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Τρίτη 26 Μαρτίου 2019

Aging Clinical and Experimental Research,Education and Information Technologies,Clinical Drug Investigation,Archives of Toxicology,

Promoter hypermethylation-mediated downregulation of tumor suppressor gene SEMA3B and lncRNA SEMA3B-AS1 correlates with progression and prognosis of esophageal squamous cell carcinoma
Abstract Frequent deletions of tumor-suppressor genes at chromosome 3p21.3 have been detected in esophageal squamous cell carcinoma (ESCC). As a candidate tumor suppressor gene, semaphorin 3B (SEMA3B) is located at 3p21.3 and is frequently inactivated in several tumors. However, the role and inactivation mechanisms of SEMA3B and its antisense long non-coding RNA (lncRNA) SEMA3B-AS1 in the carcinogenesis of ESCC have not been fully elucidated. The present study was conducted to...
Latest Results
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Insufficient radiofrequency ablation promotes the metastasis of residual hepatocellular carcinoma cells via upregulating flotillin proteins
Abstract Purpose Radiofrequency ablation (RFA) therapy has proven to be effective and feasible for early-stage hepatocellular carcinoma (HCC); however, rapid progression of residual tumor cells after RFA has been confirmed, but the molecular mechanisms of this phenomenon are poorly understood. This study evaluated the effect of the lipid raft proteins known as flotillins on the invasive and metastatic potential of residual HCC. ...
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Tue Mar 26, 2019 20:40
Aggregate analysis based on TCGA: TTN missense mutation correlates with favorable prognosis in lung squamous cell carcinoma
Abstract Purpose Lung cancer prevalence with its high mortality rate is a trending topic globally. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The human gene TTN encoding for TITIN protein is known as major mutation gene in many types of tumor including NSCLC. However, it is still controversial that TTN is a cancer-associated candidate considering tumor heterogeneity and complex genetic structure. In-depth...
Latest Results
Tue Mar 26, 2019 20:40
Lymph node ratio predictive of recurrence, distant metastasis, and survival in submandibular gland carcinoma patients
Abstract Purpose Submandibular gland (SMG) carcinoma has an unfavorable clinical course and a low survival rate. Specific tumor and nodal findings might help predict posttreatment recurrence and survival in SMG carcinoma patients. This study evaluated factors predictive of posttreatment recurrence and survival in SMG carcinoma patients. Methods ...
Latest Results
Tue Mar 26, 2019 20:40
Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium
Abstract Objective The impact of angiogenesis on long-term survival of high-grade serous ovarian cancer (HGSOC) patients remains unclear. This study investigated whether angiogenic markers correlated with 5-year progression-free survival (PFS) in a large cohort of matched advanced HGSOC tissue samples. Methods Tumor samples from 124 primary...
Latest Results
Tue Mar 26, 2019 20:40
Regorafenib in patients with recurrent high-grade astrocytoma
Abstract Purpose Antiangiogenic treatment approaches have failed to improve outcome in randomized trials of high-grade astrocytoma. One key mechanism of resistance to antiangiogenic treatment may concern the upregulation of alternative pro-angiogenic pathways. Regorafenib is a potent multikinase inhibitor that may alter some of those pathways. In this retrospective study, we investigated efficacy and radiographic tumor growth patterns...
Latest Results
Tue Mar 26, 2019 20:40
Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study
Abstract Purpose The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes. Methods We...
Latest Results
Tue Mar 26, 2019 20:40
Controversies in the Approach to Initial Therapy of Hodgkin Lymphoma
Abstract Purpose of Review Availability of highly effective novel agents has altered the approach to initial therapy in patients with classical Hodgkin lymphoma (cHL). We will review controversies in the following areas: (1) the role of radiation in early unfavorable disease and the optimal treatment strategies for (2) advanced-stage disease and (3) elderly patients. ...
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The Impact of Obesity on Breast Cancer Diagnosis and Treatment
Abstract Purpose of Review Obesity is a recognized risk factor for the development of breast cancer and recurrence even when patients are treated appropriately. We reviewed the literature that addresses the impact of obesity on diagnosis and the individual therapeutic interventions, and present a summary of the findings. Recent Findings Compared...
