Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. I...
Wed Oct 07, 2020 03:00
Abstract Background Walking outdoors can be used by many individuals to meet public health guidelines for moderate-to-vigorous-intensity physical activity. The speed at which adults walk may be a proxy for intensity. Traditional estimates of indoor walking speed are unlikely to reflect self-selected usual or other instructed paces of outdoor walking speed. Objective ...
Thu Oct 08, 2020 03:00
Tubulovillous adenoma of the duodenal papilla: radiological-endoscopic and anatomopathological correlation in the surgical proposal. Rev Assoc Med Bras (1992). 2020 Sep;66(9):1190-1195 Authors: Fernandes DA, Boteon YL, Boteon APCDS, Sousa RMP, Martins DL, Penachim TJ, Barros RHO, Martins RCP, Costa LBED, Cazzo E, Gestic MA, Chaim EA, Caserta NMG Abstract Tubulovillous adenomas of the duodenal ampulla are rare neoplasms. The present report describes...
Thu Oct 08, 2020 13:59
Gastrointestinal stromal tumor in perforated Meckel's diverticulum: a case report and literature review. Surg Case Rep. 2020 Oct 07;6(1):265 Authors: Hashizume N, Sakamoto S, Fukahori S, Ishii S, Saikusa N, Koga Y, Higashidate N, Tsuruhisa S, Nakahara H, Tanaka Y, Yagi M Abstract INTRODUCTION: Gastrointestinal stromal tumor (GIST) is rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. GIST has...
Thu Oct 08, 2020 13:59
Nasopharyngeal carcinoma metastasis to the breast. Saudi Med J. 2020 Oct;41(10):1130-1134 Authors: Albasri AM Abstract Breast metastases from extra-mammary neoplasms are rare, accounting for less than 2% of breast cancer cases. A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cells with scant to moderate,...
Thu Oct 08, 2020 13:59
Laparoscopic resection of primary retroperitoneal schwannoma: A case report. World J Clin Cases. 2020 Sep 26;8(18):4114-4121 Authors: Ribeiro MA, Elias YG, Augusto SS, Néder PR, Costa CT, Maurício AD, Sampaio AP, Fonseca AZ Abstract BACKGROUND: Schwannomas are rare, often benign, tumors deriving from Schwann cells that have low incidence in the retroperitoneal region (0.5% to 5%). Their diagnosis is hardly confirmed at early stage due to lack...
Thu Oct 08, 2020 13:59
Pancreaticogastrostomy for pancreatic body cystic neoplasms: An organ-sparing approach. Int J Surg Case Rep. 2020;76:153-155 Authors: Orhan O, Carkman S, Erginoz E, Ozcelik MF Abstract Introduction: Surgical management of pancreatic cysts differ according to the specific location of the cyst on the pancreas. Cysts located on the pancreatic head require a radical procedure such as pancreaticoduodenectomy (Whipple procedure). Cysts of the pancreatic...
Thu Oct 08, 2020 13:59
Multiple neoplasia in a patient with Gitelman syndrome harboring germline monoallelic MUTYH mutation. NPJ Genom Med. 2020;5:39 Authors: Chan JY, Toh MR, Chong ST, Ishak NDB, Kolinjivadi AM, Chan SH, Lee E, Boot A, Shao-Tzu L, Chew MH, Ngeow J Abstract Gitelman syndrome is a rare, recessively inherited disease characterized by chronic hypokalemia and hypomagnesemia as a result of defective electrolyte co-transport at the level of the distal...
Thu Oct 08, 2020 13:59
Age-related remodelling of the blood immunological portrait and the local tumor immune response in patients with luminal breast cancer. Clin Transl Immunology. 2020;9(10):e1184 Authors: Berben L, Floris G, Kenis C, Dalmasso B, Smeets A, Vos H, Neven P, Antoranz Martinez A, Laenen A, Wildiers H, Hatse S Abstract Objectives: Aging is associated with altered immune function and chronic low-grade inflammation, referred to as immunosenescence. As...
Thu Oct 08, 2020 13:59
Problematic breast tumors reassessed in light of novel molecular data. Mod Pathol. 2020 Oct 06;: Authors: Pareja F, Weigelt B, Reis-Filho JS Abstract Breast cancer is a vastly heterogeneous disease encompassing a panoply of special histological subtypes. Although rare breast tumors have largely not been investigated systematically in large scale genomics series, recent studies have shed light on the genetic underpinnings of special histologic...
Thu Oct 08, 2020 13:59
Unilateral synchronous papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations. Diagn Pathol. 2020 Oct 06;15(1):123 Authors: Lee HJ, Shin DH, Park JY, Kim SY, Hwang CS, Lee JH, Kim JY, Sol MY, Nam JK Abstract BACKGROUND: The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell...
Thu Oct 08, 2020 13:59
Allogeneic Hematopoietic Stem Cell Transplantation in Cutaneous T-Cell Lymphomas. Cancers (Basel). 2020 Oct 03;12(10): Authors: Dumont M, Peffault de Latour R, Ram-Wolff C, Bagot M, de Masson A Abstract Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin lymphomas that develop primarily in the skin. They account for almost 80% of primary cutaneous lymphomas. Epidermotropic CTCLs (mycosis fungoides (MF) and Sézary syndrome (SS)) are the most...
