Key points Twitch transdiaphragmatic pressure elicited by cervical magnetic stimulation of the phrenic nerves is a fully non‐volitional method for assessing diaphragm contractility in humans, yet it requires invasive procedures such as esophageal and gastric catheter‐balloons. Ultrafast ultrasound enables a very high frame rate allowing the capture of transient events, such as muscle contraction elicited by nerve stimulation (twitch). Whether indices derived from ultrafast ultrasound can be...
Key points Rhythmic processes in living organisms are controlled by biological clocks and the orexinergic system of the lateral hypothalamus carries circadian information to provide arousal for the brain during the active phase. Here, we show that orexins exert an excitatory action in three parts of the lateral geniculate nucleus (LGN), in particular upon directly retinorecipient neurons in the non‐image forming visual structures. We provide evidence for the high nocturnal levels of orexins...
Related Articles Blunt force abdominal trauma: a rare case of multiple splenic pseudocysts. ANZ J Surg. 2019 09;89(9):1160-1161 Authors: Sarofim M, Jarmin M, Malka V PMID: 29687587 [PubMed - indexed for MEDLINE]
Related Articles Hiatal hernia after oesophagectomy: a large European survey. Eur J Cardiothorac Surg. 2019 Jun 01;55(6):1104-1112 Authors: Gust L, Nafteux P, Allemann P, Tuech JJ, El Nakadi I, Collet D, Goere D, Fabre JM, Meunier B, Dumont F, Poncet G, Passot G, Carrere N, Mathonnet M, Lebreton G, Theraux J, Marchal F, Barabino G, Thomas PA, Piessen G, D'Journo XB Abstract OBJECTIVES: Hiatal hernias (HH) after oesophagectomy are rare, and...
Related Articles Expanded PCH1D phenotype linked to EXOSC9 mutation. Eur J Med Genet. 2020 Jan;63(1):103622 Authors: Bizzari S, Hamzeh AR, Mohamed M, Al-Ali MT, Bastaki F Abstract Pontocerebellar Hypoplasia type 1 is a rare heterogeneous neurodegenerative disorder with multiple subtypes linked to dysfunction of the exosome complex. Patients with mutations in exosome subunits exhibit a generally lethal phenotype characterized by cerebellar and...
Related Articles Late ulceration of residual abortive infantile haemangioma: a rare complication. Br J Dermatol. 2019 08;181(2):395-396 Authors: Welfringer-Morin A, Fraitag S, Balguerie X, Laaengh-Massoni C, Leclerc-Mercier S, Hadj-Rabia S, Bodemer C, Boccara O PMID: 30719710 [PubMed - indexed for MEDLINE]
Related Articles Hypertension in Potocki-Shaffer syndrome: A case report. Eur J Med Genet. 2020 Jan;63(1):103633 Authors: Wissman SD, McCool C, Potocki L, Elenberg E Abstract Potocki-Shaffer syndrome (PSS) is a rare contiguous gene deletion syndrome caused by heterozygous deletion of 11p11.2p12. Typical features described in patients with PSS include developmental delay, intellectual disability, multiple cartilaginous exostoses, biparietal...
Related Articles Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma. Sci Rep. 2019 03 26;9(1):5179 Authors: López-Nieva P, Fernández-Navarro P, Graña-Castro O, Andrés-León E, Santos J, Villa-Morales M, Cobos-Fernández MÁ, González-Sánchez L, Malumbres M, Salazar-Roa M, Fernández-Piqueras J Abstract Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence...
Related Articles Pheochromocytoma arising in the settingof adrenal-renal fusion. Can J Urol. 2019 10;26(5):9952-9955 Authors: Basourakos SP, Dean L, Van Gurp J, Reuter V, Russo P Abstract Adrenal-renal fusion is an anomaly misclassified as a renal tumor due to the absence of pathognomonic radiographic features. Herein, we report a case of a 61-year-old male who underwent a right radical nephrectomy for a presumed renal malignancy. Pathologic...
Related Articles Ectopic ACTH-secreting neuroendocrine tumor: a rare etiology of a pediatric solid renal mass. Can J Urol. 2019 10;26(5):9956-9959 Authors: Kocher NJ, Loloi J, Warrick J, Burns AS, Decter RM Abstract Neuroendocrine tumors (NETs) are rare tumors with varying clinical presentations. We describe the case of an 11-year-old female presenting with Cushingoid features in the setting of a left-sided flank mass. Her presentation and evaluation...
Related Articles Epithelioid angiomyolipoma with tumor thrombus. Can J Urol. 2019 10;26(5):9960-9962 Authors: Smentkowski K, Kelly D Abstract Epithelioid renal angiomyolipoma is a rare malignant variant of angiomyolipoma (AML); the latter being a well-characterized, benign kidney tumor derived from various connective tissue elements. In this case report, we describe a patient with an epithelioid AML and renal vein thrombus. PMID: 31629448...
Related Articles Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines. Curr Oncol. 2019 10;26(5):338-344 Authors: Thomas CM, Asa SL, Ezzat S, Sawka AM, Goldstein D Abstract Background: Medullary thyroid carcinoma (mtc) is a rare malignancy of the thyroid gland, and raising awareness of the recommended diagnostic workup and pathologic characteristics of this malignancy is therefore important. ...
Related Articles Complete resolution of chylopericardium after chemotherapy for chronic lymphocytic leukemia. Curr Oncol. 2019 10;26(5):e696-e699 Authors: Morris AL, Colbourne T, Kirkpatrick I, Banerji V Abstract Nontraumatic chylous pleural effusions (chylothorax) and pericardial effusions (chylopericardium) are rare. They can, however, accompany intrathoracic malignancies and, most commonly, lymphomas. An association of chronic lymphocytic...
Related Articles Gemcitabine-induced pseudocellulitis: a case report and review of the literature. Curr Oncol. 2019 10;26(5):e703-e706 Authors: Bami H, Goodman C, Boldt G, Vincent M Abstract Gemcitabine is a chemotherapeutic agent used in a wide variety of solid tumours. Known side effects include a dose-limiting myelosuppressive toxicity, mild rash, and radiation-dependent dermatitis. Rarely, localized inflammation in the form of pseudocellulitis...