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Chimeric Antigen Receptor–Engineered T Cell Therapy in Lymphoma
Abstract Purpose of Review Chimeric antigen receptor (CAR) T cells are a form of adoptive therapy employing autologous T cells engineered with an artificial receptor, able to recognize tumor antigens through an HLA-independent mechanism. We will review data on safety and efficacy outcomes with CAR T cell therapy in lymphomas. Recent Findings ...
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Central Nervous System Involvement of Natural Killer and T Cell Neoplasms
Abstract Purpose of Review Peripheral natural killer (NK) and T cell neoplasms comprise approximately 10–15% of non-Hodgkin lymphomas. There are 27 different subtypes of peripheral NK and T cell neoplasms, each of which is relatively uncommon. Treatment has been largely extrapolated from case series, retrospective reports, and paradigms developed for the aggressive B cell lymphomas. This review explores the current knowledge of the...
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Effects of Temperature and Ionic Strength of Dissolution Medium on the Gelation of Amorphous Lurasidone Hydrochloride
Abstract Purpose Amorphous lurasidone hydrochloride (LH) showed decreased dissolution behavior in comparison to crystalline LH owing to gelation during dissolution as reported in our previous study. The current study aims to investigate external factors including temperature and ionic strength on the gelation and hence the dissolution of amorphous LH. Methods ...
Latest Results
Tue Mar 26, 2019 02:00
Functional Replacement of the BioC and BioH Proteins of Escherichia coli Biotin Precursor Biosynthesis by Ehrlichia chaffeensis Novel Proteins
Abstract The biosynthesis of the pimelate moiety of biotin in Escherichia coli requires two specialized proteins, BioC and BioH. However, the enzymes that have BioC- or BioH-like activities show remarkable sequence diversity among biotin-producing bacteria. Here, we report that the intracellular rickettsial pathogen Ehrlichia chaffeensis encodes two novel proteins, BioT and BioU, which functionally replace the E. coli BioC and BioH proteins, respectively. The desthiobiotin assays...
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Tue Mar 26, 2019 02:00
Oxidation of high iron content electroplating sludge in supercritical water: stabilization of zinc and chromium
Abstract The stabilization of heavy metals (zinc and chromium) and the degradation of organic pollutants during supercritical water (SCW) and supercritical water oxidation (SCWO) treatment of electroplating sludge (EPS) with a high iron content were studied. Experiments were performed in a batch reactor at temperatures in the range from 623.15 to 823.15 K with an oxygen coefficient (OE) from 0 to 2.0, a reaction time of 7 min and pressure of 25 MPa to examine the effect of the...
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Fungal-mediated synthesis of pharmaceutically active silver nanoparticles and anticancer property against A549 cells through apoptosis
Abstract Generally, fungi have the ability to secrete large amounts of secondary metabolites which have the ability to reduce metal ions to metallic nanoparticles. In this report, silver nanoparticles (AgNPs) were synthesized by using an endophytic fungus isolated from the medicinal plant, Catharanthus roseus (Linn.). The endophytic fungus was identified as Botryosphaeria rhodina based on the ITS sequencing. The synthesized AgNPs were characterized by adopting various high-throughput...
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Metabolic adaptation of fungal strains in response to contamination by polychlorinated biphenyls
Abstract Polychlorinated biphenyls (PCBs) represent a large group of recalcitrant environmental pollutants. Up to now, many studies have focused on bioremediation of PCBs by fungal strains; however, the mechanisms of adaptation of these strains towards PCBs remain unknown despite their importance in developing effective bioremediation processes. We studied five species, each consisting of two strains isolated either from PCB-polluted or PCB-unpolluted substrates (control strains)....
