Abstract Food allergen threshold dose‐distributions are used in food allergen risk assessment to determine the level of risk within a food allergic population to a defined exposure amount of allergenic food protein and to help inform allergen risk management decisions. There has been a long‐standing interest in determining threshold dose‐distributions for different food allergens from a research and a risk management perspective.1–3 More recently, allergen risk management programs utilizing population...
Thu Oct 08, 2020 12:18
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance pyroxsulam. To assess the occurrence of pyroxsulam residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EU) No 188/2011 as well as the European authorisations reported by Member States. Based on the assessment...
Thu Oct 08, 2020 11:53
The effect of patient positioning on ultrasound landmarking for cricothyrotomy. Can J Anaesth. 2020 Oct 07;: Authors: Arthurs L, Erdelyi S, Kim DJ Abstract PURPOSE: Our primary objective was to assess the difference in position of the ultrasound-guided landmark of the cricothyroid membrane (CTM) when performed with the supine patient positioned at different head of bed (HOB) elevations. METHODS: In this prospective observational study...
Thu Oct 08, 2020 18:41
Publication date: Available online 7 October 2020Source: American Journal of Infection ControlAuthor(s): Peng-jun Lu, Anup Srivastav, Tammy A. Santibanez, Ashley Amaya, Jill A. Dever, Jessica Roycroft, Marshica Stanley Kurtz, Walter W. Williams
Thu Oct 08, 2020 18:40
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Farrukh Ahmad
Thu Oct 08, 2020 18:37
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Baskaran Chandrasekaran, Shifra Fernandes
Thu Oct 08, 2020 18:37
The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor gene in Wilms’ tumour. In our previous study, WTX expression was shown to be significantly reduced in gastric canc...
Thu Oct 08, 2020 03:00
Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic a...
Thu Oct 08, 2020 03:00
Publication date: October 2020Source: Journal of Plastic, Reconstructive & Aesthetic Surgery, Volume 73, Issue 10Author(s): David S. Soutar
Thu Oct 08, 2020 18:23
Publication date: October 2020Source: Journal of Plastic, Reconstructive & Aesthetic Surgery, Volume 73, Issue 10Author(s):
Thu Oct 08, 2020 18:23
Publication date: November 2020Source: Brain Research Bulletin, Volume 164Author(s):
Thu Oct 08, 2020 18:21
Frequency of S492R mutations in the epidermal growth factor receptor: analysis of plasma DNA from patients with metastatic colorectal cancer treated with panitumumab or cetuximab monotherapy. Cancer Biol Ther. 2020 Oct 07;:1-8 Authors: Price T, Ang A, Boedigheimer M, Kim TW, Li J, Cascinu S, Ruff P, Satya Suresh A, Thomas A, Tjulandin S, Peeters M Abstract BACKGROUND: Antibodies against epidermal growth factor receptor (EGFR), panitumumab,...
Thu Oct 08, 2020 18:21
miR-221-3p promotes hepatocellular carcinogenesis by downregulating O6-methylguanine-DNA methyltransferase. Cancer Biol Ther. 2020 Oct 06;:1-12 Authors: Chen Z, Xiang B, Qi L, Zhu S, Li L Abstract This study aimed to investigate the influence of miR-221-3p and O6-methylguanine-DNA methyltransferase (MGMT) interaction in human hepatocellular carcinoma (HCC), thereby revealing a novel molecular mechanism of hepatic carcinogenesis involving miR-221-3p...
Thu Oct 08, 2020 18:21
This study shows that the genetic effects for IBS are fully shared with the genetic effects for social stressors in close relationships. Our results suggest that genes involved in central stress mechanisms in the brain‐gut axis are the main source of the genetic variation in IBS‐risk. Abstract Background Social stress is related to symptom burden of irritable bowel syndrome (IBS). This study explores the associations between IBS and social strain or low support in close relationships,...
Thu Oct 08, 2020 13:17
Compared to a diagnosis of exclusion, a positive strategy uses fewer lower endoscopies, has similar organic findings and similar quality of life after five years in patients with symptoms compatible with IBS. This supports current recommendations of a positive diagnosis in IBS. Abstract Background Previously, the diagnosis of irritable bowel syndrome (IBS) required exclusion of organic causes by extensive diagnostic testing. Newer guidelines recommend IBS as a positive diagnosis based on...
