therapeutic applications due to their in situ ultrasound-mediated production of microbubbles. The first half of this presentation will provide a review of these applications (with a focus on the author’s humble contributions to the field), including a new subfield of localized dissolved gas scavenging. In addition to the direct mediation of therapies, the microbubbles can also be used to improve both therapeutic insonation focusing and image-guidance. Using microbubble scattering and emissions for guiding therapy will be reviewed in the second half of this presentation. In particular, passive cavitation imaging will be reviewed, including methods, applications, limitations, and future directions.