In western countries, lower back pain (LBP) is one of the most common disorders, experienced by more than 80% of the population. Chronic LBP due to disc degeneration has been linked to ongoing inflammatory processes in the disc and endplates. Pain effects the body in different ways, inducing a general stress response in which the body responds by releasing the stress hormone cortisol. Little is known about the impact of pain-induced stress on the progression of disc degeneration. Thus, the effects...
Wed Jul 03, 2019 16:43
In the field of wound healing, stem cell-based strategies are gaining importance for their regenerative potential. Adipose-derived stem cells (ADSCs) are a particular subset of mesenchymal stem cells present in the stromal-vascular fraction of the adipose tissue, today considered very attractive for their relative abundance and accessibility in the human body. However, ADSCs are still not routinely used in normal clinical practice. Several studies have also reported ADSC transplantation in association...
Mon Jul 01, 2019 14:58
Erratum zu: Pathologe 2019 https://doi.org/10.1007/s00292-019-0614-3 Der Artikel „Komplexität von PEComen. Diagnose, Molekulargenetik, klinisches Management“ wurde zunächst leider unter einer falschen Rubrik publiziert. Da der Beitrag bisher unveröffentlichte Daten enthält (Western Blots und …
Mon Jul 01, 2019 03:00
Abstract Introduction Malignant melanoma accounts for around 3% of all malignancies. Fine‐needle aspiration cytology (FNAC) is a convenient diagnostic procedure for the diagnosis of melanoma and its metastases. Aim To explore the cytological spectrum of malignant melanoma including the rare metastatic sites. Material and Methods A total of 51 patients of malignant melanoma or its metastases on FNAC were studied over a period of 5 years. The FNAC smears of these cases were analyzed...
Mon Jul 01, 2019 16:34
Publication date: Available online 2 July 2019Source: Human PathologyAuthor(s): Ashley M. Fuller, Linnea T. Olsson, Bentley R. Midkiff, Erin L. Kirk, Kirk K. McNaughton, Benjamin C. Calhoun, Melissa A. TroesterSummaryIn breast tumors, it is well established that intratumoral angiogenesis is crucial for malignant progression, but little is known about the vascular characteristics of extratumoral, cancer-adjacent breast. Genome-wide transcriptional data suggest that extratumoral microenvironments may...
Tue Jul 02, 2019 16:56
Publication date: Available online 30 June 2019Source: Human PathologyAuthor(s): Gian Franco Zannoni, Angela Santoro, Giuseppe Angelico, Saveria Spadola, Damiano Arciuolo, Michele Valente, Frediano Inzani, Angela Pettinato, Simona Vatrano, Francesco Fanfani, Giovanni Scambia, Filippo FraggettaSummaryThe aim of the present paper is to study a cohort of pure selected endometrial clear cell carcinomas (ECCC) from an immunohistochemical and molecular perspective in order to provide new data about the...
Mon Jul 01, 2019 14:48
Publication date: Available online 3 July 2019Source: Acta HistochemicaAuthor(s): Zhen Li, Huiqin Hao, Yuting Gao, Ze Wang, Wenjing Lu, Jin LiuAbstractRheumatoid arthritis (RA) is a complicated chronic multisystem autoimmune disease, wherein the inflammatory cascade leads to vasospasm and osteoclastogenesis, which ultimately results in bone and cartilage destruction. In this study, we investigated the expression and localization of the alpha-7 nicotinic receptor (α7nAchR) gene CHRNA7 in the heart,...
14:19
Publication date: Available online 3 July 2019Source: Acta HistochemicaAuthor(s): Simona Panzacchi, Federica Gnudi, Daniele Mandrioli, Rita Montella, Valentina Strollo, Bruce Alexander Merrick, Fiorella Belpoggi, Eva TibaldiAbstractSafety concerns on the toxic and carcinogenic effects of formalin exposure have drawn increasing attention to the search for alternative low risk fixatives for processing tissue specimens in laboratories worldwide. Alcohol-based fixatives are considered some of the most...
Wed Jul 03, 2019 13:28
Publication date: Available online 1 July 2019Source: Acta HistochemicaAuthor(s): Zuzana Fagová, Iveta Domoráková, Marianna Danková, Eva Mechírová, Alexandra Kunová, Milan StebnickýAbstractThe aim of this study was to investigate neuroprotective effect of bradykinin postconditioning on the rabbit spinal cord after 20 min of ischemia and 3 days of reperfusion. Bradykinin was administered by single i.p. application at 1, 6, 12 or 24 h after ischemia. Assessment of neurological function of hind limbs...
Mon Jul 01, 2019 13:51
Abstract Treatment with cold atmospheric plasma (CAP) has been reported to promote wound healing in animals. However, how this process is mediated remains unclear. In this study we examined the mechanisms which underlie the improved wound healing effects of CAP, and examine the roles of associated reactive oxygen and nitrogen species (RONS), which are generated by plasma. By using in vitro models which mimicked various steps of angiogenesis, we demonstrated that CAP triggered the production of nitric...
Tue Jul 02, 2019 19:14
Abstract Pulmonary arterial hypertension (PAH) is characterized by an increase in mean pulmonary arterial pressure which almost invariably leads to right heart failure and premature death. More than 70% of familial PAH and 20% of idiopathic PAH patients carry heterozygous mutations in the bone morphogenetic protein (BMP) type 2 receptor (BMPR2). However, the incomplete penetrance of BMPR2 mutations suggests that other genetic and environmental factors contribute to the disease. In the current study...
Mon Jul 01, 2019 22:38
ABSTRACT The identification of novel regulators of tumor progression is a key challenge to gain knowledge on the biology of small intestinal neuroendocrine tumors (SI‐NET). We recently identified the loss of the axon guidance protein semaphorin 3F as a pro‐tumoral event in SI‐NETs. Interestingly the expression of its receptor Neuropilin‐2 (NRP‐2) was still maintained. This study aimed at deciphering the potential role of NRP‐2 as a contributor to SI‐NET progression. The role of NRP‐2 in SI‐NET...
Mon Jul 01, 2019 22:35
Abstract Pancreatic ductal adenocarcinoma (PDAC) has a five‐year survival rate of <4% and desperately needs novel effective therapeutics. Integrin αvβ6 has been linked with poor prognosis in cancer but its potential as a target in PDAC remains unclear. We report that transcriptional expression analysis revealed high levels of β6 mRNA correlated strongly with significantly poorer survival (n=491 cases, p= 3.17x10‐8). In two separate cohorts we showed that over 80% of PDAC expressed αvβ6 protein...
Mon Jul 01, 2019 22:24
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