IJNS, Vol. 6, Pages 2: Two-Tiered Newborn Screening with Post-Analytical Tools for Pompe Disease and Mucopolysaccharidosis Type I Results in Performance Improvement and Future Direction International Journal of Neonatal Screening doi: 10.3390/ijns6010002 Authors: Hall Sanchez Hagar Jerris Wittenauer Wilcox We conducted a pilot newborn screening (NBS) study for Pompe disease (PD) and mucopolysaccharidosis type I (MPS I) in the multiethnic population of Georgia. We...
Tue Jan 14, 2020 02:00
JCM, Vol. 9, Pages 225: Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction Journal of Clinical Medicine doi: 10.3390/jcm9010225 Authors: Guillaume Ploussard Jean-Baptiste Beauval Raphaële Renard-Penna Marine Lesourd Cécile Manceau Christophe Almeras Jean-Romain Gautier Guillaume Loison Daniel Portalez Ambroise Salin Michel Soulié Christophe Tollon Bernard Malavaud Mathieu Roumiguié ...
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JCM, Vol. 9, Pages 224: Development and Disease-Dependent Dynamics of Spermatogonial Subpopulations in Human Testicular Tissues Journal of Clinical Medicine doi: 10.3390/jcm9010224 Authors: Portela Heckmann Wistuba Sansone Pelt Kliesch Schlatt Neuhaus Cancer therapy and conditioning treatments of non-malignant diseases affect spermatogonial function and may lead to male infertility. Data on the molecular properties of spermatogonia and the influence of disease...
Tue Jan 14, 2020 02:00
JCM, Vol. 9, Pages 222: Targeting the Host for New Therapeutic Perspectives in Hepatitis D Journal of Clinical Medicine doi: 10.3390/jcm9010222 Authors: Turon-Lagot Saviano Schuster Baumert Verrier Hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV) requiring HBV infection to complete its life cycle. It has been recently estimated that 13% of chronic HBV infected patients (60 million) are co-infected with HDV. Chronic hepatitis D is the most...
Tue Jan 14, 2020 02:00
JCM, Vol. 9, Pages 223: Anti-PD-1 and Novel Combinations in the Treatment of Melanoma—An Update Journal of Clinical Medicine doi: 10.3390/jcm9010223 Authors: Gellrich Schmitz Beissert Meier Until recently, distant metastatic melanoma was considered refractory to systemic therapy. A better understanding of the interactions between tumors and the immune system and the mechanisms of regulation of T-cells led to the development of immune checkpoint inhibitors. This review summarizes...
Tue Jan 14, 2020 02:00
JCM, Vol. 9, Pages 221: Obesity Does Not Increase the Risk of Asthma Readmissions Journal of Clinical Medicine doi: 10.3390/jcm9010221 Authors: Gonzalez-Barcala Nieto-Fontarigo Lourido-Cebreiro Rodríguez-García San-Jose Carreira Calvo-Alvarez Cruz Facal Garcia-Sanz Valdes-Cuadrado Salgado The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital...
Tue Jan 14, 2020 02:00
JCM, Vol. 9, Pages 220: QFR Predicts the Incidence of Long-Term Adverse Events in Patients with Suspected CAD: Feasibility and Reproducibility of the Method Journal of Clinical Medicine doi: 10.3390/jcm9010220 Authors: Buono Mühlenhaus Schäfer Trieb Schmeißer Koppe Münzel Anadol Gori AIMS: We evaluate feasibility and reproducibility of post hoc quantitative flow ratio (QFR) measurements and their prognostic predictive power during long-term follow-up....
Tue Jan 14, 2020 02:00
Metabolites, Vol. 10, Pages 36: Cervicovaginal Microbiome and Urine Metabolome Paired Analysis Reveals Niche Partitioning of the Microbiota in Patients with Human Papilloma Virus Infections Metabolites doi: 10.3390/metabo10010036 Authors: Nataliya Chorna Josefina Romaguera Filipa Godoy-Vitorino In this study, we evaluate the association between vaginal and cervical human papillomavirus infections high-risk types (HPV+H), negative controls (HPV−), the bacterial biota,...