Thu Oct 08, 2020 13:59
A Rare Case of Locally Advanced Primary Small Cell Neuroendocrine Carcinoma of the Adrenal Gland. Anticancer Res. 2020 Oct;40(10):5933-5938 Authors: Limonnik V, Shah D, Sandhu A, Monga DK Abstract BACKGROUND/AIM: Primary small cell neuroendocrine carcinoma (SCNEC) of the adrenal gland is extremely rare with limited reports in the literature. There remain no definitive treatment guidelines, largely due to the rarity of the malignancy. ...
Thu Oct 08, 2020 13:59
First Reported Case of Localized Extra-pulmonary Small Cell Carcinoma (EPSC) of the Esophagus Treated With Triple Therapy. Anticancer Res. 2020 Oct;40(10):5919-5923 Authors: Haag A, Jayakrishnan T, Shah D, Sandhu A, Monga D Abstract BACKGROUND/AIM: Early stage extra-pulmonary small cell carcinoma (EPSC) of the esophagus is very rare and is usually treated with chemo-radiation or surgical resection. CASE REPORT: A case of early stage...
Thu Oct 08, 2020 13:59
Upfront Radiotherapy in Patients With Asymptomatic Incurable Rectal Cancer: A Retrospective Cohort Study. Anticancer Res. 2020 Oct;40(10):5853-5860 Authors: Jonsson G, Philipson L, Villman K, Valachis A Abstract BACKGROUND/AIM: The optimal treatment sequencing for asymptomatic de novo metastatic rectal cancer is unclear. The aim of this study was to investigate the role of upfront radiotherapy, with or without chemotherapy on risk for local...
Thu Oct 08, 2020 13:59
Radical Nephrectomy and Pulmonary Lobectomy for Renal Cell Carcinoma With Tumor Thrombus Extension into the Inferior Vena Cava and Pulmonary Arteries. Anticancer Res. 2020 Oct;40(10):5837-5844 Authors: Manoharan A, Lugo-Baruqui A, Ciancio G Abstract BACKGROUND/AIM: Renal cell carcinoma (RCC) is one of the most common malignancies of the urinary tract. Venous migration, tumor thrombus and metastases are often seen in patients with RCC and are...
Thu Oct 08, 2020 13:59
Angiosarcomas of Primary Gynecologic Origin - A Case Series and Review of the Literature. Anticancer Res. 2020 Oct;40(10):5743-5750 Authors: Chinczewski L, Taube ET, Feldhaus FW, DrÖge LA, Chekerov R, Muallem MZ, Pietzner K, Sehouli J, Alavi S Abstract BACKGROUND/AIM: Angiosarcoma of primary gynecologic origin is an extremely rare and highly malignant tumor of endothelial origin with a 5-year survival rate of less than 35%. To date, only 61...
Thu Oct 08, 2020 13:59
Utility of Bone Scintigraphy and PET-CT in the Surgical Staging of Skeletal Chondrosarcoma. Anticancer Res. 2020 Oct;40(10):5735-5738 Authors: Johnson JD, Rainer WG, Rose PS, Houdek MT Abstract BACKGROUND/AIM: Surgical staging is paramount to treatment of primary bone sarcomas. Often, bone scintigraphy and/or positron emission tomography-computed tomography (PET-CT) are used to exclude skeletal metastases; however, skeletal metastases in chondrosarcoma...
Thu Oct 08, 2020 13:59
Cytopathological Heterogeneity of Circulating Tumor Cells in Non-metastatic Esophageal Adenocarcinoma. Anticancer Res. 2020 Oct;40(10):5679-5685 Authors: Kuvendjiska J, Pitman MB, Martini V, Braun C, Grebe K, Timme S, Fichtner-Feigl S, Glatz T, Schmoor C, Guenzle J, Hoeppner J, Kulemann B Abstract BACKGROUND/AIM: The presence of circulating tumor cells (CTC) has been reported to have an impact on prognosis in different tumor entities. Little...
Thu Oct 08, 2020 13:59
Related Articles SARS-CoV-2-related pneumonia can be successfully managed in patients with metastatic neuroendocrine tumors: a critical point of view. Endocrine. 2020 10;70(1):6-10 Authors: Spada F, Pellicori S, Zampino G, Funicelli L, Gervaso L, Laffi A, Rubino M, Garcia-Carbonero R, Fazio N Abstract Primary neuroendocrine tumors of the thymus are extremely rare. In patients with advanced disease, tumor growth control, and sometimes also...
Thu Oct 08, 2020 13:59
Related Articles [Tenosynovial giant-cell tumour - a rare disease]. MMW Fortschr Med. 2020 06;162(12):56-58 Authors: Zimmerer A, Sobau C, Wassilew GI, Miehlke W PMID: 32578090 [PubMed - indexed for MEDLINE]
Thu Oct 08, 2020 13:59
Related Articles p110δ PI3K as a therapeutic target of solid tumours. Clin Sci (Lond). 2020 06 26;134(12):1377-1397 Authors: Xenou L, Papakonstanti EA Abstract From the time of first characterization of PI3K as a heterodimer made up of a p110 catalytic subunit and a regulatory subunit, a wealth of evidence have placed the class IA PI3Ks at the forefront of drug development for the treatment of various diseases including cancer. The p110α isoform...
Thu Oct 08, 2020 13:59
Related Articles Clinicopathological study of intraductal carcinoma of the salivary gland, with emphasis on the apocrine type. Virchows Arch. 2020 Oct;477(4):581-592 Authors: Hsieh MS, Lee YH, Jin YT, Kuo YJ Abstract Intraductal carcinoma (IC) is a rare salivary gland tumor with low- to intermediate-grade cytological features. It is further classified into intercalated duct type and apocrine type based on its distinct histologic and immunohistochemical...
