Management of pembrolizumab-induced steroid refractory mucositis with infliximab: A case report. World J Clin Cases. 2020 Sep 26;8(18):4100-4108 Authors: Dang H, Sun J, Wang G, Renner G, Layfield L, Hilli J Abstract BACKGROUND: Pembrolizumab is an anti-programmed death receptor 1 (PD-1) that was shown to have a tolerable safety profile with 17% of grade 3-4 drug-related adverse events, notable response rate of 16% with median duration...
Thu Oct 08, 2020 13:28
Intratympanic dexamethasone injection for sudden sensorineural hearing loss in pregnancy. World J Clin Cases. 2020 Sep 26;8(18):4051-4058 Authors: Lyu YL, Zeng FQ, Zhou Z, Yan M, Zhang W, Liu M, Ke ZY Abstract BACKGROUND: As sudden sensorineural hearing loss (SSNHL) rarely occurs in pregnant women, there is a lack of knowledge and relevant research on its management. AIM: To investigate the effect of intratympanic dexamethasone...
Thu Oct 08, 2020 13:28
Special features of SARS-CoV-2 in daily practice. World J Clin Cases. 2020 Sep 26;8(18):3920-3933 Authors: Charitos IA, Ballini A, Bottalico L, Cantore S, Passarelli PC, Inchingolo F, D'Addona A, Santacroce L Abstract The severe acute respiratory syndrome-coronavirus-2 (commonly known as SARS-CoV-2) is a novel coronavirus (designated as 2019-nCoV), which was isolated for the first time after the Chinese health authorities reported a cluster...
Thu Oct 08, 2020 13:28
Predictive models for stage and risk classification in head and neck squamous cell carcinoma (HNSCC). PeerJ. 2020;8:e9656 Authors: Kumar S, Patnaik S, Dixit A Abstract Machine learning techniques are increasingly used in the analysis of high throughput genome sequencing data to better understand the disease process and design of therapeutic modalities. In the current study, we have applied state of the art machine learning (ML) algorithms...
Thu Oct 08, 2020 13:28
Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism.
Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism. Sci Rep. 2020 Oct 06;10(1):16564 Authors: Guan X, Cheng YS, Galaiya DJ, Rosowski JJ, Lee DJ, Nakajima HH Abstract Our ability to hear through bone conduction (BC) has long been recognized, but the underlying mechanism is poorly understood. Why certain perturbations affect BC hearing is also unclear. An example is BC hyperacusis (hypersensitive...
Thu Oct 08, 2020 13:28
Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma. Sci Rep. 2020 Oct 06;10(1):16582 Authors: Kumpitsch C, Moissl-Eichinger C, Pock J, Thurnher D, Wolf A Abstract Squamous cell carcinoma is the most common type of throat cancer. Treatment options comprise surgery, radiotherapy, and/or chemo(immuno)therapy. The salivary microbiome is shaped by the disease,...
Thu Oct 08, 2020 13:28
Posture-induced changes in the vessels of the head and neck: evaluation using conventional supine CT and upright CT. Sci Rep. 2020 Oct 06;10(1):16623 Authors: Kosugi K, Yamada Y, Yamada M, Yokoyama Y, Fujiwara H, Yoshida K, Yoshida K, Toda M, Jinzaki M Abstract Since the venous system is affected by gravity, upright computed tomography (CT) in addition to conventional supine CT has great potential for evaluating postural changes in the...
Thu Oct 08, 2020 13:28
Oncogenic driver mutations predict outcome in a cohort of head and neck squamous cell carcinoma (HNSCC) patients within a clinical trial. Sci Rep. 2020 Oct 06;10(1):16634 Authors: Fernández-Mateos J, Pérez-García J, Seijas-Tamayo R, Mesía R, Rubió-Casadevall J, García-Girón C, Iglesias L, Carral Maseda A, Adansa Klain JC, Taberna M, Vazquez S, Gómez MA, Del Barco E, Ocana A, González-Sarmiento R, Cruz-Hernández JJ Abstract 234 diagnostic...
Thu Oct 08, 2020 13:28
Effects of Wnt signaling on epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyp. Thorax. 2020 Oct 06;: Authors: Bae JS, Ryu G, Kim JH, Kim EH, Rhee YH, Chung YJ, Kim DW, Lim S, Chung PS, Shin HW, Mo JH Abstract BACKGROUND: Epithelial to mesenchymal transition (EMT) is associated with the pathophysiology of chronic rhinosinusitis with nasal polyp (CRSwNP). Wnt signaling is causative for EMT, whereas the mechanism...
Thu Oct 08, 2020 13:28
Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8. J Immunother Cancer. 2020 Oct;8(2): Authors: Hecht M, Gostian AO, Eckstein M, Rutzner S, von der Grün J, Illmer T, Hautmann MG, Klautke G, Laban S, Brunner T, Hinke A, Becker I, Frey B, Semrau S, Geppert CI, Hartmann A, Balermpas P, Budach W, Gaipl US, Iro H, Fietkau R Abstract ...