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Metabolites, Vol. 10, Pages 35: Metabolomic Profiling of Fungal Pathogens Responsible for Root Rot in American Ginseng Metabolites doi: 10.3390/metabo10010035 Authors: Natasha DesRochers Jacob P. Walsh Justin B. Renaud Keith A. Seifert Ken K.-C. Yeung Mark W. Sumarah Ginseng root is an economically valuable crop in Canada at high risk of yield loss caused by the pathogenic fungus Ilyonectria mors-panacis, formerly known as Cylindrocarpon destructans. While this pathogen...
Tue Jan 14, 2020 02:00
Metabolites, Vol. 10, Pages 34: Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids Metabolites doi: 10.3390/metabo10010034 Authors: Germain Barupal Levine Hanson The latest worldwide prevalence rate projects that over 65 million patients suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), an illness with known effects on the functioning of the immune and nervous systems. We performed an extensive...
Tue Jan 14, 2020 02:00
MPs, Vol. 3, Pages 7: Review of the Post-IR IRSL Dating Protocols of K-Feldspar Methods and Protocols doi: 10.3390/mps3010007 Authors: Zhang Li Compared to quartz, the infrared stimulated luminescence (IRSL) of K-feldspar saturates at higher dose, which has great potential for extending the dating limit. However, dating applications with K-feldspar has been hampered due to anomalous fading of the IRSL signal. The post-IR IRSL (pIRIR) signal of K-feldspar stimulated at a higher temperature...
Tue Jan 14, 2020 02:00
Microorganisms, Vol. 8, Pages 115: Probing the Role of the Chloroplasts in Heavy Metal Tolerance and Accumulation in Euglena gracilis Microorganisms doi: 10.3390/microorganisms8010115 Authors: Khatiwada Hasan Sun Kamath Mirzaei Sunna Nevalainen The E. gracilis Zm-strain lacking chloroplasts, characterized in this study, was compared with the earlier assessed wild type Z-strain to explore the role of chloroplasts in heavy metal accumulation and tolerance. Comparison...
Tue Jan 14, 2020 02:00
Microorganisms, Vol. 8, Pages 114: Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors Microorganisms doi: 10.3390/microorganisms8010114 Authors: Ayhan Prudhomme Laroche Bañuls Charrel Toscana virus (TOSV) is endemic in the Mediterranean basin, where it is transmitted by sand flies. TOSV can infect humans and cause febrile illness as well as neuroinvasive infections affecting the...
Tue Jan 14, 2020 02:00
Molbank, Vol. 2020, Article M1109: 2,9-Dimethyl-11-(3-pentadecylphenoxy)dibenzo[c,f][1,2,5]dithiaphosphepine 11-oxide Molbank doi: 10.3390/M1109 Authors: Micheletti Mazzacurati Telese Boga 2,9-Dimethyl-11-(3-pentadecylphenoxy)dibenzo[c,f][1,2,5]dithiaphosphepine 11-oxide was synthesized (yield 50%) by a two-step procedure. The first step starts with a benzothiadiphosphole and bis-Grignard reagent, and the second step consists of adding the sodium salt of a derivative of...
Tue Jan 14, 2020 02:00
Molbank, Vol. 2020, Article M1107: Dimethyl 2-{[2-(2-Methoxy-1-methoxycarbonyl-2-oxoethyl)-4,5,7-trimethoxy-3-(2,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]methyl}malonate Molbank doi: 10.3390/M1107 Authors: Maksim A. Boichenko Alexey O. Chagarovskiy Victor B. Rybakov Igor V. Trushkov Olga A. Ivanova A simple synthetic approach to dimethyl 2-{[2-(2-methoxy-1-methoxycarbonyl-2-oxoethyl)-4,5,7-trimethoxy-3-(2,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]methyl}malonate...
Tue Jan 14, 2020 02:00
Molbank, Vol. 2020, Article M1108: Unexpected Formation of Oxetanes during the Synthesis of Dodeco-6,7-diuloses Molbank doi: 10.3390/M1108 Authors: Bayer Maichle-Mössmer Ziegler During the synthesis of symmetrical dodeco-6,7-diuloses that are potential candidates for inhibition of glycosidases, an unanticipated epoxide-oxetane rearrangement was observed. A bicyclic sugar consisting of a glycal moiety and an anomeric esterified furanose was oxidized under epoxidation conditions...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 343: Chemical Composition and the Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities of the Fruit Peel Essential Oil from Spondias pinnata (Anacardiaceae) in Xishuangbanna, Southwest China Molecules doi: 10.3390/molecules25020343 Authors: Ren Li Jing-Jing Yang Xing-Zhen Song Yuan-Fei Wang Richard T. Corlett You-Kai Xu Hua-Bin Hu Spondias pinnata (Linn. f.) Kurz (Anacardiaceae) is widely distributed in tropical Asia, where it is commonly...