Thu Oct 08, 2020 13:59
Related Articles Droplet digital PCR enabled by microfluidic impact printing for absolute gene quantification. Talanta. 2020 May 01;211:120680 Authors: Pan Y, Ma T, Meng Q, Mao Y, Chu K, Men Y, Pan T, Li B, Chu J Abstract Digital PCR enabled high-sensitivity and quantitative measurements of rare biological variants. A new digital droplet-enabled PCR technology was introduced in this paper, which partitioned genetic targets into a planar nanoliter...
Thu Oct 08, 2020 13:59
Related Articles Oropharyngeal rhabdomyoma: the cause of severe sleep apnoea? BMJ Case Rep. 2020 Feb 09;13(2): Authors: Münch HJ, O'Leary P, Bille J, Kjaergaard T Abstract This case report presents an elderly male patient who on diagnosis with a large oropharyngeal tumour had no specific symptomatology apart from severe obstructive sleep apnoea. Histopathology revealed the tumour to be an adult rhabdomyoma, a rare but benign tumour arising...
Thu Oct 08, 2020 13:59
Related Articles Novel mutation in the CD27 gene in a patient presenting with hypogammaglobulinemia, bronchiectasis and EBV-driven lymphoproliferative disease. BMJ Case Rep. 2020 Feb 09;13(2): Authors: Kishore R, Gupta A, Gupta AK, Kabra SK Abstract CD27 deficiency is a rare primary immune deficiency which affects T cells, B cells and NK cells and is associated with hypogammaglobulinemia. Clinical presentation varies from asymptomatic disease...
Thu Oct 08, 2020 13:59
Related Articles Rare case: paraneoplastic syndrome affecting peripheral nerves, associated with anti-collapsin-response mediator protein-5 (anti-CRMP5) antibodies, as early manifestation of small cell lung cancer confined to a solitary lymph node without evidence of lung mass on routine CT thorax. BMJ Case Rep. 2020 Feb 06;13(2): Authors: Khan U, Warriach SA Abstract A 69-year-old woman presented with 9 months history of progressively worsening...
Thu Oct 08, 2020 13:59
Related Articles Unusual presentation of a large GIST in an extraintestinal site: a challenging diagnosis dilemma. BMJ Case Rep. 2020 Feb 06;13(2): Authors: Ashoor AA, Barefah G Abstract Gastrointestinal stromal tumour (GIST) is a recent recognised tumour entity. In the past, those tumours were classified as leiomyomas, leiomyosarcomas and leiomyoblastomas, but it is now evident that GIST is a separate tumour entity and is the most common...
Thu Oct 08, 2020 13:59
Related Articles Multifocal circumscribed choroidal hemangioma: a rare occurrence. BMJ Case Rep. 2020 Feb 05;13(2): Authors: Vempuluru VS, Kaliki S Abstract A 32-year-old Asian-Indian woman presented with painless diminution of vision in her left eye (oculus sinister (OS)) and fundus examination OS revealed a large dome-shaped orangish-red subretinal lesion at the macula along with a smaller lesion on the superotemporal arcade. Indocyanine...
Thu Oct 08, 2020 13:59
Related Articles Hepatic epitheloid haemangioendothelioma: a rare malignant tumour. BMJ Case Rep. 2020 Jan 28;13(1): Authors: Lund PS, Willemoe GL, Hansen LB, Warnecke M Abstract Our case concerns a 66-year-old man. After experiencing recurrent episodes of abdominal pain, an initial CT scan, ultrasound and gastroscopy was carried out. All of which showed normal findings.As a consequence of persisting symptoms, another CT scan was performed....
Thu Oct 08, 2020 13:59
Related Articles Rare case of acute on chronic hepatic failure in a patient with multiple myeloma-associated amyloidosis. BMJ Case Rep. 2020 Jan 28;13(1): Authors: Muhammad Khan M, Ur Rashid M, Ullah W, Hussain I, Hurairah A Abstract Amyloidosis is the extracellular deposition of unique protein fibrils in different tissue organs. It is most commonly associated with B-cell malignancy such as multiple myeloma or Waldenstrom macroglobulinaemia....
Thu Oct 08, 2020 13:59
Related Articles Primary malignant melanoma of the vagina. BMJ Case Rep. 2020 Jan 29;13(1): Authors: Jamaer E, Liang Z, Stagg B Abstract Primary malignant melanoma of the vagina is a rare gynaecological neoplasm with an aggressive course of disease. Although not many cases have been reported in the literature, its manifestations appear to be fairly consistent. The challenge comes in knowing how to approach this cancer clinically, since information...
Thu Oct 08, 2020 13:59
Related Articles Bilateral hypoglossal nerve damage due to the use of the harmonic focus scalpel. BMJ Case Rep. 2020 Jan 26;13(1): Authors: Radcliffe K, Akhtar S, Wilson A Abstract We describe the case of a 68-year-old man who presented with an anterior floor of mouth squamous cell carcinoma and underwent bilateral neck dissection. Subsequently, the patient developed permanent bilateral hypoglossal palsies, causing significant dysphagia, dysarthria...
Thu Oct 08, 2020 13:59
Related Articles Primary spinal epidural lymphoma: a rare entity with an ambiguous management. BMJ Case Rep. 2020 Jan 26;13(1): Authors: Páscoa Pinheiro J, Rato J, Rebelo O, Costa G Abstract Lymphomas are malignant lymphoid tumours arising from lymphocytic cells. They usually develop in the lymphoid tissues and can spread to other organs; however, primary extra-nodal locations such as the spinal epidural space are less common. The authors report...
