Related ArticlesDihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d]pyrimidines: Synthesis, antitumor activity and molecular modeling study. Bioorg Chem. 2019 Jun 18;90:103076 Authors: Abdelaziz OA, El Husseiny WM, Selim KB, Eisa HM Abstract A new series of pyrido[2,3-d]pyrimidines 3-18 bearing substitution at C-5 position was synthesized. All compounds were tested for their in vitro antitumor activity against five human cancer cell...
Related ArticlesThe role of Beclin 1 in IR-induced crosstalk between autophagy and G2/M cell cycle arrest. Cell Signal. 2019 Jun 28;:109353 Authors: Liang N, Liu X, Zhang S, Sun H Abstract OBJECTIVES: Beclin 1 is a well-established core mammalian autophagy protein. Autophagy has been demonstrated to play roles in cellular responses to DNA damage, such as cell cycle regulation and apoptosis. In the present study, we investigated the exact mechanism by...
Related ArticlesMG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 28;:109684 Authors: Guan F, Zhou X, Li P, Wang Y, Liu M, Li F, Cui Y, Huang T, Yao M, Zhang Y, Ma J, Ma S Abstract Neuroinflammation plays important roles in the pathogenesis and development of neurodegenerative disorders. Lipopolysaccharide (LPS) induces...
Related ArticlesInhibition of cyclin-dependent kinase activity exacerbates H2 02 -induced DNA damage in Kindler syndrome keratinocytes. Exp Dermatol. 2019 Jul 01;: Authors: Emmert H, Culley J, Brunton VG Abstract Kindler Syndrome (KS) is an autosomal recessive skin disorder characterized by skin blistering and photosensitivity. KS is caused by loss of function mutations in FERMT1, which encodes Kindlin-1. Kindlin-1 is a FERM domain containing adaptor...
Related ArticlesEmbryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PLoS One. 2019;14(7):e0219221 Authors: Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW Abstract Cul4b-null (Cul4bΔ/Y) mice undergo growth arrest and degeneration during the early embryonic stages and die at E9.5. The pathogenic causes of this lethality remain incompletely characterized. However, it has been hypothesized that the loss...
Related ArticlesEffects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines. Acta Pharm. 2019 Mar 01;69(1):75-86 Authors: Sabran A, Kumolosasi E, Jantan I Abstract Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC). Cells were treated...
Related ArticlesThe antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ. Acta Pharm. 2019 Mar 01;69(1):111-119 Authors: Wang X, Huang S, Xin X, Ren Y, Weng G, Wang P Abstract Umbelliferone exhibits extensive pharmacological activity, including anti-immunomodulatory, anti-inflammatory and antigenotoxicity activities. However, its antitumor properties still remain unclear in human renal...
Related ArticlesLNC CRYBG3 inhibits tumor growth by inducing M phase arrest. J Cancer. 2019;10(12):2764-2770 Authors: Mao W, Guo Z, Dai Y, Nie J, Li B, Pei H, Zhou G Abstract Long noncoding RNAs (lncRNAs) are usually associated with tumor development and progression and some of them are dysregulated in various human cancers. The mechanisms underlying their dysregulation are worth further study. Here, we demonstrate that the expression level of LNC CRYBG3...
Related ArticlesApplication of p16/Ki-67 dual-staining cytology in cervical cancers. J Cancer. 2019;10(12):2654-2660 Authors: Yu L, Fei L, Liu X, Pi X, Wang L, Chen S Abstract Cytology-based Papanicolaou test on and primary HPV screening have been widely used in the identification of cervical cancer and precancerous lesions, which is of great significance for the prevention and treatment of cervical cancer. Patients diagnosed as ASCUS/LSIL usually need...
Related ArticlesThe oncogenic potential of PRR11 gene in Tongue Squamous Cell Carcinoma cells. J Cancer. 2019;10(11):2541-2551 Authors: Wang C, Yu L, Ren X, Wu T, Chen X, Huang Y, Cheng B Abstract Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism...
Related ArticlesCordycepin Induces Apoptosis and G2/M Phase Arrest through the ERK Pathways in Esophageal Cancer Cells. J Cancer. 2019;10(11):2415-2424 Authors: Xu JC, Zhou XP, Wang XA, Xu MD, Chen T, Chen TY, Zhou PH, Zhang YQ Abstract Esophageal cancer is one of the most aggressive and lethal gastrointestinal tract malignancies, with a poor overall five-year survival rate. Cordycepin, a major compound of Cordyceps sinensis, has been shown to have anticancer...
Related ArticlesMUS81 Inhibition Increases the Sensitivity to Therapy Effect in Epithelial Ovarian Cancer via Regulating CyclinB Pathway. J Cancer. 2019;10(10):2276-2287 Authors: Zhong A, Zheng H, Zhang H, Sun J, Shen J, Deng M, Chen M, Lu R, Guo L Abstract MUS81 is a key endonuclease involved in homologous recombination (HR) repair after DNA double-strand damage. Structure-specific endonucleases (SSEs) plays a crucial role in DNA replication, repair...