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Molecules, Vol. 25, Pages 342: Metabolite Profiling by UPLC-MSE, NMR, and Antioxidant Properties of Amazonian Fruits: Mamey Apple (Mammea Americana), Camapu (Physalis Angulata), and Uxi (Endopleura Uchi) Molecules doi: 10.3390/molecules25020342 Authors: Larissa Gabrielly Barbosa Lima Julia Montenegro Joel Pimentel de Abreu Millena Cristina Barros Santos Talita Pimenta do Nascimento Maiara da Silva Santos Antônio Gilberto Ferreira Luiz Claudio Cameron Mariana Simões...
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Molecules, Vol. 25, Pages 341: Casticin Induces DNA Damage and Affects DNA Repair Associated Protein Expression in Human Lung Cancer A549 Cells (Running Title: Casticin Induces DNA Damage in Lung Cancer Cells) Molecules doi: 10.3390/molecules25020341 Authors: Zheng-Yu Cheng Yung-Ting Hsiao Yi-Ping Huang Shu-Fen Peng Wen-Wen Huang Kuo-Ching Liu Te-Chun Hsia Tzong-Der Way Jing-Gung Chung Casticin was obtained from natural plants, and it has been shown to exert biological...
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Molecules, Vol. 25, Pages 340: Distribution Patterns for Bioactive Constituents in Pericarp, Stalk and Seed of Forsythiae Fructus Molecules doi: 10.3390/molecules25020340 Authors: Wei Mei Zou Chen Tan Wang Cai Lin Chai Yin Liu Forsythiae Fructus (FF) is a widely used folk medicine in China, Japan, and Korea. The distribution of bioactive constituents throughout the fruit segments has rarely been addressed, although mounting evidence suggests that...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 338: A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine Molecules doi: 10.3390/molecules25020338 Authors: Bi Lv Li Lee Xie Qiu Teng Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection-spray drying method. The response surface method was used to optimize formulation to enhance the encapsulation efficiency...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 339: Engineering 3D Graphene-Based Materials: State of the Art and Perspectives Molecules doi: 10.3390/molecules25020339 Authors: Bellucci Tozzini Graphene is the prototype of two-dimensional (2D) materials, whose main feature is the extremely large surface-to-mass ratio. This property is interesting for a series of applications that involve interactions between particles and surfaces, such as, for instance, gas, fluid or charge storage, catalysis, and...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 337: Improved Magnetization Transfers among Quadrupolar Nuclei in Two-Dimensional Homonuclear Correlation NMR Experiments Applied to Inorganic Network Structures Molecules doi: 10.3390/molecules25020337 Authors: Yang Yu Philipp Keil Michael Ryan Hansen Mattias Edén We demonstrate that supercycles of previously introduced two-fold symmetry dipolar recoupling schemes may be utilized successfully in homonuclear correlation nuclear magnetic resonance (NMR)...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 330: Heteroaromatic N-Oxides in Asymmetric Catalysis: A Review Molecules doi: 10.3390/molecules25020330 Authors: Wrzeszcz Siedlecka An increasing interest in the synthesis and use of optically active pyridine N-oxides as chiral controllers for asymmetric reactions has been observed in the last few years. Chiral heteroaromatic N-oxides can work as powerful electron-pair donors, providing suitable electronic environments in the transition state formed within...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 332: Solubility and Bioavailability Enhancement of Oridonin: A Review Molecules doi: 10.3390/molecules25020332 Authors: Zhang Wang Dai Nai Zhu Sheng Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 336: Infrared and 2-Dimensional Correlation Spectroscopy Study of the Effect of CH3NH3PbI3 and CH3NH3SnI3 Photovoltaic Perovskites on Eukaryotic Cells Molecules doi: 10.3390/molecules25020336 Authors: Quaroni Benmessaoud Vileno Horváth Forró We studied the effect of the exposure of human A549 and SH-SY5Y cell lines to aqueous solutions of organic/inorganic halide perovskites CH3NH3PbI3 (MAPbI3) and CH3NH3SnI3 (MASnI3) at the molecular level...