Related Articles Primary yolk sac tumour of the prostate mimicking small round blue cell tumour. Curr Oncol. 2019 10;26(5):e707 Authors: Gui H, Kolster RA, Palmer MB, Brooks JS, Zhang M, Husson MA Abstract Prostatic yolk sac tumour is a germ cell tumour with a wide range of age of occurrence, unusual anatomic locations, diverse morphologic patterns, and aggressive biologic behavior, posing challenges both to diagnosis and clinical management....
Related Articles Reply to Dulskas et al. Colorectal Dis. 2020 04;22(4):468-469 Authors: Feddern ML, Emmertsen K, Laurberg S PMID: 31876098 [PubMed - indexed for MEDLINE]
Related Articles [Effect of surgery of pulmonary cysts related to immunoglobulin light chain deposits]. Rev Mal Respir. 2020 Feb;37(2):180-186 Authors: Delaey P, Plawny L, Nchimi A, Hirschi S, Weingertner N, Santelmo N, Wirtz G Abstract INTRODUCTION: Light chain deposition disease is a rare anatomo-clinical disorder, which rarely leads to cystic lung destruction. CASE REPORT: We report the case of a 62years old female patient with...
Related Articles [Segmental overgrowth syndromes and therapeutic strategies]. Med Sci (Paris). 2020 Mar;36(3):235-242 Authors: Venot Q, Canaud G Abstract Overgrowth syndromes are a large group of rare disorders characterized by generalized or segmental excessive growth. Segmental overgrowth syndromes are mainly due to genetic anomalies appearing during the embryogenesis and leading to mosaicism. The numbers of patients with segmental overgrowth...
Related Articles Radical excision versus local resection for primary rectal gastrointestinal stromal tumors. Cohort Study. Int J Surg. 2020 May;77:190-197 Authors: Guo W, Yang Z, Wei Y, Qin X, Li C, Huang R, Hu M, Zeng Z, Wang H, Wang H Abstract BACKGROUND: Rectal gastrointestinal stromal tumor (GIST) is a rare digestive disease that originates in mesenchymal tissues and has malignant tendencies. At present, no standard treatment has been developed,...
Related Articles Malignancies of suprapubic catheter (SPC) tracts in spinal cord injury patients: a case series and review of literature. Spinal Cord Ser Cases. 2019 04 15;5(1):34 Authors: Prattley S, New F, Davies M Abstract INTRODUCTION: Spinal cord injury (SCI) patients are at increased risk of bladder cancer. A rare variation of this is a malignancy arising or including the suprapubic catheter (SPC) tract. CASE SERIES: We present...
Related Articles Germinotropic lymphoproliferative disorder: a systematic review. Ann Hematol. 2020 Oct;99(10):2243-2253 Authors: Zanelli M, Zizzo M, Bisagni A, Froio E, De Marco L, Valli R, Filosa A, Luminari S, Martino G, Massaro F, Fratoni S, Ascani S Abstract Germinotropic lymphoproliferative disorder is a rare and rather enigmatic novel entity with distinctive clinicopathological features, one of which is the typical co-infection by Human...
Related Articles Spinal extradural arachnoid cyst in cervicothoracic junction. Spinal Cord Ser Cases. 2019 05 13;5(1):45 Authors: Özdemir M, Pelin Kavak R, Gülgönül N Abstract INTRODUCTION: Spinal extradural arachnoid cysts (SEACs) are rare expansive lesions that account for ~1% of all spinal tumors. They develop as the result of arachnoid membrane herniation through a small dural defect and are mostly reported to be located at lower thoracic...
Related Articles [Rectal cancer surgery:trends, developments, and future perspectives]. Nihon Shokakibyo Gakkai Zasshi. 2020;117(7):580-588 Authors: Kawamura J PMID: 32655118 [PubMed - indexed for MEDLINE]
Related Articles Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature. Medicine (Baltimore). 2020 Sep 18;99(38):e22297 Authors: Oyama T, Noda T, Washio K, Shimada A Abstract RATIONALE: Growing teratoma syndrome is defined as an increase in tumor size during or after systemic chemotherapy for germ cell tumors. These cases involve normal tumor maker levels and histological features of only mature teratoma....
Related Articles Endoscopic findings of gastric mixed adenoneuroendocrine carcinoma: A case report. Medicine (Baltimore). 2020 Sep 18;99(38):e22306 Authors: Takahashi K, Fujiya M, Sasaki T, Sugiyama Y, Murakami Y, Iwama T, Kunogi T, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Yuzawa S, Takei H, Okumura T Abstract RATIONALE: Gastric mixed adenoneuroendocrine carcinoma (gMANEC) is a rare malignant tumor. Most gMANECs are diagnosed at an...
Related Articles A retroperitoneal cavernous hemangioma arising from the gonadal vein: A case report. Medicine (Baltimore). 2020 Sep 18;99(38):e22325 Authors: Laih CY, Hsieh PF, Chen GH, Chang H, Lin WC, Lai CM, Chang CH Abstract RATIONALE: Cavernous hemangioma (CH) is not commonly found within the abdomen or the retroperitoneum. We report the first case of CH originating from the gonadal vein. DIAGNOSIS: A retroperitoneal tumor was...
Related Articles Right supernumerary kidney with urothelial carcinoma: A case report. Medicine (Baltimore). 2020 Sep 18;99(38):e22329 Authors: Gao X, Xing Q, Luo X, Cao T, Zhang S, Yang F, Fan D, Gao Z, Zhang L, Guo F Abstract RATIONALE: A supernumerary kidney is an extremely rare renal anomaly. Currently, <100 cases are reported in the literature. There are only 2 right unilateral supernumerary kidneys reported in the literature thus far,...
