Antibiotics, Vol. 9, Pages 28: Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains Antibiotics doi: 10.3390/antibiotics9010028 Authors: Pereira da Cruz Sampaio de Freitas Socorro Costa Lucas dos Santos Ferreira Campina Pereira Bezerra Quintans-Júnior De Souza Araújo Júnior Iriti Varoni Menezes Melo Coutinho Morais-Braga Efflux pumps are proteins present in...
Tue Jan 14, 2020 02:00
Antibiotics, Vol. 9, Pages 27: Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria Antibiotics doi: 10.3390/antibiotics9010027 Authors: Araújo Freitas Rodrigues dos Santos Barbosa Muniz Esmeraldo Rocha Neto C. da Silva Moura Pereira Ribeiro-Filho Silva Amaral Deschamps Tintino Iriti Vitalini Coutinho This study is a pioneer in reporting the antibacterial properties...
Tue Jan 14, 2020 02:00
Antioxidants, Vol. 9, Pages 73: Tomato as Potential Source of Natural Additives for Meat Industry. A Review Antioxidants doi: 10.3390/antiox9010073 Authors: Rubén Domínguez Patricia Gullón Mirian Pateiro Paulo E. S. Munekata Wangang Zhang José Manuel Lorenzo Tomato industry produces huge amounts of by-products that represent an environmental and economic problem. However, these by-products contain multiple bioactive compounds, which would make them a renewable source for...
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Atmosphere, Vol. 11, Pages 98: Sodium Resonance Wind-Temperature Lidar at PFRR: Initial Observations and Performance Atmosphere doi: 10.3390/atmos11010098 Authors: Jintai Li Bifford P. Williams Jennifer H. Alspach Richard L. Collins A narrowband sodium resonance wind-temperature lidar (SRWTL) has been deployed at Poker Flat Research Range, Chatanika, Alaska (PFRR, 65° N, 147° W). Based on the Weber narrowband SRWTL, the PFRR SRWTL transmitter was upgraded with...
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Atmosphere, Vol. 11, Pages 97: Ice Hydrometeor Shape Estimations Using Polarimetric Operational and Research Radar Measurements Atmosphere doi: 10.3390/atmos11010097 Authors: Matrosov A polarimetric radar method to estimate mean shapes of ice hydrometeors was applied to several snowfall and ice cloud events observed by operational and research weather radars. The hydrometeor shape information is described in terms of their aspect ratios, r, which represent the ratio of particle minor...
Tue Jan 14, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 34: The Contribution of Individual Psychological Features to the Determination of the Phenomenon of Work Alienation Behavioral Sciences doi: 10.3390/bs10010034 Authors: Leonid V. Vinokurov Anastasiia A. Kozhina Using the questionnaire method on a sample of 92 Russian-speaking employees of the “person-person” professions type, the relationship of work alienation with personal characteristics was investigated. It was found that...
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Biomolecules, Vol. 10, Pages 138: A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds Biomolecules doi: 10.3390/biom10010138 Authors: Liew Malagobadan Arshad Nagoor There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This...
Tue Jan 14, 2020 02:00
Biomolecules, Vol. 10, Pages 139: Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells Biomolecules doi: 10.3390/biom10010139 Authors: Kello Takac Kubatka Kuruc Petrova Mojzis In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. It is documented that spices have antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. The main mechanisms of spices action...
Tue Jan 14, 2020 02:00
Biomolecules, Vol. 10, Pages 136: Development of A 3D Tissue Slice Culture Model for the Study of Human Endometrial Repair and Regeneration Biomolecules doi: 10.3390/biom10010136 Authors: Muruganandan Fan Dhal Nayak The human endometrium undergoes sequential phases of shedding of the upper functionalis zone during menstruation, followed by regeneration of the functionalis zone from the remaining basalis zone cells, and secretory differentiation under the influence of the...
Tue Jan 14, 2020 02:00
Biomolecules, Vol. 10, Pages 135: Modulation of Mitochondrial Metabolic Reprogramming and Oxidative Stress to Overcome Chemoresistance in Cancer Biomolecules doi: 10.3390/biom10010135 Authors: Avolio Matassa Criscuolo Landriscina Esposito Metabolic reprogramming, carried out by cancer cells to rapidly adapt to stress such as hypoxia and limited nutrient conditions, is an emerging concepts in tumor biology, and is now recognized as one of the hallmarks of cancer. In contrast...