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 333: Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy Molecules doi: 10.3390/molecules25020333 Authors: Nogueira Soares Amorim Amaral Silva Martel Trindade Daniel-da-Silva Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 331: Crystallographic and NMR Investigation of Ergometrine and Methylergometrine, Two Alkaloids from Claviceps purpurea Molecules doi: 10.3390/molecules25020331 Authors: Meneghetti Ferraboschi Grisenti Reza Elahi Mori Ciceri Ergometrine and methylergometrine are two alkaloids that are used as maleate salts for the prevention and control of postpartum hemorrhage. Although the two molecules have been known for a long time, few and discordant...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 335: Flame Retardancy of Wood Fiber Materials Using Phosphorus-Modified Wheat Starch Molecules doi: 10.3390/molecules25020335 Authors: Gebke Thümmler Sonnier Tech Wagenführ Fischer Biopolymer-based flame retardants (FR) are a promising approach to ensure adequate protection against fire while minimizing health and environmental risks. Only a few, however, are suitable for industrial purposes because of their poor flame retardancy, complex...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 334: Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques Molecules doi: 10.3390/molecules25020334 Authors: Ugazio Tullio Binello Tagliapietra Dosio The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest...
Tue Jan 14, 2020 02:00
Molecules, Vol. 25, Pages 329: 3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma Molecules doi: 10.3390/molecules25020329 Authors: Cascioferro Li Petri Parrino El Hassouni Carbone Arizza Perricone Padova Funel Peters Cirrincione Giovannetti Diana A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and...
Tue Jan 14, 2020 02:00
Nanomaterials, Vol. 10, Pages 149: Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging Nanomaterials doi: 10.3390/nano10010149 Authors: Nuñez Cussó Cantelar Martin-Gracia de la Fuente Corral Balcerzyk Ocaña Uniform Nd3+-doped LuVO4 nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd3+ and vanadate precursors....
Tue Jan 14, 2020 02:00
Nanomaterials, Vol. 10, Pages 148: Combined AOPs for Formaldehyde Degradation Using Heterogeneous Nanostructured Catalysts Nanomaterials doi: 10.3390/nano10010148 Authors: Bonora Boaretti Campea Roso Martucci Modesti Lorenzetti In this paper we studied the combination of advanced oxidation processes (AOPs), i.e., TiO2-based photocatalysis and photo-Fenton process, on the degradation of aqueous solutions containing a low (90 ppm) concentration of formaldehyde....
Tue Jan 14, 2020 02:00
Nanomaterials, Vol. 10, Pages 147: The Role of the Laser-Induced Oxide Layer in the Formation of Laser-Induced Periodic Surface Structures Nanomaterials doi: 10.3390/nano10010147 Authors: Florian Déziel Kirner Siegel Bonse Laser-induced periodic surface structures (LIPSS) are often present when processing solid targets with linearly polarized ultrashort laser pulses. The different irradiation parameters to produce them on metals, semiconductors and dielectrics have been...
Tue Jan 14, 2020 02:00
Nanomaterials, Vol. 10, Pages 146: Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration Nanomaterials doi: 10.3390/nano10010146 Authors: Tanya J. Levingstone Simona Herbaj John Redmond Helen O. McCarthy Nicholas J. Dunne Bone-related injury and disease constitute a significant global burden both socially and economically. Current treatments have many limitations and thus the development of new approaches for bone-related...
Tue Jan 14, 2020 02:00
ncRNA, Vol. 6, Pages 3: The Missing “lnc” between Genetics and Cardiac Disease Non-Coding RNA doi: 10.3390/ncrna6010003 Authors: Azodi Kamps Heymans Robinson : Cardiovascular disease (CVD) is one of the biggest threats to public health worldwide. Identifying key genetic contributors to CVD enables clinicians to assess the most effective treatment course and prognosis, as well as potentially inform family members. This often involves either whole exome sequencing (WES) or...
