Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium‐Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination

Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium‐Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination:

A transition metal‐catalyzed asymmetric cascade hydrogenation/reductive amination reaction of quinolinyl‐ or quinoxalinyl‐containing ketones has been reported by Q.‐H. Fan and co‐workers (DOI: 10.1002/anie.201812647). With hydrogen as reducing agent, chiral ruthenium complexes work just like a Chinese water wheel, turning quinolinyl‐ and quinoxalinyl‐containing ketones into enantioenriched benzo‐fused quinolizidines, indolizidines, and their analogues via consecutive reactions.