Tue Jan 14, 2020 02:00
Biomolecules, Vol. 10, Pages 137: Microglia Mediated Neuroinflammation: Focus on PI3K Modulation Biomolecules doi: 10.3390/biom10010137 Authors: Antonia Cianciulli Chiara Porro Rosa Calvello Teresa Trotta Dario Domenico Lofrumento Maria Antonietta Panaro Immune activation in the central nervous system involves mostly microglia in response to pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory response aimed to restore homeostasis. However,...
Tue Jan 14, 2020 02:00
Biomolecules, Vol. 10, Pages 133: Transcriptomic Analysis Reveals the Wound Healing Activity of Mussel Myticin C Biomolecules doi: 10.3390/biom10010133 Authors: Rey-Campos Moreira Romero Medina-Gali Novoa Gasset Figueras Myticin C is the most studied antimicrobial peptide in the marine mussel Mytilus galloprovincialis. Although it is constitutively expressed in mussel hemocytes and displays antibacterial, antiviral, and chemotactic functions, recent work has...
Tue Jan 14, 2020 02:00
Biomolecules, Vol. 10, Pages 134: Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity Biomolecules doi: 10.3390/biom10010134 Authors: Gharibyan Islam Pettersson Golchin Lundgren Johansson Genot Schultz Wennström Olofsson Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest...
Tue Jan 14, 2020 02:00
Brain Sciences, Vol. 10, Pages 45: Improvements of Motor Performances in the Drosophila LRRK2 Loss-of-Function Model of Parkinson’s Disease: Effects of Dialyzed Leucocyte Extracts from Human Serum Brain Sciences doi: 10.3390/brainsci10010045 Authors: Andrea Diana Maria Collu Maria Antonietta Casu Ignazia Mocci Miguel Aguilar-Santelises Maria Dolores Setzu Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associated with its locomotor defects,...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 209: Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis Cancers doi: 10.3390/cancers12010209 Authors: Skrzypek Majka SNAIL (SNAI1) is a zinc finger transcription factor that binds to E-box sequences and regulates the expression of genes. It usually acts as a gene repressor, but it may also activate the expression of genes. SNAIL plays a key role in the regulation...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 204: A Novel Cytological Model of B-Cell/Macrophage Biphenotypic Cell Hodgkin Lymphoma in Ganp-Transgenic Mice Cancers doi: 10.3390/cancers12010204 Authors: Sakai Rezano Okada Ohtsuki Kawashima Tsukamoto Suzuki Kohara Takeya Sakaguchi Kuwahara Hodgkin lymphoma (HL) is one of the most difficult neoplasms in terms of cytopathological research owing to the lack of established cytological murine models. Although HL is believed...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 208: The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas Cancers doi: 10.3390/cancers12010208 Authors: Berta Segura-Collar Ricardo Gargini Elena Tovar-Ambel Esther Hernández-SanMiguel Carolina Epifano Ignacio Pérez de Castro Aurelio Hernández-Laín Sergio Casas-Tintó Pilar Sánchez-Gómez Despite the high frequency of EGFR and TP53 genetic alterations in gliomas, little is known about their crosstalk during tumor progression....
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 207: Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting as a Fra-1 Deubiquitinase Cancers doi: 10.3390/cancers12010207 Authors: Yun Hong Yeo Kim Cho Kim Fos-related-antigen-1 (Fra-1), a member of the activator protein-1 (AP-1) transcription factor superfamily, has an essential role in cancer progress and metastasis and Fra-1 is considered a therapeutic target in metastatic cancer including metastatic colorectal...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 203: Selective Targeting of Cancer Stem Cells (CSCs) Based on Photodynamic Therapy (PDT) Penetration Depth Inhibits Colon Polyp Formation in Mice Cancers doi: 10.3390/cancers12010203 Authors: Kim Byun Maeng Kim Choi Targeting cancer stem cells (CSCs) without damaging normal stem cells could contribute to the development of novel radical cancer therapies. Cells expressing leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) constitute...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 205: The Communication Between the PI3K/AKT/mTOR Pathway and Y-box Binding Protein-1 in Gynecological Cancer Cancers doi: 10.3390/cancers12010205 Authors: Sobočan Bračič Knez Takač Haybaeck Studies of the mechanistic (mammalian) target of rapamycin inhibitors (mTOR) represent a step towards the targeted treatment of gynecological cancers. It has been shown that women with increased levels of mTOR signaling pathway targets have worse prognosis...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 206: Outcomes of Capecitabine and Temozolomide (CAPTEM) in Advanced Neuroendocrine Neoplasms (NENs) Cancers doi: 10.3390/cancers12010206 Authors: Thomas Voros Meadows-Taylor Smeltzer Griffin Boudreaux Thiagarajan Woltering Ramirez Capecitabine and temozolomide (CAPTEM) have shown promising results in the treatment of neuroendocrine neoplasms (NEN). The aim of this study was to evaluate the outcome and role for CAPTEM in malignant...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 202: Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12010202 Authors: Orouji Peitsch Orouji Houben Utikal Merkel cell carcinoma is a deadly skin cancer, which in the majority of cases is caused by the Merkel cell polyomavirus (MCPyV). The viral small T antigen is regarded as the dominant oncoprotein expressed in the tumor cells. We used genomic screening of copy number...
