Clinical Pharmacology. Year 2019 Issue 12 is now available on CAOD.

In this issue: kang jun yao wu xun zheng yong yao lun tan (抗菌药物循证用药论坛) ...... page:1224 Pemetrexed versus docetaxel in non-small cell lung cancer (培美曲塞注射剂与多西他赛注射剂治疗非小细胞肺癌患者的临床研究) LI Ya-fang, ,WANG Yong, ,Department of Respiratory Medicine,Shangyu People’s Hospital, ,Clinical Laboratory,Shangyu People’s Hospital, , ...... page:1227-1229 Expression of human antigen R and androgen aeceptor in prostate cancer and the relation with clinical pathology (人类抗原R和雄激素受体在前列腺癌中表达及其与临床病理的相关性) ZHANG Peng, ,XIN Shi-yong, ,WU Shuo, ,LI Liang-liang, ,GAO Zhong-wei, ,ZHANG Jian-guo, ,Department of Urology, Kaiyuan District,The First Affiliated Hospital of Henan University of Science and Technology,Clinical Medical College of Henan University of Science and Technology, , ...... page:1230-1233 Effects of PXR and PPARA genetic polymorphisms on carbamazepine concentrations in epileptic patients (核受体PXR和PPARA基因多态性对癫痫患者卡马西平血药浓度的影响) ZHU Xu, ,CHEN Ya-nan, ,LU Tong, ,PANG Lu, ,LIU Li-min, ,ZHAO Li-mei, ,Department of Pharmacy,Shengjing Hospital of China Medical University, ,School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University, , ...... page:1234-1236 Correlation between the use of antibacterial drugs and Escherichia coli resistance rate (抗菌药物使用量与大肠埃希菌耐药率相关性分析) XIE Qing, ,ZHOU Ying, ,KONG Yan, ,MA Ling-yun, ,CUI Yimin, ,Department of Pharmaceutical Administration and Clinical Pharmacy,School of Pharmaceutical Science,Peking University, ,Department of Pharmacy, Peking University First Hospital, ,Department of Pharmacy,Aerospace Center Hospital, , ...... page:1237-1240 Protective effect of ulinastatin on the newborn rat acute lung injury induced by lipopolysaccharide (乌司他丁对脂多糖致新生大鼠急性肺损伤的保护作用) LI Jun, ,JI Xiang-ling, ,SHI Xiao-jun, ,YING Zhi-Ying, ,DENG Xing-qi, ,Department of Emergency Medicine,Central Hospital of Shanghai Fengxian District Affiliated to Shanghai Health Medical College, ,Emergency Department of Critical Care Medicine,Shanghai Pudong New Area Zhoupu hospital affiliated to Shanghai Health Medical College, , ...... page:1241-1243 Effects of edaravone on proinflammatory cytokines in BV-2 microglia activated by lipopolysaccharide (依达拉奉对脂多糖激活的BV-2小胶质细胞中促炎细胞因子的影响) YU Shu-bei, ,LIN Shu, ,Department of Pharmacy, Second Affiliated Hospital of Wenzhou Medical University, , ...... page:1244-1246 Influences of atorvastatin on the Wnt/β-Catenin pathway and the expression of Nephrin induced by high glucose (阿托伐他汀对高糖诱导足细胞Wnt/β-连环蛋白通路和肾病蛋白表达的影响) CAI Zhi-gen, ,LI Yue-ting, ,LIN Wei-yuan, ,ZHANG Jie-qun, ,SHI Shan-hong, ,Department of Nephrology, Second Affiliated Hospital of Fujian Medical College, , ...... page:1247-1250 Study on the anti-inflammatory and mechanisms of the Artemisia argyi in mice (艾叶对小鼠的抗炎作用及其机制的研究) LI Li-li, ,ZANG Lin-quan, ,ZHANG Hua-xian, ,LIU Wen-xiu, ,WANG Zhi-peng, ,LIU Zi-long, ,ZHU Shu-guang, ,School of Pharmacology,Guangdong Pharmaceutical University, ,Department of Cardiothoracic Surgery,The First Affiliated Hospital Guangdong Pharmaceutical University, , ...... page:1251-1254+1259 Effect of Manshenkangning prescription on kidneys of renal interstitial fibrosis rats caused by adenine (慢肾康宁对腺嘌呤致肾间质纤维化大鼠的影响) NIE Ling-hui, ,SU Ai-shan, ,ZHU