British Journal of Dermatology

Skin fragility caused by biallelic KRT10 mutations: an intriguing form of self‐improving epidermolytic ichthyosis

L. Frommherz, J. Küsel, A. Zimmer, J. Fischer, C. Has

First Published: 06 July 2019

Years Lost Due to Disability from Skin Diseases in China 1990‐2017: Findings from the Global Burden of Disease Study 2017

W. Dong, J. An, P. Geng, X. Zeng, Y. Chen, Z. Zhao, M. Zhou

First Published: 06 July 2019

Quality of life and psychological impact in the photodermatoses: a systematic review

K.J. Rutter, I. Ashraf, L. Cordingley, L.E. Rhodes

First Published: 06 July 2019

Challenges in the diagnosis of primary cutaneous CD30+ anaplastic large‐cell lymphoma

G. Dobos, M. Battistella, F. Jouenne, S. Mourah, M.D. Vignon‐Pennamen, C. Ram‐Wolff, F. Herms, J.N. Dauendorffer, J. Rivet, J.M. Cayuela, J.D. Bouaziz, P. Brice, C Lebbé, M. Bagot, A. de Masson

First Published: 06 July 2019

Comparable Efficacy and Safety of Brodalumab in Obese and Non‐Obese Patients With Psoriasis: Analysis of 2 Randomized Controlled Trials

S. Hsu, L.J. Green, M.G. Lebwohl, J.J. Wu, A. Blauvelt, A.A. Jacobson

First Published: 05 July 2019

Generalized skin hyperpigmentation as the only manifestation of X‐linked adrenoleukodystrophy

H. Lee, J.M. Ko, S.‐H. Lee

First Published: 03 July 2019

Defining Lesional, Perilesional and Unaffected Skin in Hidradenitis Suppurativa: Proposed Recommendations for Clinical Trials and Translational Research Studies

J.W. Frew, K. Navrazhina, A.S. Byrd, A. Garg, J.R. Ingram, J.S. Kirby, M.A. Lowes, H. Naik, V. Piguet, E.P. Prens

First Published: 03 July 2019

Clinical characteristics of primary cutaneous lymphoma: two centers analysis in China

S. Hao‐ze, Y.‐X. Liu, Y.‐Q. Jiang, S.‐L. Chen, X.‐L. Xu, X.‐M. Lu, W. Zhang, X.‐S. Zeng, G.‐Z. Zhou, J.‐F. Sun, H. Chen

First Published: 01 July 2019

Pediatric lichen sclerosus: A systematic review of 4516 cases

G. Balakirski, J. Grothaus, J. Altengarten, H. Ott

First Published: 01 July 2019

Increasing severity of atopic dermatitis is associated with a negative impact on work productivity among adults with atopic dermatitis in France, Germany, the UK and the US

L. Andersen, M.E. Nyeland, F. Nyberg

First Published: 01 July 2019

Responsiveness and interpretability of the Hand Eczema Severity Index (HECSI)

J.A. F Oosterhaven, M.L. A Schuttelaar

First Published: 01 July 2019

Individual and hospital‐level factors associated with epidermal necrolysis mortality: a Nationwide Multi‐Level Study, France, 2012‐2016

C. Traikia, C. Hua, L. Le Cleach, N. de Prost, F. Hemery, O. Chosidow, P. Wolkenstein, S. Ingen‐Housz‐Oro, E. Sbidian

First Published: 01 July 2019

Cross‐sectional screening study for leishmania DNA and antibodies in biologic‐treated psoriasis patients living in an area endemic for leishmaniasis

P.S. Kurizky, C.M. Gomes, M.V. Cesetti, G.A. Martins, N.A.T. Regattieri, F.F. Marianelli, L. Sevilha Santos, V. Medeiros Silva, N.A. de Paula, M.A.C. Frade, E. Freitas, L.M.H. da Mota

First Published: 01 July 2019

Three novel mutations in GPNMB in two pedigrees of Amyloidosis Cutis Dyschromica

J. Wang, Y. Li, L, Xing, M. Zhao, S. Zhang, Z. Li, Z. Yao, M. Li

First Published: 01 July 2019

Rapid Response of Pityriasis Rubra Pilaris with Psoriasis Overlap to Secukinumab

D. Cole, T. Mohammed, H. Lim

First Published: 01 July 2019

Topical treatments in atopic dermatitis: unexpectedly low use of emollients; use of topical corticosteroid is higher in juvenile patients, higher in male vs females, and shows independent associations with asthma and depression