Tue Jan 14, 2020 02:00
Cancers, Vol. 12, Pages 201: Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target Cancers doi: 10.3390/cancers12010201 Authors: Brzezinka Nevedomskaya Lesche Haegebarth ter Laak Fernández-Montalván Eberspaecher Werbeck Moenning Siegel Haendler Eheim Stresemann Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 210: Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice Cells doi: 10.3390/cells9010210 Authors: Criado-Marrero Sabbagh Jones Chaput Dickey Blair Tau dysfunction is common in several neurodegenerative diseases including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Affective symptoms have often been associated with aberrant tau pathology and are commonly comorbid in patients with tauopathies, indicating a...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 209: Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice Cells doi: 10.3390/cells9010209 Authors: Emidio Placidi Rea Rossi Falone Cristiano Nottola D’Alessandro Amicarelli Palmerini Tatone Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 211: Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity Cells doi: 10.3390/cells9010211 Authors: Akula Paivandy Fu Thorpe Pejler Hellman Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at external and internal surfaces of the body where they act in the first line of defense. MCs are found in all studied vertebrates and have also been identified...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 203: Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer Cells doi: 10.3390/cells9010203 Authors: Marín-Aguilera Jiménez Reig Montalbo Verma Castellano Mengual Victoria Pereira Milà-Guasch García-Recio Benítez-Ribas Cabezón González Juan Prat Mellado Androgen receptor (AR) signaling...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 206: The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis Cells doi: 10.3390/cells9010206 Authors: Di Giorgio Morciano Bucciarelli Porrazzo Cipressa Saraniero Manzi Rong Cenci The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 204: The Role of Ca2+ Signaling in Aging and Neurodegeneration: Insights from Caenorhabditis elegans Models Cells doi: 10.3390/cells9010204 Authors: Alvarez Alvarez-Illera García-Casas Fonteriz Montero Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation. There is ample evidence that the dysregulation of Ca2+ signaling...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 207: The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy Cells doi: 10.3390/cells9010207 Authors: Michie Kearney Hawkins Silke Oliaro One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The inhibitor of apoptosis proteins (IAPs) are a family of proteins that act to promote cell survival. For this reason, upregulation of IAPs is associated with a number of cancer...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 205: The Reverse Warburg Effect is Associated with Fbp2-Dependent Hif1α Regulation in Cancer Cells Stimulated by Fibroblasts Cells doi: 10.3390/cells9010205 Authors: Duda Janczara McCubrey Gizak Rakus Fibroblasts are important contributors to cancer development. They create a tumor microenvironment and modulate our metabolism and treatment resistance. In the present paper, we demonstrate that healthy fibroblasts induce metabolic coupling with non-small...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 201: Comprehensive Analysis of the Characteristics and Differences in Adult and Newborn Brown Adipose Tissue (BAT): Newborn BAT Is a More Active/Dynamic BAT Cells doi: 10.3390/cells9010201 Authors: Junyu Liu Chuanhai Zhang Boyang Zhang Yao Sheng Wentao Xu Yunbo Luo Xiaoyun He Kunlun Huang Brown adipose tissue (BAT) plays an essential role in maintaining body temperature and in treating obesity and diabetes. The adult BAT (aBAT) and neonatal BAT...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 200: Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing Cells doi: 10.3390/cells9010200 Authors: Maidarti Anderson Telfer The preservation of genome integrity in the mammalian female germline from primordial follicle arrest to activation of growth to oocyte maturation is fundamental to ensure reproductive success. As oocytes are formed before birth and may remain...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 202: Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin Cells doi: 10.3390/cells9010202 Authors: Urban Schaefer (1) Background: Members of the TRPC3/TRPC6/TRPC7 subfamily of canonical transient receptor potential (TRP) channels share an amino acid similarity of more than 80% and can form heteromeric channel complexes. They are directly gated by diacylglycerols in a protein kinase C-independent manner. To assess TRPC3 channel functions...