Wed Oct 07, 2020 20:36
Abstract Objectives This study compares the ontogenetic bone modeling patterns of the maxilla to the related morphological changes in three human populations to better understand how morphological variability within a species is established during ontogeny at both micro‐ and macroscopic levels. Materials and methods The maxillary bones of an ontogenetic sample of 145 subadult and adult individuals from Greenland (Inuit), Western Europe (France, Germany, and Portugal), and South Africa (Khoekhoe...
Thu Oct 08, 2020 11:53
Surfaces of a second mandibular molar tested for dentine and enamel cortisol concentrations. Abstract Objectives Cortisol is a glucocorticoid hormone produced through activation of the hypothalamic pituitary adrenal axis. It is known as the “stress hormone” for its primary role in the body's stress response and has been the focus of much modern clinical research. Within archaeology, only a few studies have analyzed cortisol in human remains and these have been restricted to hair (Webb...
Wed Oct 07, 2020 14:26
Older adults (i.e., 60 years and older), are the leading consumers of medications, and consequently are suffering the most from medication‐related adverse events. Not only are older adults the largest consumers of medications, they are more likely to experience an adverse drug event contributing to increased hospitalization, utilization of emergency medical services, and mortality. Translational Approaches to Personalized Health (TAPH) is a transdisciplinary team of researchers conducting community‐engaged...
Wed Oct 07, 2020 14:25
Abstract Retrognathia (recessed chin) and prognathism (prominent chin) often present as signs of an underlying condition. Accurate clinical definitions are important. Yet their definitions were according to “clinical impression”, or to seldom used X‐ray criteria. We propose a statistical and anthropometric definition of retrognathia and prognathism based upon the ratio between the goniomaxillar length (distance between the gonion at the mandible angle and the subnasale and the goniomandibular length...
Thu Oct 08, 2020 15:23
Abstract Biallelic mutations in SNORD118, encoding the small nucleolar RNA U8, cause leukoencephalopathy with calcifications and cysts (LCC). Given the difficulty in interpreting the functional consequences of variants in nonprotein encoding genes, and the high allelic polymorphism across SNORD118 in controls, we set out to provide a description of the molecular pathology and clinical spectrum observed in a cohort of patients with LCC. We identified 64 affected individuals from 56 families. Age...
Wed Oct 07, 2020 21:46
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Surg Neurol Int"[jour] These pubmed results were generated on 2020/10/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Oct 08, 2020 17:57
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Surg Neurol Int"[jour] These pubmed results were generated on 2020/10/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Oct 08, 2020 13:54
Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death...
Wed Oct 07, 2020 03:00
Publication date: November 2020Source: Annales de Chirurgie Plastique Esthétique, Volume 65, Issues 5–6Author(s):
Thu Oct 08, 2020 17:43
Publication date: Available online 7 October 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): C. Barani, S. Brosset, H. Person, M. Guillot, F. Braye, D. Voulliaume
Thu Oct 08, 2020 17:43
Abstract Introduction With increasing popularity of minimally invasive approaches to abdominoperineal resection (APR), thigh‐based flaps are becoming the preferred option for reconstruction. The gluteal‐thigh flap provides sufficient bulk, albeit with a high complication rate. We reevaluated the vascularization and design of the gluteal‐thigh flap. The purpose of this study is to highlight the importance of the vascularization of the posterior thigh skin by the descending branch of the inferior...
Thu Oct 08, 2020 13:53
Abstract To evaluate the management of sub-condylar and angle of mandible fracture by a trans-buccal trocar along with an intra-oral approach. Study parameters included were assessment of adequacy of anatomical repositioning, fixation and stability of fracture site by radiographs, pre and post – operative occlusion by photographs. Evaluation of anatomical repositioning was done with fracture gap measurement on orthopantomogram after 6 months by applying paired student’s T test....
Thu Oct 08, 2020 17:32
Abstract Endoscopic Sinus Surgery is evolving day by day, there is a constant need for improvisation in terms of instrumentation with clear bloodless surgical field and good postoperative results. The applications of Dr. Ahila’s Conchal Crusher for managing Concha bullosa in Functional Endoscopic Sinus Surgery (FESS) Surgery are presented. The creation/innovation of Dr. Ahila’s conchal crusher will prevent raw mucosal surface area, bleeding and scope fogging with blood during...
Thu Oct 08, 2020 17:32
Abstract The aim of this study was to investigate the efficacy and safety of Endoscopic Sinus Surgery (ESS) as a treatment modality for chronic rhinosinusitis refractory to maximal medical therapy in the elderly population. ESS has gained importance over the past 2–3 decades. A prospective review of outcome was done in fifty seven patients over age of 60 years who underwent ESS. They were evaluated preoperatively and postoperatively at 3, 6, and 12 months with a rigid nasal...