Thu Oct 08, 2020 13:59
Related Articles Adult Ileocolic Intussusception Caused by Diffuse Large B Cell Lymphoma. Korean J Gastroenterol. 2020 01 25;75(1):46-49 Authors: Park JW, Song GA, Baek DH, Kim GH, Lee BE, Lee MW, Han SY, Park YJ, Park EY Abstract Intussusception is a medical condition, in which a proximal part of the intestine folds into the distal intestine. Adult intussusceptions are rare and account for approximately 5% of all cases of intussusceptions....
Thu Oct 08, 2020 13:59
Related Articles Aldehyde dehydrogenase-positive melanoma stem cells in tumorigenesis, drug resistance and anti-neoplastic immunotherapy. Mol Biol Rep. 2020 Feb;47(2):1435-1443 Authors: Zhang S, Yang Z, Qi F Abstract Cancer stem cells (CSCs), a rare subset of cancer cells, are well known for their self-renewing capacity. CSCs play a critical role in therapeutic failure and are responsible for poor prognosis in leukemia and various solid tumors....
Thu Oct 08, 2020 13:59
Related Articles Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment. Leukemia. 2020 06;34(6):1658-1668 Authors: Caye A, Rouault-Pierre K, Strullu M, Lainey E, Abarrategi A, Fenneteau O, Arfeuille C, Osman J, Cassinat B, Pereira S, Anjos-Afonso F, Currie E, Ariza-McNaughton L, Barlogis V, Dalle JH, Baruchel A, Chomienne C, Cavé H, Bonnet D Abstract Juvenile myelomonocytic...
Thu Oct 08, 2020 13:59
Related Articles Doxorubicin and cyclophosphamide-induced parotitis: A case report. J Clin Pharm Ther. 2020 Feb;45(1):211-213 Authors: Fox-Lewis A, Tairab M, Fulton G, Kuper-Hommel M, Jameson MB Abstract WHAT IS KNOWN AND OBJECTIVE: Drug-induced parotitis is a rare adverse drug reaction (ADR). A comprehensive literature review identified only three clearly associated medications: L-asparaginase, clozapine and phenylbutazone. CASE DESCRIPTION:...
Thu Oct 08, 2020 13:59
Related Articles Ewing sarcoma/primitive neuro-ectodermal tumor of the urogenital system in children: a retrospective observational case series. J Pediatr Urol. 2019 Oct;15(5):556.e1-556.e7 Authors: He Y, Sun N, Zhang W, Ma X, Ni X, Jin M, Sun J, Song H Abstract INTRODUCTION: Pediatric Ewing sarcoma (ES)/primitive neuro-ectodermal tumor (PNET) occurring in the genitourinary system has been rarely reported. And the result of long-term follow-up...
Thu Oct 08, 2020 13:59
Related Articles APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer. Eur Urol. 2019 07;76(1):9-13 Authors: Shi MJ, Meng XY, Lamy P, Banday AR, Yang J, Moreno-Vega A, Chen CL, Dyrskjøt L, Bernard-Pierrot I, Prokunina-Olsson L, Radvanyi F Abstract FGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most...
Thu Oct 08, 2020 13:59
Related Articles Effectiveness of chemoradiotherapy for radiation-induced bilateral external auditory canal cancer: A case report and literature review. Head Neck. 2019 07;41(7):E113-E119 Authors: Maebayashi T, Ishibashi N, Aizawa T, Sakaguchi M, Ikeda A, Hirai R, Furusaka T, Homma T Abstract BACKGROUND: Radiation-induced bilateral external auditory canal cancer is an extremely rare disease that has yet to be fully characterized in the clinical...
Thu Oct 08, 2020 13:59
Related Articles Primary Ewing sarcoma of the squamous temporal bone with intracranial and extracranial extension: A rare cause of sudden sensorineural hearing loss. Head Neck. 2019 03;41(3):E38-E41 Authors: Choi SW, Ko H Abstract BACKGROUND: Primary Ewing sarcoma of the cranial bone is rare, accounting for only 1% of all Ewing sarcomas. Primary Ewing sarcoma arising in the squamous temporal bone is particularly rare. METHODS: A 16-year-old...
Thu Oct 08, 2020 13:59
Related Articles Hypopharyngeal carcinoma: Do you know your guidelines? Head Neck. 2019 03;41(3):569-576 Authors: Kwon DI, Miles BA, Education Committee of the American Head and Neck Society (AHNS) Abstract BACKGROUND: Hypopharyngeal carcinoma is relatively rare, representing approximately 3% of all head and neck malignancies. It also is characterized by having one of the worst prognoses at time of diagnosis. This is largely due to its tendency...
Thu Oct 08, 2020 13:59
Evaluation of a Managed Surgical Consultation Network in Malawi. World J Surg. 2020 Oct 07;: Authors: Mwapasa G, Pittalis C, Clarke M, Bijlmakers L, Le G, Mkandawire N, Brugha R, Borgstein E, Gajewski J Abstract BACKGROUND: Access to surgery is a challenge for low-income countries like Malawi due to shortages of specialists, especially in rural areas. District hospitals (DH) cater for the immediate surgical needs of rural patients, sending...
