Cancer Treatment Reviews

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

Publication date: Available online 27 June 2019Source: Cancer Treatment ReviewsAuthor(s): Daniela Rodrigues, Terezinha Souza, Danyel G.J. Jennen, Lieve Lemmens, Jos C.S. Kleinjans, Theo M. de KokAbstractOne of the major complications that patients experience during pharmacological treatment is the occurrence of adverse drug reactions (ADRs). The most affected organs are the liver, kidney, heart and the gastrointestinal-immune system. In comparison to the other organs, less progress has been made...

ScienceDirect Publication: Europ...

Fri Jun 28, 2019 17:58

Checkpoint inhibitors in pancreatic cancer

Publication date: Available online 27 June 2019Source: Cancer Treatment ReviewsAuthor(s): Andreas Henriksen, Anne Dyhl-Polk, Inna Chen, Dorte NielsenAbstractIntroductionImmune checkpoint inhibitors, targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and the programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathways have shown remarkable potential in several types of cancer. In this review we summarize published and ongoing studies on checkpoint inhibitors in...

ScienceDirect Publication: Europ...