Role of monoclonal antibody drugs in the treatment of COVID-19.

paythelady.612 shared this article with you from Inoreader Role of monoclonal antibody drugs in the treatment of COVID-19. Μέσω pubmed: "world j clin cases"... Role of monoclonal antibody drugs in the treatment of COVID-19. World J Clin Cases. 2020 Oct 06;8(19):4280-4285 Authors: Ucciferri C, Vecchiet J, Falasca K Abstract Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical presentation of this pathology includes fever, dry cough, fatigue and acute respiratory distress syndrome that can lead to death infected patients. Current studies on coronavirus disease 2019 (COVID-19) continue to highlight the urgent need for an effective therapy. Numerous therapeutic strategies have been used until now but, to date, there is no specific effective treatment for SARS-CoV-2 infection. Elevated inflammatory cytokines have been reported in patients with COVID-19. Evidence suggests that elevated cytokine levels, reflecting a hyperinflammatory response secondary to SARS-CoV-2 infection, are responsible for multi-organ damage in patients with COVID-19. For these reason, numerous randomized clinical trials are currently underway to explore the effectiveness of biopharmaceutical drugs, such as, interleukin-1 block ers, interleukin-6 inhibitors, Janus kinase inhibitors, in COVID-19. The aim of the present paper is to briefly summarize the pathogenetic rationale and the state of the art of therapeutic strategy blocking hyperinflammation. PMID: 33083387 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.