Thu Oct 08, 2020 17:32
Abstract In this study we report a case with foreign body in the infratemporal fossa. The anatomic position of this region and the presence of important neurovascular structures make this region a sophisticated one. Commonly used open procedures can have morbidity of neurovascular system. To prevent probable complications like facial nerve injury in this case which was the most important factor for us, we decided to remove the foreign body under endoscopic guide.
Thu Oct 08, 2020 17:32
Abstract The surgical procedures in the temporal bone have the potential to generate aerosols which could affect the health care personnel. An innovative way to avoid aerosolization during ear surgery has been highlighted in this manuscript.
Thu Oct 08, 2020 17:32
Abstract To compare the outcome of ossiculoplasty using ‘lenticular process of incus replacement prosthesis [LPIRP]’ with that of ‘conventional autologous tissue ossiculoplasty techniques’ in patients with lenticular process of incus necrosis [LPI] in terms of: 1. Hearing results. 2. Graft take-up. 3. Complications like extrusion. Total 16 patients found intraoperatively to have LPI necrosis were allocated randomly using (simple random sampling technique) in two groups. Total...
Thu Oct 08, 2020 17:32
Abstract Benign positional vertigo (BPV) occurs when freely floating otoconia which are normally attached to the utricular macula, enter the posterior semicircular canal and move under the influence of gravity. It is the most common cause of peripheral vertigo. Migraine is a common headache disorder which is characterized by hemicranial, throbbing pain and may be preceded by aura. The relation between vertigo and migraine is intriguing and in day to day practice, often not clear....
Thu Oct 08, 2020 03:00
Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) represents a standardized reporting system for salivary gland lesions. The recent literature has demonstrated a wide range of data regarding range of malignancy (ROM) and interobserver variability. The objective of the current study was to evaluate the reproducibility and interobserver agreement of MSRSGC, and establish the ROM in a unique patient population residing within a designated Health Professional Shortage Area....
Thu Oct 08, 2020 16:30
Background The ThyroSeq v3 genomic classifier is a commercial molecular test that examines a wide spectrum of genomic alterations in a thyroid fine‐needle aspiration (FNA) sample and reports test results as either negative or positive. The authors report their institutional experience with ThyroSeq v3. Methods Thyroid FNA specimens diagnosed as either atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) (Bethesda category III [Bethesda III] according...
Thu Oct 08, 2020 16:30
Abstract Background Among several potential transmission sources in the spreading of the COVID-19, dental services have received a high volume of attention. Several reports, papers, guidelines, and suggestions have been released on how this infection could be transmitted through dental services and what should be done. This study aimed to review the guidelines in order to develop a practical feasibility protocol for the re-opening...
Thu Oct 08, 2020 03:00
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors’ clinical recommendations. Stage. A 75-year-old…
Thu Oct 08, 2020 03:00
Presentation of Case. Dr. Olivia C. Smibert: A 48-year-old man with diffuse large B-cell lymphoma was evaluated in the oncology clinic of this hospital because of abdominal pain. The patient had been generally well until 12 years before this presentation, when lymphadenopathy in the axillary and…
Thu Oct 08, 2020 03:00
"Have you heard about Covid toes?" My wife, while working through her clinical notes from her pediatrics practice that day, asked the question with a tone of resignation. I hadn’t, but I quickly searched the Web and found a number of reports of rashes on the toes of children infected with…
Wed Oct 07, 2020 03:00
In March 2020, when there were 30,000 confirmed Covid-19 cases in the United States, one of us wrote about the pandemic’s effects on undocumented immigrants. By August, there were about 50,000 new U.S. cases per day, and we had spent several months caring for patients with Covid-19. Today,…
Wed Oct 07, 2020 03:00
Intratympanic dexamethasone injection for sudden sensorineural hearing loss in pregnancy. World J Clin Cases. 2020 Sep 26;8(18):4051-4058 Authors: Lyu YL, Zeng FQ, Zhou Z, Yan M, Zhang W, Liu M, Ke ZY Abstract BACKGROUND: As sudden sensorineural hearing loss (SSNHL) rarely occurs in pregnant women, there is a lack of knowledge and relevant research on its management. AIM: To investigate the effect of intratympanic dexamethasone injection...