Thu Oct 08, 2020 13:39
Esophageal Lipoma and Liposarcoma: A Systematic Review. World J Surg. 2020 Oct 07;: Authors: Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L Abstract BACKGROUND: Esophageal lipomatous tumors, also reported as fibrovascular polyp, fibrolipoma, angiolipoma, and liposarcoma, account for less than 1% of all benign mesenchymal submucosal tumors of the esophagus. Clinical presentation and therapy may differ based on location, size,...
Thu Oct 08, 2020 13:39
The Value of Reporting Perioperative Mortality Rates (POMR). World J Surg. 2020 Oct 06;: Authors: Watters DA PMID: 33025155 [PubMed - as supplied by publisher]
Thu Oct 08, 2020 13:39
Biosynthetic Resorbable Prosthesis is Useful in Single-Stage Management of Chronic Mesh Infection After Abdominal Wall Hernia Repair. World J Surg. 2020 Oct 06;: Authors: Bueno-Lledó J, Ceno M, Perez-Alonso C, Martinez-Hoed J, Torregrosa-Gallud A, Pous-Serrano S Abstract BACKGROUND: The goal of this article was to report the results about the efficacy of treatment of chronic mesh infection (CMI) after abdominal wall hernia repair (AWHR) in...
Thu Oct 08, 2020 13:39
Cell-Penetrating Peptides in Oncologic Pharmacotherapy: A Review. Pharmacol Res. 2020 Oct 04;:105231 Authors: Vale N, Duarte D, Silva S, Correia AS, Costa B, Gouveia MJ, Ferreira A Abstract Cancer is the second leading cause of death in the world and its treatment is extremely challenging, mainly due to its complexity. Cell-Penetrating Peptides (CPPs) are peptides that can transport into the cell a wide variety of biologically active conjugates...
Thu Oct 08, 2020 13:39
The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest. Cell Rep. 2020 Oct 06;33(1):108230 Authors: Moustafa-Kamal M, Kucharski TJ, El-Assaad W, Abbas YM, Gandin V, Nagar B, Pelletier J, Topisirovic I, Teodoro JG Abstract mTOR is a serine/threonine kinase and a master regulator of cell growth and proliferation. Raptor, a scaffolding protein that recruits substrates to mTOR complex 1 (mTORC1), is known to be phosphorylated...
Thu Oct 08, 2020 13:39
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma. EMBO Mol Med. 2020 Oct 07;:e12525 Authors: Leiendecker L, Jung PS, Krecioch I, Neumann T, Schleiffer A, Mechtler K, Wiesner T, Obenauf AC Abstract Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent...
Thu Oct 08, 2020 13:39
Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme. Mol Ther Oncolytics. 2020 Jun 26;17:518-530 Authors: Chen X, Li H, Fan X, Zhao C, Ye K, Zhao Z, Hu L, Ma H, Wang H, Fang Z Abstract Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression in...
Thu Oct 08, 2020 13:39
Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway. Cell Death Discov. 2020;6:91 Authors: Zhang J, Wu L, Lian C, Lian S, Bao S, Zhang J, Wang P, Ma J, Li Y Abstract Nitidine chloride (NC) has significant anti-tumor properties; however, the precise mechanism related to NC still needs further investigation. This study intends to investigate the anti-tumor functions and the feasible...
Thu Oct 08, 2020 13:39
Synergistic Combination of Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid and Natural Flavonoid Curcumin Exhibits Anticancer and Antibacterial Activity. Anticancer Agents Med Chem. 2020 Oct 06;: Authors: Altundağ EM, Toprak K, Şanlıtürk G, Güran M, Özbilenler C, Kerküklü NR, Yılmaz AM, Yalçın AS Abstract BACKGROUND AND OBJECTIVE: Curcumin is an effective anti-cancer agent used in thyroid cancer treatments. However, its use...
Thu Oct 08, 2020 13:39
Curcumin exerts anti-tumor effects on diffuse large B cell lymphoma via regulating PPARγ expression.
Related Articles Curcumin exerts anti-tumor effects on diffuse large B cell lymphoma via regulating PPARγ expression. Biochem Biophys Res Commun. 2020 03 26;524(1):70-76 Authors: Zhang W, Li Q, Yang C, Yang H, Rao J, Zhang X Abstract Given the highly heterogeneity of diffuse large B cell lymphoma (DLBCL) and the diverse demands for proper treatment, many patients would relapse or show resistance to current therapeutic regimens, new treatment...
Thu Oct 08, 2020 13:39
Related Articles Effects of LncRNA KCNQ1OT1 on proliferation and migration of ovarian cancer cells by Wnt/β-catenin. Eur Rev Med Pharmacol Sci. 2019 Oct;23(20):8788-8794 Authors: Luo ZP, Jin H Abstract OBJECTIVE: To explore the role of long noncoding ribonucleic acid (lncRNA) KCNQ1OT1 in the proliferation, apoptosis, and migration of ovarian cancer cells via Wnt/β-catenin. MATERIALS AND METHODS: Ovarian cancer A2780 cells were divided...
Thu Oct 08, 2020 13:39
Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders. Diabet Med. 2020 Oct 06;:e14415 Authors: Eslami M, Bahar A, Hemati M, Rasouli Nejad Z, Mehranfar F, Karami S, Kobyliak NM, Yousefi B Abstract In this review, the numerous possible mechanisms that provide supportive evidence for how colonic dysbiosis denotes metabolic dysfunction, dysregulates glucose homeostasis and...