[A Case of Fibroepithelial Polyp that was Difficult to Distinguish from Renal Pelvic Carcinoma]. Hinyokika Kiyo. 2020 Sep;66(9):303-306 Authors: Toyota T, Fukuta F, Shindo T, Tanaka T, Masumori N Abstract A 56-year-old woman presented with left flank pain. Computed tomography revealed hydronephrosis and a 35 mm mass in the left renal pelvis. Ureteroscopy revealed a white elevated lesion in the left renal pelvis. Tissue biopsy was performed...
[A Case of Retroperitoneal Bronchogenic Cyst Successfully Resected with Retroperitoneoscopic Surgery]. Hinyokika Kiyo. 2020 Sep;66(9):307-311 Authors: Tanaka T, Hoshi A, Yamaguchi A, Nonaka H, Nitta S, Kojo K, Nagumo Y, Ikeda A, Matsuoka T, Kimura T, Kandori S, Waku N, Negoro H, Kojima T, Kawai K, Nishiyama H Abstract A 32-year-old woman was referred to our hospital for consultation with a suspected left adrenal tumor detected by ultrasonography...
Malignant phyllodes tumor with extensive lipomatous differentiation. Radiol Case Rep. 2020 Nov;15(11):2401-2405 Authors: Landy J, Johal P, Sevrukov A, Teberian I, Shames J, Sebastiano C, Kaufman T Abstract Phyllodes tumors are uncommon neoplasms of the breast. Lipomatous differentiation of malignant phyllodes tumor is a rare stromal alteration of this fibroepithelial tumor, demonstrated as a fat-containing mass on imaging. We present the case...
Primary vaginal leiomyosarcoma: case report of a rare gynaecological malignancy and diagnostic challenge in a resource-constraint setting. Oxf Med Case Reports. 2020 Sep;2020(9):omaa081 Authors: Okunowo AA, Ugwu AO, Owie E, Kolawole HF, Adebayo LA, Kusamotu OA, Kuku JO, Soibi-Harry AP, Ohazurike EO, Banjo AAF Abstract Primary vaginal leiomyosarcoma (VLMS) is an extremely rare variant of primary vaginal cancers with very poor prognosis irrespective...
Open versus laparoscopic surgery for primary appendiceal tumors: a large multicenter retrospective propensity score-matched cohort study in Japan. Surg Endosc. 2020 Sep 29;: Authors: Inoue A, Murata K, Komori T, Takeda T, Fujii M, Yamaguchi T, Yamaguchi T, Masuishi T, Shiota T, Morita S, Suzuki Y, Ito M, Kanemitsu Y, Shiozawa M, Yasui M, Kagawa Y, Sugihara K, Study Group of Appendiceal Neoplasms from the Japan Society of Colorectal Cancer Research Group ...
Expression of laminin-5 gamma 2 chain predicts invasion of extramammary Paget's disease cell. APMIS. 2020 Sep 29;: Authors: Tohmatsu Y, Imura J, Sakai T, Takagi K, Minamisaka T, Tanaka S, Noguchi A, Nakajima T, Nagata T, Makino T, Shimizu T, Fujii T Abstract Extramammary Paget's disease (EMPD) is a rare malignant skin neoplasm characterized by intraepidermal proliferation of tumor cells. The tumor cells of EMPD may sometimes invade into the...
Cardiac Involvement by Burkitt Lymphoma in a 49-Year-Old Man. Tex Heart Inst J. 2020 Jun 01;47(3):210-212 Authors: Khalid K, Faza N, Lakkis NM, Tabbaa R Abstract Malignant metastases are among the most common cardiac masses. We report a rare case of cardiac involvement by Burkitt lymphoma in a 49-year-old man who presented with a 2-month history of dyspnea and palpitations. A transthoracic echocardiogram revealed 2 intracardiac masses in the...
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Publication date: Available online 30 September 2020Source: Journal of the American College of SurgeonsAuthor(s): John Stirrat, Neeral R. Patel, Stefan F. Stella, Sebastian Mafeld, Chia-Sing Ho, Eran Shlomovitz
Related Articles Scrippsiella acuminata versus Scrippsiella ramonii: A Physiological Comparison. Cytometry A. 2019 09;95(9):985-996 Authors: Fagín E, Bravo I, Garrido JL, Rodríguez F, Figueroa RI Abstract Scrippsiella is a cosmopolitan dinoflagellate genus that is able to form Harmful Algal Blooms in coastal waters. The large physiological, morphological, and genetic variability that characterizes this genus suggest the existence of cryptic...
Related Articles Hypophysitis on immunotherapy with checkpoint inhibitors. J Dtsch Dermatol Ges. 2019 11;17(11):1168-1170 Authors: Jäger IM, Kohlmann J, Simon JC, Sandner B, Tönjes A, Ziemer M PMID: 31701648 [PubMed - indexed for MEDLINE]
Related Articles Targeting survivin sensitizes cervical cancer cells to radiation treatment. Bioengineered. 2020 12;11(1):130-140 Authors: Zhou J, Guo X, Chen W, Wang L, Jin Y Abstract Survivin is an inhibitor of apoptosis protein that functions to inhibit apoptosis, promote proliferation, and enhance invasion. It is selectively up-regulated in many human tumors and implicated in cellular radiation response through its role in apoptosis, cell...
A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway. Mar Drugs. 2020 Sep 27;18(10): Authors: Wang L, Huang Y, Huang CH, Yu JC, Zheng YC, Chen Y, She ZG, Yuan J Abstract Ascomylactam A was reported for the first time as a new 13-membered-ring macrocyclic alkaloid in 2019 from the mangrove endophytic fungus Didymella sp. CYSK-4 from the South China Sea. The aim of...
Photocatalytic reduction and anti-bacterial activity of biosynthesized silver nanoparticles against multi drug resistant Staphylococcus saprophyticus BDUMS 5 (MN310601). Mater Sci Eng C Mater Biol Appl. 2020 Sep;114:111024 Authors: Rajivgandhi GN, Maruthupandy M, Li JL, Dong L, Alharbi NS, Kadaikunnan S, Khaled JM, Alanzi KF, Li WJ Abstract In this study, silver nanoparticles (Ag NPs) was eco-friendly synthesized using purified flavonoid...
Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity. Ther Adv Med Oncol. 2020;12:1758835920947976 Authors: Zhang X, Chen J, Cheng C, Li P, Cai F, Xu H, Lu Y, Cao N, Liu J, Wang J, Hua ZC, Zhuang H Abstract Background: Aspirin has recently emerged as an anticancer drug, but its therapeutic effect on lung cancer has been rarely reported, and the mechanism of...
Anticancer effect of purified polysaccharide from marine clam Donax variabilis on A549 cells. J Food Biochem. 2020 Sep 29;:e13486 Authors: Sahayanathan GJ, Padmanaban D, Raja K, Chinnasamy A Abstract The marine invertebrates are one of the main leads to the derivation of anticancer compounds. The present investigation was to explore the anticancer effect of a potentially active polysaccharide fraction from marine clam Donax variabilis...
Context is key: Understanding the regulation, functional control, and activities of the p53 tumour suppressor. Cell Biochem Funct. 2020 Sep 30;: Authors: Moxley AH, Reisman D Abstract The p53 tumour suppressor is considered one of the most critical genes in cancer biology. By upregulating apoptosis, cell cycle arrest, and DNA damage repair in normal cells, p53 prevents the propagation of cells with tumorigenic potential; therefore, mutations...
Targeting both BET and CBP/EP300 proteins with the novel dual inhibitors NEO2734 and NEO1132 leads to anti-tumor activity in Multiple Myeloma. Eur J Haematol. 2020 Sep 30;: Authors: Ryan KR, Giles F, Morgan GJ Abstract OBJECTIVES: Two promising epigenetic therapeutic targets have emerged for the treatment of hematologic malignancies, BET and CBP/EP300 proteins. Several studies have shown that targeting these individual classes of proteins...
Indole-6-Carboxaldehyde Isolated from Sargassum thunbergii (Mertens) Kuntze Prevents Oxidative Stress-Induced Cellular Damage in V79-4 Chinese Hamster Lung Fibroblasts through the Activation of the Nrf2/HO-1 Signaling Pathway. Cell Physiol Biochem. 2020 Oct 01;54(5):959-974 Authors: Kim SO, Choi YH Abstract BACKGROUND/AIMS: The disruption of redox equilibrium by oxidative stress, which is characterized by an overproduction of reactive...
Ruthenium(II) Phosphine/Mercapto Complexes: Their in Vitro Cytotoxicity Evaluation and Actions as Inhibitors of Topoisomerase and Proteasome Acting as Possible Triggers of Cell Death Induction. Inorg Chem. 2020 Sep 30;: Authors: Ribeiro GH, Guedes APM, de Oliveira TD, de Correia CRSTB, Colina-Vegas L, Lima MA, Nóbrega JA, Cominetti MR, Rocha FV, Ferreira AG, Castellano EE, Teixeira FR, Batista AA Abstract In this paper, a series of new...
Erratum: Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells. Oncol Lett. 2020 Nov;20(5):243 Authors: Xu F, Zhu Y, Lu Y, Yu Z, Zhong J, Li Y, Pan J Abstract [This corrects the article DOI: 10.3892/ol.2018.8006.]. PMID: 32994810 [PubMed]
Optimized algorithm in solid thyroid nodule elastography. Oncol Lett. 2020 Nov;20(5):248 Authors: Wu H, Chen Q, Liu Y, Chen J, Deng W Abstract The present study aimed to evaluate the reproducibility and accuracy of the optimized algorithm of shear-wave elastography (SWE) in diagnosing solid thyroid nodules. Two hundred and sixty-three solid thyroid nodules in 248 patients who underwent conventional ultrasound and SWE, respectively, by two operators...
Metformin regulation of progesterone receptor isoform-B expression in human endometrial cancer cells is glucose-dependent. Oncol Lett. 2020 Nov;20(5):249 Authors: Saguyod SJU, Alhallak I, Simmen RCM, Velarde MC Abstract Metformin (MET) constitutes the first-line treatment against type 2 diabetes. Growing evidence linking insulin resistance and cancer risk has expanded the therapeutic potential of MET to several cancer types. However, the oncostatic...
TUFM-knockdown inhibits the migration and proliferation of gastrointestinal stromal tumor cells. Oncol Lett. 2020 Nov;20(5):250 Authors: Weng X, Zheng S, Shui H, Lin G, Zhou Y Abstract Gastrointestinal stromal tumors (GISTs) are the most common pathologic type of mesenchymal tumor in the digestive tract. Patients with GIST face the risk of metastasis, postoperative recurrence and imatinib mesylate (IM) resistance. Mitochondrial Tu translation...
Brother of regulator of imprinted sites inhibits cisplatin-induced DNA damage in non-small cell lung cancer. Oncol Lett. 2020 Nov;20(5):251 Authors: Zhang Y, Song Y, Li C, Ren J, Fang M, Fang J, Wang X Abstract Cisplatin (DDP) chemotherapy is the primary modality of treatment for non-small cell lung cancer (NSCLC). However, due to the occurrence of DDP resistance, only a limited number of patients benefit from this treatment regimen. Brother...
Two common polymorphic variants of OATP4A1 as potential risk factors for colorectal cancer. Oncol Lett. 2020 Nov;20(5):252 Authors: Buxhofer-Ausch V, Német O, Sheikh M, Andrikovics H, Reiner A, Ausch C, Mechtcheriakova D, Tordai A, Gleiss A, Özvegy-Laczka C, Jäger W, Thalhammer T Abstract Genetic variations in the organic-anion-transporting polypeptide (OATP)-encoding solute carrier of organic anions (SLCO) genes can promote cancer development...