Thu Oct 08, 2020 16:54
Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8. J Immunother Cancer. 2020 Oct;8(2): Authors: Hecht M, Gostian AO, Eckstein M, Rutzner S, von der Grün J, Illmer T, Hautmann MG, Klautke G, Laban S, Brunner T, Hinke A, Becker I, Frey B, Semrau S, Geppert CI, Hartmann A, Balermpas P, Budach W, Gaipl US, Iro H, Fietkau R Abstract BACKGROUND:...
Thu Oct 08, 2020 16:54
Potential and limitations of orthodontic biomechanics: recognizing the gaps between knowledge and practice. J World Fed Orthod. 2020 Oct;9(3S):S31-S39 Authors: Ghafari JG, Macari AT, Zeno KG, Haddad RV Abstract The perennial goals of efficient biomechanics are to obtain more controlled and faster movement and using more discrete appliances. The most recent technological advances have buttressed these goals. Temporary anchorage devices have...
Thu Oct 08, 2020 16:54
Related Articles Frontal Crash Injury Metrics Are Below Mandated Limits for a Spica Casted Child Dummy in Currently Available Restraints. J Pediatr Orthop. 2020 May/Jun;40(5):e394-e400 Authors: Collins AC, Caskey S, Peck JB, Walter N, Atkinson TS, Atkinson PJ Abstract BACKGROUND: There is a paucity of data defining safe transport protocols for children treated with hip spica casting. Although restraint devices for casted children are available,...
Thu Oct 08, 2020 16:54
Related Articles Promotion of skin wound healing using prevascularized oral mucosal cell sheet. Head Neck. 2019 03;41(3):774-779 Authors: Lee J, Shin D, Roh JL Abstract BACKGROUND: This study examined the potential use of our newly developed prevascularized oral mucosal cell sheet for the treatment of skin wounds. METHODS: Mucosal cell sheets containing cultured keratinocytes and plasma fibrin without (K sheet) or with a mixture of...
Thu Oct 08, 2020 16:54
Morphometric characteristics of anencephalic skulls-a comparative study. Ann Anat. 2020 Oct 04;:151607 Authors: Schimp J, Dornia C, Fanghänel J, Proff P, Blanck-Lubarsch M, Weingärtner J, Kirschneck C Abstract Anencephaly is the most severe form of a neural tube defect resulting from the incomplete occlusion of the anterior neuropore in the fourth week of development and associated with a severely underdeveloped brain mass. As desmal ossification...
Thu Oct 08, 2020 16:47
Four-dimensional computed tomography angiography analysis of internal carotid arteries opacification at the skull base to detect delayed cerebral ischemia: a feasibility study. Int J Comput Assist Radiol Surg. 2020 Oct 07;: Authors: Ognard J, Cheddad El Aouni M, Dissaux B, Jomaah R, Rousseau PY, Burdin V, Ben Salem D, Gentric JC Abstract PURPOSE: Delayed cerebral ischemia represents a significant cause of poor functional outcome for patients...
Thu Oct 08, 2020 16:47
Hemifacial Spam: Endoscopic Assistance in Facial Nerve Decompression With Lateral Spread Response Corroboration: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2020 Oct 07;: Authors: Brimley CJ, Sampath R Abstract This video depicts the case of a 48-yr-old female with 3 yr of progressive left hemifacial spasm (HFS) refractory to medication. Magnetic resonance imaging showed a large anterior inferior cerebellar artery (AICA) and...
Thu Oct 08, 2020 16:47
Role of fine-needle aspiration cytology in evaluating thyroid nodules. A retrospective study from a tertiary care center of Western region, Saudi Arabia. Saudi Med J. 2020 Oct;41(10):1098-1103 Authors: Bahaj AS, Alkaff HH, Melebari BN, Melebari AN, Sayed SI, Mujtaba SS, Abdelmonim SK, Alghamdi SA, Alghamdi FE, Abu Suliman OA, Alessa MA, Abi Sheffah FR, Al-Tammas AH, Al-Zahrani RA, Marglani OA, Heaphy JC, Bawazir OA, Alherabi AZ Abstract OBJECTIVES:...
Thu Oct 08, 2020 16:47
[Proton therapy-a chance in the treatment of tumors of the head and neck and base of skull]. Radiologe. 2020 Oct 06;: Authors: Timmermann B Abstract BACKGROUND: Radiotherapy (RT) is an integral part of the treatment of many tumors located in the vicinity of sensitive organs and structures, including tumors of the head and neck and base of skull in particular. Due to the risk of side effects associated with RT, the use of highly conformal RT...