Tue Jan 14, 2020 02:00
Nutrients, Vol. 12, Pages 216: Non-Responsive Coeliac Disease: A Comprehensive Review from the NHS England National Centre for Refractory Coeliac Disease Nutrients doi: 10.3390/nu12010216 Authors: Hugo A. Penny Elisabeth M. R. Baggus Anupam Rej John A. Snowden David S. Sanders Coeliac disease is a common small intestinal enteropathy which manifests following ingestion of gluten in genetically susceptible individuals. Since gluten was identified as the driving factor in coeliac...
Tue Jan 14, 2020 02:00
Nutrients, Vol. 12, Pages 215: Comment on: “The Utility of Thirst as a Measure of Hydration Status Following Exercise-Induced Dehydration” Nutrients doi: 10.3390/nu12010215 Authors: Goulet In their study, Adams et al. [1] attempted to determine whether thirst perception could serve as a reliable marker of hydration status during 3 h of exercise where participants either dehydrated by 3% of their body mass or maintained euhydration through water intake, and following exercise where they...
Tue Jan 14, 2020 02:00
Nutrients, Vol. 12, Pages 214: Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial Nutrients doi: 10.3390/nu12010214 Authors: Fornari Morandi Piona Tommasi Corradi Maffeis The aim of this study is to test the hypothesis that the intake of Policaptil Gel Retard® (PGR) is able to affect appetite, metabolic and hormonal postprandial profile in obese children. 46 obese children were randomly...
Tue Jan 14, 2020 02:00
Nutrients, Vol. 12, Pages 213: A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses Nutrients doi: 10.3390/nu12010213 Authors: Najmanová Pourová Mladěnka Quercetin is proven to decrease arterial blood pressure when given orally. Its bioavailability is, however, low and, therefore, its metabolites could rather be responsible for this effect. In particular, the colonic metabolites of quercetin,...
Tue Jan 14, 2020 02:00
Pathogens, Vol. 9, Pages 57: Protein Elicitor PeBL1 of Brevibacillus laterosporus Enhances Resistance Against Myzus persicae in Tomato Pathogens doi: 10.3390/pathogens9010057 Authors: Javed Qiu Myzus persicae, a destructive aphid of tomato usually managed by chemical pesticides, is responsible for huge annual losses in agriculture. In the current work, a protein elicitor, PeBL1, was investigated for its capacity to induce a defense response against M. persicae in tomato. Population...
Tue Jan 14, 2020 02:00
Pathogens, Vol. 9, Pages 58: Evaluation of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) in Equine Sarcoid: An Immunohistochemical and Biochemical Study Pathogens doi: 10.3390/pathogens9010058 Authors: Martano Altamura Power Restucci Carella Borzacchiello Maiolino Background: equine sarcoids are the most frequent skin tumors in equidae worldwide. It is well known that delta bovine papillomaviruses are their causative agents. We have recently shown the presence in...
Tue Jan 14, 2020 02:00
Pharmaceuticals, Vol. 13, Pages 14: Acknowledgement to Reviewers of Pharmaceuticals in 2019 Pharmaceuticals doi: 10.3390/ph13010014 Authors: Pharmaceuticals Editorial Office
Tue Jan 14, 2020 02:00
Pharmaceutics, Vol. 12, Pages 64: Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles Pharmaceutics doi: 10.3390/pharmaceutics12010064 Authors: Hisako Ibaraki Takanori Kanazawa Minami Owada Keiko Iwaya Yuuki Takashima Yasuo Seta Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of...
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Pharmacy, Vol. 8, Pages 8: Medication-Focused Patient Counseling Upon Discharge: A Feasibility Study of Effect on Patient Satisfaction Pharmacy doi: 10.3390/pharmacy8010008 Authors: Lundby Filipsen Rasmussen Pottegård Objective: To develop and test a simple medication-focused patient counseling intervention at hospital discharge, with the aim of improving patient satisfaction. Methods: The intervention was developed during a workshop and carried out by pharmaconomists. The...
Tue Jan 14, 2020 02:00
Plants, Vol. 9, Pages 104: Exogenously Applied Ascorbic Acid-Mediated Changes in Osmoprotection and Oxidative Defense System Enhanced Water Stress Tolerance in Different Cultivars of Safflower (Carthamus tinctorious L.) Plants doi: 10.3390/plants9010104 Authors: Farooq Bukhari Akram Ashraf Wijaya Alyemeni Ahmad The present study was conducted to examine the effect of exogenously applied ascorbic acid (AsA) on osmoprotectants and the oxidative defense system in...