Calcitonin gene-related peptide: A promising bridge between cancer development and cancer-associated pain in oral squamous cell carcinoma. Oncol Lett. 2020 Nov;20(5):253 Authors: Zhang Y, Lin C, Wang X, Ji T Abstract Nerves have been widely demonstrated to exert major effects in tumor-associated microenvironments. Due to the characteristic innervation of the oral cavity and the fact that cancer-associated pain is a distinct feature of oral...
Diagnostic value and clinical significance of circulating miR-650 and CA211 in detecting of gastric carcinoma. Oncol Lett. 2020 Nov;20(5):254 Authors: Chen J, Wu L, Sun Y, Luo C, Chen X, Wu L, Ding J, Pan G, Han C, Wu Z, Shen Y Abstract The present study determined the levels of plasma biomarkers in patients with gastric carcinoma (GC) and investigated their clinical significance and diagnostic value. Between April 2014 and December 2018, 90...
Mammaglobin B may be a prognostic biomarker of uterine corpus endometrial cancer. Oncol Lett. 2020 Nov;20(5):255 Authors: Li J, Xu W, Zhu Y Abstract Mammaglobin B, also referred to as secretoglobin family 2A member 1 (SCGB2A1), has been reported to be highly expressed in uterine corpus endometrial cancer (UCEC) compared with in the normal endometrium. However, the prognostic value of SCGB2A1 in UCEC remains unclear. The Oncomine, The Cancer...
Prognostic value of immune scores in the microenvironment of colorectal cancer. Oncol Lett. 2020 Nov;20(5):256 Authors: Yuan W, Cai W, Huang X, Peng S Abstract Cancer immunotherapy has become an important means of cancer treatment; however, the complex composition and heterogeneity of the colorectal cancer (CRC) microenvironment pose a huge challenge to cancer immunotherapy. Using data downloaded from The Cancer Genome Atlas database, the differences...
CXCL5 expression in tumor tissues is associated with poor prognosis in patients with pancreatic cancer. Oncol Lett. 2020 Nov;20(5):257 Authors: Wu B, Wang J, Wang X, Zhu M, Chen F, Shen Y, Zhong Z Abstract Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic cancer and the influencing factors of the immune microenvironment....
Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer. Oncol Lett. 2020 Nov;20(5):258 Authors: Akagi J, Baba H Abstract As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial...
Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities. World Allergy Organ J. 2020 Sep;13(9):100462 Authors: Crimi C, Campisi R, Cacopardo G, Intravaia R, Nolasco S, Porto M, Pelaia C, Crimi N Abstract Background: Data on mepolizumab in patients with severe eosinophilic asthma (EA) and comorbidities are needed to assess whether randomized controlled trial results are applicable...
Publication date: Available online 1 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Gamze Er Karaoğlu, Zeliha Uğur Aydın, Demet Erdönmez, Cem Göl, Mahmut Durmuş
Publication date: Available online 1 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Shima Afrasiabi, Maryam Pourhajibagher, Nasim Chiniforush, Mahdi Aminian, Samaneh Sadat Rasi Varaei, Abbas Bahador
Publication date: Available online 1 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Jianna Yan, Peiru Wang, Liang Li, Linglin Zhang, Guolong Zhang, Yichen Tang, Xiuli Wang
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Pengfei Zhao, Xiuxiu Song, Lulingxiao Nie, Qian Wang, Peng Zhang, Yi Ding, Qi Wang
Publication date: October 2020Source: Journal of Human Evolution, Volume 147Author(s):
Systematic review on infection and disease caused by Thelazia callipaeda in Europe: 2001-2020. Parasite. 2020;27:52 Authors: do Vale B, Lopes AP, da Conceição Fontes M, Silvestre M, Cardoso L, Coelho AC Abstract Cases of thelaziosis by Thelazia callipaeda have been increasing considerably in Europe throughout the 21st century, with recent emphasis on Eastern Europe. A systematic review was conducted using defined search terms across three...
Figure 1.
To the Editor: The standard care for chronic spontaneous urticaria includes second-generation H1-antihistamines, but such treatment is often ineffective, even with four times the dose recommended by the Food and Drug Administration. Urticarial lesions are characterized pathologically by increased…
[Liquid biopsy-a possible key player in immuno-oncology]. HNO. 2020 Sep 29;: Authors: Wallesch M, Wirth M, Wollenberg B Abstract BACKGROUND: Clinical application of immune checkpoint inhibitors (ICI), whether as monotherapy or in combination with established methods, is revolutionizing treatment of head and neck cancer. However, this change in therapeutic concepts requires reevaluation and further development of predictive and prognostic...
[Dorsal preservation septorhinoplasty]. HNO. 2020 Sep 29;: Authors: Kovacevic M, Buttler E, Haack S, Riedel F, Veit JA Abstract BACKGROUND: Nasal dorsum deprojection is a very important tool in functional and aesthetic rhinoplasty. In classic techniques, resection of dorsal bone and cartilage renders dorsal reconstruction necessary. The concept of dorsal preservation rhinoplasty has been known for more than a century but has experienced...
[The microbiome in head and neck tumors-initial findings and outlook]. HNO. 2020 Sep 29;: Authors: Lang S, Brandau S, Marchesi JR, Jablonska J, Thurnher D, Mattheis S, Buer J, Hussain T Abstract Technical progress in molecular biology has allowed for a more detailed analysis of the composition of the human microbiome in recent years. Inter- and intraindividual differences in microbiome composition have been demonstrated, which in part...
[Accreditation and certification of skull base centres in Germany by the German Society for Skull Base Surgery (Gesellschaft für Schädelbasischirurgie, GSB). German version]. HNO. 2020 Sep 30;: Authors: Schipper J, Schaumann K, Gerlach R, Reinert S, Schramm A, Schwager K Abstract The German Society for Skull Base Surgery (Gesellschaft für Schädelbasischirurgie, GSB) has developed a protocol for the certification of GSB skull base centres....