Thu Oct 08, 2020 16:47
Superficial temporal artery-superior cerebellar artery bypass and proximal occlusion through anterior petrosal approach for subarachnoid hemorrhage due to basilar artery dissection. Surg Neurol Int. 2020;11:256 Authors: Hirano Y, Ono H, Inoue T, Aono T, Tanishima T, Tamura A, Saito I Abstract Background: Subarachnoid hemorrhage (SAH) due to rupture of basilar artery dissection (BAD) is extremely rare and often has a poor prognosis. Since ruptured...
Thu Oct 08, 2020 16:47
Image-guided endonasal endoscopic excision of Meckel's cave trigeminal schwannoma from cavernous and petrous carotid artery. J Surg Case Rep. 2020 Sep;2020(9):rjaa374 Authors: Almomen A, Alyousif A, Ali Z, Al Yaeesh I, AlOmirin A, Al Yahya A, AlSuqair H, Almolani F Abstract Trigeminal schwannoma is the second most common schwannoma after vestibular schwannoma. Symptoms vary depending on the anatomical structures affected by the tumor, including...
Thu Oct 08, 2020 16:47
Tentorial Venous Anatomy: Variation in the Healthy Population. AJNR Am J Neuroradiol. 2020 Oct;41(10):1825-1832 Authors: Rosenblum JS, Tunacao JM, Chandrashekhar V, Jha A, Neto M, Weiss C, Smirniotopoulos J, Rosenblum BR, Heiss JD Abstract BACKGROUND AND PURPOSE: A new transtentorial venous system consisting of medial, intermediate, and lateral tentorial veins, connecting infra- and supratentorial compartments, was recently shown in 2 cadaver...
Thu Oct 08, 2020 16:47
An operative barrier system for skull base and mastoid surgery: creating a safe operative theatre in the era of COVID-19. J Otolaryngol Head Neck Surg. 2020 Oct 06;49(1):71 Authors: Cottrell J, Lui J, Le T, Chen J Abstract Within Neurotology, special draping systems have been devised for mastoid surgery recognizing that drilling of middle ear mucosa is an aerosol generating medical procedure (AGMP) which can place surgical teams at risk of...
Thu Oct 08, 2020 16:47
Front cover: Cover image: Photograph illustrating the gross anatomy of the hindlimb muscles in cat, with the proximal end of the limb facing right. See I. Boehm et al., ‘Comparative anatomy of the mammalian neuromuscular junction’, this issue.
Thu Oct 08, 2020 11:15
The notarium is the structure formed by fusion of the dorsal vertebrae which occurred independently in pterosaurs and birds. Here we identify the fusion sequence of pterosaur notarial elements, demonstrating the order of ossification in vertebral bodies and neural spines. In both Pterosauria and Aves, the notarium generally develops in a antero‐posterior direction, but the actual order of each fusion locus may present slight variations. Based on our data, we were able to identify seven developmental...
Wed Oct 07, 2020 12:15
Publication date: Available online 7 October 2020Source: Auris Nasus LarynxAuthor(s): Yusuke Ayani, Shin-Ichi Haginomori, Shin-Ichi Wada, Haruki Nakano, Yuko Inaka, Akiko Ozaki, Takahiro Ichihara, Takaki Inui, Ryo Kawata
Thu Oct 08, 2020 16:45
Publication date: Available online 7 October 2020Source: Auris Nasus LarynxAuthor(s): Yen-Bin Hsu, Ming-Ying Lan, Yun-Chen Huang, Tung-Tsun Huang, Ming-Chin Lan
Thu Oct 08, 2020 16:45
CD9 expression in vascular aging and atherosclerosis. Histol Histopathol. 2020 Oct 07;:18268 Authors: Kim JR, Choi JH Abstract CD9 is a transmembrane glycoprotein belonging to the tetraspanin family. CD9 expression has been reported to be associated with cellular signaling, cell adhesion, cell migration, and tumor related processes. The aim of this study was to examine the immunohistochemical expression of CD9 in vascular senescence and atherosclerosis....
Thu Oct 08, 2020 16:41
Summary Background The association between Borrelia burgdorferi and primary cutaneous lymphoma is still unclear. This systematic review and meta‐analysis aims to define the association of Borrelia burgdorferi with primary cutaneous lymphoma and its different entities. Methods Electronic databases were searched for all studies that assessed the presence of Borrelia burgdorferi DNA in specimens of primary cutaneous lymphoma. The association between Borrelia and primary cutaneous lymphomas...