Tue Jan 14, 2020 02:00
Plants, Vol. 9, Pages 103: The Effect of Water-Soluble Polysaccharide from Jackfruit (Artocarpus heterophyllus Lam.) on Human Colon Carcinoma Cells Cultured In Vitro Plants doi: 10.3390/plants9010103 Authors: Wiater Paduch Trojnar Choma Pleszczyńska Adamczyk Pięt Próchniak Szczodrak Strawa Tomczyk Various phytochemical studies have revealed that jackfruit (Artocarpus heterophyllus Lam.) is rich in bioactive compounds, including carotenoids, flavonoids,...
Tue Jan 14, 2020 02:00
Plants, Vol. 9, Pages 102: Phytotoxic Activity and Identification of Phytotoxic Substances from Schumannianthus dichotomus Plants doi: 10.3390/plants9010102 Authors: Rob Hossen Iwasaki Suenaga Kato-Noguchi The phytotoxic potential of plants and their constituents against other plants is being increasingly investigated as a possible alternative to synthetic herbicides to control weeds in crop fields. In this study, we explored the phytotoxicity and phytotoxic substances...
Tue Jan 14, 2020 02:00
Social Sciences, Vol. 9, Pages 5: Processes of Sub-Citizenship: Neoliberal Statecrafting ‘Citizens,’ ‘Non-Citizens,’ and Detainable ‘Others’ Social Sciences doi: 10.3390/socsci9010005 Authors: Rung Increasingly, scholars are exploring the politics of migration and the shifting terrain of citizenship from a critical mobilities perspective. To contribute to these discussions, in this paper, I explore how processes of sub-citizenship occur as nation-states craft immigration, citizenship,...
Tue Jan 14, 2020 02:00
Toxins, Vol. 12, Pages 49: Degradation of Aflatoxin B1 by a Sustainable Enzymatic Extract from Spent Mushroom Substrate of Pleurotus eryngii Toxins doi: 10.3390/toxins12010049 Authors: Branà Sergio Haidukowski Logrieco Altomare Ligninolytic enzymes from white-rot fungi, such as laccase (Lac) and Mn-peroxidase (MnP), are able to degrade aflatoxin B1 (AFB1), the most harmful among the known mycotoxins. The high cost of purification of these enzymes has limited their implementation...
Tue Jan 14, 2020 02:00
Toxins, Vol. 12, Pages 48: Role of Shiga Toxins in Cytotoxicity and Immunomodulatory Effects of Escherichia coli O157:H7 during Host-Bacterial Interactions in vitro Toxins doi: 10.3390/toxins12010048 Authors: Bruballa Shiromizu Bernal Pineda Sabbione Trevani Bentancor Ramos Fernández-Brando Muñoz Palermo Enterohemorrhagic Escherichia coli (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or...
Tue Jan 14, 2020 02:00
Toxins, Vol. 12, Pages 47: Characterization of Venom Components and Their Phylogenetic Properties in Some Aculeate Bumblebees and Wasps Toxins doi: 10.3390/toxins12010047 Authors: Yoon Kim Kim Bang Ahn Bae Yeo Lee : To identify and compare venom components and expression patterns, venom gland-specific transcriptome analyses were conducted for 14 Aculeate bees and wasps. TPM (transcripts per kilobase million) values were normalized using the average transcription...
Tue Jan 14, 2020 02:00
TropicalMed, Vol. 5, Pages 11: Product Development Partnerships: Delivering Innovation for the Elimination of African Trypanosomiasis? Tropical Medicine and Infectious Disease doi: 10.3390/tropicalmed5010011 Authors: Emma Michelle Taylor James Smith African trypanosomiasis has been labelled as a ‘tool-deficient’ disease. This article reflects on the role that Product Development Partnerships (PDPs) have played in delivering new tools and innovations for the control...
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Vaccines, Vol. 8, Pages 27: Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA Vaccines doi: 10.3390/vaccines8010027 Authors: Tannig Peter Lapuente Klessing Damm Tenbusch Überla Temchura The importance of a balanced TH1/TH2 humoral immune response against the HIV-1 envelope protein (Env) for antibody-mediated HIV-1 control is increasingly recognized. However, there is no defined vaccination strategy to...