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An integrative assessment to determine the sediment toxicity of Kaohsiung Harbor in Taiwan: combining chemical analysis and cytotoxicity assay
Abstract To evaluate the toxicity of sediments collected from the mouths of four  rivers and entrances of Kaohsiung Harbor, Taiwan, a combination of in vitro cytotoxicity assays (Clone 9 cells) and chemical analysis that quantified 16 polycyclic aromatic hydrocarbons (PAHs), 10 phthalate esters (PAEs), and 2 alkylphenols (APs) was employed. Results showed that the total concentrations of PAHs, PAEs, and APs ranged between 77.9 and 24,363 ng/g dw, between 268 and 118,010 ng/g dw,...
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Effects of Bacillus subtilis on the growth, colony maintenance, and attached bacterial community composition of colonial cyanobacteria
Abstract In freshwater aquaculture ponds, application of algicidal Bacillus is a promising way in the control of cyanobacterial blooms. To best understand Bacillus algicidal characters and mechanisms in the field, different-sized colonial cyanobacteria were isolated from an aquaculture pond, and the effects of B. subtilis on their growth, colony maintenance, and colony-attached bacterial community composition were investigated. The results showed that B. subtilis could inhibit...
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Carbon emission intensity of electricity generation in Belt and Road Initiative countries: a benchmarking analysis
Abstract The scope of this study is to analyze the carbon emissions intensity of electricity generation in "Belt and Road Initiative" (BRI) countries. The total CO2 emissions from electricity generation in BRI nations increases from 4232.34 Mt in 2013 to 4402.38 Mt in 2015, accounting for 34.45% of global CO2 emissions from electricity generation. Logarithmic mean Divisia index methodology is applied to analyze the drivers of carbon emissions intensity in BRI nations. The decomposition...
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The effects of economic growth and innovation on CO 2 emissions in different regions
Abstract Economic growth and economic energy consumption have received greater attention due to its contribution to global CO2 emissions in recent decades. The literature on CO2 emissions and innovation for regional differences is very scanty as there is not enough study that considered different regions in a single analysis. We adopt a holistic approach by incorporating different regions so as to assess how innovation contributes to emission reduction. The study, therefore, examined...
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Hydroponics: are we moving towards that direction only because of the environment? A discussion on forecasting and a systems review
Abstract During the evolution of the human, agriculture and land utilization was inevitably connected with survival in nature. Human activity was not only restricted to the production of agricultural products but also extended into many other sectors, such as the production of several industrial-made products, mining, and usage of fossil fuels as a standard method of generating electricity. However, the intense urbanization phenomenon ultimately caused, during the last few decades,...
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Guarana improves behavior and inflammatory alterations triggered by methylmercury exposure: an in vivo fruit fly and in vitro neural cells study
Abstract Methylmercury (MeHg) is a well-known environmental pollutant associated with neurological and developmental deficits in animals and humans. However, epidemiological data showed that people living in the Amazon region although exposed to MeHg do not present these effects probably due to the protective effect of certain foods. We hypothesized here if guarana, a highly caffeinated fruit and consumed on a daily basis by Amazon people, could have some protective effect against...
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Study of the effects of zinc pyrithione in biochemical parameters of the Polychaeta Hediste diversicolor : evidences of neurotoxicity at ecologically relevant concentrations
Abstract Nowadays there are various groups of biocidal chemical agents, which can be used in diverse areas, such as personal hygiene, disinfection, antiparasitic action, and also in antifouling mixtures or paints. The versatility and efficacy of some of these agents favors their use and ultimate release into the aquatic environment, where they may still exert toxic activity. Zinc pyrithione is classified as a metal biocide with bactericidal, algicidal, and fungicidal actions. It...
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Tue Mar 26, 2019 02:00
The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities
Abstract In the current report, we examined the potential beneficial role of soursop fruit extract (SSFE) on liver injury induced by a single paracetamol (APAP) overdose (2000 mg/kg). Thirty-five Wistar albino rats were randomly divided into five groups as follows: control, SSFE, APAP, SSFE+APAP, and silymarin (SIL)+APAP. APAP intoxication was found to elevate alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels. Moreover, it increased...