Tue Jan 14, 2020 02:00
Cells, Vol. 9, Pages 208: Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment Cells doi: 10.3390/cells9010208 Authors: Clemenceau Diorio Durocher In mice, the lack of secreted frizzled-related protein 1 (SFRP1) is responsible for mammogenesis and hyperplasia, while, in bovines, its overexpression is associated with post-lactational mammary gland involution. Interestingly, there are no reports dealing...
Tue Jan 14, 2020 02:00
Chemosensors, Vol. 8, Pages 8: Formaldehyde and Total VOC (TVOC) Commercial Low-Cost Monitoring Devices: From an Evaluation in Controlled Conditions to a Use Case Application in a Real Building Chemosensors doi: 10.3390/chemosensors8010008 Authors: Goletto Mialon Faivre Wang Lesieur Petigny Vijapurapu Formaldehyde and volatile organic compounds (VOCs) are major indoor pollutants with multiple origins. Standard methods exist to measure them that require analytical...
Tue Jan 14, 2020 02:00
Climate, Vol. 8, Pages 13: Implications of Winter NAO Flavors on Present and Future European Climate
Climate, Vol. 8, Pages 13: Implications of Winter NAO Flavors on Present and Future European Climate Climate doi: 10.3390/cli8010013 Authors: Rousi Rust Ulbrich Anagnostopoulou The North Atlantic Oscillation (NAO), a basic variability mode in the Northern Hemisphere, undergoes changes in its temporal and spatial characteristics, with significant implications on European climate. In this paper, different NAO flavors are distinguished for winter in simulations of a Coupled...
Tue Jan 14, 2020 02:00
Cosmetics, Vol. 7, Pages 7: The Chemical Composition, Antioxidant and Anti-Tyrosinase Activities, and Irritation Properties of Sripanya Punica granatum Peel Extract Cosmetics doi: 10.3390/cosmetics7010007 Authors: Laosirisathian Saenjum Sirithunyalug Eitssayeam Sirithunyalug Chaiyana This is the first study to investigate the effect of ethanol concentrations on the phenolic content and biological activities of Sripanya Punica granatum peel extract. Various concentrations...
Tue Jan 14, 2020 02:00
Dentistry Journal, Vol. 8, Pages 9: Impact of the Consistency of Food Substances on Health and Related Factors of Residents in Welfare Facilities for Seniors in Japan Dentistry Journal doi: 10.3390/dj8010009 Authors: Sakashita Sato Ono Hamaue Hamada The aim of this study is to determine the effect of food consistency on health and related factors among residents in welfare facilities for seniors (n = 227; mean age, 86.2 ± 8.0 years; 78.9% female). Residents...
Tue Jan 14, 2020 02:00
Diagnostics, Vol. 10, Pages 44: Cross-Dataset Evaluation of Deep Learning Networks for Uterine Cervix Segmentation Diagnostics doi: 10.3390/diagnostics10010044 Authors: Guo Xue Long Antani Evidence from recent research shows that automatic visual evaluation (AVE) of photographic images of the uterine cervix using deep learning-based algorithms presents a viable solution for improving cervical cancer screening by visual inspection with acetic acid (VIA). However, a significant...
Tue Jan 14, 2020 02:00
Diagnostics, Vol. 10, Pages 43: Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer Diagnostics doi: 10.3390/diagnostics10010043 Authors: Riggs Pandalai Kim Dietrich Hyperthermic intraperitoneal chemotherapy (HIPEC) in conjunction with cytoreductive surgery (CRS) holds promise as an adjunctive treatment strategy in malignancies affecting the peritoneal surface, effectively targeting remaining microscopic residual tumor. HIPEC increases concentrations of chemotherapy...
Tue Jan 14, 2020 02:00
Diagnostics, Vol. 10, Pages 42: Development of a Flow-Free Automated Colorimetric Detection Assay Integrated with Smartphone for Zika NS1 Diagnostics doi: 10.3390/diagnostics10010042 Authors: Kabir Zilouchian Sher Asghar The Zika virus (ZIKV) is an emerging flavivirus transmitted to humans by Aedes mosquitoes that can potentially cause microcephaly, Guillain–Barré Syndrome, and other birth defects. Effective vaccines for Zika have not yet been developed....