Related ArticlesUBE2C overexpression in melanoma and its essential role in G2/M transition. J Cancer. 2019;10(10):2176-2184 Authors: Liu G, Zhao J, Pan B, Ma G, Liu L Abstract Ubiquitin‑conjugating enzyme E2C (UBE2C) is a key regulator of cell cycle progression, and its aberrant expression has been implicated in various malignancies. However, its clinical and biological roles in malignant melanoma is still unclear. In this study, we found a significant...
Related ArticlesArsenic trioxide and tetraarsenic oxide induce cytotoxicity and have a synergistic effect with cisplatin in paclitaxel-resistant ovarian cancer cells. Acta Oncol. 2019 Jul 01;:1-9 Authors: Byun JM, Lee DS, Landen CN, Kim DH, Kim YN, Lee KB, Sung MS, Park SG, Jeong DH Abstract Background: Arsenic compounds (As2O3 and As4O6) have demonstrated anticancer effects in various malignancies. In this study, the cytotoxicity of arsenic compounds...
Related ArticlesKnockdown of GC binding factor 2 by RNA interference inhibits invasion and migration of vascular smooth muscle cells. Mol Med Rep. 2019 Jun 21;: Authors: Ma Y, Ren Y, Guan J Abstract GC binding factor 2 (GCF2) is a transcriptional repressor that inhibits the transcription of GC‑rich promoters, thereby regulating biological processes, including proliferation. However, the role of GCF2 in vascular smooth muscle cells (VSMCs) remains unclear....
Related ArticlesPropionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer. Mol Med Rep. 2019 Jun 26;: Authors: Kim K, Kwon O, Ryu TY, Jung CR, Kim J, Min JK, Kim DS, Son MY, Cho HS Abstract Short‑chain fatty acids (SCFAs; butyrate, propionate and acetate) are metabolites derived from the gut microbiota via dietary fiber fermentation. In colon cancer, treatment with SCFAs, mainly butyrate and propionate, suppresses...
Related ArticlesBenzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway. Mol Med Rep. 2019 Jun 18;: Authors: Xie B, Zhao L, Guo L, Liu H, Fu S, Fan W, Lin L, Chen J, Wang B, Fan L, Wei H Abstract Benzyl isothiocyanate (BITC) has been reported to exhibit antitumor properties in various cancer types; however, the underlying mechanisms of its action remain unclear. In the present study,...
Related ArticlesIdentification of key pathways and genes in different types of chronic kidney disease based on WGCNA. Mol Med Rep. 2019 Jun 28;: Authors: Guo Y, Ma J, Xiao L, Fang J, Li G, Zhang L, Xu L, Lai X, Pan G, Chen Z Abstract Chronic kidney disease (CKD) is a highly heterogeneous nephrosis that occurs when the structure and function of the kidney is damaged. Gene expression studies have been widely used to elucidate various biological processes;...
Related ArticlesNME4 may enhance non‑small cell lung cancer progression by overcoming cell cycle arrest and promoting cellular proliferation. Mol Med Rep. 2019 Jun 24;: Authors: Wang W, Dong M, Cui J, Xu F, Yan C, Ma C, Yi, Tang W, Dong J, Wei Y Abstract Nucleoside diphosphate kinase 4 (NME4) is abnormally expressed in a variety of cancer types. However, the function of the NME4 gene in non‑small cell lung cancer (NSCLC) remains to be elucidated. In...
Related ArticlesBetaine alleviates high glucose‑induced mesangial cell proliferation by inhibiting cell proliferation and extracellular matrix deposition via the AKT/ERK1/2/p38 MAPK pathway. Mol Med Rep. 2019 Jun 18;: Authors: Li X, Wang L, Ma H Abstract Diabetic nephropathy (DN) is a major cause of chronic renal failure in diabetic patients worldwide. Betaine, a zwitterionic quaternary ammonium salt compound, is involved in numerous biological processes....
Related ArticlesBubR1 Is Essential for Thio-Dimethylarsinic Acid-Induced Spindle Assembly Checkpoint and Mitotic Cell Death for Preventing the Accumulation of Abnormal Cells. Biol Pharm Bull. 2019;42(7):1089-1097 Authors: Kita K, Imai Y, Asaka N, Suzuki T, Ochi T Abstract Thio-dimethylarsinic acid (thio-DMA) was detected in human urine after exposure to inorganic arsenic and arsenosugars consumed by marine algae. Our previous studies have shown that...