Tue Jan 14, 2020 02:00
Vaccines, Vol. 8, Pages 26: HPV-Specific Systemic Antibody Responses and Memory B Cells are Independently Maintained up to 6 Years and in a Vaccine-Specific Manner Following Immunization with Cervarix and Gardasil in Adolescent and Young Adult Women in Vaccination Programs in Italy Vaccines doi: 10.3390/vaccines8010026 Authors: Nicoli Mantelli Gallerani Telatin Bonazzi Marconi Gavioli Gabrielli Lazzarotto Barzon Palù Caputo : Human papillomavirus...
Tue Jan 14, 2020 02:00
Vaccines, Vol. 8, Pages 25: Development and Optimization of a GMP-Compliant Manufacturing Process for a Personalized Tumor Lysate Dendritic Cell Vaccine Vaccines doi: 10.3390/vaccines8010025 Authors: Boudousquié Boand Lingre Dutoit Balint Danilo Harari Gannon Kandalaft With the emergence of immune checkpoint inhibitors and adoptive T-cell therapies, there is a considerable interest in using personalized autologous dendritic cell (DC) vaccines in combination...
Tue Jan 14, 2020 02:00
Viruses, Vol. 12, Pages 98: Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins Viruses doi: 10.3390/v12010098 Authors: Hao Chang Lowela Siarot Ryosuke Matsuura Chieh-Wen Lo Hirotaka Sato Hiroyuki Otsuki Yoko Aida Viral protein R (Vpr) is an accessory protein found in various primate lentiviruses, including human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) as well as simian immunodeficiency viruses (SIVs). Vpr modulates many...
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Viruses, Vol. 12, Pages 96: Origin of Bluetongue Virus Serotype 8 Outbreak in Cyprus, September 2016
Viruses, Vol. 12, Pages 96: Origin of Bluetongue Virus Serotype 8 Outbreak in Cyprus, September 2016 Viruses doi: 10.3390/v12010096 Authors: Rajko-Nenow Christodoulou Thurston Ropiak Savva Brown Qureshi Alvanitopoulos Gubbins Flannery Batten In September 2016, clinical signs, indicative of bluetongue, were observed in sheep in Cyprus. Bluetongue virus serotype 8 (BTV-8) was detected in sheep, indicating the first incursion of this serotype into...
Tue Jan 14, 2020 02:00
Viruses, Vol. 12, Pages 95: Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes Viruses doi: 10.3390/v12010095 Authors: Domínguez Soldevila Torner Martínez Godoy Rius Jané the PIDIRAC Sentinel Surveillance Program of Catalonia This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological...
Tue Jan 14, 2020 02:00
Viruses, Vol. 12, Pages 97: Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population Viruses doi: 10.3390/v12010097 Authors: Su Le Muo Te Sung Yeh Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of...
Tue Jan 14, 2020 02:00
Viruses, Vol. 12, Pages 94: Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits Viruses doi: 10.3390/v12010094 Authors: Tsoleridis Chappell Monchatre-Leroy Umhang Shi Bennett Tarlinton McClure Holmes Ball The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited. We...
Tue Jan 14, 2020 02:00
Vision, Vol. 4, Pages 7: Effects of Normative Aging on Eye Movements during Reading Vision doi: 10.3390/vision4010007 Authors: Paterson McGowan Warrington Li Li Xie Chang Zhao Pagán White Wang Substantial progress has been made in understanding the mostly detrimental effects of normative aging on eye movements during reading. This article provides a review of research on aging effects on eye movements during reading for different writing systems...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 235: Multi-Objective Optimization for Selecting and Siting the Cost-Effective BMPs by Coupling Revised GWLF Model and NSGAII Algorithm Water doi: 10.3390/w12010235 Authors: Zuoda Qi Gelin Kang Xiaojin Wu Yuting Sun Yuqiu Wang Best management practices (BMPs) are an effective way to control water pollution. However, identification of the optimal distribution and cost-effect of BMPs provides a great challenge for watershed policy makers. In this paper,...
