Behavioural Brain Research

Hearing loss as a risk factor for cognitive impairment and loss of synapses in the hippocampus

Publication date: Available online 2 July 2019Source: Behavioural Brain ResearchAuthor(s): Munyoung Chang, Haeng Jun Kim, Inhee Mook-Jung, Seung-ha OhAbstractAlthough epidemiological studies have identified an association between hearing loss and cognitive impairment, there is a lack of biological evidence detailing the mechanisms underlying this association. The present study investigated the effects of hearing loss on cognitive impairment using an at-risk model. In this animal model, amyloid-β...

Behavioural Brain Research

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Reversal of ultrasonic vocalization deficits in a mouse model of Fragile X Syndrome with minocycline treatment or genetic reduction of MMP-9

Publication date: Available online 2 July 2019Source: Behavioural Brain ResearchAuthor(s): Maximiliano A. Toledo, Teresa H. Wen, Devin K. Binder, Iryna M. Ethell, Khaleel A. RazakAbstractFragile X Syndrome (FXS) is a leading genetic cause of autism and intellectual disabilities. The Fmr1 knockout (KO) mouse is a commonly studied pre-clinical model of FXS. Adult male Fmr1 KO mice produce fewer ultrasonic vocalizations (USVs) during mating, suggestive of abnormal social communication. Minocycline treatment...

Behavioural Brain Research

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<span class="small-caps">How and Why the Brain Evolves Time</span>

Publication date: Available online 2 July 2019Source: Behavioural Brain ResearchAuthor(s): P.A. HancockAbstractThe present work evaluates the proposition that the dimension of time is iatrogenically created. That is, time is a property that necessarily emerges alongside the genesis of living systems. Humans, as the most complex known expression of such living creatures, exhibit the most intricate and sophisticated incarnation of this fabricated temporality. Evidence is considered to support this...

Behavioural Brain Research

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Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged <em>Octodon degus</em>

Publication date: Available online 30 June 2019Source: Behavioural Brain ResearchAuthor(s): Cristina Estrada, Lorena Cuenca, Lorena Cano-Fernandez, Ana Luisa Gil-Martinez, Consuelo Sanchez-Rodrigo, Emiliano Fernandez-Villalba, Maria Trinidad HerreroAbstractSleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer’s disease (AD)....

Behavioural Brain Research

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