Related Articles1,3-dimethyl-6-nitroacridine derivatives induce apoptosis in human breast cancer cells by targeting DNA. Drug Dev Ind Pharm. 2019 Feb;45(2):212-221 Authors: Zhou Q, Wu H, You C, Gao Z, Sun K, Wang M, Chen F, Sun B Abstract The acridine derivatives can interact with the double-stranded DNA, which is regarded as the biological target of the anticancer drugs in cancer treatment. We designed and synthesized a new series of 1,3-dimethyl-6-nitroacridine...
Related ArticlesSumoylation promotes optimal APC/C Activation and Timely Anaphase. Elife. 2018 03 08;7: Authors: Lee CC, Li B, Yu H, Matunis MJ Abstract The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin E3 ligase that functions as the gatekeeper to mitotic exit. APC/C activity is controlled by an interplay of multiple pathways during mitosis, including the spindle assembly checkpoint (SAC), that are not yet fully understood. Here, we...
Related ArticlesAlterations in the host transcriptome in vitro following Rift Valley fever virus infection. Sci Rep. 2017 10 30;7(1):14385 Authors: Pinkham C, Dahal B, de la Fuente CL, Bracci N, Beitzel B, Lindquist M, Garrison A, Schmaljohn C, Palacios G, Narayanan A, Campbell CE, Kehn-Hall K Abstract Rift Valley fever virus (RVFV) causes major outbreaks among livestock, characterized by "abortion storms" in which spontaneous abortion occurs in almost...
Related ArticlesExtraction, isolation and in vitro evaluation of affinisine from Tabernaemontana catharinensis in human melanoma cells. Bioorg Chem. 2019 Jun 19;90:103079 Authors: Fagundes Rosales P, Gower A, Lucia Ruiz Benitez M, Silveira Pacheco B, Vieira Segatto N, Roesch-Ely M, Collares T, Kömmling Seixas F, Moura S Abstract Plant compounds have been identified as new drug prototypes. In this line, this work aimed to isolate the indole alkaloid affinisine...
Related ArticlesSNHG5 Promotes Breast Cancer Proliferation by Sponging the miR-154-5p/PCNA Axis. Mol Ther Nucleic Acids. 2019 Jun 04;17:138-149 Authors: Chi JR, Yu ZH, Liu BW, Zhang D, Ge J, Yu Y, Cao XC Abstract Breast cancer is the most common malignant tumor and the main cause of cancer-associated mortality in females worldwide. Long non-coding RNAs (lncRNAs) have been reported to play vital roles in breast cancer development and progression; however,...
Related ArticlesDDT exposure induces cell cycle arrest and apoptosis of skin fibroblasts from Indo-Pacific humpback dolphin via mitochondria dysfunction. Aquat Toxicol. 2019 Jun 19;213:105229 Authors: Yu X, Yu RQ, Zhang X, Zhan F, Sun X, Wu Y Abstract Although the global use of the 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (p,p'-DDT) has been prohibited, its persistence in the environment has caused long-lasting exposure on marine mammals. Our...
Related ArticlesPreclinical Combination Studies of an FGFR2 Targeted Thorium Conjugate and the ATR Inhibitor BAY 1895344. Int J Radiat Oncol Biol Phys. 2019 Jun 27;: Authors: Wickstroem K, Hagemann UB, Kristian A, Ellingsen C, Sommer A, Ellinger-Ziegelbauer H, Wirnitzer U, Hagelin EM, Larsen A, Smeets R, Bjerke RM, Karlsson J, Ryan OB, Wengner AM, Linden L, Mumberg D, Cuthbertson AS Abstract PURPOSE: Fibroblast growth factor receptor 2 (FGFR2) has been...
Related ArticlesNeferine and isoliensinine enhance 'intracellular uptake of cisplatin' and induce 'ROS-mediated apoptosis' in colorectal cancer cells - A comparative study. Food Chem Toxicol. 2019 Jun 27;:110652 Authors: Manogaran P, Beeraka NM, Huang CY, Vijaya Padma V Abstract Cisplatin (CDDP) is a potent platinum-based chemotherapeutic agent used to treat solid tumors including colorectal cancer via inducing cytotoxicity. CDDP usage is limited due...
Related ArticlesTetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells. Chem Biol Interact. 2019 Jun 27;:108726 Authors: Xu W, Wang X, Tu Y, Masaki H, Tanaka S, Onda K, Sugiyama K, Yamada H, Hirano T Abstract Tetrandrine (TET) and cepharanthine (CEP) are two bisbenzylisoquinoline alkaloids isolated...
Related ArticlesPRKDC is a prognostic marker for poor survival in gastric cancer patients and regulates DNA damage response. Pathol Res Pract. 2019 Jun 20;:152509 Authors: Zhang Y, Wen GM, Wu CA, Jing ZL, Li DZ, Liu GL, Wei XX, Tang MS, Li YH, Zhong Y, Deng YJ, Yang WK Abstract A hallmark of gastric cancer is the high rate of genomic instability associated with deregulation of DNA damage repair pathways. DNA-Dependent Protein Kinase Catalytic Subunit...
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