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Water, Vol. 12, Pages 234: Physical Model Study on Discharge over a Dam Due to Landslide Generated Waves Water doi: 10.3390/w12010234 Authors: Netsanet Nigatu Tessema Fjóla G. Sigtryggsdóttir Leif Lia Asie Kemal Jabir Impulse waves generated by landslides falling into reservoirs may lead to overtopping of a dam and, in turn, to flooding of the downstream area. In the case of an embankment dam, the overtopping may lead to erosion of the downstream slope, ultimately resulting...
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Water, Vol. 12, Pages 233: Water Markets in the Western United States: Trends and Opportunities Water doi: 10.3390/w12010233 Authors: Schwabe Nemati Landry Zimmerman Efforts to address water scarcity have traditionally relied on changing the spatial and temporal availability of water through water importation, storage, and conveyance. More recently, water managers have invested heavily in improving water use efficiency and conservation. Yet as new supply options become harder...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 230: Spatial and Temporal Characterization of Drought Events in China Using the Severity-Area-Duration Method Water doi: 10.3390/w12010230 Authors: Yang Zhang Wang Singh Xu Ren Zhang Liu Jiang Yuan Global climate change not only affects the processes within the water cycle but also leads to the frequent occurrences of local and regional extreme drought events. In China, spatial and temporal characterizations of drought events...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 232: A Fast Calculation Model for Local Head Loss of Non-Darcian Flow in Flexural Crack Water doi: 10.3390/w12010232 Authors: Liu Mou Song Luo He Bai Local head loss caused by fracture intersection is often ignored because there has not been a simple method to calculate it until now. Relevant research shows that neglecting the local flow resistance leads to inaccurate results, especially when the velocity and cross angle are large. Therefore,...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 231: Analysis of the Radiation Dose in UV-Disinfection Flow Reactors Water doi: 10.3390/w12010231 Authors: Artichowicz Luczkiewicz Sawicki UV-disinfection reactors may appear in a variety of forms, but it is useful for all types to identify the inflow and outflow zones (those in which the fluid approaches or, respectively, recedes from the radiation source) and the direct radiation zone (in which the flow occurs along the UV lamp). Due to the spatial variability...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 228: Identification of Parameters of Evaporation Equations Using an Optimization Technique Based on Pan Evaporation Water doi: 10.3390/w12010228 Authors: Ghumman Ghazaw Alodah Rauf Shafiquzzaman Haider Countries in arid regions are presently facing challenges in managing their limited water resources. Assessing the evaporation losses from various sources of water is a daunting task that is inevitable for the sustainability of water resource...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 229: Uncertainty Analysis of Spatiotemporal Models with Point Estimate Methods (PEMs)—The Case of the ANUGA Hydrodynamic Model Water doi: 10.3390/w12010229 Authors: Issermann Chang Practitioners often neglect the uncertainty inherent to models and their inputs. PointEstimate Methods (PEMs) offer an alternative to the common, but computationally demanding,method for assessing model uncertainty, Monte Carlo (MC) simulation. PEMs rerun the model withrepresentative...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 226: Long-Term Isotope Records of Precipitation in Zagreb, Croatia Water doi: 10.3390/w12010226 Authors: Krajcar Bronić Barešić Borković Sironić Mikelić Vreča The isotope composition of precipitation has been monitored in monthly precipitation at Zagreb, Croatia, since 1976. Here, we present a statistical analysis of available long-term isotope data (3H activity concentration, 2H, 18O, and deuterium excess) and compare them to basic meteorological...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 227: Analysis of the Flow in a Typified USBR II Stilling Basin through a Numerical and Physical Modeling Approach Water doi: 10.3390/w12010227 Authors: Macián-Pérez García-Bartual Huber Bayon Vallés-Morán Adaptation of stilling basins to higher discharges than those considered for their design implies deep knowledge of the flow developed in these structures. To this end, the hydraulic jump occurring in a typified United States Bureau of Reclamation...
Tue Jan 14, 2020 02:00
Water, Vol. 12, Pages 225: An Analysis of Electricity Consumption Patterns in the Water and Wastewater Sectors in South East England, UK Water doi: 10.3390/w12010225 Authors: Aman Majid Iliana Cardenes Conrad Zorn Tom Russell Keith Colquhoun René Bañares-Alcantara Jim W. Hall The water and wastewater sectors of England and Wales (E&W) are energy-intensive. Although E&W’s water sector is of international interest, in particular due to the early...
Tue Jan 14, 2020 02:00
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