Thu Oct 08, 2020 11:10
Thu Oct 08, 2020 11:06
Consequences of atmospheric contamination by radioiodine: the Chernobyl and Fukushima accidents. Endocrine. 2020 Oct 06;: Authors: Ory C, Leboulleux S, Salvatore D, Le Guen B, De Vathaire F, Chevillard S, Schlumberger M Abstract PURPOSE: After the accidents of nuclear power plants at Chernobyl and at Fukushima, huge amounts of radioactive iodine were released into the atmosphere. METHODS: We reviewed data on the health consequences...
Thu Oct 08, 2020 16:40
Effect of repetitive potassium iodide on thyroid and cardiovascular functions in elderly rats. Biochem Biophys Rep. 2020 Dec;24:100816 Authors: Lebsir D, Cantabella E, Cohen D, Sache A, Ebrahimian T, Kereselidze D, Amine Benadjaoud M, Maurisier FC, Guigon P, René Jourdain J, Benderitter M, Lestaevel P, Souidi M Abstract Background: To date, paediatric thyroid cancer has been the most severe health consequence of the Chernobyl accident,...
Thu Oct 08, 2020 16:40
In the original publication, there are errors in Fig. 3D and Fig. 5C and are corrected as follows.
Thu Oct 08, 2020 03:00
STOP-Bang and NoSAS questionnaires as a screening tool for OSA: which one is the best choice? Rev Assoc Med Bras (1992). 2020 Sep;66(9):1203-1209 Authors: Costa JC, Rebelo-Marques A, Machado JPN, Valentim BMF, Ferreira CSAV, Gonçalves JDO, Gama JMDR, Teixeira MFL, Moita JJM Abstract INTRODUCTION: Currently there has been significant growth in the number of patients with suspected obstructive sleep apnea (OSA) referred to sleep clinics. In this...
Thu Oct 08, 2020 16:38
Evaluation of the Oropharyngeal Airway Space in Class II Malocclusion Treated with Mandibular Activator: A Retrospective Study. J Contemp Dent Pract. 2020 Jun 01;21(6):666-672 Authors: Cortese M, Pigato G, Casiraghi G, Ferrari M, Bianco E, Maddalone M Abstract AIM: The development of a class II malocclusion is usually related to a reduced oropharyngeal airway space. In order to prevent airway obstruction, functional appliances are commonly...
Thu Oct 08, 2020 16:38
Abstract Objective The aim of this multi‐center, randomized controlled trial was to compare the clinical and radiographic outcomes of 6‐mm or 11‐mm implants, placed in the posterior maxilla and mandible, during a 5‐years follow‐up period. Materials and methods Ninety‐five patients with adequate bone height for 11‐mm implants, were randomly allocated to a 6‐mm group (test group with short implants) or an 11‐mm group (control group with standard length implants). Two or three implants of...
Tue Oct 06, 2020 21:23
Publication date: January 2021Source: World Neurosurgery, Volume 145Author(s): Stephen Garrett Whipple, Amey R. Savardekar, Shilpa Rao, Anita Mahadevan, Bharat Guthikonda, Jennifer A. Kosty
Thu Oct 08, 2020 16:33
Abstract Optoacoustic tomography aims to reconstruct maps of the initial pressure rise induced by the absorption of light pulses in tissue. This reconstruction is an illconditioned and under‐determined problem, when the data acquisition protocol involves limited detection positions. The aim of the work is to develop an inversion method which integrates denoising procedure within the iterative model‐based reconstruction to improve quantitative performance of optoacoustic imaging. Among the model‐based...
Wed Oct 07, 2020 22:44
Abstract Pancreatic islet isolation from donor pancreases is an essential step for the transplantation of insulin‐secreting β‐cells as a therapy to treat type 1 diabetes mellitus. This process however damages islet basement membranes, which can lead to islet dysfunction or death. Post‐transplantation, islets are further stressed by a hypoxic environment and immune reactions that cause poor engraftment and graft failure. The current standards to assess islet quality before transplantation are destructive...
Wed Oct 07, 2020 14:25
Abstract Indocyanine greed (ICG) is a human compatible dye and is ideal for deep‐tissue 2‐photon fluorescence (2PF) microscopy excited at the 1700‐nm window in vivo. However, the 2‐photon excitation and emission properties of this dye remain unknown. Here we demonstrate measurement of the 2‐photon excitation and emission properties of ICG in both water and human plasma, using home‐built 2‐photon action cross section measurement and 2‐photon emission spectrum measurement systems. Our results show...