Thu Oct 08, 2020 13:35
Olfactory and Gustatory Dysfunctions as a Clinical Manifestation of Coronavirus Disease 2019 in a Malaysian Tertiary Center. Ann Otol Rhinol Laryngol. 2020 Oct 07;:3489420963165 Authors: Ramasamy K, Saniasiaya J, Abdul Gani N Abstract OBJECTIVE: To investigate the prevalence of olfactory and gustatory dysfunction among patients with COVID-19 infection and the recovery rate. METHODS: Adult patients (≥18 years) tested positive...
Thu Oct 08, 2020 13:34
Recurrent Hemoptysis: A Bronchial Dieulafoy's Lesion in a Pediatric Patient. Ann Otol Rhinol Laryngol. 2020 Oct 07;:3489420962132 Authors: Ruthberg JS, Abrol A, Howard NS Abstract OBJECTIVE: This paper presents a case of a bronchial Dieulafoy's lesion in a pediatric patient with recurrent hemoptysis. CASE REPORT: A 11-year old female presented multiple times with dry cough and hemoptysis to an outside hospital, each time leading...
Thu Oct 08, 2020 13:34
An amendment to this paper has been published and can be accessed via the original article.
Wed Oct 07, 2020 03:00
Leaves have highly diverse morphologies. However, with an evolutionary history of approximately 200 million years, leaves of the pine family are relatively monotonous and often collectively called “needles”, a...
Wed Oct 07, 2020 03:00
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. PD associated human UCHL1 (Ubiquitin C-terminal hydrolase L1) gene belongs to the family of deubiquitinases and is known to be highly...
Wed Oct 07, 2020 03:00
Investigation of an Outcomes-Driven, Computer-Assisted Approach to CI Fitting in Newly Implanted Patients. Ear Hear. 2020 Oct 05;: Authors: Zwolan TA, Presley R, Chenier L, Buck B Abstract OBJECTIVE: To evaluate the efficacy of outcomes received by newly implanted cochlear implant recipients when an outcomes-driven, computer-assisted approach to cochlear implantation fitting was used. This approach, referred to as "Fitting to Outcome eXpert,"...
Thu Oct 08, 2020 13:28
Cerebrospinal Fluid Leak After Septoplasty in Crouzon Syndrome. J Craniofac Surg. 2020 Oct 06;: Authors: Demir B, Abuzaid G, Binnetoglu A Abstract Crouzon syndrome presents with craniofacial deformities due to early fusion of cranial sutures. Deviation of the nasal septum could be seen clinically in Crouzon syndrome. Cerebrospinal fluid leaks (CSF) after septoplasty are extremely rare and typically present with simple rhinorrhea, meningitis,...
Thu Oct 08, 2020 13:28
A Novel Laryngoscope-assisted Method for Sealing Pharyngocutaneous Fistula. J Craniofac Surg. 2020 Oct 06;: Authors: Du Z, Zhang CP, Wang YA Abstract Pharyngocutaneous fistula (PCF) is one of the most common but stranded complications for salvage laryngectomy. As for localized fistula, there is no convincing standard and method to cure. This paper described a patient who was submitted to extensive resection of mass in right lingual root,...
Thu Oct 08, 2020 13:28
Chemotherapy and dysphagia: the good, the bad, the ugly. Curr Opin Otolaryngol Head Neck Surg. 2020 Oct 06;: Authors: Dewan K Abstract PURPOSE OF REVIEW: Dysphagia is a debilitating, depressing and potentially life-threatening complication in cancer patients that is likely underreported. The purpose of this review is to critically synthesize the current knowledge regarding the impact of chemotherapeutic regimens on swallowing function....
Thu Oct 08, 2020 13:28
Does our swallow go to sleep? Changes in swallow function during sleep and implications for symptoms. Curr Opin Otolaryngol Head Neck Surg. 2020 Oct 06;: Authors: Sato K Abstract PURPOSE OF REVIEW: Swallowing is a vital function and the clearance of the pharynx by deglutition, which removes matter that could be aspirated, and the respiratory phase patterns associated with deglutition are important in protecting the airways and lungs against...
Thu Oct 08, 2020 13:28
Pediatric tracheostomy care updates. Curr Opin Otolaryngol Head Neck Surg. 2020 Oct 06;: Authors: Smith MM, Benscoter D, Hart CK Abstract PURPOSE OF REVIEW: The aim of this review is to provide an update on the management of pediatric tracheostomies. RECENT FINDINGS: Recent literature has focused on optimization of care for children with tracheostomies including prevention and management of skin breakdown, timing of tracheostomy...
Thu Oct 08, 2020 13:28
Radiation exposure in modified barium swallow studies. Curr Opin Otolaryngol Head Neck Surg. 2020 Oct 06;: Authors: Bonilha HS, Martin-Harris B, O'Rourke AK, Tipnis SV Abstract PURPOSE OF REVIEW: The modified barium swallow study (MBSS) is an X-ray examination of swallowing used to detect the presence and type impairment, aspiration risk, and to develop intervention plans. In this review, we will cover the use of ionizing radiation in...
Thu Oct 08, 2020 13:28
Preimplant Hearing Threshold: An Important Predictor of Hearing Preservation in Cochlear Implantation With Lateral Wall Electrodes. Otol Neurotol. 2020 Sep 22;: Authors: Lee G, Lee S, Chung JH, Choi JW Abstract OBJECTIVE: To evaluate the outcomes and association factors of long-term hearing preservation (HP) in cochlear implantation with lateral wall (LW) electrode arrays. STUDY DESIGN: Retrospective case review. SETTING:...