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Tue Mar 26, 2019 02:00
Preparation, characterization, and photocatalytic activity under UV and visible light of Co, Mn, and Ni mono-doped and (P,Mo) and (P,W) co-doped TiO 2 nanoparticles: a comparative study
Abstract In this work, TiO2-based nanomaterials have been successfully synthesized by doping TiO2 with Co, Mn, and Ni and by co-doping it with (P,Mo) or (P,W). The structural, optical, and morphological properties of the synthesized nanomaterials have been investigated using various techniques such as XRD, FTIR spectroscopy, UV-vis diffuse reflectance spectroscopy, XPS, and SEM-EDS. The obtained results showed that the crystalline structure of the doped TiO2-based nanomaterials...
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Tue Mar 26, 2019 02:00
Monte Carlo fingerprinting of the terrestrial sources of different particle size fractions of coastal sediment deposits using geochemical tracers: some lessons for the user community
Abstract A sediment source fingerprinting method, including a Monte Carlo simulation framework, was used to quantify the contributions of terrestrial sources of fine- (< 63 μm) and coarse-grained (63–500 μm) sediments sampled from three categories of coastal sediment deposits in the Jagin catchment, south-east of Jask, Hormozgan province, southern Iran: coastal dunes (CD), terrestrial sand dunes or onshore sediments (TSD), and marine or offshore sediments (MD). Forty-nine geochemical...
Latest Results
Tue Mar 26, 2019 02:00
Linking nano-ZnO contamination to microbial community profiling in sanitary landfill simulations
Abstract Nanomaterials (NMs) commercially used for various activities mostly end up in landfills. Reduced biogas productions reported in landfill reactors create a need for more comprehensive research on these greatly-diverse microbial pools. In order to evaluate the impact of one of the most widely-used NMs, namely nano-zinc oxide (nano-ZnO), simulated bioreactor and conventional landfills were operated using real municipal solid waste (MSW) for 300 days with addition nano-ZnO....
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Tue Mar 26, 2019 02:00
Tomotherapy in malignant mesothelioma: a planning study to establish dose constraints
Abstract Purpose A planning study was performed for helical tomotherapy treatment. We evaluated the maximum achievable protection of organs at risk (OARs) in patients with malignant pleural mesothelioma after pleurectomy with simultaneous optimal target coverage. Materials and methods The datasets of 13 patients were included. The applied dose to the planning...
Latest Results
Tue Mar 26, 2019 02:00
European Society of Paediatric Radiology abdominal imaging task force: statement on imaging in very early onset inflammatory bowel disease
Abstract Very early onset inflammatory bowel disease (VEO-IBD) is defined as disease presenting before the age of 6. These children require a tailored imaging approach because conventional imaging studies can be difficult to perform at such a young age. Unlike inflammatory bowel disease in older children and adults, colonic disease predominates in VEO-IBD, and small-bowel disease is rare. Distinguishing Crohn disease from ulcerative colitis is challenging both clinically and on...
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02:00
Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation
Abstract The current investigation aimed at formulating self-microemulsifying drug delivery system (SMEDDS) to ameliorate oral bioavailability of a hydrophobic functional ingredient, limonene. Solubility test, compatibility test, and pseudo-ternary phase diagrams (PTPD) were adopted to screen the optimal compositions of limonene-SMEDDS (L-SMEDDS). The characteristics of this system assessed in vitro, mainly included determination of particle size distribution, observation of...
Latest Results for AAPS PharmSciTech
Tue Mar 26, 2019 02:00
Imaging features of immune-mediated genitourinary disease
Abstract Purpose Imaging features of immune-mediated genitourinary diseases often overlap, and the same disease may manifest in different ways, so understanding imaging findings in the context of the patient's entire clinical picture is important in providing the correct diagnosis. Methods In this article, diseases mediated by the immune system which affect...
Latest Results for Abdominal Imaging
02:00
Running out of developmental program and selfish anti-aging: a new hypothesis explaining the aging process in primates
Abstract Of the three complementary theories of aging, two (mutation accumulation and antagonistic pleiotropy) were formulated over fifty years ago before the introduction of molecular biology, and the third (disposable soma) is over thirty years old. Despite rigorous research in the past fifty years, none have gained substantial experimental support. Here, I review these theories and introduce a new hypothesis called the selfish anti-aging (SAA). Aging happens because natural...