J.Y. Choi, R. Dawe, S. Ibbotson, C. Fleming, A. Doney, J. Foerster

First Published: 30 June 2019

No evidence for viral transcripts in dermatofibrosarcoma protuberans

A. Du‐Thanh, P. Pérot, V. Foulongne, O. Dereure, B. Guillot, M. Eloit

Version of Record online: 04 July 2019

 Open Access

Assessment of the effects of immunogenicity on the pharmacokinetics, efficacy and safety of tildrakizumab

A.B. Kimball, T. Kerbusch, F. van Aarle, P. Kulkarni, Q. Li, A. Blauvelt, K.A. Papp, K. Reich, D. Montgomery

Version of Record online: 04 July 2019

What's already known about this topic?

• Unwanted immune responses – for example immunogenicity and antidrug antibodies (ADAs) – have been observed with therapeutic monoclonal antibodies and can affect efficacy and safety.
• Tildrakizumab is a humanized monoclonal antibody targeting interleukin‐23 and is currently approved for patients with plaque psoriasis.

What does this study add?

• ADA development in tildrakizumab‐treated patients with psoriasis over 52 weeks was low.
• The small proportion of patients who had treatment‐emergent ADAs and had neutralizing antibodies experienced lower serum tildrakizumab concentrations and reduced efficacy.
• No relationship between ADAs and safety events was observed.

Respond to this article

Factors influencing prognosis for occupational hand eczema: new trends

C.M. Olesen, T. Agner, N.E. Ebbehøj, T.K. Carøe

Version of Record online: 02 July 2019

What's already known about this topic?

• Occupational hand eczema has a relapsing course and a poor overall prognosis.
• Atopic dermatitis and contact sensitization have previously been reported as risk factors for a poor prognosis.

What does this study add?

• The results indicate that lifestyle factors are of importance for the prognosis of occupational hand eczema.
• Traditionally reported risk factors such as atopic dermatitis and contact sensitization do not currently influence prognosis.

Respond to this article

Image Gallery: Squamous cell carcinoma arising from chronic radiodermatitis

J.‐W. Liu, W. Liu, Y.‐T. Qian, D.‐L. Ma

Version of Record online: 02 July 2019

Do sunscreens block vitamin D production? A critical review by an international panel of experts

D.D. Bikle

Version of Record online: 01 July 2019

Chronic tissue damage: a common pathomechanism of genodermatoses

C. Has

Version of Record online: 01 July 2019

 Open Access

Clinical response of psoriasis to subcutaneous methotrexate correlates with inhibition of cutaneous T helper 1 and 17 inflammatory pathways

K. Reich, J.L.K. Reich, T.M. Falk, N. Blödorn‐Schlicht, U. Mrowietz, R. von Kiedrowski, C. Pfeiffer, J. Niesmann, Y. Frambach, R.B. Warren

Version of Record online: 01 July 2019

Presence of anti‐BP180 and anti‐BP230 in the cerebrospinal fluid of patients with bullous pemphigoid and neurological disease: is there any intrathecal synthesis?

L. Meudec, R. Amode, F. Brunet‐Possenti, S. Mignot, V. Descamps

Version of Record online: 01 July 2019

 Open Access

Investigating the beneficial experiences of online peer support for those affected by alopecia: an interpretative phenomenological analysis using online interviews

L.L. Iliffe, A.R. Thompson

Version of Record online: 01 July 2019

What's already known about this topic?

• Alopecia may be associated with psychosocial distress due to both the individual impact and the reactions of others.
• Online peer support is known to be a beneficial method of providing psychosocial support for people living with a range of health conditions.

What does this study add?

• An in‐depth view of the benefits experienced through belonging to an online peer support group for those diagnosed with alopecia, in addressing the psychosocial effects experienced with the condition.
• This research highlights the need for further investigation of the utility of supporting the development of online peer support for people living with skin conditions.
• Online peer support groups could be highly effective to use in combination with existing psychological therapies to connect others with shared experience.

What are the clinical implications of this work?

• People living with alopecia can benefit from peer support, and healthcare professionals should ensure that patients know where they can gain access to both psychological support and peer support.

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The role of misclassification of exposure in the association between aspirin and nonsteroidal anti‐inflammatory drug use and keratinocyte cancers

S. Abtahi, O.A. Oshagbemi, A. van Veelen, R.M.J.M. van Geel

Version of Record online: 01 July 2019

Mosaicism: time matters

A. Torrelo

Version of Record online: 01 July 2019