Wed Oct 07, 2020 13:26
Abstract Delivery of therapeutic genes into retina is proving to reverse degeneration and restore vision, however, viral vector‐based gene delivery is prone to immunorejection, inflammatory/immune‐response and non‐targeted. Here, we report non‐viral gene delivery and expression of opsin encoding genes in mouse retina in‐vitro and in‐vivo by use of pulsed femtosecond laser microbeam. In‐vitro patch clamp recording of the opsin‐sensitized retinal cells and visually evoked in‐vivo electrical recording...
Wed Oct 07, 2020 12:09
Abstract Emerging evidence indicates the clinical benefits of photobiomodulation therapy (PBMT) in the management of skin and mucosal wounds. Here we decided to explore the effects of different regiments of PBMT on epithelial cells and stem cells, and the potential implications over the epigenetic circuitry during healing. Scratch‐wound migration, immunofluorescence (anti‐acetyl‐Histone H3, anti‐acetyl‐CBP/p300, and anti‐BMI1), nuclear morphometry, and western blotting (anti‐Phospho‐S6, anti‐MBD2)...
Wed Oct 07, 2020 11:33
Abstract Optical coherence tomography (OCT) imaging shows a significant potential in clinical routines due to its noninvasive property. However, the quality of OCT images is generally limited by inherent speckle noise of OCT imaging and low sampling rate. To obtain high signal‐to‐noise ratio (SNR) and high‐resolution (HR) OCT images within a short scanning time, we presented a learning‐based method to recover high‐quality OCT images from noisy and low‐resolution OCT images. We proposed a semi‐supervised...
Wed Oct 07, 2020 11:27
Abstract We present a method to map fluorescence resonance energy transfer (FRET) parameters of a bifunctional photodynamic therapy agent, HPPH‐CD conjugate, which consists of a photosensitizer (HPPH) and a fluorescent agent cyanine dye (CD). We utilized time‐domain fluorescence diffuse optical tomography, the normalized Born ratio model in the Fourier‐domain, and an iterative algorithm to map depth‐resolved spatial heterogeneities of FRET parameters. Our results exhibited depth‐resolved changes...
Tue Oct 06, 2020 19:21
Abstract The sun protection factor (SPF) values are currently determined using an invasive procedure, in which the volunteers are irradiated with ultraviolet (UV) light. Non‐invasive approaches based on hybrid diffuse reflectance spectroscopy (HDRS) have shown a good correlation with conventional SPF testing. Here, we present a novel compact and adjustable DRS test system. The in vivo measurements were performed using a multi‐lambda‐LED light source and an 84‐channel imaging spectrograph with a...
Tue Oct 06, 2020 19:19
ABSTRACT Background Ex‐vivo confocal laser scanning microscopy (CLSM) provides rapid, high‐resolution imaging, fluorescence detection and digital hematoxylin‐eosin (H&E)‐like staining. Objectives Assessing the performance of ex‐vivo CLSM in identifying histomorphology and immunoreactivity in lichen planus (LP) and comparing its accuracy with conventional histopathology and direct immunofluorescence (DIF). Methods 33 sections of 17 LP patients stained with acridine orange (AO)...
Tue Oct 06, 2020 19:01
Abstract Growing popularity of laser treatment has understandably resulted in increased incidence of potential complications. The analysis of complications, taking into account the causes of their occurrence, is, , of particular interest. The identification of etiological factors and the development of a step‐by‐step prophylactic algorithm with their consideration is the way to reduce the number of possible complications in future practice. In this article we present a classification of the causes...
Thu Oct 08, 2020 16:27
ABSTRACT Adalimumab is the only biologic therapy approved for the treatment of patients with hidradenitis suppurativa, a chronic and disabling skin condition. To date, there are no studies in the literature about the effectiveness of adalimumab biosimilar SB5 in hidradenitis suppurativa. The aim of this study was to evaluate its efficacy and safety. A retrospective observational study was performed in hidradenitis suppurativa adalimumab naive patients and in patients who were switched from the...
Thu Oct 08, 2020 13:02
Thu Oct 08, 2020 12:57
Abstract Intralesional methotrexate (il‐MTX) has been reported as a useful therapy in keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC). However, the data available on the histological changes induced by this therapy are very scarce. We conducted a single center, prospective study that included 65 cases of cSCC treated with il‐MTX before surgical treatment. Two histological studies were conducted in all patients: before intralesional treatment and after surgical removal. Lesions...