Shi-ping, ,Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute,Guangdong Second Provincial General Hospital, ,Center for Drug and Clinical Research,Southern Hospital, Southern Medical University, ,Department of Traditional Chinese Medicine, First Affiliated Hospital, Jinan University, , ...... page:1255-1259 Protective effect of ursolic acid on retinal injury in diabetic retinopathy mice (熊果酸对糖尿病视网膜病变小鼠视网膜损伤的保护作用) GONG Yi, ,WU Hai-jian, ,CHEN Zhe-Yi, ,Department of Ophthalmology,Taizhou Municipal Hospital, ,Ophthalmology Department,The Eye Hospital of Wenzhou Medical University, , ...... page:1260-1262 Effect and mechanism of exogenous NAD~+ on microglia activation-induced apoptosis of neural stem cells (外源性NAD~+对小胶质细胞激活诱导神经干细胞凋亡的作用及机制研究) LI Jing-lan, ,WANG Yu-hang, ,LI Zhi-lei, ,WANG Yong, ,Department of Pharmacy, Zhujiang Hospital, Southern Medical University, , ...... page:1263-1265+1277 Effect of recombinant human tumor necrosis factor in combination with cyclophosphamide on glioma (重组人肿瘤坏死因子-α联合环磷酰胺对胶质瘤的作用) GUO Cheng-yong, ,YANG Ji-peng, ,LIANG Zhao-hui, ,NAN Cheng-rui, ,FAN Bo, ,LIU Li-qiang, ,Department of Neurosurgery,The Second Hospital of Hebei Medical University, , ...... page:1266-1268 Effect of rapamycin on proliferation of nasopharyngeal cancer stem cells (雷帕霉素对鼻咽癌肿瘤干细胞增殖的影响) SONG Wei, ,CUI Yun, ,ZHANG Jian-bo, ,SUN Miao-miao, ,XIA Qing-xin, ,Tumor Hospital Affiliated to Zhengzhou University,Department of Pathology, ,Tumor Hospital Affiliated to Zhengzhou University,Department of Integrated Traditional Chinese and Western Medicine, , ...... page:1269-1271 Effects of salinomycin on the radiotherapy sensitivity of nasopharyngeal carcinoma cells (盐霉素对鼻咽癌细胞放疗敏感性的影响) LI Meng-ting, ,LIU Chang-lin, ,XU Hua, ,WANG Yang, ,Department of Pharmacy, Wuhan Children’s Hospital, Tongji Medical College,Huazhong University of Science and Technology, , ...... page:1272-1274 Effect of platycodin D on the proliferation,invasion and migration capacity of gastric cancer BGC823 cell (桔梗皂苷-D对胃癌BGC823细胞增殖、侵袭及迁移能力的影响) SI Xian-ke, ,YANG Jia-hua, ,LI Wei, ,ZHANG Ji-xun, ,CAO Yi-jun, ,Department of General Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, , ...... page:1275-1277 Effect of baicalin on the human gastric carcinoma MGC-803 cell apoptosis and the expression of apoptosis related genes (黄芩苷对人胃癌MGC-803细胞凋亡及相关凋亡基因表达的影响) LIN Fang-de, ,HUANG Bo, ,Department of General Surgery,People’s Hospital of Wenchang, , ...... page:1278-1280 Squamocin inhibits proliferation and invasion of gastric cancer cell line MGC803 by downregulation of the MYH-9 protein expression (番荔枝内酯单体squamocin下调MYH-9蛋白表达抑制胃癌MGC803细胞侵袭) LIU Jia-xin, ,LIU Dong-bing, ,WANG Xin-yan, ,XU Su, ,Department of Gastroenterology,Huzhou Traditional Chinese Medicine Hospital, , ...... page:1281-1283 Effect of cornel polysaccharide on the proliferation of human cervical carcinoma HeLa cells (山茱萸多糖对宫颈癌HeLa细胞增殖的影响) WANG Zhi-jun, ,LI Jin, ,DENG Cheng-huan, ,Department of Obstetrics and Gynecology,The 307th Hospital of the Chinese People’s Liberation Army, ,Department of Pathology,The 307th Hospital of the Chinese People’s Liberation Army, , ...... page:1284-1286 Study on hemostatic effect of the Pegaeophyti Radix Et Rhizoma (高山辣根菜的止血效果研究) LONG Hai-chun, ,HU Xuan-kai, ,WEI Qiao, ,WEI Yu-xia, ,HUANG