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Τετάρτη 19 Οκτωβρίου 2022

Associations of Prenatal First Trimester Essential and Nonessential Metal Mixtures with Body Size and Adiposity in Childhood.

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Background: Prenatal nonessential metals may contribute to postnatal adiposity, while essential metals may have metabolic benefits. We evaluated joint and individual associations between prenatal metals and childhood adiposity. Methods: We measured concentrations of six nonessential (arsenic, barium, cadmium, cesium, lead, mercury) and four essential (magnesium, manganese, selenium, zinc) metals in first trimester maternal blood from a pre-birth cohort. We collected anthropometric measures in early childhood, mid-childhood, and early adolescence including subscapular+tricep skinfold thickness (mm) (N=715-859), waist circumference (cm) (N=717-882), and BMI (z-score) (N=716-875). We measured adiposity in mid-childhood and early adolescence using bone densitometry total- and trunk fat-mass index (kg/m2) (N=511-599). We estimated associations using adjusted quantile g-computation and linear regression. Results: The nonessential metal mixture was associated with higher total (β=0.07, 95% CI: 0.01, 0.12) and trunk fat-mass index (β=0.12, CI: 0.02, 0.22), waist circumference (β=0.01, CI: 0.00, 0.01), and BMI (β=0.24, CI: 0.07, 0.41) in mid-childhood, and total fat-mass index (β=0.07, CI: 0.01, 0.14) and BMI (β=0.19, CI: 0.02, 0.37) in early adolescence. The essential metal mixture was associated with lower early adolescence total (β= –0.11, CI: -0.17, -0.04) and trunk fat-mass index (β=-0.13, CI: -0.21, -0.05), subscapular+tricep skinfold thickness (β=-0.02, CI: -0.03, -0.00), waist circumference (β=-0.003, CI: -0.01, -0.00), and BMI (β=-0.16, CI: -0.28, -0.04). Cadmium and cesium were individually associated with childhood adiposity at different timepoints. Conclusions: Prenatal first trimester essential metals were associated with lower childhood adiposity, whereas nonessential metals were associated with higher adiposity into adolescence. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
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