Tue Jan 14, 2020 02:00
Environments, Vol. 7, Pages 7: Use of Fertilizers in Agriculture: Individual Effective Dose Estimate
Environments, Vol. 7, Pages 7: Use of Fertilizers in Agriculture: Individual Effective Dose Estimate Environments doi: 10.3390/environments7010007 Authors: Ugolini Caldognetto Trotti Natural radioactivity might be present in fertilizers above ordinary levels, in particular for 40K and for the radionuclides of the 238U series. A modeling evaluation of the individual effective dose deriving from the use of fertilizers in agriculture is presented here. Dose assessment is useful...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 533: Clinical Presentation of Community-Acquired Legionella Pneumonia Identified by Universal Testing in an Endemic Area International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020533 Authors: Shruti Puri Monique Boudreaux-Kelly Jon D. Walker Cornelius J. Clancy Brooke K. Decker The rapid identification of Legionella pneumonia is essential to optimize patient treatment and outcomes, and to identify potential public health...
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IJERPH, Vol. 17, Pages 532: Explaining Income-Related Inequalities in Dietary Knowledge: Evidence from the China Health and Nutrition Survey International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020532 Authors: Yongjian Xu Siyu Zhu Tao Zhang Duolao Wang Junteng Hu Jianmin Gao Zhongliang Zhou Lack of adequate dietary knowledge may result in poor health conditions. This study aims to measure income-related inequality in dietary knowledge,...
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IJERPH, Vol. 17, Pages 531: Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020531 Authors: Tang Wang Yang Zheng Liu Qu Xu Zhang Liang Fan Objective: This study was conducted to evaluate the acute and subchronic toxicity of gardenia yellow, a natural colorant widely used in China and other Asian countries. An acute toxicity...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 527: Effect of Aerobic Physical Activity on Health-Related Quality of Life in Middle Aged Women with Osteoarthritis: Korea National Health and Nutrition Examination Survey (2016–2017) International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020527 Authors: Ryu Lee Kim Baek Kimm : Background: There have been few studies reporting the association between health-related quality of life (HRQoL) and osteoarthritis (OA)...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 530: Numerical Analysis of Stress and Temperature Fields in a Composite Stratum Based on a New Method of Shield Construction for Safety and Environmental Protection International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020530 Authors: Dai Xia Ning Yang Safety and environmental protection are key issues in shield construction. Due to wear, the cutter of a shield machine must be changed after a period of excavation. In...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 529: Are Environmental Interventions Targeting Skin Cancer Prevention among Children and Adolescents Effective? A Systematic Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020529 Authors: Thoonen Osch Vries Jongen Schneider Skin cancer, which is increasing exceedingly worldwide, is substantially preventable by reducing unprotected exposure to ultraviolet radiation (UVR). Several comprehensive interventions...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 525: VIKOR Method for MAGDM Based on Q-Rung Interval-Valued Orthopair Fuzzy Information and Its Application to Supplier Selection of Medical Consumption Products International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020525 Authors: Gao Ran Wei Wei Wu The VIKOR model has been considered a viable tool for many decision-making applications in the past few years, given the advantages of considering the compromise between...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 526: Sugarcane Bagasse as an Efficient Biosorbent for Methylene Blue Removal: Kinetics, Isotherms and Thermodynamics International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020526 Authors: Andrade Siqueira Zanette da Silva Rubio Bergamasco Gasparotto Paccola Yamaguchi Adsorption in biomass has proven to be a cost-effective option for treatment of wastewater containing dyes and other pollutants, as it is a...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 528: Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020528 Authors: Pan Leonardi Croxford Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 524: Resilience Assessment of Complex Urban Public Spaces International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020524 Authors: Hui Xu Yang Li Lin Wang Risk events frequently occur in “complex urban public spaces” (CUPSs) and cause serious economic losses and casualties. To reduce the risks and enhance the system resilience, this paper formulates a theoretical framework to assess the resilience of CUPSs....