Thu Oct 08, 2020 13:28
Comparison of Speech Recognition and Localization Ability in Single-sided Deaf Patients Implanted With Different Cochlear Implant Electrode Array Designs. Otol Neurotol. 2020 Sep 22;: Authors: Speck I, Ketterer MC, Arndt S, Aschendorff A, Jakob TF, Hassepass F Abstract OBJECTIVE: Choice of electrode array (EA) design and differences in outcome are major concerns both to patients with single-sided deafness (SSD) and to surgeons before cochlear...
Thu Oct 08, 2020 13:28
Posterior Tympanotomy Versus Subtotal Petrosectomy: A Comparison of Complications in Cochlear Implantation. Otol Neurotol. 2020 Sep 22;: Authors: Lee S, Lee JB, Chung JH, Choi JW Abstract OBJECTIVE: To compare the postoperative complications between posterior tympanotomy cochlear implantation (PTCI) and subtotal petrosectomy cochlear implantation (SPCI). STUDY DESIGN: A retrospective cohort study. SETTING: Two tertiary...
Thu Oct 08, 2020 13:28
[ENT and head and neck manifestations of the IgG4-related disease]. Rev Med Suisse. 2020 Oct 07;16(709):1870-1875 Authors: Liard Y, Nigolian H, Lobrinus JA, Lenoir V, Becker M, Nieke JP, Seebach JD, Landis B, Guinand N Abstract IgG4-related disease is a rare multi-organic inflammatory disease that frequently involves the ENT and head and neck areas. In these cases, salivary gland and lacrimal gland involvement is very common and includes...
Thu Oct 08, 2020 13:28
[ENT management of head and neck cutaneous melanoma]. Rev Med Suisse. 2020 Oct 07;16(709):1853-1859 Authors: Jaballah Vinckenbosch P, Litzistorf Y, Gaide O, Özdemir BC, Michielin O, Reinhard A Abstract A quarter of cutaneous melanomas occur on the head and neck. Despite close collaboration between the dermatology, oncology, pathology, nuclear medicine and otorhinolaryngology departments, the survival of patients presenting with this type...
Thu Oct 08, 2020 13:28
Targeting hepatocyte growth factor/c-mesenchymal-epithelial transition factor axis in hepatocellular carcinoma: Rationale and therapeutic strategies. Med Res Rev. 2020 Oct 07;: Authors: Yu J, Chen GG, Lai PBS Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. The outcome of current standard treatments, as well as targeted therapies in advanced stages, are still unsatisfactory. Attention has been drawn...
Thu Oct 08, 2020 13:28
Full percutaneous intraoperative neuromonitoring technique in remote thyroid surgery: Porcine model feasibility study. Head Neck. 2020 Oct 07;: Authors: Huang TY, Lin YC, Tseng HY, Kim HY, Dionigi G, Lu IC, Chang PY, Chiang FY, Wu CW Abstract BACKGROUND: In remote thyroid surgery, a reliable intraoperative neuromonitoring (IONM) procedure is an important tool for reducing injury to recurrent laryngeal nerve (RLN). This study proposes an...
Thu Oct 08, 2020 13:28
Opioid Prescribing Patterns Following Pediatric Tonsillectomy in the United States, 2009-2017. Laryngoscope. 2020 Oct 07;: Authors: Qian ZJ, Alyono JC, Jin MC, Cooperman SP, Cheng AG, Balakrishnan K Abstract OBJECTIVES: Assess national trends in opioid prescription following pediatric tonsillectomy: 1) overall percentage receiving opioids and mean quantity, 2) changes during 2009-2017, and 3) determinants of prescription patterns. ...
Thu Oct 08, 2020 13:28
Outcomes of Adenotonsillectomy for Obstructive Sleep Apnea in Prader-Willi Syndrome: Systematic Review and Meta-analysis. Laryngoscope. 2020 Jul 27;: Authors: Clements AC, Dai X, Walsh JM, Sterni LM, Prichett L, Boss EF, Seal SM, Ryan MA Abstract OBJECTIVES: Prader-Willi syndrome (PWS) increases the risk of obstructive sleep apnea (OSA) due to obesity, hypotonia, and abnormal ventilatory responses. We evaluated post-adenotonsillectomy...
Thu Oct 08, 2020 13:28
Voice-Related Quality of Life Is Associated with Postoperative Change in Subglottic Stenosis. Laryngoscope. 2020 Oct 07;: Authors: Schuman AD, Neevel A, Morrison RJ, Hogikyan ND, Kupfer RA Abstract OBJECTIVES: To characterize the impact of subglottic stenosis (SGS) on voice-related quality of life (V-RQOL) and quantify the effect of treatment on voice outcomes. STUDY DESIGN: Case series. METHODS: Retrospective review...
Thu Oct 08, 2020 13:28
Investigation of the serum vitamin D level in infants followed up with the diagnosis of laryngomalacia: a case-control study. Eur Arch Otorhinolaryngol. 2020 Oct 07;: Authors: Bozkurt HB, Çelik M Abstract OBJECTIVE: The possible etiological relationship of the vitamin D with laryngomalacia is unclear. The aim of the study was to demonstrate the relationship between laryngomalacia and vitamin D levels. METHODS: Twenty-three non-syndromic...