Thu Oct 08, 2020 13:28
Clinical outcomes following surgical treatment of lentigo maligna of the head and neck. Eur J Surg Oncol. 2020 Sep 23;: Authors: Crouch G, Sinha S, Lo S, Saw RPM, Lee KK, Stretch J, Shannon K, Guitera P, Scolyer RA, Thompson JF, Ch'ng S Abstract INTRODUCTION: Lentigo maligna (LM), a subtype of melanoma in-situ commonly occurring in the head and neck region, often presents a treatment challenge due to anatomical constraints, particularly...
Thu Oct 08, 2020 13:28
Patients with vertigo/dizziness of unknown origin during follow-ups by general otolaryngologists at outpatient town clinic. Auris Nasus Larynx. 2020 Oct 03;: Authors: Nishikawa D, Wada Y, Shiozaki T, Shugyo M, Ito T, Ota I, Kitahara T Abstract OBJECTIVES: The purpose of this study was to access the contribution of vertigo/dizziness-related patients' interview and examinations during short-term hospitalization in determining the accurate...
Thu Oct 08, 2020 13:28
Potential and limitations of orthodontic biomechanics: recognizing the gaps between knowledge and practice. J World Fed Orthod. 2020 Oct;9(3S):S31-S39 Authors: Ghafari JG, Macari AT, Zeno KG, Haddad RV Abstract The perennial goals of efficient biomechanics are to obtain more controlled and faster movement and using more discrete appliances. The most recent technological advances have buttressed these goals. Temporary anchorage devices...
Thu Oct 08, 2020 13:28
Surgical anatomy of the lymphatic drainage of the salivary glands: a systematic review. J Laryngol Otol. 2020 Oct 07;:1-7 Authors: Abou-Foul AK Abstract BACKGROUND: Nodal metastasis in salivary gland malignancies has important clinical implications; a good understanding of their complex anatomy is paramount to the head and neck surgeon. METHODS: A contemporary and comprehensive literature review was conducted of the lymphatic...
Thu Oct 08, 2020 13:28
Long noncoding RNA RP11-757G1.5 sponges miR-139-5p and upregulates YAP1 thereby promoting the proliferation and liver, spleen metastasis of colorectal cancer. J Exp Clin Cancer Res. 2020 Oct 06;39(1):207 Authors: Zhu X, Bu F, Tan T, Luo Q, Zhu J, Lin K, Huang J, Luo C, Zhu Z Abstract BACKGROUND: Accumulating evidence indicates that long non-coding RNAs (lncRNAs) acting as crucial regulators in tumorigenesis. However, its biological functions...
Thu Oct 08, 2020 13:28
Construction of an 11-microRNA-based signature and a prognostic nomogram to predict the overall survival of head and neck squamous cell carcinoma patients. BMC Genomics. 2020 Oct 06;21(1):691 Authors: Huang Y, Liu Z, Zhong L, Wen Y, Ye Q, Cao D, Li P, Liu Y Abstract BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a fatal malignancy owing to the lack of effective tools to predict overall survival (OS). MicroRNAs (miRNAs) play...
Thu Oct 08, 2020 13:28
Indications and strategy for active surveillance of adult low-risk papillary thyroid microcarcinoma: consensus statements from the Japan Association of Endocrine Surgery task force on management for papillary thyroid microcarcinoma. Thyroid. 2020 Oct 06;: Authors: Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A Abstract BACKGROUND: The...
Thu Oct 08, 2020 13:28
Facial Nerve Meningioma: A Case Mimicking Facial Nerve Schwannoma. Ear Nose Throat J. 2020 Oct 06;:145561320962582 Authors: Gao W, Zi D, Lu L Abstract Facial nerve meningioma is exceedingly rare and tends to affect the geniculate ganglion. We present a case of facial nerve meningioma located in the internal auditory canal with a "labyrinthine tail," mimicking facial nerve schwannoma. The clinical and radiological features, growth patterns,...
Thu Oct 08, 2020 13:28
Primary First Bite Syndrome of the Parotid Gland: Case Report and Literature Review. Ear Nose Throat J. 2020 Oct 06;:145561320962584 Authors: Yang X, Yang X, Wang W, Zhang P, Hou R, Yang Y, Lei D, Wei J Abstract OBJECTIVE: A case of primary first bite syndrome (FBS), diagnosed in a patient with nonspecific adenocarcinoma of the deep lobe of the parotid gland. DATA SOURCES: A Medline literature search was conducted on PubMed,...
Thu Oct 08, 2020 13:28
Alternative therapies for chronic rhinosinusitis: A review. Ear Nose Throat J. 2020 Oct 06;:145561320939415 Authors: Griffin AS, Cabot P, Wallwork B, Panizza B Abstract The use of alternative medicine in chronic rhinosinus-itis (CRS) continues to increase in popularity, for the most part without meeting the burden of being based on sound clinical evidence. New and emerging treat-ments, both natural and developed, are numerous, and it remains...
Thu Oct 08, 2020 13:28
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