Do increased risks of cancer mean we need to change our approach to treatment? J Dermatolog Treat. 2020 Sep 30;:1-4 Authors: Senthilnathan A, Feldman SR PMID: 32997562 [PubMed - as supplied by publisher]
Ceftobiprole and pneumonia in adults admitted to the emergency department is it time to assess a new therapeutic algorithm? J Chemother. 2020 Sep 30;:1-6 Authors: Crapis M, Venturini S, Della Siega P, Tonizzo M, Garlatti E, Rosa R, Basso B, Pontoni E Abstract OBJECTIVE: Ceftobiprole is an advance generation cephalosporin which has broad-spectrum bacterial activity (both against Gram-positive and negative pathogens) and was approved for the...
Epidemiology and risk factors for healthcare-associated infections caused by Pseudomonas aeruginosa.
Epidemiology and risk factors for healthcare-associated infections caused by Pseudomonas aeruginosa. J Chemother. 2020 Sep 30;:1-8 Authors: Folic MM, Djordjevic Z, Folic N, Radojevic MZ, Jankovic SM Abstract Pseudomonas aeruginosa (PA) is a globally recognized cause of healthcare-associated infections (HAIs). The aim of our cross-sectional study, conducted in a Serbian tertiary care hospital, was to investigate clinical characteristics of HAIs...
Related Articles Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2019 09;16(9):e17-e32 Authors: Ruhl AP, Sadreameli SC, Allen JL, Bennett DP, Campbell AD, Coates TD, Diallo DA, Field JJ, Fiorino EK, Gladwin MT, Glassberg JA, Gordeuk VR, Graham LM, Greenough A, Howard J, Kato GJ, Knight-Madden J, Kopp BT, Koumbourlis AC, Lanzkron SM, Liem RI, Machado RF, Mehari...
Related Articles Atypical Electrocardiographic Changes on Polysomnogram. Ann Am Thorac Soc. 2019 09;16(9):1192-1194 Authors: Kim DE, Hefter G, Jun JC PMID: 31469314 [PubMed - indexed for MEDLINE]
Related Articles Associated syndromes in patients with Pierre Robin Sequence. Int J Pediatr Otorhinolaryngol. 2020 Apr;131:109842 Authors: Karempelis P, Hagen M, Morrell N, Roby BB Abstract OBJECTIVES: Classically, Pierre Robin Sequence (PRS) is a triad of micrognathia, glossoptosis, and airway obstruction, although frequently associated with cleft palate. Current literature reports that Stickler syndrome is the most common syndrome associated...
Polysomnography and Nocturia Evaluations after Uvulopalatopharyngoplasty for Obstructive Sleep Apnea Syndrome. J Clin Med. 2020 Sep 25;9(10): Authors: Tsou YA, Chou EC, Shie DY, Lee MJ, Chang WD Abstract A higher incidence rate of nocturia in patients with obstructive sleep apnea (OSA) has been observed. We investigated the differences in clinical examinations between OSA patients with and without nocturia, and further compared those with successful...
[Relationship between cognitive impairment and sleep-related respiratory indexes in patients with obstructive sleep apnea]. Zhonghua Yi Xue Za Zhi. 2020 Oct 13;100(37):2929-2933 Authors: Chen HD, Wang J, Wang XS, Yao XB, Wu XF, Wu JL, Huang GP Abstract Objectives: To investigate the cognitive impairment in patients with obstructive sleep apnea (OSA), and it's relationship with sleep-related respiratory indexes. Methods: A total of 126 patients...
[Clinical features of patients with hypertrophic obstructive cardiomyopathy combining obstructive sleep apnea]. Zhonghua Yi Xue Za Zhi. 2020 Oct 13;100(37):2934-2939 Authors: Wang J, Xu HB, Zhang HP, Cui JG, Hu FH, Yang WX, Yuan JS, Liu R, Qiao SB, Guo C, Luo XL Abstract Objective: To investigate the clinical features of patients with hypertrophic obstructive cardiomyopathy (HOCM) combined with obstructive sleep apnea (OSA). Methods: From 2010...
Impact of weight loss predictors in severe-morbid obesity patients in the Saudi population. Saudi J Biol Sci. 2020 Oct;27(10):2509-2513 Authors: Al-Nbaheen MS Abstract Universally, obesity has been affected more than 650 million and converts as global health problem. Obesity is equally affecting starting from children to elder population. Obese subjects are converting into severe obese and then into morbid obesity. Body mass index is proning...
Non-traditional risk factors and the risk of myocardial infarction in the young in the US population-based cohort. Int J Cardiol Heart Vasc. 2020 Oct;30:100634 Authors: Krittanawong C, Liu Y, Mahtta D, Narasimhan B, Wang Z, Jneid H, Tamis-Holland JE, Mahboob A, Baber U, Mehran R, Wilson Tang WH, Ballantyne CM, Virani SS Abstract Although most prevalent in elderly, myocardial infarction (MI) also affects younger adults. We sought to investigate...
OSA in patients with head and neck cancer is associated with cancer size and oncologic outcome. Eur Arch Otorhinolaryngol. 2020 Sep 29;: Authors: Huppertz T, Horstmann V, Scharnow C, Ruckes C, Bahr K, Matthias C, Gouveris H Abstract PURPOSE: Obstructive sleep apnea (OSA) is associated with severe daytime sleepiness and reduced quality of life. These symptoms are also present in patients with squamous cell carcinoma of the head and neck (SCCHN)...
The Economic Burden of Comorbid Obstructive Sleep Apnea Among Patients with Chronic Obstructive Pulmonary Disease. J Manag Care Spec Pharm. 2020 Oct;26(10):1353-1362 Authors: Hong YD, Onukwugha E, Slejko JF Abstract BACKGROUND: Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on patients and the health care system. The presence of comorbid obstructive sleep apnea (OSA) has been shown to increase the risk of morbidity...
The predictive value of photogrammetry for obstructive sleep apnea. J Clin Sleep Med. 2020 Sep 30;: Authors: He S, Li Y, Xu W, Kang D, Li H, Wang C, Ding X, Han D Abstract STUDY OBJECTIVES: The aim of this study was to develop a prediction model for obstructive sleep apnea (OSA) based on photographic measurements of upper airway structures and to compare this to the model based on general physical examination. METHODS: Participants...