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 523: Extent of Primary DNA Damage Measured by the Comet Assay in Health Professionals Exposed to Antineoplastic Drugs: A Systematic Review and Meta-Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020523 Authors: Gianfredi Nucci Fatigoni Salvatori Villarini Moretti Background: Antineoplastic drugs (ANDs) are a broad group of chemicals showing, at the same time, carcinogenic effects. The potential,...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 521: Usability of Clinical Information in Discharge Summary Data in the Diagnosis Procedure Combination Survey for Cancer Patients International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020521 Authors: Okuyama Higashi Valid data are required to monitor and measure the quality of cancer treatment. This study aims to assess the usability of diagnosis procedure combination (DPC) survey discharge summary data. DPC survey data were...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 522: Labor Costs, Market Environment and Green Technological Innovation: Evidence from High-Pollution Firms International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020522 Authors: Gong Wu Chen Yan Emerging economies face the challenge of increasing labor costs but also provide an opportunity to promote environmental governance and green development. Based on the perspectives of impetus and capability, the effects of rising...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 519: E-Cigarette Use by Smoking Status in Estonia, 2012–2018 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020519 Authors: Reile Pärna Abstract: Background: In the context of declining smoking rates in Estonia, this study aims to analyze the recent trends in e-cigarette use and its associations with smoking status and sociodemographic factors. Methods: Nationally representative data from biennial cross-sectional health...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 520: How Does Positive Work-Related Stress Affect the Degree of Innovation Development? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020520 Authors: Albort-Morant Ariza-Montes Leal-Rodríguez Giorgi Many studies sustain that work-related stress exerts pervasive consequences on the employees’ levels of performance, productivity, and wellbeing. However, it remains unclear whether certain levels of stress...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 516: Technical Blossom in Medical Care: The Influence of Big Data Platform on Medical Innovation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020516 Authors: Liu Guo Ding Medical innovation has consistently been an essential subject and a source of support for public health research. Furthermore, improving the level of medical research and development is of great concern in this field. This paper highlights the...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 517: Built and Natural Environmental Correlates of Parental Safety Concerns for Children’s Active Travel to School International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020517 Authors: Kim Lee This cross-sectional study examines built and natural environmental correlates of parental safety concerns for children’s active travel to school (ATS), controlling for socio-demographic, attitudinal, and social factors. Questionnaire...
Tue Jan 14, 2020 02:00
IJERPH, Vol. 17, Pages 518: Effect of the Modification of the Number of Players, the Size of the Goal, and the Size of the Field in Competition on the Play Actions in U-12 Male Football International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020518 Authors: García-Angulo Palao Giménez-Egido García-Angulo Ortega-Toro A player’s sports development involves a long process. The modification of rules for youth players seeks to adapt...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 542: Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21020542 Authors: Kendal Prill John F. Dawson Sarcomere assembly and maintenance are essential physiological processes required for cardiac and skeletal muscle function and organism mobility. Over decades of research, components of the sarcomere and factors involved in the formation and maintenance of this contractile unit...
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IJMS, Vol. 21, Pages 541: P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future
IJMS, Vol. 21, Pages 541: P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future International Journal of Molecular Sciences doi: 10.3390/ijms21020541 Authors: Arnold J. Levine The p53 field was born from a marriage of the techniques of cancer virus research and immunology. Over the past 40 years, it has followed the path of cancer research. Now cancer treatments are turning to immunotherapy, and there are many hints of the role of the p53 protein in both the regulation...
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IJMS, Vol. 21, Pages 540: Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats International Journal of Molecular Sciences doi: 10.3390/ijms21020540 Authors: Gonzalo Soto María José Rodríguez Roberto Fuentealba Adriana V. Treuer Iván Castillo Daniel R. González Jessica Zúñiga-Hernández Maresin-1 (MaR1) is a specialized pro-resolving mediator, derived from omega-3 fatty...
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IJMS, Vol. 21, Pages 538: A Sub-Clone of RAW264.7-Cells Form Osteoclast-Like Cells Capable of Bone Resorption Faster than Parental RAW264.7 through Increased De Novo Expression and Nuclear Translocation of NFATc1 International Journal of Molecular Sciences doi: 10.3390/ijms21020538 Authors: Laia Mira-Pascual Anh N. Tran Göran Andersson Tuomas Näreoja Pernilla Lång The murine macrophage cell line RAW264.7 is extensively used as a progenitor to study osteoclast (OC) differentiation....