Thu Oct 08, 2020 12:55
ABSTRACT Psoriasis and psoriatic arthritis (PsA) have been linked to metabolic syndrome (MS). The impact of adipokines on psoriasis, PsA, and MS pathogenesis has recently received investigative attention. A total of 80 subjects with psoriasis, 40 subjects with PsA, and 60 healthy controls were enrolled. Serum omentin and visfatin levels were measured, and MS presence was determined. PASI and DAS28 were used to measure disease severity for psoriasis and PsA, respectively. The prevalence of MS was...
Thu Oct 08, 2020 11:28
ABSTRACT H syndrome is a complex multi‐organ disorder with autosomal recessive inheritance. The skin manifestations include early onset hyperpigmentation and hypertrichosis, followed by skin induration often diagnosed as scleromyxedema and morphea. There is no effective treatment. Our objective was to study the efficacy of mycophenolate mofetil in a patient with genetically‐confirmed H syndrome. We sought the genetic cause of H syndrome with whole‐exome sequencing (WES) of the proband. Genome‐wide...
Thu Oct 08, 2020 11:10
Abstract In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily for 8 weeks. Adobe photoshop CS6 was used to measure the surface area of the lesions before treatment and after 8 weeks. There...
Tue Oct 06, 2020 13:35
Quantifying Patient Preferences for Systemic Atopic Dermatitis Treatments Using a Discrete-Choice Experiment. J Dermatolog Treat. 2020 Oct 07;:1-31 Authors: Boeri M, Sutphin J, Hauber B, Cappelleri JC, William R, Marco D Abstract Objectives: To identify meaningful treatment attributes and quantify patient preferences for attributes of systemic atopic dermatitis (AD) treatments.Materials and Methods: Qualitative interviews were conducted with...
Thu Oct 08, 2020 16:25
Clinical efficacy and safety of secukinumab in patients with psoriasis and comorbidities: pooled analysis of 4 phase 3 clinical trials. J Dermatolog Treat. 2020 Oct 07;:1-34 Authors: Gottlieb AB, Wu JJ, Griffiths CEM, Marfo K, Muscianisi E, Meng X, Frueh J, Lebwohl M Abstract Background: The influence of comorbidities on the efficacy and safety of biologic therapies in psoriasis has not been rigorously explored.Objective: To assess the incremental...
Thu Oct 08, 2020 16:25
Objective To evaluate human glymphatics and meningeal lymphatics noninvasively. Methods This prospective study implemented 3‐dimensional isotropic contrast‐enhanced T2 fluid‐attenuated inversion recovery (3D isotropic CE‐T2‐FLAIR) imaging with a 3‐tesla (T) magnetic resonance machine to study cerebral glymphatics and meningeal lymphatics in patients with reversible cerebral vasoconstriction syndrome (RCVS) with (n=92) or without (n=90) blood‐brain barrier (BBB) disruption and a disease control...
Thu Oct 08, 2020 12:33
IAEA contribution to the development of copper-64 radiopharmaceuticals for theranostic applications.
IAEA contribution to the development of copper-64 radiopharmaceuticals for theranostic applications. Q J Nucl Med Mol Imaging. 2020 Oct 07;: Authors: Jalilian AR, Osso JA, Vera-Araujo J, Kumar V, Harris MJ, Gutfilen B, Guérin B, Li H, Zhuravlev F, Chakravarty R, Alirezapour B, Ávila-Rodríguez MA, Khan IU, Aljammaz I, Assaad T, Luurtsema G, Smith J, Duatti A Abstract Copper-64 is a very attractive radioisotope with unique nuclear properties...
Thu Oct 08, 2020 16:21
The emerging value of copper-64 for molecular imaging and therapy. Q J Nucl Med Mol Imaging. 2020 Oct 07;: Authors: Bolzati C, Duatti A Abstract Along with other novel metallic radionuclides, copper-64 (64Cu) is currently being investigated as an alternative option to the gallium-68 (68Ga) and lutetium-177 (177Lu) radiopharmaceuticals widely used for targeting somatostatin receptors, expressed by neuroendocrine tumors (NETs), and recently prostate...
Thu Oct 08, 2020 16:21
Copper-64 based radiopharmaceuticals for brain tumors and hypoxia imaging. Q J Nucl Med Mol Imaging. 2020 Oct 07;: Authors: Pasquali M, Martini P, Shahi A, Jalilian AR, Osso J, Boschi A Abstract INTRODUCTION: The most common and aggressive primary malignancy of the central nervous system is Glioblastoma that, as a wide range of malignant solid tumor, is characterized by extensive hypoxic regions. A great number of PET radiopharmaceuticals have...
Thu Oct 08, 2020 16:21
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