Different responses to nivolumab therapy between primary and metastatic tumors in a patient with recurrent hypopharyngeal squamous cell carcinoma
Author links open overlay panelKiminobuSatoaTakeharuOnoaFumihikoSatoaAkihikoKawaharabKoichiAzumacToshihikoKawaguchiaJunAkibabHirohitoUmenoa
a
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
b
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka, Japan
c
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Received 22 June 2019, Revised 4 July 2019, Accepted 6 July 2019, Available online 9 July 2019.
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https://doi.org/10.1016/j.oraloncology.2019.07.009Get rights and content
Abstract
We report the case of a 70-year-old man with primary and metastatic tumors, showing clinically progressive disease and complete response to nivolumab therapy, respectively. He underwent total pharyngo-laryngectomy, bilateral neck dissection, and reconstruction with free-jejunum after nivolumab therapy failure, and had no recurrent or newly arising lesions 8 months after the surgery. Immunohistochemistry analysis revealed that metastatic neck tumor with the clinical complete response to nivolumab showed higher PD-L1 expression with higher CD8+ TIL density, while primary lesion with progressive disease showed lower PD-L1 expression with lower CD8+ TIL density. This represents the first case reported on head and neck squamous cell carcinoma treated with salvage surgery after nivolumab therapy failure.
Keywords
Hypopharyngeal cancerNivolumabBio-radiotherapyPD-L1CD8+ tumor infiltrating lymphocytes
Author links open overlay panelKiminobuSatoaTakeharuOnoaFumihikoSatoaAkihikoKawaharabKoichiAzumacToshihikoKawaguchiaJunAkibabHirohitoUmenoa
a
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
b
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka, Japan
c
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Received 22 June 2019, Revised 4 July 2019, Accepted 6 July 2019, Available online 9 July 2019.
Show less
https://doi.org/10.1016/j.oraloncology.2019.07.009Get rights and content
Abstract
We report the case of a 70-year-old man with primary and metastatic tumors, showing clinically progressive disease and complete response to nivolumab therapy, respectively. He underwent total pharyngo-laryngectomy, bilateral neck dissection, and reconstruction with free-jejunum after nivolumab therapy failure, and had no recurrent or newly arising lesions 8 months after the surgery. Immunohistochemistry analysis revealed that metastatic neck tumor with the clinical complete response to nivolumab showed higher PD-L1 expression with higher CD8+ TIL density, while primary lesion with progressive disease showed lower PD-L1 expression with lower CD8+ TIL density. This represents the first case reported on head and neck squamous cell carcinoma treated with salvage surgery after nivolumab therapy failure.
Keywords
Hypopharyngeal cancerNivolumabBio-radiotherapyPD-L1CD8+ tumor infiltrating lymphocytes
Oral Oncology
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