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 524: Idiopathic Pulmonary Fibrosis: Pathogenesis and the Emerging Role of Long Non-Coding RNAs International Journal of Molecular Sciences doi: 10.3390/ijms21020524 Authors: Hadjicharalambous Lindsay Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disease characterized by excessing scarring of the lungs leading to irreversible decline in lung function. The aetiology and pathogenesis of the disease are still unclear, although lung fibroblast and...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 525: A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease International Journal of Molecular Sciences doi: 10.3390/ijms21020525 Authors: Schena Esposito Rossini In April 2012, a group of nephrologists organized a consensus conference in Cambridge (UK) on type II membranoproliferative glomerulonephritis and decided to use a new terminology, “C3 glomerulopathy” (C3 GP). Further knowledge on the complement system and on kidney biopsy...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 526: Suppression of β1-Adrenoceptor Autoantibodies is Involved in the Antiarrhythmic Effects of Omega-3 Fatty Acids in Male and Female Hypertensive Rats International Journal of Molecular Sciences doi: 10.3390/ijms21020526 Authors: Bacova Radosinska Wallukat Barancik Wallukat Knezl Sykora Paulis Tribulova The arrhythmogenic potential of β1-adrenoceptor autoantibodies (β1-AA), as well as antiarrhythmic properties...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 528: Preparation and Characterization of Surface Heat Sintered Nanohydroxyapatite and Nanowhitlockite Embedded Poly (Lactic-co-glycolic Acid) Microsphere Bone Graft Scaffolds: In Vitro and in Vivo Studies International Journal of Molecular Sciences doi: 10.3390/ijms21020528 Authors: Jose Shalumon Liao Kuo Chen In the context of using bone graft materials to restore and improve the function of damaged bone tissues, macroporous biodegradable composite...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 537: Inhibitory Effects of Peptide Lunasin in Colorectal Cancer HCT-116 Cells and Their Tumorsphere-Derived Subpopulation International Journal of Molecular Sciences doi: 10.3390/ijms21020537 Authors: Fernández-Tomé Xu Han Hernández-Ledesma Xiao The involvement of cancer stem-like cells (CSC) in the tumor pathogenesis has profound implications for cancer therapy and chemoprevention. Lunasin is a bioactive peptide from soybean and other vegetal sources...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 529: Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences International Journal of Molecular Sciences doi: 10.3390/ijms21020529 Authors: Barabás Szabó-Meleg Ábrahám : Inflammation has a well-known suppressive effect on fertility. The function of gonadotropin-releasing hormone (GnRH) neurons, the central regulator of fertility is substantially altered during inflammation in females. In our review we discuss...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 536: The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21020536 Authors: Eftekhari Maleki Dizaj Sharifi Salatin Rahbar Saadat Zununi Vahed Samiei Ardalan Rameshrad Ahmadian Cucchiarini The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 539: Hemmule: A Novel Structure with the Properties of the Stem Cell Niche International Journal of Molecular Sciences doi: 10.3390/ijms21020539 Authors: Vitaly Vodyanoy Oleg Pustovyy Ludmila Globa Randy J. Kulesza Iryna Sorokulova Stem cells are nurtured and regulated by a specialized microenvironment known as stem cell niche. While the functions of the niches are well defined, their structure and location remain unclear. We have identified, in rat bone...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 533: Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models International Journal of Molecular Sciences doi: 10.3390/ijms21020533 Authors: Hong Park Kim Arthritis, including osteoarthritis (OA) and rheumatoid arthritis (RA), is the leading cause of years lived with disability (YLD) worldwide. Although pain is the cardinal symptom of arthritis, which is directly related to function and quality of life, the...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 532: Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels International Journal of Molecular Sciences doi: 10.3390/ijms21020532 Authors: Bustos Bedoya Ramírez Concha Zúñiga Decher Hernández-Rodríguez Sepúlveda Martínez González Two-pore domain potassium (K2P) channels maintain the cell’s background conductance by stabilizing the resting membrane potential. They assemble as...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 534: Allosteric Binding Sites On Nuclear Receptors: Focus On Drug Efficacy and Selectivity International Journal of Molecular Sciences doi: 10.3390/ijms21020534 Authors: André Fischer Martin Smieško Nuclear receptors (NRs) are highly relevant drug targets in major indications such as oncologic, metabolic, reproductive, and immunologic diseases. However, currently, marketed drugs designed towards the orthosteric binding site of NRs often suffer from resistance...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 520: Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects International Journal of Molecular Sciences doi: 10.3390/ijms21020520 Authors: Vianello Dozio Bandera Froldi Micaglio Lamont Tacchini Schmitz Romanelli There is recent evidence that the dysfunctional responses of a peculiar...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 522: Degenerated Cones in Cultured Human Retinas Can Successfully Be Optogenetically Reactivated International Journal of Molecular Sciences doi: 10.3390/ijms21020522 Authors: Kamar Howlett Klooster Graaff Csikós Rabelink Hoeben Kamermans Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made towards this end, especially when retinal...