Jin-li, ,LIU Qian, ,HUANG Suo-yi, ,College of Clinical Medicine,Youjiang Medical University for Nationalities, ,Science Experiment Center,Youjiang Medical University for Nationalities, ,Key Laboratory of Guangxi’s College for The Study of Characteristic Medicine in Youjiang River Basin, , ...... page:1287-1288+1302 Pharmacokinetics and pharmacodynamic studies of S-(-)-pantoprazole sodium injections in healthy subjects (注射用左旋泮托拉唑钠在健康受试者体内的药代动力学和药效学研究) LI Xiao-yu, ,XIANG Rong-feng, ,FENG Wei, ,YU Ming-jie, ,XIONG Li-rong, ,SUN Feng-jun, ,CHENG Lin, ,WANG Yu, ,FU Pei-shu, ,CHEN Yong-chuan, ,Department of Pharmacy,the First Affiliated Hospital of Army Medical University, ,Department of Pharmacy, Handan Branch of Chinese People ’s Liberation Army 980 Hospital, , ...... page:1289-1293 Determination of zolpidem tartrate,zaleplon and zopiclone in human plasma by UPLC-MS/MS (UPLC-MS/MS法测定人血浆中唑吡坦、扎来普隆及佐匹克隆的浓度) AN Jing, ,XUE Chao-jun, ,DONG Zhan-jun, ,Department of Pharmacy,Hebei General Hospital, , ...... page:1294-1297 Status analysis of clinical application and acute renal injury monitoring of vancomycin in some areas of China (万古霉素的临床应用及急性肾损伤监测现状分析) ZHOU Ying, ,LIU Xiao, ,MA Ling-yun, ,CHEN Chao-yang, ,YANG Ting, ,ZHANG Xiang-lin, ,CHEN Wen-qian, ,CUI Yi-min, ,YANG Li, ,Department of Pharmacy,Peking University First Hospital, ,Department of Pharmacy,China-Japan Friendship Hospital, ,Department of Nephrology,Peking University First Hospital, , ...... page:1298-1302 Triglyceride change on placebo during phase Ⅰ trials (在新药Ⅰ期临床试验中安慰剂引起的三酰甘油变化) XIE Ran, ,ZHAO Xia, ,ZHANG Yan, ,LIANG Yan, ,ZHAO Nan, ,XU Jun-yu, ,SHENG Xiao-yan, ,WANG Zi-ning, ,CUI Yi-min, ,Department of Pharmacy,Peking University First Hospital, ,Department of Cardiology,Peking University First Hospital, , ...... page:1303-1305 The management and quality control of investigational products (临床试验用药物的质量控制) ZHOU Xin-na, ,WANG Shu-mei, ,XIE Zheng-zheng, ,SUN Lu-lu, ,REN Jun, ,Medical Oncology Department,Beijing Shijitan Hospital, Capital Medical University, ,Center of Drug Clinical Trials,Beijing Shijitan Hospital, Capital Medical University, ,Department of Pharmacy,Beijing Shijitan Hospital, Capital Medical University, , ...... page:1306-1307 Research progress of the regulation mechanism of inflammatory factors and signaling pathways in osteoarthritis of the knee (炎症因子与炎症因子相关信号通路在膝骨关节炎中的调控机制研究进展) HE Juan-juan, ,YAN Chun-lu, ,AN Fang-yu, ,LI Sheng-hua, ,ZHANG Yan-xia, ,ZHAO Lei, ,YANG Xiao-rong, ,CHENG Xin-ping, ,JIN An-shun, ,College of Clinical Medicene,Gansu University of Traditional Chinese Medicine, ,Key Laboratory of Dunhuang Medicine, Ministry of Education, ,Key Laboratory of Medicinal Chemistry and Quality Research,Colleges of Gansu Province, , ...... page:1308-1311 Research status in regulations of drug metabolic enzymes and transporters by baicalin (黄芩苷对药物代谢酶和转运体影响的研究现状) ZHANG Jia-li, ,TIAN Xin, ,KAN Quan-cheng, ,Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, , ...... page:1312-1315+1320 Introduction to the guidance for industry on adaptive designs for clinical trials of drugs and biologics issued by FDA (对美国FDA适应性设计指导原则的介绍) HENG Ming-li, ,WANG Bei-qi, ,WANG Jun, ,Center for Drug Evaluation,National Medical Products Administration, , ...... page:1316-1320