Latest Results for AGE
Tue Mar 26, 2019 02:00
Supplemental calcium intake in the aging individual: implications on skeletal and cardiovascular health
Abstract Adequate calcium intake during childhood is necessary to achieve optimal peak bone mass and this has the potential by increasing bone reserves, to modulate the rate of age-associated bone loss. However, data regarding the efficacy of calcium obtained either through the diet or in the form of medicinal supplementation, for prevention of bone loss and osteoporotic fractures in the elderly is conflicting. Calcium alone is unlikely to be of benefit for this purpose though...
Latest Results for Aging Clinical and Experimental Research
Tue Mar 26, 2019 02:00
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
Abstract Drug-induced liver injury remains a frequent reason for drug withdrawal. Accordingly, more predictive and translational models are required to assess human hepatotoxicity risk. This study presents a comprehensive evaluation of two promising models to assess mechanistic hepatotoxicity, microengineered Organ-Chips and 3D hepatic spheroids, which have enhanced liver phenotype, metabolic activity and stability in culture not attainable with conventional 2D models. Sensitivity...
Latest Results for Archives of Toxicology
Tue Mar 26, 2019 02:00
Sunitinib Rechallenge After Other Targeted Therapies in Metastatic Renal Cell Carcinoma Patients: A Single-Center, Retrospective Study
Abstract Background Sunitinib is still one of the standard therapies in metastatic renal cell carcinoma (mRCC). Despite the benefit of sunitinib resistance will develop in the majority of patients. Most of them receive multiple sequential therapies during the course of disease. Objectives To retrospectively investigate the efficacy and safety of rechallenged...
Latest Results for Clinical Drug Investigation
Tue Mar 26, 2019 02:00
Finding model through latent semantic approach to reveal the topic of discussion in discussion forum
Abstract There are lots of information and knowledge can be extracted from a discussion forum. Despite a discussion is opened by submitting a thread as the topic of discussion, however, the discussion may open out to different topics. This paper aims to present a model to find out a topic of discussion through latent semantic approach, named Topics Finding Model (TFM). The model proposes a complete step to reveal the topic of discussion from a thread in a discussion forum, consisting...
Latest Results for Education and Information Technologies
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Internet addiction among college students: Some causes and effects
Abstract Internet addiction among college students in terms of causes and effects are investigated. Correlation study method is utilized; structural equation modelling is applied to analyze the data. There are fifteen hypotheses generated for the model. The data is collected via numerous instruments proven as reliable and valid by the previous studies. There are 159 undergraduate students as participants of the study. Antecedent variables are game addiction, bad relationships with...
Latest Results for Education and Information Technologies
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Correction to: Classroom dialogue and digital technologies: a scoping review
The authors of this review [1] wish to draw the attention of readers to a correction for Section 3.3.2. The text relating to [S11], a paper by Deaney, Chapman, & Hennessy (2009) [2], is not an accurate representation of the work of the authors of this 2009 paper.
Latest Results for Education and Information Technologies
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Investigation of Turkish preservice teachers' intentions to use IWB in terms of technological and pedagogical aspects
Abstract The purpose of this study was to investigate the technological and pedagogical constructs underlying Turkish preservice teachers' behavioral intentions to use interactive whiteboard based on UTAUT model and TPACK using three structural equation models; technological framework, pedagogical framework, and integrated model. Within this scope, preservice teachers' behavioral intentions to use IWB was defined as the dependent variable. Performance expectancy, effort expectancy,...
Latest Results for Education and Information Technologies
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Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective
Abstract Biologic products encounter various types of interfacial stress during development, manufacturing, and clinical administration. When proteins come in contact with vapor–liquid, solid–liquid, and liquid–liquid surfaces, these interfaces can significantly impact the protein drug product quality attributes, including formation of visible particles, subvisible particles, or soluble aggregates, or changes in target protein concentration due to adsorption of the molecule to...
Latest Results for The AAPS Journal
Tue Mar 26, 2019 02:00

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