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 521: Site-Specific Expression Pattern of PIWI-Interacting RNA in Skin and Oral Mucosal Wound Healing International Journal of Molecular Sciences doi: 10.3390/ijms21020521 Authors: Chen Chen Simões Wu Dai DiPietro Zhou The oral mucosa exhibits exceptional healing capability when compared to skin. Recent studies suggest that intrinsic differences in coding genes and regulatory small non-coding RNA (sncRNA) genes (e.g., microRNAs) may underlie...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 535: Foliar Application of Chitosan Increases Tomato Growth and Influences Mycorrhization and Expression of Endochitinase-Encoding Genes International Journal of Molecular Sciences doi: 10.3390/ijms21020535 Authors: Fatima El Amerany Abdelilah Meddich Said Wahbi Andrea Porzel Moha Taourirte Mohammed Rhazi Bettina Hause Nowadays, applying bio-organic fertilizer (e.g., chitosan, Ch) or integrating beneficial microorganisms (e.g., arbuscular mycorrhizal...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 530: Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes International Journal of Molecular Sciences doi: 10.3390/ijms21020530 Authors: Cassandra M. Barrett Reilly McCracken Jacob Elmer Karmella A. Haynes A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 527: Enteropathogenic Escherichia coli (EPEC) Recruitment of PAR Polarity Protein Atypical PKCζ to Pedestals and Cell–Cell Contacts Precedes Disruption of Tight Junctions in Intestinal Epithelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21020527 Authors: Rocio Tapia Sarah E. Kralicek Gail A. Hecht Enteropathogenic Escherichia coli (EPEC) uses a type three secretion system to inject effector proteins into host intestinal epithelial...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 531: Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5 International Journal of Molecular Sciences doi: 10.3390/ijms21020531 Authors: Tanja Mang Sven Lindemann Anne Gigout The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 517: Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia International Journal of Molecular Sciences doi: 10.3390/ijms21020517 Authors: Ułamek-Kozioł Czuczwar Januszewski Pluta Currently available pharmacological treatment of post-ischemia-reperfusion brain injury has limited effectiveness. This review provides an assessment of the current state of neurodegeneration treatment due to ischemia-reperfusion...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 519: Cancer Nano-Immunotherapy from the Injection to the Target: The Role of Protein Corona International Journal of Molecular Sciences doi: 10.3390/ijms21020519 Authors: Mikelez-Alonso Aires Cortajarena Immunotherapy has become a promising cancer therapy, improving the prognosis of patients with many different types of cancer and offering the possibility for long-term cancer remission. Nevertheless, some patients do not respond to these treatments and immunotherapy...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 518: Comprehensive Analysis of GABAA-A1R Developmental Alterations in Rett Syndrome: Setting the Focus for Therapeutic Targets in the Time Frame of the Disease International Journal of Molecular Sciences doi: 10.3390/ijms21020518 Authors: Oyarzabal Xiol Castells Grau O’Callaghan Fernández Alcántara Pineda Armstrong Altafaj García-Cazorla Rett syndrome, a serious neurodevelopmental disorder, has been associated with an altered...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 523: Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21020523 Authors: Eleonora Bassino Franco Gasparri Luca Munaron Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 515: Finding the Keys to the CAR: Identifying Novel Target Antigens for T Cell Redirection Immunotherapies International Journal of Molecular Sciences doi: 10.3390/ijms21020515 Authors: Abbott Cross Jenkins Oncology immunotherapy has been a significant advancement in cancer treatment and involves harnessing and redirecting a patient’s immune response towards their own tumour. Specific recognition and elimination of tumour cells was first proposed...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 516: Genetic Analyses in Dent Disease and Characterization of CLCN5 Mutations in Kidney Biopsies International Journal of Molecular Sciences doi: 10.3390/ijms21020516 Authors: Gianesello Ceol Bertoldi Terrin Priante Murer Peruzzi Giordano Paglialonga Cantaluppi Musetti Valle Prete Anglani Network Dent disease (DD), an X-linked renal tubulopathy, is mainly caused by loss-of-function mutations in CLCN5 (DD1)...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 514: Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation International Journal of Molecular Sciences doi: 10.3390/ijms21020514 Authors: Thiel Christoffel Tauber Vahlensieck Zélicourt Layer Lauber Polzer Ullrich Cellular processes are influenced in many ways by changes in gravitational force. In previous studies, we were able to demonstrate, in various cellular...
Tue Jan 14, 2020 02:00
IJMS, Vol. 21, Pages 513: Vertebrate Alpha2,8-Sialyltransferases (ST8Sia): A Teleost Perspective International Journal of Molecular Sciences doi: 10.3390/ijms21020513 Authors: Tindara Venuto Decloquement Martorell Ribera Noel Rebl Cogez Petit Galuska Harduin-Lepers We identified and analyzed α2,8-sialyltransferases sequences among 71 ray-finned fish species to provide the first comprehensive view of the Teleost ST8Sia repertoire. This repertoire...
Tue Jan 14, 2020 02:00
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