Mechanisms of intermittent hypoxia-mediated macrophage activation - potential therapeutic targets for obstructive sleep apnoea. J Sleep Res. 2020 Sep 30;:e13202 Authors: Fitzpatrick SF, King AD, O'Donnell C, Roche HM, Ryan S Abstract Intermittent hypoxia (IH) plays a key role in the pathogenesis of insulin resistance (IR) in obstructive sleep apnoea (OSA). IH induces a pro-inflammatory phenotype of the adipose tissue with M1 macrophage polarisation,...
Prevalence of chronic insomnia in patients with obstructive sleep apnea. Braz J Psychiatry. 2020 Sep 28;: Authors: Stelzer FG, Garcia E, Schorr F, Barea LM, Barros HT Abstract OBJECTIVES: To investigate the prevalence of and factors associated with chronic insomnia and obstructive sleep apnea (CIOSA) comorbidity in obstructive sleep apnea (OSA) patients. METHODS: Between March 2014 and March 2015, we conducted a prospective, cross-sectional...
The European Portuguese version of the insomnia severity index. J Sleep Res. 2020 Sep 30;:e13198 Authors: Clemente V, Ruivo Marques D, Miller-Mendes M, Morin C, Serra J, Allen Gomes A Abstract Insomnia is the most prevalent sleep complaint, but remains largely an unidentified public health issue. The Insomnia Severity Index (ISI) is a brief self-report questionnaire to assess insomnia, long-established both in clinical and research settings....
Detection and Classification of Sleep Apnea and Hypopnea using PPG and SpO2 signals. IEEE Trans Biomed Eng. 2020 Sep 30;PP: Authors: Lazazzera R, Deviaene M, Varon C, Buyse B, Testelmans D, Laguna P, Gil E, Carrault G Abstract In this work, a detection and classification method for sleep apnea and hypopnea, using photopletysmography (PPG) and peripheral oxygen saturation ( SpO2) signals, is proposed. The detector consists of two parts: one...
Should compulsive sexual behavior (CSB) be considered as a behavioral addiction? A debate paper presenting the opposing view. J Behav Addict. 2020 Sep 29;: Authors: Sassover E, Weinstein A Abstract Background and aims: Compulsive sexual behavior disorder (CSBD) has been a long debated issue. While formerly the discussion was about whether to regard CSBD as a distinctive disorder, the current debate is dealing with the classification of this...
Publication date: Available online 30 September 2020Source: CortexAuthor(s): Mante S. Nieuwland, Yana Arkhipova, Pablo Rodríguez-Gómez
Publication date: Available online 30 September 2020Source: CortexAuthor(s): Xiaodong Liu, Luc Vermeylen, David Wisniewski, Marc Brysbaert
Publication date: Available online 30 September 2020Source: CortexAuthor(s): Carlotta Lega, Elisa Santandrea, Oscar Ferrante, Rossana Serpe, Carola Dolci, Eleonora Baldini, Luigi Cattaneo, Leonardo Chelazzi
Publication date: Available online 1 October 2020Source: CortexAuthor(s): Daniel Wiesen, Hans-Otto Karnath, Christoph Sperber
Scientists have challenged a popular theory behind the evolution of similar traits in island lizards.
Leishmaniasis is a neglected tropical disease caused by an intracellular parasite of the genus Leishmania. Damage-associated molecular patterns (DAMPs) such as UTP and ATP are released from infected cells and, once in the extracellular medium, activate P2 purinergic receptors. P2Y2 and P2X7 receptors cooperate to control Leishmania amazonensis infection. NLRP3 inflammasome activation and IL-1β release resulting from P2X7 activation are important for outcomes of L. amazonensis infection. The cytokine...
Disrupted immune response is an important feature of many neurodegenerative conditions, including sepsis-associated cognitive impairment. Accumulating evidence has demonstrated that immune memory occurs in microglia, which has a significant impact on pathological hallmarks of neurological diseases. However, it remains unclear whether immune memory can cause subsequent alterations in the brain immune response and affect neurobehavioral outcomes in sepsis survivors. In the present study, mice received...
Related Articles Metastatic Breast Cancer: TIL it is Too Late. Clin Cancer Res. 2020 02 01;26(3):526-528 Authors: Savas P, Loi S Abstract Paired analysis of primary and metastatic triple-negative breast cancers shows that metastatic disease is an immunodepleted state. This understanding has important implications for targeting the immune microenvironment in breast cancer, placing a greater emphasis on earlier stage disease and shaping future...
Mitoxantrone-Loaded Nanoparticles for Magnetically Controlled Tumor Therapy-Induction of Tumor Cell Death, Release of Danger Signals and Activation of Immune Cells. Pharmaceutics. 2020 Sep 27;12(10): Authors: Ratschker T, Egenberger L, Alev M, Zschiesche L, Band J, Schreiber E, Frey B, Derer A, Alexiou C, Janko C Abstract Stimulating the patient`s immune system represents a promising therapeutic strategy to fight cancer. However, low immunogenicity...
Employment status and information needs of patients with breast cancer: a multicentre cross-sectional study of first oncology consultations. BMJ Open. 2020 Sep 29;10(9):e038543 Authors: Mazzi MA, Perlini C, Deledda G, Ghilardi A, Buizza C, Bottacini A, Goss C, Del Piccolo L Abstract OBJECTIVES: To investigate the early information needs of women with a recent diagnosis of breast cancer (BC) according to their employment status. DESIGN:...
Daily Physical Activity and Symptom Reporting in Breast Cancer Patients Undergoing Chemotherapy: An Intensive Longitudinal Examination. Cancer Epidemiol Biomarkers Prev. 2020 Sep 29;: Authors: Phillips SM, Welch WA, Fanning J, Santa-Maria CA, Gavin KL, Auster-Gussman LA, Solk P, Lu M, Cullather E, Khan SA, Kulkarni SA, Gradishar W, Siddique J Abstract BACKGROUND: Increased activity is beneficial during chemotherapy, but treatment-related symptoms...
