Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus:



Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus, Published online: 24 January 2019; doi:10.1038/s41467-018-08248-w

The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both biochemically and in cells.