Thu Oct 08, 2020 13:28
Patient-reported factors that influence the vestibular schwannoma treatment decision: a qualitative study. Eur Arch Otorhinolaryngol. 2020 Oct 07;: Authors: Neve OM, Soulier G, Hendriksma M, van der Mey AGL, van Linge A, van Benthem PPG, Hensen EF, Stiggelbout AM Abstract PURPOSE: In cases of small- to medium-sized vestibular schwannomas, three management strategies can be opted for: active surveillance, surgery or radiotherapy. In these...
Thu Oct 08, 2020 13:28
Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer. J Mater Chem B. 2020 Oct 14;8(38):8781-8793 Authors: Ding Z, Sigdel K, Yang L, Liu Y, Xuan M, Wang X, Gu Z, Wu J, Xie H Abstract Oral cancer is a common malignant life-threatening tumor. Despite some advances in traditional therapy, mortality and mobidity rates are high due to delayed diagnosis and ineffective treatment. Additionally, some patients...
Thu Oct 08, 2020 13:28
Role of fine-needle aspiration cytology in evaluating thyroid nodules. A retrospective study from a tertiary care center of Western region, Saudi Arabia. Saudi Med J. 2020 Oct;41(10):1098-1103 Authors: Bahaj AS, Alkaff HH, Melebari BN, Melebari AN, Sayed SI, Mujtaba SS, Abdelmonim SK, Alghamdi SA, Alghamdi FE, Abu Suliman OA, Alessa MA, Abi Sheffah FR, Al-Tammas AH, Al-Zahrani RA, Marglani OA, Heaphy JC, Bawazir OA, Alherabi AZ Abstract ...
Thu Oct 08, 2020 13:28
Recurrent Hemoptysis: A Bronchial Dieulafoy's Lesion in a Pediatric Patient. Ann Otol Rhinol Laryngol. 2020 Oct 07;:3489420962132 Authors: Ruthberg JS, Abrol A, Howard NS Abstract OBJECTIVE: This paper presents a case of a bronchial Dieulafoy's lesion in a pediatric patient with recurrent hemoptysis. CASE REPORT: A 11-year old female presented multiple times with dry cough and hemoptysis to an outside hospital, each time leading...
Thu Oct 08, 2020 13:28
Hobnail variant of papillary thyroid carcinoma: a systematic review and meta-analysis. Endocrine. 2020 Oct 06;: Authors: Donaldson LB, Yan F, Morgan PF, Kaczmar JM, Fernandes JK, Nguyen SA, Jester RL, Day TA Abstract OBJECTIVE: The hobnail variant of papillary thyroid carcinoma (HVPTC) has emerged as a rare and aggressive variant of papillary thyroid carcinoma (PTC). We aim to determine the prevalence and clinicopathologic factors of HVPTC....
Thu Oct 08, 2020 13:28
Comparison of Laboratory and On-Field Performance of American Football Helmets. Ann Biomed Eng. 2020 Oct 06;: Authors: Bailey AM, McMurry TL, Cormier JM, Funk JR, Crandall JR, Mack CD, Myers BS, Arbogast KB Abstract The relationship between laboratory and on-field performance of football helmets was assessed for 31 football helmet models selected from those worn by players in the 2015-2019 National Football League (NFL) seasons. Linear...
Thu Oct 08, 2020 13:28
A snapshot on radiotherapy for head and neck cancer patients during the COVID-19 pandemic: a survey of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) head and neck working group. Radiol Med. 2020 Oct 06;: Authors: De Felice F, D'Angelo E, Ingargiola R, Iacovelli NA, Alterio D, Franco P, Bonomo P, Merlotti A, Bacigalupo A, Maddalo M, Di Rito A, Fanetti G, D'Onofrio I, Dionisi F, Miccichè F, Trignani M, Musio D, Paiar F, Romanello DA,...
Thu Oct 08, 2020 13:28
Approach to the Patient with Unknown Primary Squamous Cell Carcinoma of the Head and Neck. Curr Treat Options Oncol. 2020 Oct 06;21(12):93 Authors: Moy J, Li R Abstract OPINION STATEMENT: Head and neck cancer of unknown primary (HNCUP) is increasingly encountered in both community otolaryngology practice and the academic head and neck cancer program. A stepwise diagnostic evaluation will identify many primary sites. However, true HNCUP...
Thu Oct 08, 2020 13:28
[Proton therapy-a chance in the treatment of tumors of the head and neck and base of skull]. Radiologe. 2020 Oct 06;: Authors: Timmermann B Abstract BACKGROUND: Radiotherapy (RT) is an integral part of the treatment of many tumors located in the vicinity of sensitive organs and structures, including tumors of the head and neck and base of skull in particular. Due to the risk of side effects associated with RT, the use of highly conformal...
Thu Oct 08, 2020 13:28
[Guideline on diagnosis, treatment, and follow-up of laryngeal cancer]. Radiologe. 2020 Oct 06;: Authors: Bootz F Abstract The German S3 guideline on diagnosis, treatment, and follow-up of laryngeal cancer was developed in 2019 as part of the oncology guideline program of the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF) of the German Cancer...
Thu Oct 08, 2020 13:28
Management of pembrolizumab-induced steroid refractory mucositis with infliximab: A case report. World J Clin Cases. 2020 Sep 26;8(18):4100-4108 Authors: Dang H, Sun J, Wang G, Renner G, Layfield L, Hilli J Abstract BACKGROUND: Pembrolizumab is an anti-programmed death receptor 1 (PD-1) that was shown to have a tolerable safety profile with 17% of grade 3-4 drug-related adverse events, notable response rate of 16% with median duration...
Thu Oct 08, 2020 13:28
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