Efficacy of stress management program for depressive patients with advanced head and neck cancer: A single-center pilot study. Int J Clin Health Psychol. 2020 Sep-Dec;20(3):213-221 Authors: Ichikura K, Nakayama N, Matsuoka S, Ariizumi Y, Sumi T, Sugimoto T, Fukase Y, Murayama N, Tagaya H, Asakage T, Matsushima E Abstract Background/Objective: Patients with head and neck cancer (HNC) have some problems such as dysfunction of breathing, eating,...
Artificial intelligence (AI) and big data in cancer and precision oncology. Comput Struct Biotechnol J. 2020;18:2300-2311 Authors: Dlamini Z, Francies FZ, Hull R, Marima R Abstract Artificial intelligence (AI) and machine learning have significantly influenced many facets of the healthcare sector. Advancement in technology has paved the way for analysis of big datasets in a cost- and time-effective manner. Clinical oncology and research are...
Vape shop owners'/managers' attitudes about CBD, THC, and marijuana legal markets. Prev Med Rep. 2020 Dec;20:101208 Authors: Berg CJ, Getachew B, Pulvers K, Sussman S, Wagener TL, Meyers C, Park A, Dorvil S, Patterson A, Weber A, Hayes RB, Barker DC, Henriksen L Abstract Over the past decade in the US there have been marked pivotal changes in the policy and retail environment regarding cannabinoids, particularly cannabidiol (CBD) and delta-9-tetrahydrocannabinol...
Blood supply sufficiency and safety management in Iran during the COVID-19 outbreak. Vox Sang. 2020 Sep 30;: Authors: Maghsudlu M, Eshghi P, Amini Kafi-Abad S, Sedaghat A, Ranjbaran H, Mohammadi S, Tabatabai SM Abstract BACKGROUND: COVID-19 first appeared in Iran on 19 February 2020, and then spread rapidly over the country. In this article, we review the action plan of the Iranian Blood Transfusion Organization with respect to this disease....
Development of a prognostic model based on an immunogenomic landscape analysis of colorectal cancer.
Development of a prognostic model based on an immunogenomic landscape analysis of colorectal cancer. Future Oncol. 2020 Sep 30;: Authors: Li HJ, Wang YL, Ming L, Guo XQ, Li YL, Wang JC, Zhang YQ, Cheng L Abstract Screening and therapeutic programs for colorectal cancer (CRC) are invasive or not effective and unable to meet patient needs. Major advances in immunogenomics may change this status but need more exploration. Differentially expressed...
Healthcare utilization and total costs of care among patients with advanced metastatic gastric and esophageal cancer. Future Oncol. 2020 Sep 30;: Authors: Abraham P, Wang L, Jiang Z, Gricar J, Tan H, Kelly RJ Abstract Aim: Study first-line (1L) treatment patterns and economic outcomes among patients with advanced metastatic gastric cancer (GC) and esophageal cancer (EC). Materials & methods: Newly diagnosed patients with systemic GC and...
Randomized Clinical Trial of a Legacy Intervention for Quality of Life in Children with Advanced Cancer. J Palliat Med. 2020 Sep 30;: Authors: Akard TF, Dietrich MS, Friedman DL, Wray S, Gerhardt CA, Hendricks-Ferguson V, Hinds PS, Rhoten B, Gilmer MJ Abstract Background: Legacy-making (actions/behaviors aimed at being remembered) may be a significant component for quality of life (QOL) during advanced illness and end of life. Although legacy...
Changes in serum PSA after endoscopic enucleation of the prostate are predictive for the future diagnosis of prostate cancer. World J Urol. 2020 Sep 30;: Authors: Lambert E, Goossens M, Palagonia E, Vollemaere J, Mazzone E, Dell'Oglio P, Pauwels E, De Groote R, D'Hondt F, Mottrie A, De Naeyer G, Schatteman P Abstract PURPOSE: After Endoscopic Enucleation of the Prostate (EEP) for benign prostatic obstruction (BPO), men remain at risk for prostate...
Delivering Cancer Care During the COVID-19 Pandemic: Recommendations and Lessons Learned From ASCO Global Webinars. JCO Glob Oncol. 2020 Sep;6:1461-1471 Authors: Jazieh AR, Chan SL, Curigliano G, Dickson N, Eaton V, Garcia-Foncillas J, Gilmore T, Horn L, Kerr DJ, Lee J, Mathias C, Nogueira-Rodrigues A, Pierce L, Rogado A, Schilsky RL, Soria JC, Warner JL, Yoshida K Abstract PURPOSE: In response to the COVID-19 pandemic, the ASCO launched a...
Telemedicine in Oncology and Reimbursement Policy During COVID-19 and Beyond. J Natl Compr Canc Netw. 2020 Sep 30;:1-7 Authors: Kircher SM, Mulcahy M, Kalyan A, Weldon CB, Trosman JR, Benson AB Abstract The first confirmed case of coronavirus disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of September 17, 2020, there were more than 6.6 million confirmed cases and 196,277 deaths. Limited data are available...
Improving peri-operative psychosocial interventions for children with autism spectrum disorder undergoing ENT procedures. J Laryngol Otol. 2020 Sep 30;:1-7 Authors: Fahy R, Corbett M, Keogh I Abstract OBJECTIVES: Children with autism spectrum disorder face a broad range of communication and sensory challenges. Many of these children also have chronic ENT issues. This study aims to better understand these challenges and improve our services...
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10138
Related Articles Insights into the natural history of spontaneous intracranial hypotension from infusion testing. Neurology. 2020 07 21;95(3):e247-e255 Authors: Häni L, Fung C, Jesse CM, Ulrich CT, Miesbach T, Cipriani DR, Dobrocky T, Z'Graggen WJ, Raabe A, Piechowiak EI, Beck J Abstract OBJECTIVE: To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and on the...
Soft Robotics, Ahead of Print.
Soft Robotics, Ahead of Print.
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